AutismKB 2.0

Annotation Detail for HPRT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HPRT1 ( HGPRT,HPRT )
Gene Full Name: hypoxanthine phosphoribosyltransferase 1
Band: Xq26.2-q26.3
Quick LinksEntrez ID:3251; OMIM: 308000; Uniprot ID:HPRT_HUMAN; ENSEMBL ID: ENSG00000165704; HGNC ID: 5157
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
SALVADEHYPOX-PWYsalvage pathways of adenine, hypoxanthine, and their nucleosides
SALVPURINE2-PWYsalvage pathways of guanine, xanthine, and their nucleosides
Pathway IDPathway Name
hsa00230Purine metabolism
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
Pathway IDPathway Name
P02788Xanthine and guanine salvage pathway
P02723Adenine and hypoxanthine salvage pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00194Lesch-Nyhan syndrome
Inherited disorders of nucleotide metabolism
Genetic disorders
Desease IDDesease Name
1848Embryoma
1876Gouts
1902Kidney failure
2051Leukemia
2053Colon cancer
2082Ataxia telangiectasia
2126Encephalopathies
2231Arthritis
1882Malaria
Desease Name
Lesch-Nyhan syndrome
METABOLIC
cytogenetic studies
No data
Desease Name
Lesch-Nyhan syndrome
HPRT-related gout
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C090203 1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene 1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene results in increased mutagenesis of HPRT1 geneincreases mutagenesis 8706010
C080053 3,4-epoxybutane-1,2-diol 3,4-epoxybutane-1,2-diol results in increased mutagenesis of HPRT1 exonincreases mutagenesis 12521305
C080053 3,4-epoxybutane-1,2-diol 3,4-epoxybutane-1,2-diol results in increased mutagenesis of HPRT1 gene SNPincreases mutagenesis 12521305
C026729 4-aminophenol 4-aminophenol results in increased mutagenesis of HPRT1 geneincreases mutagenesis 7556113
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased mutagenesis of HPRT1 geneincreases mutagenesis 15613823
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone Dibutyl Phthalate promotes the reaction [[Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 gene]affects cotreatment|increases mutagenesis|increases reaction 15613823
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone [Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 geneaffects cotreatment|increases mutagenesis 15613823
C009785 4-pentenoic acid 4-pentenoic acid results in increased expression of HPRT1 mRNAincreases expression 12883083
D000082 Acetaminophen Acetaminophen results in increased expression of HPRT1 mRNAincreases expression 12883083
D020106 Acrylamide Acrylamide results in increased mutagenesis of HPRT1 geneincreases mutagenesis 18407966
D020106 Acrylamide Acrylamide results in increased mutagenesis of HPRT1 geneincreases mutagenesis 15957192
D000638 Amiodarone Amiodarone affects the expression of HPRT1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HPRT1 mRNAaffects expression 16483693
D001280 Atrazine Atrazine results in increased mutagenesis of HPRT1 proteinincreases mutagenesis 8379213
D001553 Benzbromarone Benzbromarone affects the expression of HPRT1 mRNAaffects expression 19483382
C002615 benzo(c)phenanthrene benzo(c)phenanthrene analog affects the mutagenesis of HPRT1 geneaffects mutagenesis 11765016
D001564 Benzo(a)pyrene Benzo(a)pyrene analog affects the mutagenesis of HPRT1 geneaffects mutagenesis 11765016
D002330 Carmustine Carmustine results in increased mutagenesis of HPRT1 geneincreases mutagenesis 17116724
D002994 Clofibrate Clofibrate affects the expression of HPRT1 mRNAaffects expression 19483382
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HPRT1 mRNAaffects cotreatment|affects expression 17602206
D003474 Curcumin Curcumin results in increased expression of HPRT1 mRNAincreases expression 16101141
C007168 cyanazine cyanazine results in increased mutagenesis of HPRT1 proteinincreases mutagenesis 8379213
D003520 Cyclophosphamide Cyclophosphamide results in increased mutagenesis of HPRT1 geneincreases mutagenesis 17116724
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in increased expression of HPRT1 mRNAincreases expression 18709148
C460375 dibenz(c,h)acridine dibenz(c,h)acridine analog affects the mutagenesis of HPRT1 geneaffects mutagenesis 11765016
D015946 Ethylene Dibromide Ethylene Dibromide results in increased mutagenesis of HPRT1 geneincreases mutagenesis 9491396
D003993 Dibutyl Phthalate Dibutyl Phthalate promotes the reaction [[Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 gene]affects cotreatment|increases mutagenesis|increases reaction 15613823
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased mutagenesis of HPRT1 geneincreases mutagenesis 15613823
D003993 Dibutyl Phthalate [Ozone co-treated with Dibutyl Phthalate] results in increased mutagenesis of HPRT1 geneaffects cotreatment|increases mutagenesis 15613823
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HPRT1 mRNAaffects cotreatment|affects expression 17602206
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in decreased expression of HPRT1 mRNAdecreases expression 12883083
C007366 erythritol anhydride erythritol anhydride results in increased mutagenesis of HPRT1 exonincreases mutagenesis 12521305
C007366 erythritol anhydride erythritol anhydride results in increased mutagenesis of HPRT1 gene SNPincreases mutagenesis 12521305
D004958 Estradiol Estradiol results in increased expression of HPRT1 mRNAincreases expression 18709148
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HPRT1 mRNAincreases expression 17555576
