AutismKB 2.0

Annotation Detail for APCS


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:APCS ( MGC88159,PTX2,SAP )
Gene Full Name: amyloid P component, serum
Band: 1q23.2
Quick LinksEntrez ID:325; OMIM: 104770; Uniprot ID:SAMP_HUMAN; ENSEMBL ID: ENSG00000132703; HGNC ID: 584
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1818Systemic scleroderma
1918Atherosclerosis
1963Amyloidosis
2166Influenza
No data
No data
Desease Name
Amyloidosis, secondary, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of APCS mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of APCS mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of APCS proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of APCS mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of APCS mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of APCS mRNAaffects expression 19483382
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APCS mRNAaffects cotreatment|decreases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of APCS mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of APCS mRNAincreases expression 15963578
C019304 ciprofibrate ciprofibrate results in increased expression of APCS mRNAincreases expression 12771043
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in decreased expression of APCS mRNA]affects reaction|decreases expression 17585979
D002994 Clofibrate Clofibrate affects the expression of APCS mRNAaffects expression 19483382
D002995 Clofibric Acid Clofibric Acid affects the expression of APCS mRNAaffects expression 17602206
C030123 coumarin coumarin results in decreased expression of APCS mRNAdecreases expression 18480146
D016572 Cyclosporine Cyclosporine results in decreased expression of APCS mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APCS mRNAaffects cotreatment|decreases expression 18164116
D004958 Estradiol Estradiol results in decreased expression of APCS mRNAdecreases expression 20106945
D005001 Ethionine Ethionine affects the expression of APCS mRNAaffects expression 19483382
C056933 fumonisin B1 fumonisin B1 results in decreased expression of APCS mRNAdecreases expression 16221962
D007657 Ketone Bodies Ketone Bodies results in decreased expression of APCS mRNAdecreases expression 16807920
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of APCS proteinincreases expression 9205823
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of APCS mRNAincreases expression 17321000
D009151 Mustard Gas Mustard Gas results in increased expression of APCS proteinincreases expression 11428626
C042763 olive oil olive oil analog affects the expression of APCS mRNAaffects expression 17349074
D009853 Omeprazole Omeprazole affects the expression of APCS mRNAaffects expression 19483382
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of APCS mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of APCS mRNA]decreases expression|increases reaction 18467677
D010634 Phenobarbital Phenobarbital results in increased expression of APCS mRNAincreases expression 19363144
C006253 pirinixic acid pirinixic acid results in decreased expression of APCS mRNAdecreases expression 20059764
17321000
16221962
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in decreased expression of APCS mRNA]affects reaction|decreases expression 17321000
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of APCS mRNA]decreases expression|increases reaction 20059764
C006253 pirinixic acid pirinixic acid affects the expression of APCS mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of APCS mRNAaffects expression 19483382
C030984 pyrene pyrene results in increased expression of APCS mRNAincreases expression 15963578
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of APCS mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of APCS mRNAdecreases expression 18796159
16054898
D013853 Thioacetamide Thioacetamide affects the expression of APCS mRNAaffects expression 19483382
C032910 triadimefon triadimefon results in increased expression of APCS mRNAincreases expression 19363144
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.326195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3214514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.1411850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.1418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.0211473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.216695378
MESH:D000236 Adenoma beta-Naphthoflavone 10.2119389873
MESH:D000236 Adenoma Diethylnitrosamine 10.2110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.4219061943 19052882 17620307 16434500 17162532 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.4217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6911748828
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7819183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5520041841 18218290 18057881
MESH:D001249 Asthma Mustard Gas 2.6210378619
MESH:D050197 Atherosclerosis olive oil 4.1716216721
MESH:D001281 Atrial Fibrillation Amiodarone 3.6919698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001768 Blister Mustard Gas 4.8619167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 53.0919483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 53.0919483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 53.0919483382
MESH:D001778 Blood Coagulation Disorders Ethionine 53.0919483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 53.0919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 53.0919483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 53.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 53.0912125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 53.0919483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8717474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8717474063
