AutismKB 2.0

Annotation Detail for HRAS


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Basic Information Top
Gene Symbol:HRAS ( C-BAS/HAS,C-H-RAS,C-HA-RAS1,CTLO,H-RASIDX,HAMSV,HRAS1,K-RAS,N-RAS,RASH1 )
Gene Full Name: v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Band: 11p15.5
Quick LinksEntrez ID:3265; OMIM: 190020; Uniprot ID:RASH_HUMAN; ENSEMBL ID: ENSG00000174775; HGNC ID: 5173
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04912GnRH signaling pathway
hsa04910Insulin signaling pathway
hsa04916Melanogenesis
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa04144Endocytosis
hsa04540Gap junction
hsa04730Long-term depression
hsa05219Bladder cancer
hsa04530Tight junction
hsa04722Neurotrophin signaling pathway
hsa05211Renal cell carcinoma
hsa05216Thyroid cancer
hsa05223Non-small cell lung cancer
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
Pathway IDPathway Name
Synaptic Transmission
Signalling by NGF
Axon guidance
Hemostasis
Signaling by EGFR
Signaling by Insulin receptor
Signaling by PDGF
Signaling in Immune system
Pathway IDPathway Name
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200003Fc-epsilon receptor I signaling in mast cells
200004Endothelins
200005BCR signaling pathway
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200157EPO signaling pathway
200012Insulin Pathway
200127PDGFR-beta signaling pathway
200084IGF1 pathway
200145Nongenotropic Androgen signaling
200095EGFR-dependent Endothelin signaling events
200164Syndecan-2-mediated signaling events
200162a6b1 and a6b4 Integrin signaling
200161Signaling events mediated by VEGFR1 and VEGFR2
200011LPA receptor mediated events
200041EPHB forward signaling
200057CDC42 signaling events
200058Signaling events regulated by Ret tyrosine kinase
Pathway IDPathway Name
P00053T cell activation
P04398p53 pathway feedback loops 2
P00056VEGF signaling pathway
P00018EGF receptor signaling pathway
P00005Angiogenesis
P00052TGF-beta signaling pathway
P00010B cell activation
P00048PI3 kinase pathway
P00047PDGF signaling pathway
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P04393Ras Pathway
Pathway IDPathway Name
500178Ras activation uopn Ca2+ infux through NMDA receptor
500177CREB phophorylation through the activation of Ras
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00030Cervical cancer
Cancers of the urinary system and male genital organs
Skin cancers
H00022Bladder cancer
H00025Penile cancer
H00032Thyroid cancer
Cancers of endocrine organs
H00040Squamous cell carcinoma
H00048Hepatocellular carcinoma
Cancers of the breast and female genital organs
Desease IDDesease Name
1727Pancreas disease
1754Actinic keratosis
1818Systemic scleroderma
1850Herpes
1870Drug abuse
1934Cancer
1986Eating disorder
1912Penile disease
Desease Name
H-ras allele loss
patient prognosis A retrospective study of 103 cases
CANCER
PSYCH
bladder cancer
breast cancer
adenocarcinomas of the parotid gland
thyroid cancer
schistosomiasis
anomalous connection of pancreatobiliary ducts
lung cancer
nodular type of malignant melanoma
cervical cancer
Autism
colorectal carcinomas
tumor progression of BCR/ABL negative chronic myeloproliferative disorders
No data
Desease Name
Thyroid carcinoma, follicular, somatic
Costello syndrome
Bladder cancer, somatic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031903 1-UFT protocol HRAS protein results in decreased susceptibility to 1-UFT protocoldecreases response to substance 16734730
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HRAS mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HRAS mRNAaffects expression 21346803
C004726 2-dichlorobenzene 2-dichlorobenzene results in increased expression of HRAS mRNAincreases expression 10614693
C024836 4-nitrophenol HRAS protein affects the glucuronidation of 4-nitrophenolaffects glucuronidation 11695553
C080417 4-octylphenol 4-octylphenol affects the reaction [HRAS protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene]affects reaction|increases response to substance 12117780
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA]decreases reaction|increases expression 15945272
D000244 Adenosine Diphosphate Adenosine Diphosphate binds to and affects the folding of HRAS proteinaffects binding|affects folding 16388579
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HRAS proteinaffects expression 20106945
C006632 arsenic trioxide [Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of HRAS mRNAaffects cotreatment|increases expression 18922899
C018003 benzo(a)pyrene-3,6-quinone benzo(a)pyrene-3,6-quinone results in increased expression of HRAS mRNAincreases expression 11008122
C017228 benzo(a)pyrene 7,8-dihydrodiol benzo(a)pyrene 7,8-dihydrodiol results in increased expression of HRAS mRNAincreases expression 11008122
D001564 Benzo(a)pyrene Benzo(a)pyrene metabolite results in increased expression of HRAS mRNAincreases expression 11008122
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HRAS mRNAincreases expression 11008122
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HRAS mRNAincreases expression 18973830
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HRAS proteinincreases expression 18973830
D001564 Benzo(a)pyrene epicatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]decreases reaction|increases expression 18973830
D001564 Benzo(a)pyrene epicatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]decreases reaction|increases expression 18973830
D001564 Benzo(a)pyrene epigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]decreases reaction|increases expression 18973830
D001564 Benzo(a)pyrene epigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]decreases reaction|increases expression 18973830
D001564 Benzo(a)pyrene theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]decreases reaction|increases expression 18973830
D001564 Benzo(a)pyrene theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]decreases reaction|increases expression 18973830
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HRAS mRNAincreases expression 20064080
19408242
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HRAS proteinincreases expression 20064080
19408242
D001564 Benzo(a)pyrene [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of HRAS mRNAaffects cotreatment|increases expression 19408242
D001564 Benzo(a)pyrene [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of HRAS proteinaffects cotreatment|increases expression 19408242
D001564 Benzo(a)pyrene Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]increases expression|increases reaction 20064080
D001564 Benzo(a)pyrene Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]increases expression|increases reaction 20064080
D001608 Beryllium Beryllium results in increased mutagenesis of HRAS geneincreases mutagenesis 7545909
C477843 bicyclol bicyclol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HRAS mRNA]decreases reaction|increases expression 17106253
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in decreased methylation of HRAS genedecreases methylation 9780227
D000001 Calcimycin Calcimycin promotes the reaction [RASGRF2 protein binds to HRAS protein]affects binding|increases reaction 16000378
C110904 capecitabine HRAS protein results in decreased susceptibility to capecitabinedecreases response to substance 16734730
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of HRAS mRNAincreases expression 8847708
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of HRAS mRNAaffects cotreatment|decreases expression 18636392
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of HRAS mRNAincreases expression 8471063
D003300 Copper [N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of HRAS geneaffects cotreatment|increases mutagenesis 11275476
C061481 dibenzoylmethane dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of HRAS mRNA]decreases reaction|increases expression 16051634
D002945 Cisplatin Cisplatin results in increased expression of HRAS mRNAincreases expression 18172885
D015127 9,10-Dimethyl-1,2-benzanthracene 4-octylphenol affects the reaction [HRAS protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene]affects reaction|increases response to substance 12117780
D015127 9,10-Dimethyl-1,2-benzanthracene Estradiol affects the reaction [HRAS protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene]affects reaction|increases response to substance 12117780
