AutismKB 2.0

Annotation Detail for HOXD10


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HOXD10 ( HOX4,HOX4D,HOX4E,Hox-4.4 )
Gene Full Name: homeobox D10
Band: 2q31.1
Quick LinksEntrez ID:3236; OMIM: 142984; Uniprot ID:HXD10_HUMAN; ENSEMBL ID: ENSG00000128710; HGNC ID: 5133
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1726Charcot-Marie-Tooth disease
Desease Name
talipes equinovarus
DEVELOPMENTAL
No data
Desease Name
Vertical talus, congenital
Charcot-Marie-Tooth disease, foot deformity of
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004041 Dietary Fats Dietary Fats results in increased expression of HOXD10 mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of HOXD10 mRNAincreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HOXD10 mRNAincreases expression 17101203
D014635 Valproic Acid Valproic Acid results in increased expression of HOXD10 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.5015322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 10.508875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3519490988
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000550 Amblyopia Valproic Acid 5.9617688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.9017497229
MESH:D001161 Arteriosclerosis Dietary Fats 4.4515238619
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 17568789
MESH:D001321 Autistic Disorder Valproic Acid 1.9818396377 17507914 17157402 20603192 16609825 18316065 18940202 18558336 18177632 15238991 19232924 18985861 17688650 18775368 19460635
MESH:D001714 Bipolar Disorder Valproic Acid 3.2420046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.8015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.808888407
MESH:D001943 Breast Neoplasms Dietary Fats 1.9520435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618670907 16120746 18850075
MESH:D002607 Charcot-Marie-Tooth Disease marker/mechanism
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2415668235 15340226 12621046 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5617688650 8888407 16575769
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.081733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D050171 Dyslipidemias Dietary Fats 3.7318367378
MESH:D004421 Dystonia Valproic Acid 4.511851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.7117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.643922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.1120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.967562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.693659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Dietary Fats 9.3418296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Valproic Acid 9.3419224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005315 Fetal Diseases Valproic Acid 5.6116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.648888407 18558336
MESH:D005355 Fibrosis Dietary Fats 10.5618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.5620067830
MESH:D005532 Foot Deformities, Congenital marker/mechanism
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 12621046 16120746
MESH:D006849 Hydrocephalus Valproic Acid 5.5017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7715340226 18606429 8697196 16959395 16354765
MESH:D006937 Hypercholesterolemia Dietary Fats 4.0221332399
MESH:D006949 Hyperlipidemias Dietary Fats 4.0821332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218850075 18670907
MESH:D007249 Inflammation Dietary Fats 5.5220412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5212878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.3411836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.2016294345 17596541
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0718296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D038061 Lower Extremity Deformities, Congenital marker/mechanism 9409668
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.9817228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008881 Migraine Disorders Valproic Acid 3.4718803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.458888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.3716359493 8888407
MESH:D009765 Obesity Dietary Fats 2.3621332399 16723640 17217161 11836018 18674790 18457598 20518802 19632207 20132043
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.6611399792 11222880 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 11.6620603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.2612752131 11422049
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.6419155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9914763951 11738929 1511512 15475178 3137016 17978042 11044598 16876388
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0919490988
MESH:D013226 Status Epilepticus Valproic Acid 5.2612833885
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.9617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.153119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.208888407
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:C536345 Vertical talus, congenital marker/mechanism
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
MESH:D015430 Weight Gain Dietary Fats 4.1116723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved