AutismKB 2.0

Annotation Detail for HOXD13


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Basic Information Top
Gene Symbol:HOXD13 ( BDE,BDSD,HOX4I,SPD )
Gene Full Name: homeobox D13
Band: 2q31.1
Quick LinksEntrez ID:3239; OMIM: 142989; Uniprot ID:HXD13_HUMAN; ENSEMBL ID: ENSG00000128714; HGNC ID: 5136
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
2051Leukemia
Desease Name
cryptochidism
talipes equinovarus
DEVELOPMENTAL
No data
Desease Name
Brachydactyly, type D
Brachydactyly, type E
VACTERL association
Synpolydactyly with foot anomalies
Brachydactyly-syndactyly syndrome
Synpolydactyly, type II
Syndactyly, type V
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D005031 Ethylenethiourea Ethylenethiourea results in decreased expression of HOXD13 mRNAdecreases expression 18082712
17161201
D013739 Testosterone Testosterone affects the expression of HOXD13 mRNAaffects expression 17138648
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HOXD13 mRNAdecreases expression 19897914
17035482
D014212 Tretinoin Tretinoin results in increased expression of HOXD13 mRNAincreases expression 1673231
1672266
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of HOXD13 mRNAincreases expression 17982090
D014635 Valproic Acid Valproic Acid results in increased expression of HOXD13 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.9015322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.908875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000230 Adenocarcinoma Ethylenethiourea 3.957955072
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000987 Antisocial Personality Disorder Testosterone 6.387506515
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 17568789
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001321 Autistic Disorder Valproic Acid 1.9918558336 20603192 18316065 18940202 15238991 18775368 17507914 19460635 18985861 16609825 18396377 17157402 17688650 19232924 18177632
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.2120046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.0416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.6515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.658888407
OMIM:610713 BRACHYDACTYLY-SYNDACTYLY SYNDROME marker/mechanism
OMIM:113200 BRACHYDACTYLY, TYPE D marker/mechanism
OMIM:113300 BRACHYDACTYLY, TYPE E1 marker/mechanism
MESH:D001943 Breast Neoplasms Testosterone 1.9817261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9816443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.911917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3616096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002659 Child Development Disorders, Pervasive Testosterone 6.5820678186
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 6.5820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1315340226 16354765 8697196 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 6.139407595
MESH:D003092 Colitis Tretinoin 11.2117035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 11.2116782535 17991707 16804969 18023891 16474422 16867261 18200517 17936198 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5317276891
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.919211117 16925845 9142499 17551590 9125849 10589399 8800419 9664655 9224671 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9117688650 16575769 8888407
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.021733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.7415322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 13.7418230668
MESH:D016889 Endometrial Neoplasms Ethylenethiourea 8.727955072
MESH:D016889 Endometrial Neoplasms Tretinoin 8.7216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.573659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.4416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0718234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.877562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.6116938888 9664655
MESH:D005234 Fatty Liver Valproic Acid 3.6219224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.4620067830
MESH:D005355 Fibrosis Tretinoin 17.4617994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 17.4617994277
MESH:D005391 Firesetting Behavior Testosterone 6.387506515
MESH:D005909 Glioblastoma Testosterone 8.1417162496
MESH:D005909 Glioblastoma Tretinoin 8.1417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 7.0214991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006628 Hirsutism Testosterone 6.1717019078
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D017588 Hyperandrogenism Testosterone 5.8317019078
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007006 Hypogonadism Testosterone 4.7912002444
MESH:D007018 Hypopituitarism Testosterone 6.7217426086
MESH:D007174 Impulse Control Disorders Testosterone 6.387506515
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.6818200517
MESH:D007410 Intestinal Diseases Tretinoin 11.4217994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 11.4217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 11.0416580747
MESH:D007569 Jaw Abnormalities Tretinoin 11.0415992940 17551590
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0419850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0416294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3416140955 19035177 16331271 17712046 15748426 17107899 17301526 16891316 19029980 9834237 16935935 19642359 19225113 17649720 16766008 19075265 17506722 17339181 17368321 17361223 17217047 17294898 16823087 12679006 16788101
MESH:D017880 Limb Deformities, Congenital marker/mechanism 8620844
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3816248980 18397230
MESH:D008113 Liver Neoplasms Ethylenethiourea 5.3611940454
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 5.3616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D008881 Migraine Disorders Valproic Acid 3.4118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.9317596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.9317596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms Tretinoin 2.5416594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.8114600291
MESH:D009421 Nervous System Malformations Tretinoin 10.819125849
MESH:D009436 Neural Tube Defects Tretinoin 7.959142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.9516359493 8888407
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5515976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.5517698068
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.0511118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 11.0520603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 5.3820887781
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D019310 Pseudolymphoma Valproic Acid 5.0612752131 11422049
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 12.0616116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 12.0619155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9414763951 17978042 1511512 16876388 11044598 11738929 3137016 15475178
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 6.7216631401
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9916192470
MESH:D012878 Skin Neoplasms Tretinoin 5.9916467112
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:C538155 Syndactyly, type v marker/mechanism
OMIM:186000 SYNPOLYDACTYLY 1 marker/mechanism
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Ethylenethiourea 8.6111940454
MESH:D013964 Thyroid Neoplasms Tretinoin 8.6117045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:C536534 VATER association marker/mechanism 19006232
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29410
    • No data
    Releated disease ID Related disease Name
    PA445788Syndactyly
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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