D015127 9,10-Dimethyl-1,2-benzanthracene HRAS protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthraceneincreases response to substance 12117780
11376698
C067311 docetaxel docetaxel results in increased expression of and results in increased activity of HRAS proteinincreases activity|increases expression 15970518
C025034 doxifluridine HRAS protein results in decreased susceptibility to doxifluridinedecreases response to substance 16734730
D004317 Doxorubicin Doxorubicin results in increased expression of HRAS mRNAincreases expression 16001973
C062669 epicatechin gallate epicatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]decreases reaction|increases expression 18973830
C062669 epicatechin gallate epicatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]decreases reaction|increases expression 18973830
C045651 epigallocatechin gallate epigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]decreases reaction|increases expression 18973830
C045651 epigallocatechin gallate epigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]decreases reaction|increases expression 18973830
C500988 estradiol-3,4-quinone estradiol-3,4-quinone results in increased mutagenesis of HRAS geneincreases mutagenesis 17261777
D004958 Estradiol dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of HRAS mRNA]decreases reaction|increases expression 16051634
D004958 Estradiol Estradiol affects the reaction [HRAS protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene]affects reaction|increases response to substance 12117780
D004958 Estradiol Estradiol results in increased expression of HRAS mRNAincreases expression 16051634
D004967 Estrogens [Malathion co-treated with Estrogens] results in increased expression of HRAS mRNAaffects cotreatment|increases expression 18204794
D004967 Estrogens [Parathion co-treated with Estrogens] results in increased expression of HRAS mRNAaffects cotreatment|increases expression 18204794
D005038 Ethylnitrosourea HRAS protein results in increased susceptibility to Ethylnitrosoureaincreases response to substance 11182032
C093323 farnesylthiosalicylic acid farnesylthiosalicylic acid results in decreased activity of HRAS proteindecreases activity 15328380
C093323 farnesylthiosalicylic acid farnesylthiosalicylic acid results in decreased expression of HRAS proteindecreases expression 16780807
C020748 ferrous sulfate ferrous sulfate affects the localization of HRAS proteinaffects localization 17172471
C020748 ferrous sulfate ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]affects binding|increases reaction 17172471
C020748 ferrous sulfate HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]affects reaction|increases phosphorylation 17172471
C020748 ferrous sulfate HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 17172471
C020748 ferrous sulfate HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 17172471
C020748 ferrous sulfate HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]affects reaction|increases phosphorylation 17172471
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of HRAS proteinincreases expression 11350689
D005472 Fluorouracil Fluorouracil results in increased expression of HRAS mRNAincreases expression 16557594
D005480 Flurbiprofen HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]affects reaction|increases expression 16949054
D005947 Glucose Glucose results in increased activity of HRAS proteinincreases activity 16572112
D005947 Glucose manumycin inhibits the reaction [Glucose results in increased activity of HRAS protein]decreases reaction|increases activity 16572112
D017127 Glycosylation End Products, Advanced Glycosylation End Products, Advanced results in increased activity of HRAS proteinincreases activity 16572112
D017127 Glycosylation End Products, Advanced manumycin inhibits the reaction [Glycosylation End Products, Advanced results in increased activity of HRAS protein]decreases reaction|increases activity 16572112
D006533 Heptachlor Heptachlor results in decreased expression of HRAS mRNAdecreases expression 1771636
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of HRAS mRNAincreases expression 11008122
D007501 Iron HRAS protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]affects reaction|increases phosphorylation 17172471
D007501 Iron HRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 17172471
D007501 Iron HRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 17172471
D007501 Iron HRAS protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]affects reaction|increases phosphorylation 17172471
D007501 Iron Iron affects the localization of HRAS proteinaffects localization 17172471
D007501 Iron Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]affects binding|increases reaction 17172471
D007854 Lead Lead inhibits the reaction [HSPA5 protein binds to HRAS enhancer]affects binding|decreases reaction 15111246
C008261 lead acetate lead acetate inhibits the reaction [HSPA5 protein binds to HRAS enhancer]affects binding|decreases reaction 15111246
C008281 limonene limonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea]decreases reaction|increases response to substance 11802805
C115354 lonafarnib lonafarnib inhibits the reaction [TNF protein results in increased activity of HRAS protein]decreases reaction|increases activity 15090542
D008294 Malathion [Malathion co-treated with Estrogens] results in increased expression of HRAS mRNAaffects cotreatment|increases expression 18204794
D008294 Malathion Malathion results in increased expression of HRAS mRNAincreases expression 18204794
C054474 manumycin manumycin inhibits the reaction [Glucose results in increased activity of HRAS protein]decreases reaction|increases activity 16572112
C054474 manumycin manumycin inhibits the reaction [Glycosylation End Products, Advanced results in increased activity of HRAS protein]decreases reaction|increases activity 16572112
D008627 Mercuric Chloride Mercuric Chloride promotes the reaction [HSPA5 protein binds to HRAS enhancer]affects binding|increases reaction 15111246
D008628 Mercury Mercury promotes the reaction [HSPA5 protein binds to HRAS enhancer]affects binding|increases reaction 15111246
D008770 Methylnitrosourea HRAS protein results in increased susceptibility to Methylnitrosoureaincreases response to substance 11376698
12117780
11802805
11182032
D008770 Methylnitrosourea limonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea]decreases reaction|increases response to substance 11802805
D008770 Methylnitrosourea HRAS protein results in decreased susceptibility to Methylnitrosoureadecreases response to substance 11973638
D008770 Methylnitrosourea Methylnitrosourea results in increased mutagenesis of HRAS geneincreases mutagenesis 10767621
15688392
C014593 N-hydroxy-4-aminobiphenyl [N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of HRAS geneaffects cotreatment|increases mutagenesis 11275476
D009538 Nicotine Nicotine results in increased activity of HRAS proteinincreases activity 15983034
D009583 Nitrofurazone Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA]decreases reaction|increases expression 15945272
D009583 Nitrofurazone Nitrofurazone results in increased expression of HRAS mRNAincreases expression 15945272
D009705 Nucleosides Nucleosides results in increased expression of HRAS mRNAincreases expression 15173389
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of HRAS mRNAaffects cotreatment|decreases expression 18636392
D010278 Parathion [Parathion co-treated with Estrogens] results in increased expression of HRAS mRNAaffects cotreatment|increases expression 18204794
D011005 Plutonium Plutonium results in increased mutagenesis of HRAS geneincreases mutagenesis 9255578
D011794 Quercetin Quercetin results in decreased expression of HRAS mRNAdecreases expression 10652438
D011794 Quercetin Quercetin results in decreased expression of HRAS proteindecreases expression 10652438
C059514 resveratrol resveratrol affects the expression of HRAS mRNA mutant formaffects expression 16369916
C059514 resveratrol resveratrol affects the expression of HRAS protein mutant formaffects expression 16369916
D012402 Rotenone Rotenone results in decreased expression of HRAS mRNAdecreases expression 10630619