MESH:D001943 Breast Neoplasms Estradiol 1.8717261762 17018787 19861407 16675129 17289903 12948864 18497071 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6817687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4916050911 15673190 16011737 16227642 16192424 18705752 3786805 15700767 16097048 15721981 16124888 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 19363144
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.8716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.873084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 18.8721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 18.871701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 18.8718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.8720524982 18210153 19394651 16569478 19539802 20727157 17173139 19052882 3581430 3084413 18785209 10672840 16830150 19208518 20007298 16935385 19171122 20214788 16698587 17761372 17428255 19919837 19519916 17055752 19822196 18393292 17978847 16681979 18506893 18971187 16807293 18494052 19701751 16328049 16288022 20514400 16540662 20512989 21159647 20101231 20935162 18978308 16779866 18665156 20084675 10737359 19335982 16502159 17138121 19418558 11831363 18788625 20432363 19107877 16878318 18691550 19383236 17162532 18056438
MESH:D006528 Carcinoma, Hepatocellular Estradiol 18.8716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 18.871701930 17173139 20007298 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 18.8717997003
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9720419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2116120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7915710769 19225199
MESH:D002318 Cardiovascular Diseases olive oil 4.3416216721
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7918974383
MESH:D002386 Cataract Acetaminophen 2.4110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 18.966135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 18.961399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.9612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.9617174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.9618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.964080065
MESH:D002637 Chest Pain Omeprazole 4.8115447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.6916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.6918291259
MESH:D002779 Cholestasis Cyclosporine 7.0419486331
MESH:D002779 Cholestasis pirinixic acid 7.0419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7316354765 15668235 12621046 15340226 8697196
MESH:D002972 Cleft Palate triadimefon 5.7316781842
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7410048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities triadimefon 2.7415834900 16875885
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 6.7419647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1719279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 20.6118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 20.6117562736 10915739 19370779 18071297 10774834 11739529 14550746 19416960 12540782 11287661 18713872 19739265 12153990 12705907 16393943 11529661 12392966 11461765 10663392 16781746 16485898 14725611 11834606 11743745 16177239 14986274 19085960 2444490 16081117 16109766 12594235 19923254 15968718 17522070 17906064 19420014 16227642 19164858 11421492 15619225 12958197
MESH:D056486 Drug-Induced Liver Injury Amiodarone 20.6118218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 20.617120509 10915739 15998439 6884620 3786805 7179309 6623471 10092053 11566570 21278145 19336974 2869522 16227642 4309450 7440962 17522070 9327722 15027814 19085960 16177239 15968718 3732212
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 20.6119107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 20.6116221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 20.6120420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 20.6112963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.0515991576 21218061 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 3.8616707586
MESH:D004421 Dystonia Phenobarbital 3.731851702
MESH:D004487 Edema Mustard Gas 14.3011428647 11402378 11428631 9260866
MESH:D004487 Edema perfluorooctanoic acid 14.3017259670 12083418
MESH:D004487 Edema pirinixic acid 14.3012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.3011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6018230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 2.7919148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7710568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1015821434 15328337 17637181
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.823659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.5711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.306401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.967750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.723659116
MESH:D004890 Erythema Mustard Gas 4.869357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005218 Fat Necrosis Thioacetamide 5.4216456712
MESH:D005234 Fatty Liver Amiodarone 27.2914986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.2916045604 12795759 15959796 61145 16239168 19224547 17595544 12631006
MESH:D005234 Fatty Liver Clofibrate 27.2919224547
MESH:D005234 Fatty Liver Cyclosporine 27.2919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 27.2921071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 27.2919236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005334 Fever Lipopolysaccharides 3.769205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 13.0418705752
MESH:D005355 Fibrosis Cyclosporine 13.0412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.0420067830
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3115929193 18665440 17276928
MESH:D006505 Hepatitis Carbon Tetrachloride 8.5519110552 19900420