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HPRT1 mRNAaffects cotreatment|increases expression 17942748
D005001 Ethionine Ethionine affects the expression of HPRT1 mRNAaffects expression 19483382
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of HPRT1 geneincreases mutagenesis 17066413
C071834 glycidamide glycidamide results in increased mutagenesis of HPRT1 geneincreases mutagenesis 15957192
D007538 Isoniazid Isoniazid results in increased expression of HPRT1 mRNAincreases expression 12883083
D001556 Lindane Lindane results in decreased expression of HPRT1 mRNAdecreases expression 17785943
D008770 Methylnitrosourea Methylnitrosourea results in increased mutagenesis of HPRT1 geneincreases mutagenesis 18249417
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of HPRT1 mRNAincreases expression 17616710
D009853 Omeprazole Omeprazole affects the expression of HPRT1 mRNAaffects expression 19483382
D010126 Ozone Dibutyl Phthalate promotes the reaction [[Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 gene]affects cotreatment|increases mutagenesis|increases reaction 15613823
D010126 Ozone [Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 geneaffects cotreatment|increases mutagenesis 15613823
D010126 Ozone [Ozone co-treated with Dibutyl Phthalate] results in increased mutagenesis of HPRT1 geneaffects cotreatment|increases mutagenesis 15613823
D010126 Ozone Ozone results in increased mutagenesis of HPRT1 geneincreases mutagenesis 15613823
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of HPRT1 mRNAincreases expression 18709148
D010634 Phenobarbital Phenobarbital results in decreased expression of HPRT1 mRNAdecreases expression 16940010
C006253 pirinixic acid pirinixic acid results in increased expression of HPRT1 mRNAincreases expression 18301758
C006253 pirinixic acid pirinixic acid affects the expression of HPRT1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of HPRT1 mRNAaffects expression 19483382
D011794 Quercetin Quercetin results in increased mutagenesis of HPRT1 proteinincreases mutagenesis 8379213
C009166 retinol acetate retinol acetate results in increased expression of HPRT1 mRNAincreases expression 16772331
D020058 Styrene GSTP1 gene polymorphism promotes the reaction [Styrene results in increased mutagenesis of HPRT1 gene]increases mutagenesis|increases reaction 12893075
D020058 Styrene Styrene results in increased mutagenesis of HPRT1 geneincreases mutagenesis 12893075
11535253
D013629 Tamoxifen Tamoxifen affects the expression of HPRT1 mRNAaffects expression 17555576
C047246 temozolomide MGMT protein inhibits the reaction [temozolomide results in increased mutagenesis of HPRT1 gene]decreases reaction|increases mutagenesis 17116724
C047246 temozolomide temozolomide results in increased mutagenesis of HPRT1 geneincreases mutagenesis 17116724
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HPRT1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HPRT1 mRNAincreases expression 17942748
D013853 Thioacetamide Thioacetamide affects the expression of HPRT1 mRNAaffects expression 19483382
D015215 Zidovudine Zidovudine results in increased mutagenesis of HPRT1 exonincreases mutagenesis 10526209
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0214745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.596195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.5915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.0418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4117505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.329612607
MESH:D055371 Acute Lung Injury pirinixic acid 2.6418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.8520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 8.8511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.8514692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 8.8515688392 15113128
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 13.4316176798
MESH:D000236 Adenoma Benzo(a)pyrene 13.436695378
MESH:D000236 Adenoma Diethylnitrosamine 13.4310737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 13.436695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.6116434500 17620307 18056438 19052882 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.6116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.6116835633
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.2617302879
MESH:D000382 Agricultural Workers' Diseases Atrazine 7.4411874814
MESH:D000382 Agricultural Workers' Diseases Lindane 7.4412661182
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5517887948
MESH:D000544 Alzheimer Disease Curcumin 3.9215590663
MESH:D000544 Alzheimer Disease Ozone 3.9215513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5011748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7817084956
MESH:D000799 Angioedema Acetaminophen 3.3210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5719183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3518057881 18218290 20041841
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.4915014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.4911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3315885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.3416807698
MESH:D001172 Arthritis, Rheumatoid Ozone 4.3415570426
MESH:D001249 Asthma Ozone 2.4717854713 16373670
MESH:D001254 Astrocytoma temozolomide 5.9615865885
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4615336622
MESH:D050197 Atherosclerosis Curcumin 3.0018704882
MESH:D001281 Atrial Fibrillation Amiodarone 3.5119698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4818445737
MESH:D001327 Autoimmune Diseases Curcumin 9.1919761891
MESH:D001327 Autoimmune Diseases Quercetin 9.1919761891
MESH:D001778 Blood Coagulation Disorders Amiodarone 49.0619483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 49.0619483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 49.0619483382
MESH:D001778 Blood Coagulation Disorders Ethionine 49.0619483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 49.0619483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 49.0619483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 49.0619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 49.0612125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 49.0619483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4215746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.4314991843
MESH:D002545 Brain Ischemia Curcumin 3.8216770732
MESH:D001932 Brain Neoplasms Carmustine 12.2616187019
MESH:D001932 Brain Neoplasms Curcumin 12.2617596214
MESH:D001932 Brain Neoplasms Ethylnitrosourea 12.2616357521 15144691 18412241 16436596 16651633
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 11.5720146248
MESH:D001943 Breast Neoplasms Acrylamide 11.5716253758 18183576
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.5717474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 11.5719250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms Cyclophosphamide 11.5711325840 15136595 17388661 17020986 18234424 18323546 12006526 15093573 16978400
MESH:D001943 Breast Neoplasms Diethylnitrosamine 11.5717474063
MESH:D001943 Breast Neoplasms Estradiol 11.5712948864 17261762 17289903 19861407 14630087 16675129 17018787 18497071
MESH:D001943 Breast Neoplasms Ethylene Dibromide 11.5711921183
MESH:D001943 Breast Neoplasms Lindane 11.5714688026
MESH:D001943 Breast Neoplasms Methylnitrosourea 11.5714633655 11306469 16253758
MESH:D001943 Breast Neoplasms Quercetin 11.5718628248
MESH:D001943 Breast Neoplasms Styrene 11.5715986119
MESH:D001943 Breast Neoplasms Tamoxifen 11.5721138602 20544844 16818667 11161223 19066611 16202921 17440819 17893378 20005174 19221464 16273361 19189212 17261762 19084267 19288272 20135344 17242785 19115204 19410462 19011961 19200415 18629630 18984771 19189210 19103187 18815881 18425577 15565566 20065188 19142967 19244106 15668708 19487384 18855134 21152245 18351453 19289846 19155303 20390343 18997820 20859285 17049068 19059307 18821012 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.5720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2715516495 19059883 18417511 17626835 18315731 14754758 16777450
MESH:D002100 Cachexia Ozone 4.2216183385
MESH:D002105 Cadmium Poisoning Quercetin 5.0216962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9416111702
MESH:D002277 Carcinoma Curcumin 6.9118593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0019066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 17.723084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 17.721701930
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 17.7219701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 17.7219171122 18971187 19539802 19519916 16328049 18494052 18210153 20432363 17978847 18056438 18978308 19394651 19701751 16681979 20214788 20935162 16935385 18691550 16502159 17162532 17761372 20084675 17173139 20101231 20727157 16698587 18788625 20007298 19052882 19107877 18506893 19383236 19208518 16540662 19919837 20524982 16569478 18785209 17138121 18665156 20514400 16830150 10672840 10737359 17055752 19418558 3084413 17428255 16878318 20512989 18393292 11831363 16288022 16807293 3581430 21159647 19335982 16779866 19822196
MESH:D006528 Carcinoma, Hepatocellular Estradiol 17.7216924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 17.7217173139 20935162 20007298 6705139 1701930
MESH:D006528 Carcinoma, Hepatocellular Quercetin 17.7219519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 17.7216924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 17.7217997003
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.3716152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7818414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4517234771
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.2816201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.8020419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 6.8018462866
MESH:D002294 Carcinoma, Squamous Cell erythritol anhydride 6.8010925838
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1617572228
MESH:D006332 Cardiomegaly Quercetin 5.7819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.7818670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.6919225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5618974383
MESH:D002386 Cataract Acetaminophen 6.4810977129
MESH:D002386 Cataract Methylnitrosourea 6.4812484553
MESH:D002418 Cattle Diseases Acrylamide 4.9212510666
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 17.251399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 17.2521159647 17174075 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.2518566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 17.2516003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 17.257505956 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.754080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.4517160924
MESH:D002637 Chest Pain Omeprazole 4.5815447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.5919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.5916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 13.5918291259
MESH:D002779 Cholestasis Ethinyl Estradiol 6.4516105132 16919318 17681005 17110522 15861022 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 6.4519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.878697196 15340226 15668235 12621046 16354765
MESH:D003092 Colitis Curcumin 3.6718200517 16804969 16782535
MESH:D003103 Coloboma Curcumin 4.0818809619
MESH:D003110 Colonic Neoplasms Curcumin 3.6016340194 19359593
MESH:D003110 Colonic Neoplasms Quercetin 3.6017148506 11134977 17191121 15741050 19056647 19440933 16640504
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6217141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.3918497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2310048152 20055451 15322242
MESH:D003456 Cryptorchidism Dibutyl Phthalate 4.9616037377
MESH:D003556 Cystitis Cyclophosphamide 4.4618295254 18093676 16989017 16614059 12161096 15643279 18483878 18372110 17010015 10498854 17979934 15276878 16651033 12913760 18710439 18433785 10700343 12388444 11948286 16413132
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8619031437
MESH:D017449 Dermatitis, Allergic Contact 4-aminophenol 4.9511906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1718249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 7.2615331540 11751995 10990075
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.2619496084
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 5.4718772604
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 5.4716616286
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.2118403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.2120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2117107852
MESH:D003928 Diabetic Nephropathies Curcumin 12.5018204486
MESH:D003928 Diabetic Nephropathies Estradiol 12.5019279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.5019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.8412392966 12705907 11743745 11287661 11529661 12958197 14550746 16781746 19370779 14725611 15619225 17906064 2444490 11421492 11739529 19739265 19164858 17522070 16485898 19416960 19923254 11461765 17562736 18071297 12540782 15968718 19420014 16177239 10915739 19085960 12594235 14986274 10663392 16081117 16393943 11834606 18713872 16227642 12153990 16109766 10774834
MESH:D056486 Drug-Induced Liver Injury Amiodarone 15.8415265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.8419107877
MESH:D056486 Drug-Induced Liver Injury Ethylene Dibromide 15.842862719
MESH:D056486 Drug-Induced Liver Injury Isoniazid 15.8414986274 17950035 16770646
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.8420420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 15.8412963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.9411462148
MESH:D004362 Drug Toxicity Zidovudine 6.9415040536
MESH:D004381 Duodenal Ulcer Curcumin 7.8617351913
MESH:D004381 Duodenal Ulcer Omeprazole 7.8615991576 16613094 17151854 21218061
MESH:D050171 Dyslipidemias Clofibrate 3.6916707586
MESH:D004421 Dystonia Phenobarbital 3.531851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.4518357618
MESH:D004487 Edema perfluorooctanoic acid 8.8217259670 12083418
MESH:D004487 Edema pirinixic acid 8.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.8212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.3212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.3219031437
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.0320641076
MESH:D016889 Endometrial Neoplasms Estradiol 6.2219148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.2219155303 16202921 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.5710568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 3.7211006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.603659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.353922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.116401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.757750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.503659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.0716530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.0715623463 15547733 15547721 16510608 16805852 15878914 16704527 15264214 15150132
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6211564622
MESH:D005218 Fat Necrosis Thioacetamide 5.1916456712
MESH:D005234 Fatty Liver Amiodarone 35.2114986274
MESH:D005234 Fatty Liver Clofibrate 35.2119224547
MESH:D005234 Fatty Liver Curcumin 35.2119297423
MESH:D005234 Fatty Liver Diethylnitrosamine 35.2121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 35.2115345470
MESH:D005234 Fatty Liver pirinixic acid 35.2120131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 35.2119224547 14986274
MESH:D005234 Fatty Liver Zidovudine 35.2118299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6619069698
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.7111555667
MESH:D005355 Fibrosis Curcumin 11.9718705752
MESH:D005355 Fibrosis Quercetin 11.9719474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.9720067830
MESH:D005756 Gastritis Acetaminophen 3.1516983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1918462866
MESH:D005909 Glioblastoma Carmustine 18.6016187019
MESH:D005909 Glioblastoma Curcumin 18.6017596214
MESH:D005909 Glioblastoma Ethylnitrosourea 18.6016436596
MESH:D005909 Glioblastoma Quercetin 18.6019804834
MESH:D005909 Glioblastoma temozolomide 18.6015865885
MESH:D005910 Glioma Ethylnitrosourea 12.3716357521 16651633 18412241
MESH:D005910 Glioma Methylnitrosourea 12.379825942
MESH:D005910 Glioma Quercetin 12.3717643826
MESH:D005910 Glioma temozolomide 12.3716327979 10871815
MESH:D018316 Gliosarcoma Cyclophosphamide 4.9911389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0710696789
OMIM:300323 GOUT, HPRT-RELATED marker/mechanism
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.5316376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms Curcumin 3.3018829502 18462866
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 9.3420641076
MESH:D034381 Hearing Loss Styrene 9.3417420221
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.4720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.4710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.2120558911
MESH:D006402 Hematologic Diseases Zidovudine 4.2312579204
MESH:D006467 Hemophilia A Cyclophosphamide 4.7811918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8711000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.1118665440 17276928 15929193
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.0014986274
MESH:D006505 Hepatitis Thioacetamide 3.7316456712
MESH:D006529 Hepatomegaly Amiodarone 21.7915265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 21.793609246
MESH:D006529 Hepatomegaly Phenobarbital 21.7916109766
MESH:D006529 Hepatomegaly pirinixic acid 21.7919772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 21.7915340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5317701891
MESH:D006558 Herpes Genitalis Estradiol 4.5015709030
MESH:D015658 HIV Infections Zidovudine 3.2120032539 11363243 11698656 11141242 17358032
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.3616135485 17606976
MESH:D019584 Hot Flashes Estradiol 3.2317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5215340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.5016870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.5012083418
MESH:D006937 Hypercholesterolemia Amiodarone 7.809751232 8137927
MESH:D006937 Hypercholesterolemia Curcumin 7.8018704882
MESH:D006943 Hyperglycemia pirinixic acid 7.7420558911
MESH:D006943 Hyperglycemia Quercetin 7.7411834736 18262572
MESH:D006973 Hypertension Quercetin 4.4818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3016945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 9.9317991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 9.9318031379 8137927
MESH:D007154 Immune System Diseases Cyclophosphamide 4.8016076520
MESH:D007247 Infertility, Female Acrylamide 8.8011020651
MESH:D007247 Infertility, Female Ethinyl Estradiol 8.8012013081
MESH:D007248 Infertility, Male Acrylamide 17.3812507653 11020651 15355880 15749267
MESH:D007248 Infertility, Male Atrazine 17.3812948887
MESH:D007248 Infertility, Male Cyclophosphamide 17.387193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 17.3817937319
MESH:D007248 Infertility, Male Methylnitrosourea 17.387193160
MESH:D007249 Inflammation Curcumin 12.7716956363 18403477 17151092
MESH:D007249 Inflammation Diethylnitrosamine 12.7718785209
MESH:D007249 Inflammation perfluorooctanoic acid 12.7712083418
MESH:D007249 Inflammation Tamoxifen 12.7719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.7712878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9818596194 18200517
MESH:D007251 Influenza, Human Quercetin 3.9816624496
MESH:D007333 Insulin Resistance Estradiol 6.0316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.0316306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.7710783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8716580747
MESH:D007627 Keloid Quercetin 4.4517086741
MESH:D007674 Kidney Diseases Acetaminophen 11.9415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 11.9415618244
MESH:D007674 Kidney Diseases Ethylene Dibromide 11.9412628311
MESH:D007674 Kidney Diseases Quercetin 11.9416962696
MESH:D007680 Kidney Neoplasms Estradiol 14.3815610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 14.3817379185
MESH:D007680 Kidney Neoplasms Tamoxifen 14.3818625569
MESH:D007680 Kidney Neoplasms Zidovudine 14.3812579204
MESH:D007889 Leiomyoma Curcumin 4.0918555241
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.6819248655
MESH:D007926 Lesch-Nyhan Syndrome marker/mechanism
MESH:D007938 Leukemia Curcumin 12.8018462866
MESH:D007938 Leukemia Cyclophosphamide 12.8010602166
MESH:D007938 Leukemia Quercetin 12.8017468513
MESH:D007938 Leukemia temozolomide 12.8017500047
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.2617802794 17008537 17658394 17296974 18172266 18587576
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.4516106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.4520370541
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.7010373061
MESH:D015458 Leukemia, T-Cell Curcumin 4.2716106398
MESH:D007970 Leukopenia Cyclophosphamide 4.4510052129 11830472
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.718812269
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 3.8315526292
MESH:D008064 Lipidoses Amiodarone 6.6517567588 15342952
MESH:D008064 Lipidoses Tamoxifen 6.6515342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.6319638242 18522880 18407596 18665156 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 5.6321047994
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 11.7318006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 11.7311682029
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.7314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 11.7315474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 11.7312741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 11.7318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.7312878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 11.7316511523 17292413 18606216 15474484 10677585 17355460 16489207 15316131 15334695 16248980 16097051 18458672 14739098 11682029 17050028 15716488 16098781 15158331 15465738 16343077 12679928 18295389 18263696 15078482 15362042 15095483 12891558 18380797 17127702 18031379 15288473 17629604 18615449 15288472 12085344 11172339 12175628 16126171 12557150 18032466 12531686 15075984 18395095 11481614 18416461
MESH:D008107 Liver Diseases Acetaminophen 13.7212587719 12969438 16610002 19460945 11587558 19784758 16611625 19014921
MESH:D008107 Liver Diseases Curcumin 13.7216956363
MESH:D008107 Liver Diseases Diethylnitrosamine 13.7217034775
MESH:D008107 Liver Diseases Lindane 13.721715830
MESH:D008107 Liver Diseases Phenobarbital 13.7219363144
MESH:D008107 Liver Diseases Thioacetamide 13.7216337175 15158337 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 8.1417185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 8.1415633222 12479984 15313186 17276928
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 33.4015890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 33.4020195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 33.4017602206
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 33.4018709148
MESH:D008113 Liver Neoplasms Diethylnitrosamine 33.4021047994 18644402 19833225 19812893 19073162 12112319 20492335 18648771 10737359 12771043 20405173 19499222 19255062 18754104 19256749 20101389 19642983 20452335 20118626 19690152 21167192 20137499 15885732 18977376 20501860 19254457 2862719 19426721 18978307 19638242 16942905 21278145 21071580 15175105 20434301 19294768 19996281 19850985 20583210 9163691 19551842 2422723 19090486 19427195
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 33.4014757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 33.4019482888 19812893 15975961 19073162 21047994 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 33.4016377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 33.4018980244
MESH:D008113 Liver Neoplasms Tamoxifen 33.4016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 33.4016984957
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 15.098603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.0918093689 19539802 3124819 16842330 18164116 9362446 17942915 19009564 19004024 16267830 18282651 18775883 21159647 18079962 19126423 18544905 19519916 17854601 17174075 2563599 18308698 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.0918308698 1399818 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Quercetin 15.0919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.0912151625
MESH:D008133 Long QT Syndrome Amiodarone 3.1811989578 15350150 17391786
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 4.9616080182
MESH:D008171 Lung Diseases Amiodarone 6.4012587719
MESH:D008171 Lung Diseases Ozone 6.408266340 19066396
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9518516814
MESH:D055370 Lung Injury Ozone 3.3520417186
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 21.0415893417 9255578 18508827 12438228 14755239 18813816 19931552 16401635 17139156 16061637 15172992
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 21.0420464547 17053015 18569708 20869020 18816296 18520028 20135361 20064080 6695378
MESH:D008175 Lung Neoplasms Curcumin 21.0416243823 19359593 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 21.0420512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Ethylnitrosourea 21.046695378 17703301 16019985 16271038
MESH:D008175 Lung Neoplasms Methylnitrosourea 21.0418062963
MESH:D008175 Lung Neoplasms Ozone 21.048597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 21.0416280456
MESH:D008175 Lung Neoplasms Styrene 21.0412562636
MESH:D008175 Lung Neoplasms Tamoxifen 21.0418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 21.0411884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 21.0418800350
MESH:D008223 Lymphoma Curcumin 14.8818462866
MESH:D008223 Lymphoma Cyclophosphamide 14.8812854902
MESH:D008223 Lymphoma Ethylnitrosourea 14.8815790496
MESH:D008223 Lymphoma Methylnitrosourea 14.8811418001 16257854
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 9.0616675587
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 9.0614633661
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.7411911406
MESH:D016399 Lymphoma, T-Cell Curcumin 10.0616173963
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 10.0615375218
MESH:D015674 Mammary Neoplasms, Animal Styrene 8.7312562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.7319428831
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 19.1116457693
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 19.1116891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Ethylene Dibromide 19.1111921183
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 19.1110838139 10767621 18041768
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 19.1110767621 14999141 15113128 16944150 11751437 10838139 16619500 17131329 15313902 16051031 11807958 17020996 15688392 19196723 16827153 14633655 12931682
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 19.1119196723 11731420 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 10.8919453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.8919453300