C079198 S 1 (combination) HRAS protein results in decreased susceptibility to S 1 (combination)decreases response to substance 16734730
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of HRAS mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of HRAS mRNAincreases expression 19244175
D017632 Asbestos, Serpentine Asbestos, Serpentine results in increased expression of HRAS proteinincreases expression 10905503
D017632 Asbestos, Serpentine tobacco tar promotes the reaction [Asbestos, Serpentine results in increased expression of HRAS protein]increases expression|increases reaction 10905503
C017947 sodium arsenite sodium arsenite results in increased expression of HRAS mRNAincreases expression 19464579
C017947 sodium arsenite sodium arsenite results in increased expression of HRAS proteinincreases expression 16039940
C017947 sodium arsenite sodium arsenite results in decreased expression of HRAS mRNAdecreases expression 19822182
C017947 sodium arsenite sodium arsenite results in increased expression of HRAS mRNAincreases expression 16876216
11241755
D013458 Sulfur Dioxide [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of HRAS mRNAaffects cotreatment|increases expression 19408242
D013458 Sulfur Dioxide [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of HRAS proteinaffects cotreatment|increases expression 19408242
D013458 Sulfur Dioxide Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]increases expression|increases reaction 20064080
D013458 Sulfur Dioxide Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]increases expression|increases reaction 20064080
D013458 Sulfur Dioxide Sulfur Dioxide results in increased expression of HRAS mRNAincreases expression 19408242
20064080
D013458 Sulfur Dioxide Sulfur Dioxide results in increased expression of HRAS proteinincreases expression 20064080
19408242
C452601 sulindac derivative IND 12 HRAS protein affects the reaction [sulindac derivative IND 12 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]affects reaction|decreases activity|decreases phosphorylation 11912145
C452601 sulindac derivative IND 12 HRAS protein affects the reaction [sulindac derivative IND 12 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]affects reaction|decreases activity|decreases phosphorylation 11912145
D013481 Superoxides HRAS protein mutant form results in increased abundance of Superoxidesincreases abundance 11313892
D013481 Superoxides [HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF proteindecreases response to substance|increases abundance 11313892
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of HRAS mRNAaffects cotreatment|increases expression 18922899
D013755 Tetradecanoylphorbol Acetate bicyclol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HRAS mRNA]decreases reaction|increases expression 17106253
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of HRAS mRNAincreases expression 17106253
D013774 Tetranitromethane Tetranitromethane results in increased mutagenesis of HRAS geneincreases mutagenesis 9255578
C056068 theaflavin theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]decreases reaction|increases expression 18973830
C056068 theaflavin theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]decreases reaction|increases expression 18973830
C402769 tipifarnib HRAS gene mutant form results in increased susceptibility to tipifarnibincreases response to substance 16403772
16648579
C402769 tipifarnib tipifarnib results in decreased activity of HRAS proteindecreases activity 15970518
C024746 tobacco tar tobacco tar promotes the reaction [Asbestos, Serpentine results in increased expression of HRAS protein]increases expression|increases reaction 10905503
D014520 Urethane HRAS protein promotes the reaction [Urethane results in increased expression of CCND1 protein]increases expression|increases reaction 11307925
D014520 Urethane HRAS protein results in increased susceptibility to Urethaneincreases response to substance 11552296
10779650
D014520 Urethane Urethane results in increased mutagenesis of HRAS geneincreases mutagenesis 10779650
12765245
D001335 Vehicle Emissions HRAS protein results in increased susceptibility to Vehicle Emissionsincreases response to substance 11516524
D014750 Vincristine Vincristine results in increased expression of HRAS mRNAincreases expression 16001973
C017963 vinyl carbamate vinyl carbamate results in increased mutagenesis of HRAS geneincreases mutagenesis 12765245
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of HRAS mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of HRAS mRNAincreases expression 19244175
C088658 zoledronic acid zoledronic acid results in decreased localization of HRAS proteindecreases localization 11986784
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 19.6415814532 12690470 17670903
MESH:D058186 Acute Kidney Injury Mercuric Chloride 19.6411274264
MESH:D058186 Acute Kidney Injury resveratrol 19.6416538975
MESH:D058186 Acute Kidney Injury Superoxides 19.6418460982
MESH:D058186 Acute Kidney Injury zoledronic acid 19.6419715164
MESH:D055371 Acute Lung Injury Chlorine 3.6220601635
MESH:D000210 Acute-Phase Reaction zoledronic acid 4.7220200999
MESH:D000230 Adenocarcinoma 9,10-Dimethyl-1,2-benzanthracene 30.4210697514 12844480
MESH:D000230 Adenocarcinoma arsenic trioxide 30.4211798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 30.4220127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 30.4211798837 17638652
MESH:D000230 Adenocarcinoma Doxorubicin 30.4217418594
MESH:D000230 Adenocarcinoma Estradiol 30.4211473722
MESH:D000230 Adenocarcinoma Fluorouracil 30.4217638652
MESH:D000230 Adenocarcinoma Methylnitrosourea 30.4215688392 15113128
MESH:D000230 Adenocarcinoma Urethane 30.4218316556
MESH:D000230 Adenocarcinoma Vincristine 30.4219825857
MESH:D000230 Adenocarcinoma vinyl carbamate 30.4217363558 16247444
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 4.9315814487
MESH:D000236 Adenoma 2-Acetylaminofluorene 19.8110737359
MESH:D000236 Adenoma 9,10-Dimethyl-1,2-benzanthracene 19.8111376689
MESH:D000236 Adenoma Benzo(a)pyrene 19.816695378
MESH:D000236 Adenoma Ethylnitrosourea 19.816695378
MESH:D000236 Adenoma resveratrol 19.8115688382
MESH:D000236 Adenoma Urethane 19.8110822126 17195641 16926031 11497255 6695378 17093202 10530776
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.236705139
MESH:D018248 Adenoma, Liver Cell vinyl carbamate 4.8612371669
MESH:D011125 Adenomatous Polyposis Coli dibenzoylmethane 8.4817942926
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 8.4810680582
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 3.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.1217306315 16712894
MESH:D000382 Agricultural Workers' Diseases Heptachlor 10.5612661182
MESH:D000382 Agricultural Workers' Diseases Malathion 10.5617119214 11874814
MESH:D000382 Agricultural Workers' Diseases Parathion 10.5611874814 17119214
MESH:D000419 Albuminuria Doxorubicin 3.8121441931
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 4.8916640825
MESH:D000544 Alzheimer Disease Copper 9.8616866297 16325427 16410023 17119284 16886094 16962711
MESH:D000544 Alzheimer Disease Iron 9.8616563566 16640825
MESH:D000544 Alzheimer Disease Nicotine 9.8616627626
MESH:D000544 Alzheimer Disease Ozone 9.8615513908
MESH:D000544 Alzheimer Disease resveratrol 9.8616162502 16183991
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 3.7710694572
MESH:D000740 Anemia Fluorouracil 6.9716511603 17963324 15504547
MESH:D000740 Anemia Iron 6.9716434484 16566752
MESH:D000743 Anemia, Hemolytic Quercetin 3.5517084956
MESH:D018798 Anemia, Iron-Deficiency Copper 8.2316614410
MESH:D018798 Anemia, Iron-Deficiency Iron 8.2316569441 17147795 17162259 17375513 17163184
MESH:D000756 Anemia, Sideroblastic Iron 8.9516910769
MESH:D000756 Anemia, Sideroblastic Superoxides 8.9516910769
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.3319183758
MESH:D001145 Arrhythmias, Cardiac Iron 3.7016604332
MESH:D001169 Arthritis, Experimental resveratrol 2.9917115116
MESH:D001172 Arthritis, Rheumatoid Ozone 2.3315570426
MESH:D001195 Asbestosis Asbestos, Serpentine 4.9410751356
MESH:D001249 Asthma epigallocatechin gallate 4.3016516891
MESH:D001249 Asthma Ozone 4.3016373670 17854713
MESH:D001260 Ataxia Telangiectasia Iron 10.5715336622
MESH:D001260 Ataxia Telangiectasia Quercetin 10.5715336622
MESH:D050197 Atherosclerosis Iron 5.3816640825 16632123
MESH:D050197 Atherosclerosis resveratrol 5.3817967414 16873680
MESH:D001321 Autistic Disorder marker/mechanism 8098541
MESH:D001321 Autistic Disorder Iron 2.6817352947
MESH:D001321 Autistic Disorder Mercury 2.6817497416
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 13.9319761891
MESH:D001327 Autoimmune Diseases Mercury 13.9316634805
MESH:D001327 Autoimmune Diseases Quercetin 13.9319761891
MESH:D001424 Bacterial Infections Iron 4.4316640825
MESH:D001607 Berylliosis Beryllium 5.4119589099
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.4916206674
MESH:D001778 Blood Coagulation Disorders ferrous sulfate 7.496421970
MESH:D019046 Bone Marrow Neoplasms Cisplatin 9.4714601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 9.4714601052
MESH:D001859 Bone Neoplasms zoledronic acid 4.2516778634 11697798 15867366 19442620 17312309 16121404
MESH:D001862 Bone Resorption zoledronic acid 4.0115845617 8053405 18404659 16769263 11869084 18496637
MESH:D001927 Brain Diseases Ethylnitrosourea 4.2014991843
MESH:D002545 Brain Ischemia resveratrol 3.5317600658
MESH:D001932 Brain Neoplasms Copper 10.9817079463
MESH:D001932 Brain Neoplasms Doxorubicin 10.9817150277
MESH:D001932 Brain Neoplasms Ethylnitrosourea 10.9816651633 15144691 16436596 18412241 16357521
MESH:D001943 Breast Neoplasms marker/mechanism 17474063 15958052
MESH:D001943 Breast Neoplasms 9,10-Dimethyl-1,2-benzanthracene 13.4020435547 17127718 18840765 15565634 16153821
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 13.4017474063 20146248
MESH:D001943 Breast Neoplasms capecitabine 13.4012972520 18473752
MESH:D001943 Breast Neoplasms Cisplatin 13.4018382427 19526202
MESH:D001943 Breast Neoplasms Copper 13.4017079463 15986119
MESH:D001943 Breast Neoplasms docetaxel 13.4016495393 18628466 15567936 16264153 15692762 19526202 17369602
MESH:D001943 Breast Neoplasms Doxorubicin 13.4015939500 15993339 18628466 17369602 16096432 16322301 18695136 18382427 15136595 15567936 16264153 18234424 19526202 15634643 11325840 15692762 17426702 17983394 16935488 15994142 16115903 16826403 16595493 15668708
MESH:D001943 Breast Neoplasms Estradiol 13.4017289903 14630087 12948864 17018787 17261762 16675129 19861407 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 13.4019217205 16595493 15136595 18357371 18608205 16110121 16557594
MESH:D001943 Breast Neoplasms Heptachlor 13.408738476
MESH:D001943 Breast Neoplasms Malathion 13.4012762645
MESH:D001943 Breast Neoplasms Methylnitrosourea 13.4016253758 14633655 11306469
MESH:D001943 Breast Neoplasms Parathion 13.4012762645
MESH:D001943 Breast Neoplasms Quercetin 13.4018628248
MESH:D001943 Breast Neoplasms resveratrol 13.4016393696 17651959 17534123
MESH:D001943 Breast Neoplasms zoledronic acid 13.4018695136 16096432
MESH:D016535 Bronchial Hyperreactivity Ozone 3.0618315731 14754758 15516495 19059883 18417511 16777450 17626835
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.6211589617
MESH:D002100 Cachexia Ozone 3.9816183385
MESH:D002105 Cadmium Poisoning Quercetin 4.7716962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 7.4616050911 15700767 16011737 16124888 18705752 16227642 16097048 15673190 16192424 15721981 3786805 10355542
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 7.4616050911
MESH:D002276 Carcinoid Tumor Doxorubicin 9.7716051944
MESH:D002276 Carcinoid Tumor Fluorouracil 9.7716051944
MESH:D002277 Carcinoma Fluorouracil 2.9517121937
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 9311599
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 33.2616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 33.2616705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 33.2617761372 6705139 3084413 10737359 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 33.2612907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 33.2615553829 14691202 11135700 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 33.2618788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 33.2617982673
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 33.2618059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 33.2616924424
MESH:D006528 Carcinoma, Hepatocellular Estrogens 33.2615341023
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 33.2618930000 16332177 16799960 17045692 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Quercetin 33.2612508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 33.2619321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 33.2615276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular vinyl carbamate 33.2612371669
MESH:D018827 Carcinoma, Lewis Lung resveratrol 3.8316675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 13.2016685392 12023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung docetaxel 13.2011894018
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 13.2018212800 18347146
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinyl carbamate 13.2016247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 13.2019233551
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.2117234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.0919014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 11.9416201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 11.9418695887
MESH:D002292 Carcinoma, Renal Cell Vincristine 11.9416201981
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 11.9418507039
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.4412490120
MESH:D002294 Carcinoma, Squamous Cell 9,10-Dimethyl-1,2-benzanthracene 31.5211376689
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 31.5217015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 31.5220419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 31.5217066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 31.526189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 31.5218986760 16280240 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell resveratrol 31.5216227395
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 31.5215984520
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 31.5218572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 31.5218922899
MESH:D002294 Carcinoma, Squamous Cell Vincristine 31.526189445
MESH:C535579 Cardiofaciocutaneous syndrome marker/mechanism 17703371
MESH:D006332 Cardiomegaly Copper 5.8017327471
MESH:D006332 Cardiomegaly Quercetin 5.8019794523
MESH:D009202 Cardiomyopathies Doxorubicin 6.3417928571 16364871 17382496 16651473 17007740 16455267 16952015 15505089 16612575 18627295 16278810 17329180 17974986 15476868 17924179 16269455 16242529 17519947 15811867 17351982 16731534 16109756 15792986 17308081 17131338
MESH:D009202 Cardiomyopathies Iron 6.3416640825
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 7.7317334414 16243910
MESH:D002311 Cardiomyopathy, Dilated Iron 7.7316604332
MESH:D002311 Cardiomyopathy, Dilated Mercury 7.7310334427
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 5.7116936243
MESH:D002318 Cardiovascular Diseases resveratrol 5.7115458977
MESH:D002386 Cataract Methylnitrosourea 3.4912484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 27.486135515
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 27.4818226522
MESH:D002471 Cell Transformation, Neoplastic Estradiol 27.4818566989
MESH:D002471 Cell Transformation, Neoplastic estradiol-3,4-quinone 27.4818226522
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 27.4816003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 27.482727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 27.4819524636 20056578
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 27.4819559774
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.2017160924
MESH:D014355 Chagas Disease Nitrofurazone 6.4011354658
MESH:D002972 Cleft Palate Urethane 3.3912810352
MESH:D003092 Colitis resveratrol 7.1916474422
MESH:D003092 Colitis Selenium 7.1917936198
MESH:D003110 Colonic Neoplasms Fluorouracil 6.5516340194 15001691 17018589 17725105 17016597 16510598 18772588 17172411 17169374 17287894
MESH:D003110 Colonic Neoplasms Iron 6.5516640825
MESH:D003110 Colonic Neoplasms Quercetin 6.5517148506 19056647 19440933 16640504 11134977 15741050 17191121
MESH:D003110 Colonic Neoplasms resveratrol 6.5516338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 8.5720501625
MESH:D015179 Colorectal Neoplasms capecitabine 8.5718473752 18448328
MESH:D015179 Colorectal Neoplasms Cisplatin 8.5715273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 8.5718259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 8.5717016601 17401013 16391804 17695437 18448328 18383874 18288408 16303861 14970324 17454858 18949393 15148649 17094418 16524972 17594712 16331619 15289873 18509181 17255274 16282729 20501625 18802399
MESH:D015179 Colorectal Neoplasms Quercetin 8.5718852136 18095365
MESH:D015179 Colorectal Neoplasms resveratrol 8.5716550006
MESH:D003327 Coronary Disease resveratrol 3.2116507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.4612609071
MESH:D003329 Coronary Vasospasm capecitabine 5.0817465463
MESH:D056685 Costello Syndrome marker/mechanism 17468812 19132118 17703371
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.4710525206
MESH:D019465 Craniofacial Abnormalities Lead 4.4719769572
MESH:D019465 Craniofacial Abnormalities lead acetate 4.4719769572
MESH:D019465 Craniofacial Abnormalities Vitamin E 4.4719769572
MESH:D016638 Critical Illness Estrogens 5.1816670151
MESH:D003490 Cyanosis 2,4-dinitrotoluene 8.4218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 8.4218551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 3.7119747007
MESH:D007644 Darier Disease Fluorouracil 4.0316733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.3815213294
MESH:D003704 Dementia Lead 4.5616140633
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.1116823706
MESH:D048909 Diabetes Complications Glycosylation End Products, Advanced 5.8519471234
MESH:D003920 Diabetes Mellitus Iron 3.8016640825 16604332
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 6.4319496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 6.4316873680
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.0616506275
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 4.2716988119
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.2716506275
MESH:D003928 Diabetic Nephropathies Estradiol 6.8419279558
MESH:D003928 Diabetic Nephropathies resveratrol 6.8416286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.7021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 19.7011287661
MESH:D056486 Drug-Induced Liver Injury bicyclol 19.7015998439
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 19.7016177239 6884620 10915739 15998439 15968718 10092053 9327722 11566570 17522070 6623471 2869522 7179309 16227642 15027814 7440962 19336974 21278145 7120509 19085960 3732212 4309450 3786805
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 19.7017851650
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 19.7017416283
MESH:D056486 Drug-Induced Liver Injury manumycin 19.7019739265
MESH:D056486 Drug-Induced Liver Injury Selenium 19.7015131321
MESH:D004362 Drug Toxicity Cisplatin 6.5312649298 19839026 15033597 12231392
MESH:D004362 Drug Toxicity Doxorubicin 6.5318602426
MESH:D004417 Dyspnea Chlorine 3.8520016425
MESH:D020821 Dystonic Disorders Nicotine 5.1617881519
MESH:C538011 Eales disease Vitamin E 3.929068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.2018357618
MESH:D004487 Edema resveratrol 5.108985016
MESH:D004487 Edema Tetradecanoylphorbol Acetate 5.1011698051 8113982 15177302 7812673 16716910 9599246 8273558
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.3117872969
MESH:D016889 Endometrial Neoplasms Doxorubicin 5.7317359293
MESH:D016889 Endometrial Neoplasms Estradiol 5.7319148513 11473722 18566989
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.3818037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.1017923197
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.8712903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.8716530937
MESH:D004938 Esophageal Neoplasms Cisplatin 10.8716785472 15464296 17638652 15173087 16481741
MESH:D004938 Esophageal Neoplasms docetaxel 10.8716337965
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.8716337965 16785472 15173087 17638652 16481741
MESH:D020329 Essential Tremor Lead 5.1614594619 18007985
MESH:D005234 Fatty Liver arsenic trioxide 13.3315073043
MESH:D005234 Fatty Liver bicyclol 13.3316409862
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.3316239168 12795759 61145 12631006 19224547 15959796 16045604 17595544
MESH:D005234 Fatty Liver Iron 13.3316640825
MESH:D005264 Femoral Fractures zoledronic acid 5.0616234978
MESH:D005317 Fetal Growth Retardation Lead 9.2919769572
MESH:D005317 Fetal Growth Retardation lead acetate 9.2919769572
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 3.8319069698
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.4711555667
MESH:D005355 Fibrosis Carbon Tetrachloride 6.4918705752
MESH:D005355 Fibrosis Quercetin 6.4919474275
MESH:D005621 Friedreich Ataxia Iron 4.6816604332 16640825
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 9.3616904648
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 9.3619093184
MESH:D005739 Gas Poisoning Chlorine 4.2320016425
MESH:D005833 Genital Neoplasms, Female sodium arsenite 3.9116452187
MESH:D005909 Glioblastoma Doxorubicin 8.9117150277
MESH:D005909 Glioblastoma Ethylnitrosourea 8.9116436596
MESH:D005909 Glioblastoma Quercetin 8.9119804834
MESH:D005910 Glioma Ethylnitrosourea 11.0516651633 16357521 18412241
MESH:D005910 Glioma Fluorouracil 11.0516145905
MESH:D005910 Glioma Methylnitrosourea 11.059825942
MESH:D005910 Glioma Quercetin 11.0517643826
MESH:D006030 Glycosuria, Renal Mercuric Chloride 5.142918855
MESH:D006099 Granuloma Beryllium 6.7419070257
MESH:D006258 Head and Neck Neoplasms Cisplatin 13.9815464296 15102660
MESH:D006258 Head and Neck Neoplasms Doxorubicin 13.9815692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 13.9815162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 13.9818607998 15984520
MESH:D034381 Hearing Loss Cisplatin 3.6419898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 3.7715464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.1320471113
MESH:D006330 Heart Defects, Congenital Vitamin E 5.1316080930
MESH:D006331 Heart Diseases Doxorubicin 6.2116244372 12587719 14766674 16707910 17875725 18674790 16879835 16144979 16495754 16244371 18006777 16330681 17888722
MESH:D006331 Heart Diseases Urethane 6.2116046796
MESH:D006333 Heart Failure Doxorubicin 5.5117481944
MESH:D006333 Heart Failure Selenium 5.5117162251
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.546705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 7.126705139
MESH:D006394 Hemangiosarcoma Doxorubicin 7.1215692506
MESH:D006432 Hemochromatosis Iron 3.9017255318 16640825 17053826 16574947 16604332 17236123
MESH:D006486 Hemosiderosis Iron 4.4416604332
MESH:D006505 Hepatitis Carbon Tetrachloride 2.8719110552 19900420
MESH:D006521 Hepatitis, Chronic Copper 4.5017338147
MESH:D006525 Hepatitis, Viral, Human Iron 4.6916640825
MESH:D006527 Hepatolenticular Degeneration Copper 8.9917109627 17276780 16607473 17182432 19888908
MESH:D006527 Hepatolenticular Degeneration Iron 8.9917182432
MESH:D006529 Hepatomegaly Iron 3.5916890145
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.3716863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.2515709030
MESH:D006561 Herpes Simplex resveratrol 3.4316876885
MESH:D015658 HIV Infections Iron 3.2216597321
MESH:D006689 Hodgkin Disease Cisplatin 12.2416200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 12.2415147373 18501091 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 12.2412676792
MESH:D006689 Hodgkin Disease Vincristine 12.2417606976 16135485 16794504 15147373
MESH:D019584 Hot Flashes Estradiol 7.4817088409
MESH:D019584 Hot Flashes Vitamin E 7.4814716179
MESH:D006930 Hyperalgesia zoledronic acid 3.6416769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.7716899240
MESH:D006934 Hypercalcemia zoledronic acid 4.3519622757 18089816
MESH:D006937 Hypercholesterolemia resveratrol 3.3217188708
MESH:D006943 Hyperglycemia Quercetin 3.3611834736 18262572
MESH:D020138 Hyperhomocysteinemia Superoxides 4.6112615666
MESH:D006949 Hyperlipidemias resveratrol 3.3316873680
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 3.8417604070
MESH:D006973 Hypertension Quercetin 2.5218356687
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.3415338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.6317488730
MESH:D006996 Hypocalcemia zoledronic acid 5.4112669777
MESH:D007006 Hypogonadism Iron 3.8316640825