MESH:D006505 Hepatitis Thioacetamide 8.5516456712
MESH:D006529 Hepatomegaly Amiodarone 36.1415265979
MESH:D006529 Hepatomegaly fumonisin B1 36.1416221962
MESH:D006529 Hepatomegaly perfluorooctanoic acid 36.143609246
MESH:D006529 Hepatomegaly Phenobarbital 36.1416109766
MESH:D006529 Hepatomegaly pirinixic acid 36.1416221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 36.1415340226 16120746 12621046
MESH:D006529 Hepatomegaly triadimefon 36.1417178689 17178688
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7515340226 16959395 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.1016870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.1012083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2416899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.619751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006973 Hypertension Cyclosporine 4.5610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8015338365
MESH:D007037 Hypothyroidism Amiodarone 10.6517991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.6518031379 8137927
MESH:D007249 Inflammation Diethylnitrosamine 14.2318785209
MESH:D007249 Inflammation Lipopolysaccharides 14.2312878042 17255318 9205823 17237260 17963957
MESH:D007249 Inflammation Mustard Gas 14.239357497 11428631 8975870 16001271 17524151 11402378 11428620 9260866 11428647
MESH:D007249 Inflammation perfluorooctanoic acid 14.2312083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.2312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.5616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.5616306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3617255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.4416580747
MESH:D007569 Jaw Abnormalities triadimefon 9.4415992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Acetaminophen 8.9912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 8.998314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 8.9915618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.9916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 10.9912371664
MESH:D007680 Kidney Neoplasms Estradiol 10.9915610895
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8619248655
MESH:D007970 Leukopenia Lipopolysaccharides 4.4015821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.938812269
MESH:D008064 Lipidoses Amiodarone 3.3015342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.0711408273 17157831 17174718 21278145 11903743 16221502 16943688 17334410 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.0718522880 19638242 20032147 18407596 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 10.0721047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.2115925388 16011737 18054572 16033810 12632514 18420326 12445418 17869086 18251166 17944888 16015684 12741479 18376398 18472094 17805973 18166357 15730626 11481614 15338365 17922224 17708605 15057751 16248980 18395095 17714472 18277467 14716496 12609069 17761835 18317297 15673190 15931870 14512876 15052691 15370692 17900296 12666154 16136751 17823541 18705752 18210741 14748882 17698563 15893842 12389079 14716833 14620537 17976157 18006644 15650968 18395914 16097048 18279442 16638106 15123356 17481882 12546737 12649538 15876570 15996030 18339082 18472332 18187930 18263696 18418968 18481824 18429990 15959796 10355542 16116963 13678700 12586293 17557913 17565644 16027843 12958196 17525996 14724832 15362042 20821823 17631135 12632512 12898905 15818738 17640975 17721639 12445421 16192424 18205269 12667390 17766677 18412020 18156304
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.2112878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2112878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 8.2116248980 15465738 16126171 17629604 15316131 17050028 17355460 18395095 18032466 11682029 17292413 18416461 18458672 18263696 11172339 15474484 15078482 15095483 15716488 15075984 18380797 18295389 18031379 17127702 15288472 12531686 15362042 16098781 12557150 12679928 15158331 14739098 16097051 15334695 12175628 15288473 12891558 11481614 18615449 18606216 16511523 16343077 10677585 12085344 16489207
MESH:D008107 Liver Diseases Acetaminophen 14.8119784758 19460945 12969438 19014921 16611625 12587719 16610002 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 14.8116964402 15720792 17285989 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 14.8117034775
MESH:D008107 Liver Diseases Phenobarbital 14.8119363144
MESH:D008107 Liver Diseases Thioacetamide 14.8115158337 16337175 18374380
MESH:D008107 Liver Diseases triadimefon 14.8119363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.7816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.7814706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 14.7815313186 12479984 15633222 17276928
MESH:D008113 Liver Neoplasms marker/mechanism 20195826
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 44.907678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 44.9015890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 44.9020195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 44.9019389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 44.9019294768
MESH:D008113 Liver Neoplasms ciprofibrate 44.9012771043
MESH:D008113 Liver Neoplasms Clofibric Acid 44.9017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 44.9019090486 19833225 21071580 20405173 21167192 19255062 15885732 19638242 20501860 19073162 20118626 19427195 18978307 19690152 19850985 19499222 19642983 12771043 2862719 9163691 2422723 21278145 20434301 21047994 19551842 19256749 18754104 10737359 19254457 16942905 18644402 19426721 19294768 12112319 15175105 20137499 18648771 19996281 19812893 20492335 20101389 20583210 18977376 20452335
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 44.9014757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 44.9019812893 8742319 15975961 19073162 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 44.9020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 44.9016984957
MESH:D008113 Liver Neoplasms triadimefon 44.9019028983
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 30.092876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 30.098603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 30.0918164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 30.0912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 30.0919519916 18775883 18253720 18544905 19126423 18079962 18093689 16267830 18164116 18308698 18282651 19009564 17942915 16842330 3124819 2563599 17854601 19004024 21159647 17174075 19539802 9362446
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 30.0917172636 1399818 18308698 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 30.0912151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 30.0917178689
MESH:D008133 Long QT Syndrome Amiodarone 3.3611989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 6.9612587719
MESH:D008171 Lung Diseases Mustard Gas 6.9618161513 18702808
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1818516814
MESH:D055370 Lung Injury Lipopolysaccharides 3.7221114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.1614755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.166695378 18520028 20064080 20464547 20135361 17053015 20869020 18816296 18569708
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.166695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Mustard Gas 6.168781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.1611884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.3817203775 16891317 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009181 Mycoses Amiodarone 4.6017974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.0219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1817484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.5718551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.459029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.3311141357
MESH:D009369 Neoplasms pirinixic acid 4.3317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.5311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5314600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D009503 Neutropenia Mustard Gas 3.707688884 16761898
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 11.109802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 11.109802331
MESH:D009765 Obesity pirinixic acid 1.7420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.1816049721
MESH:D010018 Osteomalacia Phenobarbital 4.0717016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.1319401270
MESH:D010146 Pain Acetaminophen 2.1616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9016540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 4.9016965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.2611605937 12224865
MESH:D011041 Poisoning Mustard Gas 3.5315727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.8412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.842563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.842563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.6917132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6911222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.2216740699
MESH:D011537 Pruritus Mustard Gas 3.8018058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.2012752131
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.4611597910 12832656 12490602
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.4617894541 17620002 10334151 17720292 17266442
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5410835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012640 Seizures 2,6-dinitrotoluene 5.2718551238
MESH:D012640 Seizures Phenobarbital 5.273137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.536407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7918724381
MESH:D012871 Skin Diseases Mustard Gas 2.6415451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.0010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.0016192470
MESH:D013272 Stomach Diseases Omeprazole 4.3218545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.2520155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.2518456281
MESH:D013276 Stomach Ulcer Amiodarone 10.8218087811
MESH:D013276 Stomach Ulcer olive oil 10.8212498302 16252198
MESH:D013276 Stomach Ulcer Omeprazole 10.8217977527 18237397 11906479 10750652 16755016 15991576
MESH:D013610 Tachycardia Amiodarone 4.0111238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9119225199
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9115821434
MESH:D013959 Thyroid Diseases Amiodarone 11.0519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.0512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.367505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.361399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 15.3615710170
MESH:D013964 Thyroid Neoplasms triadimefon 15.3617178689
MESH:D013971 Thyrotoxicosis Amiodarone 4.5719584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D016171 Torsades de Pointes Amiodarone 3.9017467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.5816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.5817053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0210091137
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D014605 Uveitis Cyclosporine 3.681336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D014689 Venous Insufficiency coumarin 5.4812708602
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01651 - Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside
DB07579 - BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE
DB07580 - BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved