AutismKB 2.0

Annotation Detail for HOXD4


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Basic Information Top
Gene Symbol:HOXD4 ( HHO.C13,HOX-5.1,HOX4,HOX4B,Hox-4.2 )
Gene Full Name: homeobox D4
Band: 2q31.1
Quick LinksEntrez ID:3233; OMIM: 142981; Uniprot ID:HXD4_HUMAN; ENSEMBL ID: ENSG00000170166; HGNC ID: 5138
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Leukemia, acute lymphoblastic, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of HOXD4 mRNAincreases expression 15073043
D009151 Mustard Gas Mustard Gas results in increased expression of HOXD4 mRNAincreases expression 15674843
D014212 Tretinoin Tretinoin promotes the reaction [YY1 protein binds to HOXD4 promoter]affects binding|increases reaction 16757478
D014212 Tretinoin Tretinoin results in increased expression of HOXD4 mRNAincreases expression 19897914
16757478
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3619825857 11798837
MESH:D000505 Alopecia Tretinoin 3.9815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.3216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3416292516
MESH:D001249 Asthma Mustard Gas 5.3310378619
MESH:D001249 Asthma Tretinoin 5.3316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.9916935849
MESH:D001768 Blister Mustard Gas 5.9019167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.8216206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.8216197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2316873071 16443354 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.9015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.8417687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.3316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.8611589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 6.0316168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.2315073043 14691202 15553829 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.231917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.7419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5712490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3816096774 16051514
MESH:D002386 Cataract Tretinoin 3.3217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.3316129372
MESH:D002822 Choriocarcinoma Tretinoin 6.0316461808
MESH:D002972 Cleft Palate Tretinoin 2.819407595
MESH:D003092 Colitis Tretinoin 4.3517035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8720501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.7712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7710525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.778800419 16925845 9125849 10589399 14991402 17551590 9211117 9142499 9664655 9224671
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.6315213294
MESH:D004487 Edema Mustard Gas 3.789260866 11428631 11428647 11402378
MESH:D004489 Edema, Cardiac Tretinoin 5.3318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3716569247
MESH:D004890 Erythema Mustard Gas 5.909357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3912903497
MESH:D005124 Eye Abnormalities Tretinoin 3.909664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 3.7715073043
MESH:D005355 Fibrosis Tretinoin 4.1617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.8516904648
MESH:D005909 Glioblastoma Tretinoin 3.2717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 6.0316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0914991402 9664655
MESH:D006930 Hyperalgesia Tretinoin 3.5716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.2216778211
MESH:D007249 Inflammation Mustard Gas 2.9811428647 17524151 16001271 9260866 11402378 8975870 9357497 11428620 11428631
MESH:D007410 Intestinal Diseases Tretinoin 4.4217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3917551590 15992940
MESH:D007938 Leukemia arsenic trioxide 6.9615070760
MESH:D007938 Leukemia Tretinoin 6.9617143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 5.0516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 11.1319077051
MESH:D007951 Leukemia, Myeloid Tretinoin 11.1316482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0816467208 20471514 19850784 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0817596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.5417869043 19035177 15622746 15213294 12018890 17712046 15336539 17649720 16966277 12712474 17217047 17107899 16331271 16891316 16330433 19642359 11161223 19075265 19225113 11468182 12679006 16112521 15748426 9834237 16823087
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.549834237 17301526 19035177 16766008 16891316 16935935 17361223 19225113 17107899 16140955 16823087 17368321 16788101 15748426 17712046 19029980 19075265 17506722 17339181 17217047 17649720 16331271 17294898 12679006 19642359
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.9416882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.629224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4714682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9820377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6915213294
MESH:D008171 Lung Diseases Mustard Gas 3.7318702808 18161513
MESH:D008175 Lung Neoplasms arsenic trioxide 2.7319825857 11798837
MESH:D008175 Lung Neoplasms Mustard Gas 2.733148597 8781369
MESH:D008527 Medulloblastoma Tretinoin 2.9217453147
MESH:D008545 Melanoma Tretinoin 1.9916752155
MESH:D008591 Meningomyelocele Tretinoin 5.0816940565
MESH:D009101 Multiple Myeloma arsenic trioxide 3.4119417148 19549372 14977855 15949261 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 8.1316882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.1317596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.5416624393
MESH:D009369 Neoplasms Tretinoin 2.5916594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.369125849
MESH:D009436 Neural Tube Defects arsenic trioxide 8.2010525206
MESH:D009436 Neural Tube Defects Tretinoin 8.209142499
MESH:D009503 Neutropenia Mustard Gas 4.507688884 16761898
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2316624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2316936753
MESH:D010146 Pain Tretinoin 3.2816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.7115580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.7115976015
MESH:D010235 Paraganglioma arsenic trioxide 4.6919927285
MESH:D011041 Poisoning Mustard Gas 4.3215727166
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma marker/mechanism
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2019131511
MESH:D011507 Proteinuria Tretinoin 4.1316636307
MESH:D011537 Pruritus Mustard Gas 4.8318058305
MESH:D011625 Pterygium Tretinoin 5.5416723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0617720292 17266442 17620002 17894541 10334151
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.6316116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.5416646077
MESH:D012871 Skin Diseases Mustard Gas 2.8012880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tretinoin 2.7816467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5417007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.5417261132
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.3719014326
MESH:D013964 Thyroid Neoplasms Tretinoin 8.3717045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.2416051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.7015213294
MESH:D014376 Tuberculosis Tretinoin 3.4716040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6120435036 12845720 11780464 12973940
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.1216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.4816752155
MESH:D014820 Vitiligo Tretinoin 4.6416761959
MESH:D009396 Wilms Tumor Tretinoin 4.3916287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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