MESH:D007037 Hypothyroidism Iron 4.3316640825
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 3.9017600658
MESH:D007248 Infertility, Male Lead 11.7216780224
MESH:D007248 Infertility, Male Methylnitrosourea 11.727193160
MESH:D007248 Infertility, Male Parathion 11.7216029889
MESH:D007248 Infertility, Male sodium arsenite 11.7212646999 15346721
MESH:D007249 Inflammation Flurbiprofen 6.0511099482
MESH:D007249 Inflammation resveratrol 6.0516366677
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 6.057812673 7562506 8273558 11698051 15177302
MESH:D007251 Influenza, Human Quercetin 20.3016624496
MESH:D007251 Influenza, Human resveratrol 20.3016624496
MESH:D007251 Influenza, Human Selenium 20.3016624496
MESH:D007251 Influenza, Human Vitamin E 20.3016624496
MESH:D007333 Insulin Resistance Estradiol 2.4316627594 16393666
MESH:D007410 Intestinal Diseases Superoxides 4.7010210152
MESH:D019189 Iron Metabolism Disorders Iron 4.3217163184
MESH:D007627 Keloid Quercetin 4.2117086741
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.3615464296
MESH:D007674 Kidney Diseases 2-dichlorobenzene 25.238440869
MESH:D007674 Kidney Diseases Cisplatin 25.2312649298 19839026 12231392 15190930 18289764
MESH:D007674 Kidney Diseases Doxorubicin 25.2315699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 25.2315618244
MESH:D007674 Kidney Diseases Mercury 25.2317934191
MESH:D007674 Kidney Diseases Quercetin 25.2316962696
MESH:D007674 Kidney Diseases sodium arsenite 25.2320008137
MESH:D007674 Kidney Diseases Vitamin E 25.2312488133
MESH:D007676 Kidney Failure, Chronic Copper 18.2116518626
MESH:D007676 Kidney Failure, Chronic Doxorubicin 18.2116707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 18.2116518626
MESH:D007676 Kidney Failure, Chronic Selenium 18.2116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.6416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.6416705839
MESH:D007680 Kidney Neoplasms Estradiol 16.6415610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 16.6417379185
MESH:D007680 Kidney Neoplasms Fluorouracil 16.6416985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.0211231351
MESH:D007855 Lead Poisoning Lead 5.1616700817
MESH:D007859 Learning Disorders Copper 7.9517134702
MESH:D007859 Learning Disorders Lead 7.9516384672
MESH:D007938 Leukemia arsenic trioxide 4.9915070760
MESH:D007938 Leukemia Quercetin 4.9917468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.3816085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 7.6717077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 7.6718089816
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.8314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.0719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 1.9820471514 16467208 17050201 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 5.9717107899 17869043 11468182 12018890 16112521 15622746 19075265 16331271 16823087 15748426 16891316 15336539 9834237 17217047 17649720 16330433 15213294 16966277 12712474 12679006 19035177 11161223 19642359 19225113 17712046
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 5.9716087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.6216882451
MESH:D020961 Lewy Body Disease Iron 4.6816563566
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 3.6215526292
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.3416221502 16943688 17174718 11408273 17334410 17157831 16239168 21278145 11903743
MESH:D008103 Liver Cirrhosis Iron 5.3416640825
MESH:D008106 Liver Cirrhosis, Experimental bicyclol 10.5116603200 15730626
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.5118006644 15876570 16248980 12958196 14716496 12667390 12649538 16011737 18395914 16192424 15925388 18156304 15931870 18263696 17922224 14716833 12389079 17766677 18412020 16027843 15338365 13678700 17708605 15052691 16638106 18395095 16015684 18187930 17805973 18317297 12632514 16033810 14620537 14512876 17761835 16097048 17481882 18429990 18054572 15362042 12445418 12445421 18472332 15650968 17869086 17900296 16136751 18166357 15730626 17631135 14748882 18339082 15673190 17944888 17698563 18420326 18210741 17823541 18472094 15893842 18277467 12609069 18251166 18205269 17557913 15057751 17714472 17565644 12741479 10355542 12898905 18279442 15818738 20821823 12546737 17640975 18376398 15996030 12586293 15123356 12632512 12666154 18481824 17976157 18705752 14724832 15959796 15370692 17525996 16116963 18418968 17721639 11481614
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 10.5116439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 10.5117481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.5114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental farnesylthiosalicylic acid 10.5115288472
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.5112741479
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.5116169303
MESH:D008107 Liver Diseases 2-dichlorobenzene 5.441949037 8440869 1853346 8661352
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.4416246199 16964402 17285989 15830285 15720792
MESH:D008107 Liver Diseases limonene 5.441715830
MESH:D008108 Liver Diseases, Alcoholic Iron 4.2616737972 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.0116899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 49.107678174
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 49.1010672840 10737359 16273603 11376686 18001218 14678523
MESH:D008113 Liver Neoplasms 9,10-Dimethyl-1,2-benzanthracene 49.109643874
MESH:D008113 Liver Neoplasms Aflatoxin B1 49.102125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 49.1014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 49.1021137059 20195826
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 49.1018177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 49.1019294768
MESH:D008113 Liver Neoplasms Copper 49.1020302851
MESH:D008113 Liver Neoplasms Fluorouracil 49.1017045692 16603448 15113037 18383874
MESH:D008113 Liver Neoplasms Heptachlor 49.109544696 2422723
MESH:D008113 Liver Neoplasms Iron 49.1016640825 20302851
MESH:D008113 Liver Neoplasms Quercetin 49.1018980244
MESH:D008113 Liver Neoplasms resveratrol 49.1019321006 19812893 19073162 20405173
MESH:D008113 Liver Neoplasms sodium arsenite 49.1016712894 15276417
MESH:D008113 Liver Neoplasms Urethane 49.1017559639 16391232 17093202
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 24.066135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 24.066150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental 9,10-Dimethyl-1,2-benzanthracene 24.061399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 24.068603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 24.0620377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 24.0612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 24.0617085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Quercetin 24.0619519916
MESH:D008133 Long QT Syndrome arsenic trioxide 2.7515213294
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 4.7116080182
MESH:D008171 Lung Diseases Acetylcysteine 17.2412815614
MESH:D008171 Lung Diseases Asbestos, Serpentine 17.2417200189
MESH:D008171 Lung Diseases Ozone 17.2419066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 17.2419095001
MESH:D008171 Lung Diseases Vitamin E 17.2416863852
MESH:D055370 Lung Injury Ozone 3.1220417186
MESH:D008175 Lung Neoplasms marker/mechanism 10779650 11307925 11552296 12765245
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 63.0011376686
MESH:D008175 Lung Neoplasms 9,10-Dimethyl-1,2-benzanthracene 63.0011376689
MESH:D008175 Lung Neoplasms Aflatoxin B1 63.0014755239
MESH:D008175 Lung Neoplasms arsenic trioxide 63.0019825857 11798837
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 63.0011198217
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 63.0018816296 20064080 20464547 17053015 18569708 6695378 20135361 18520028 20869020
MESH:D008175 Lung Neoplasms Beryllium 63.009255578 8933044 7545909 9715507
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 63.0019925653 11696405 18597497 19359593 16337739 15390079 11246140
MESH:D008175 Lung Neoplasms Cisplatin 63.006189445 11798837 17225452
MESH:D008175 Lung Neoplasms Doxorubicin 63.006189445 17418594
MESH:D008175 Lung Neoplasms Ethylnitrosourea 63.0016019985 6695378 16271038 17703301
MESH:D008175 Lung Neoplasms Fluorouracil 63.0015246190