MESH:D008545 Melanoma Carmustine 6.4712393984
MESH:D008545 Melanoma Curcumin 6.4718462866 17885582
MESH:D008545 Melanoma Tamoxifen 6.4712393984 19393235
MESH:D008545 Melanoma temozolomide 6.4716225601 16260693 17576461 10623706 12374674 15577323 18281670 16248763 12829675 16260697 16432458 17623835
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.1519513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.1516388313
MESH:D008569 Memory Disorders Curcumin 3.6717263510
MESH:D008579 Meningioma Ethylnitrosourea 5.4517943659
MESH:D008654 Mesothelioma Atrazine 3.301916698
MESH:D008679 Metaplasia Ozone 4.5810496685
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.3117358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7916381670
MESH:D009101 Multiple Myeloma Curcumin 3.1419372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.4017962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0016239165
MESH:D009164 Mycobacterium Infections Isoniazid 5.4418474467
MESH:D009181 Mycoses Amiodarone 4.3712754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 4.9219151258
MESH:D009203 Myocardial Infarction Quercetin 4.9219595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.8616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.8616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 11.8619207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9617484760
MESH:D009361 Neoplasm Invasiveness Curcumin 3.8818495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.953581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.9519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3319410462
MESH:D009369 Neoplasms Benzo(a)pyrene 16.1711141357
MESH:D009369 Neoplasms Cyclophosphamide 16.1718854779
MESH:D009369 Neoplasms Lindane 16.1712807735 16818664
MESH:D009369 Neoplasms Methylnitrosourea 16.1715533788
MESH:D009369 Neoplasms pirinixic acid 16.1717405874
MESH:D009369 Neoplasms Quercetin 16.1715185748
MESH:D009374 Neoplasms, Experimental erythritol anhydride 12.8310925838
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 12.8316707424
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 12.8312696579
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.0912497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.0919189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2217289903
MESH:D009410 Nerve Degeneration Acrylamide 4.2912387366 11264303 12387367
MESH:D009422 Nervous System Diseases Acrylamide 4.5512507653 12164553
MESH:D009421 Nervous System Malformations Estradiol 7.8311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.8314600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.1018462866
MESH:D009442 Neurilemmoma Ethylnitrosourea 11.5616003739 16651423 17160924
MESH:D009442 Neurilemmoma Methylnitrosourea 11.5611555667
MESH:D009447 Neuroblastoma Cyclophosphamide 6.838761367 16115947 15176712
MESH:D009447 Neuroblastoma temozolomide 6.8315176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.7718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.7720387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.378761367 12837982
MESH:D020078 Neurogenic Inflammation Quercetin 3.8817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5920387270
MESH:D009503 Neutropenia Cyclophosphamide 3.858291058
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.389802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.389802331
MESH:D009669 Nose Neoplasms Ethylene Dibromide 5.009385384
MESH:D009765 Obesity Curcumin 4.0819297423
MESH:D009765 Obesity pirinixic acid 4.0820558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.4517160924
MESH:D009845 Oligospermia Cyclophosphamide 4.2016517039
MESH:D010018 Osteomalacia Phenobarbital 3.8517016548
MESH:D010024 Osteoporosis Curcumin 3.1418719352
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 8.9016397352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.9019495926
MESH:D010051 Ovarian Neoplasms Curcumin 6.8619020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 6.8619401270
MESH:D010051 Ovarian Neoplasms Quercetin 6.8619005980
MESH:D010146 Pain Acetaminophen 5.4716870215
MESH:D010146 Pain Cyclophosphamide 5.4712161096 18093676
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 21.5812384795
MESH:D010190 Pancreatic Neoplasms Curcumin 21.5819401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 21.5811332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 21.5816540662
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 21.5816965848
MESH:D010190 Pancreatic Neoplasms Phenobarbital 21.5816965848
MESH:D010190 Pancreatic Neoplasms Quercetin 21.5816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2111578682
MESH:D010300 Parkinson Disease Atrazine 3.0717218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7212520081
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.6211510240
MESH:D010538 Peritonitis Ozone 3.6316369182
MESH:D011014 Pneumonia Ozone 3.8818007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 12.842563599
MESH:D011230 Precancerous Conditions Phenobarbital 12.842563599
MESH:D011230 Precancerous Conditions Quercetin 12.8419056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.5021297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 7.9617132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.9611399792 11118676 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2917292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.2910851300 15129424 11398177 18769126 12497104 18156803 18226269
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.2917136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.2916740699
MESH:D011471 Prostatic Neoplasms Lindane 2.2912661182 14688026
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.2912376480 15682402
MESH:D011471 Prostatic Neoplasms Quercetin 2.2917292933 14715546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.2915067354
MESH:D011537 Pruritus Ethinyl Estradiol 2.8015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 3.9712752131
MESH:D011656 Pulmonary Emphysema Curcumin 4.0719168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.2312832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.2316636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.1119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.5518379247 10666014
MESH:D012135 Respiratory Sounds Atrazine 4.0211874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3418990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.0218172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 4.9711555667
MESH:D012509 Sarcoma Curcumin 3.6718462866
MESH:D012554 Schistosomiasis japonica Quercetin 5.0216862918
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.3416636934
MESH:D012640 Seizures Isoniazid 8.1516107249
MESH:D012640 Seizures Lindane 8.1515475178 12842176 7539098
MESH:D012640 Seizures Phenobarbital 8.1511442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.306407741
MESH:D018805 Sepsis Curcumin 3.6518389075
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5618724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.5910029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.5916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 9.8016709447
MESH:D013088 Spermatocele Tamoxifen 9.8016709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.9916517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.5219457130
MESH:D013272 Stomach Diseases Omeprazole 4.1018545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.4020155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.4018456281
MESH:D013274 Stomach Neoplasms Ethylene Dibromide 7.403768853
MESH:D013274 Stomach Neoplasms Methylnitrosourea 7.4016257854 15930296 18593901
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 7.4012958204 17575124
MESH:D013274 Stomach Neoplasms Zidovudine 7.4017696246
MESH:D013276 Stomach Ulcer Amiodarone 9.5518087811
MESH:D013276 Stomach Ulcer Curcumin 9.5519188055 16631530
MESH:D013276 Stomach Ulcer Omeprazole 9.5511906479 18237397 15991576 10750652 16755016 17977527
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.5412837982
MESH:D013610 Tachycardia Amiodarone 3.8011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7019225199
MESH:D013733 Testicular Diseases Acrylamide 4.7115864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7215669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 10.5815790496
MESH:D013953 Thymus Neoplasms Methylnitrosourea 10.5811418001
MESH:D013959 Thyroid Diseases Amiodarone 10.2919731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.2912697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 13.917505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 13.913078959 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 13.911399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 13.9115710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.3518020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.1619048282
MESH:D016171 Torsades de Pointes Amiodarone 3.6811989578 17467628
MESH:D014376 Tuberculosis Isoniazid 4.8516770646 15236969 17720495 15673755 18397238 17950035
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.3717053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 13.3718593936
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 13.3714692829
MESH:D001749 Urinary Bladder Neoplasms Quercetin 13.3716720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 13.3717572228 16712894 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 4.7418462866
MESH:D014581 Urticaria Acetaminophen 2.5010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8114692618
MESH:D014625 Vaginal Neoplasms temozolomide 10.0215577323
MESH:D014625 Vaginal Neoplasms Zidovudine 10.0212579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7215886252
Pathway ID Pathway Name
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00230 Purine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29427
    • No data
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA444748Lesch-Nyhan Syndrome
    PA443434Arthritis, Rheumatoid
    Releated drug ID Related drug Name
    PA448048adenine
    PA448049adenosine
    PA449014cisplatin
    PA449748gemcitabine
    PA451663thioguanine
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00993 antagonist Azathioprine Antirheumatic Agents;Antimetabolites;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    DB01033 antagonist Mercaptopurine Antineoplastic Agents;Antimetabolites;Immunosuppressive Agents;Nucleic Acid Synthesis Inhibitors;Purine analogues;Antimetabolites, Antineoplastic
    DB01632 - Alpha-Phosphoribosylpyrophosphoric Acid
    DB02212 - Pyrophosphate 2-
    DB02309 - 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine
    DB03153 - 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol
    DB04356 - 9-Deazaguanine
    Drugbank ID Action Drug Name Description
    DB00352 substrate Thioguanine Antimetabolites, Antineoplastic
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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