MESH:D008175 Lung Neoplasms Iron 63.0016640825
MESH:D008175 Lung Neoplasms Methylnitrosourea 63.0018062963
MESH:D008175 Lung Neoplasms Ozone 63.008597069 7614698
MESH:D008175 Lung Neoplasms Plutonium 63.009255578
MESH:D008175 Lung Neoplasms Quercetin 63.0016280456
MESH:D008175 Lung Neoplasms sodium arsenite 63.0016712894 15276417 19931552 17077188 17306315
MESH:D008175 Lung Neoplasms Sulfur Dioxide 63.0020064080
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 63.0011807781
MESH:D008175 Lung Neoplasms Tetranitromethane 63.0014713543 9255578
MESH:D008175 Lung Neoplasms tipifarnib 63.0016885199
MESH:D008175 Lung Neoplasms Urethane 63.0012957351 16337739 11893704 11062179 16289808 17093202 15166089 11246140 11544531 15136453 6695378 17195641 17255336 11307925 12466968 11497255 10997738 12117781 15902970 16007126 12765245 11074608 11807781 10779650 11323394 10530776 16926031 11552296 10822126 11992545 16204055 14587096 7750092 16788158 16391232
MESH:D008175 Lung Neoplasms Vehicle Emissions 63.009255578
MESH:D008175 Lung Neoplasms Vincristine 63.0019825857 6189445
MESH:D008175 Lung Neoplasms vinyl carbamate 63.0011134547 12765245 17361011 16885199 12438228 14755239 15824018 16247444 15172992 17363558 12117777 11195469 17163412
MESH:D008175 Lung Neoplasms Vitamin E 63.0011062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.0315086387
MESH:D008223 Lymphoma 9,10-Dimethyl-1,2-benzanthracene 13.2711376689
MESH:D008223 Lymphoma Doxorubicin 13.2716098063
MESH:D008223 Lymphoma Ethylnitrosourea 13.2715790496
MESH:D008223 Lymphoma Methylnitrosourea 13.2716257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 8.1814633661
MESH:D016393 Lymphoma, B-Cell resveratrol 8.1817088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 6.7517654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 6.7514749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 9.2115621674
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 9.2115375218
MESH:D008268 Macular Degeneration Iron 3.5016640825
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.4915688416
MESH:D008325 Mammary Neoplasms, Experimental marker/mechanism 11376698
MESH:D008325 Mammary Neoplasms, Experimental 9,10-Dimethyl-1,2-benzanthracene 36.4418840765 16153821 1500032 8985016 16082771 11807958 10697514 12844480
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 36.441500032
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 36.4415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 36.4411807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 36.4410767621 10838139 18041768
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 36.4410767621 14999141 11751437 16827153 15113128 17020996 15313902 19196723 11807958 16051031 16619500 16944150 17131329 15688392 10838139 12931682 14633655
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 36.4411606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 36.4415318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 36.448985016
MESH:D008325 Mammary Neoplasms, Experimental tipifarnib 36.4416648579
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 36.4417312309
MESH:D020149 Manganese Poisoning Estradiol 3.7019453300
MESH:D008545 Melanoma Cisplatin 14.7218176117 17761969 12393984 18505091 11135225 16432458 12883367 17023156 18332650 16248763 12374674 15577323 16809738
MESH:D008545 Melanoma docetaxel 14.7212417787
MESH:D008545 Melanoma Doxorubicin 14.7216827129
MESH:D008545 Melanoma epigallocatechin gallate 14.7211746506 17992120
MESH:D008545 Melanoma farnesylthiosalicylic acid 14.7212535206
MESH:D008545 Melanoma Glucose 14.7214993021
MESH:D008545 Melanoma resveratrol 14.7217992120
MESH:D008545 Melanoma sodium arsenite 14.7216487513 19082730
MESH:D018328 Melanoma, Amelanotic Cisplatin 9.5715990972
MESH:D018328 Melanoma, Amelanotic Vincristine 9.5715990972
MESH:D008569 Memory Disorders Lead 4.4416384672 17263510
MESH:D008579 Meningioma Ethylnitrosourea 5.2017943659
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.1217268249 17109627
MESH:D008654 Mesothelioma Cisplatin 11.4417638057
MESH:D008654 Mesothelioma Doxorubicin 11.4417638057
MESH:D008654 Mesothelioma Selenium 11.4415107826
MESH:D008654 Mesothelioma zoledronic acid 11.4416675582
MESH:D008659 Metabolic Diseases resveratrol 3.6817112576
MESH:D008679 Metaplasia Ozone 4.3310496685
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.8015792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 6.4916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 6.4916757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.0317415656
MESH:D009101 Multiple Myeloma arsenic trioxide 12.6719549372 19417148 15949261 11468182 14977855
MESH:D009101 Multiple Myeloma lonafarnib 12.6716996129
MESH:D009101 Multiple Myeloma resveratrol 12.6714749477 16490592 16267019 17049120 17164350 17935668
MESH:D009101 Multiple Myeloma zoledronic acid 12.6719621390 18089719 16996129
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 4.8917086897
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 10.0917962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.0917962980
MESH:D009181 Mycoses Iron 4.6916640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 3.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.6516882451 16105982
MESH:D009203 Myocardial Infarction Doxorubicin 10.4219429709 15857846
MESH:D009203 Myocardial Infarction Quercetin 10.4219595682
MESH:D009203 Myocardial Infarction resveratrol 10.4217015251 17188708 16456233 16525036 17125593 16317513
MESH:D009203 Myocardial Infarction Vincristine 10.4217284715
MESH:D017202 Myocardial Ischemia Iron 7.4516604332
MESH:D017202 Myocardial Ischemia resveratrol 7.4517125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Estradiol 10.8316810080
MESH:D015428 Myocardial Reperfusion Injury Iron 10.8316604332
MESH:D015428 Myocardial Reperfusion Injury Quercetin 10.8319207477
MESH:D009205 Myocarditis resveratrol 4.0017322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 7.8218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 7.827678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.2316624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 10.6014720322
MESH:D009362 Neoplasm Metastasis capecitabine 10.6012972520
MESH:D009362 Neoplasm Metastasis Doxorubicin 10.6018259882
MESH:D009362 Neoplasm Metastasis zoledronic acid 10.6017312309 19139120 15867366
MESH:D009369 Neoplasms 9,10-Dimethyl-1,2-benzanthracene 31.3811544531
MESH:D009369 Neoplasms Benzo(a)pyrene 31.3811141357
MESH:D009369 Neoplasms capecitabine 31.3816374040
MESH:D009369 Neoplasms Cisplatin 31.3816773208
MESH:D009369 Neoplasms Fluorouracil 31.3818239605 18600527 16928823
MESH:D009369 Neoplasms Methylnitrosourea 31.3815533788
MESH:D009369 Neoplasms Nicotine 31.3816365874
MESH:D009369 Neoplasms Nitrofurazone 31.3815488632
MESH:D009369 Neoplasms Quercetin 31.3815185748
MESH:D009369 Neoplasms sodium arsenite 31.3811559025
MESH:D009369 Neoplasms Urethane 31.3815625555
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 25.8411704859
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 25.8416707424
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 25.8412696579
MESH:D009374 Neoplasms, Experimental resveratrol 25.848985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 25.8420056578
MESH:D009374 Neoplasms, Experimental Urethane 25.8415582191
MESH:D009389 Neovascularization, Pathologic Copper 12.8017308104
MESH:D009389 Neovascularization, Pathologic Estradiol 12.8017289903
MESH:D009389 Neovascularization, Pathologic Nicotine 12.8016365874
MESH:D009395 Nephritis, Interstitial Cisplatin 3.7215464296
MESH:D009401 Nephrosis Doxorubicin 4.0216899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.5615640375 16889571
MESH:D009404 Nephrotic Syndrome Iron 7.5617178036
MESH:D009410 Nerve Degeneration Rotenone 3.2715790535 18619942 17356569
MESH:D009421 Nervous System Malformations Estradiol 2.9311399458 16427766
MESH:D009436 Neural Tube Defects Acetylcysteine 9.1319446573
MESH:D009436 Neural Tube Defects arsenic trioxide 9.1310525206
MESH:D009436 Neural Tube Defects sodium arsenite 9.1312854658
MESH:D009442 Neurilemmoma Ethylnitrosourea 10.7516003739 17160924 16651423
MESH:D009442 Neurilemmoma Methylnitrosourea 10.7511555667
MESH:D009447 Neuroblastoma Cisplatin 5.618761367
MESH:D009447 Neuroblastoma Doxorubicin 5.6115555623
MESH:D019636 Neurodegenerative Diseases Iron 6.7317296847 16604332
MESH:D019636 Neurodegenerative Diseases resveratrol 6.7317652729
MESH:D017599 Neuroectodermal Tumors Cisplatin 9.298761367
MESH:D017599 Neuroectodermal Tumors Vincristine 9.2912837982
MESH:D020078 Neurogenic Inflammation Quercetin 8.3317929310
MESH:D020078 Neurogenic Inflammation resveratrol 8.3317929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 6.6816436463
MESH:D020258 Neurotoxicity Syndromes Malathion 6.6815081274
MESH:D009634 Noonan Syndrome marker/mechanism 17703371
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 6.6512819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 6.6516049721
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.2017160924
MESH:D010003 Osteoarthritis Iron 3.4616640825
MESH:D010014 Osteolysis zoledronic acid 4.6115867366
MESH:D010024 Osteoporosis Iron 6.0516640825 16648989
MESH:D010024 Osteoporosis zoledronic acid 6.0517882678
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 7.8419495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 7.8417513867
MESH:D012516 Osteosarcoma Doxorubicin 3.4815930896
MESH:D010051 Ovarian Neoplasms 9,10-Dimethyl-1,2-benzanthracene 21.4416891317
MESH:D010051 Ovarian Neoplasms arsenic trioxide 21.4419769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Cisplatin 21.4419769630 6897625 17225452 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 21.4419401270
MESH:D010051 Ovarian Neoplasms Nitrofurazone 21.4411026599
MESH:D010051 Ovarian Neoplasms Quercetin 21.4419005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 21.4415276417 17306315
MESH:D010051 Ovarian Neoplasms Urethane 21.4416391232
MESH:D010146 Pain zoledronic acid 3.3416475674
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.9015580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 15.9019003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.9016500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 15.9016965848
MESH:D010190 Pancreatic Neoplasms Quercetin 15.9016965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 15.9015976015
MESH:D010212 Papilloma marker/mechanism 8330346
MESH:D010212 Papilloma 9,10-Dimethyl-1,2-benzanthracene 16.2215173996 17234724 16517061
MESH:D010212 Papilloma Hydrogen Peroxide 16.2212065085
MESH:D010212 Papilloma Iron 16.2212065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 16.228330346 12065085 18404319 18922899
MESH:D010235 Paraganglioma arsenic trioxide 3.4519927285
MESH:D020447 Parasomnias Iron 5.2417352947
MESH:D010300 Parkinson Disease Iron 4.5716563566 16640825
MESH:D010300 Parkinson Disease Rotenone 4.5719114014 18619942 11445065 19232380 11535288 18191903 15451049 16412576 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 3.4115927086 18197244 15795934 15574749
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.5815464296
MESH:D010538 Peritonitis Ozone 3.3916369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.3817983394
MESH:D010900 Pituitary Diseases Iron 4.8916604332
MESH:D010911 Pituitary Neoplasms Urethane 4.6716391232
MESH:D010954 Plasmacytoma Selenium 4.1115087411
MESH:D010995 Pleural Diseases Asbestos, Serpentine 4.9410923243
MESH:D010997 Pleural Neoplasms Cisplatin 11.3517638057
MESH:D010997 Pleural Neoplasms Doxorubicin 11.3517638057
MESH:D011014 Pneumonia Butylated Hydroxytoluene 8.8011893704
MESH:D011014 Pneumonia Ozone 8.8018007984 18929643 18381685
MESH:D011041 Poisoning Iron 3.5916604332
MESH:D011085 Polycystic Ovary Syndrome Glycosylation End Products, Advanced 5.3917201808
MESH:D017119 Porphyria Cutanea Tarda Iron 4.2516640825
MESH:D011230 Precancerous Conditions Quercetin 3.3319056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 4.1421297632
MESH:D011225 Pre-Eclampsia Iron 3.8116640825
MESH:D011297 Prenatal Exposure Delayed Effects Lead 7.8216384672
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 7.8216679765
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.1920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 8.6019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 8.6017292933
MESH:D011471 Prostatic Neoplasms Copper 8.6017308104 17079463
MESH:D011471 Prostatic Neoplasms docetaxel 8.6018824434 16644109 16520278 19103299
MESH:D011471 Prostatic Neoplasms Doxorubicin 8.6016888761 15897917 16868541 18437689 15749863 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 8.6016740699
MESH:D011471 Prostatic Neoplasms farnesylthiosalicylic acid 8.6016780807
MESH:D011471 Prostatic Neoplasms Fluorouracil 8.6019082440 18626508
MESH:D011471 Prostatic Neoplasms Flurbiprofen 8.6017409433
MESH:D011471 Prostatic Neoplasms Heptachlor 8.6012661182
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 8.6015682402 12376480
MESH:D011471 Prostatic Neoplasms Quercetin 8.6014715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 8.6017675339 17718901 17636462 16731767 17804756 15767336
MESH:D011471 Prostatic Neoplasms sodium arsenite 8.6016039940
MESH:D011471 Prostatic Neoplasms theaflavin 8.6017499812
MESH:D011471 Prostatic Neoplasms Vitamin E 8.6015084515
MESH:D011471 Prostatic Neoplasms zoledronic acid 8.6019103299 12438248
MESH:D011528 Protozoan Infections Iron 5.2416640825
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 3.4815511213 18569384
MESH:D012004 Rectal Neoplasms Fluorouracil 3.3515538739 16160472 18722050 18286688
MESH:D000608 Renal Aminoacidurias Mercuric Chloride 5.322918855
MESH:D051437 Renal Insufficiency Cisplatin 7.9115464296
MESH:D051437 Renal Insufficiency Doxorubicin 7.9117922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.8016325855
MESH:D015427 Reperfusion Injury resveratrol 5.8816314181 17520802 17058453 15827377 16317513
MESH:D015427 Reperfusion Injury Superoxides 5.8818460982
MESH:D012120 Respiration Disorders Chlorine 4.4318579056
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 3.8212210543
MESH:D012135 Respiratory Sounds Malathion 12.3211874814 17119214
MESH:D012135 Respiratory Sounds Parathion 12.3211874814 17119214
MESH:D012135 Respiratory Sounds Vehicle Emissions 12.3218950799
MESH:D012140 Respiratory Tract Diseases Malathion 8.9317119214
MESH:D012140 Respiratory Tract Diseases Parathion 8.9317119214
MESH:D012148 Restless Legs Syndrome Iron 3.9416930377
MESH:D012162 Retinal Degeneration Methylnitrosourea 3.8118155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 4.7211555667
MESH:D012509 Sarcoma Doxorubicin 3.3218313854 16767912 15675481 15625365 17710206 17203757
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 18.6916646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 18.6914601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 18.6914601052 16326096
MESH:D012512 Sarcoma, Ewing's zoledronic acid 18.6916121404
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.0317846226
MESH:D012554 Schistosomiasis japonica Quercetin 4.7716862918
MESH:D012559 Schizophrenia Copper 2.9616842975
MESH:D012640 Seizures 2,4-dinitrotoluene 6.7518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7518551238
MESH:D012640 Seizures Nicotine 6.7517873105
MESH:D018239 Seminoma marker/mechanism 19855393
MESH:D012871 Skin Diseases Vitamin E 2.1918709164
MESH:D012878 Skin Neoplasms marker/mechanism 8330346 18758463 15958052
MESH:D012878 Skin Neoplasms 9,10-Dimethyl-1,2-benzanthracene 32.6615173996 11376689 16517061 8985016
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 32.6610029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 32.6615692506
MESH:D012878 Skin Neoplasms Glucose 32.6614993021
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 32.6612065085
MESH:D012878 Skin Neoplasms Iron 32.6612065085
MESH:D012878 Skin Neoplasms resveratrol 32.668985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 32.6618572023 19524636
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 32.6618404319 12065085 8330346 8985016 11807781
MESH:D012878 Skin Neoplasms Urethane 32.6611807781
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.5615464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.8217203757 15625365 16767912
MESH:D016135 Spinal Dysraphism sodium arsenite 3.1812854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 8.4017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 8.4020155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 8.4017522103 18396642 15958060
MESH:D013274 Stomach Neoplasms docetaxel 8.4016557585
MESH:D013274 Stomach Neoplasms Fluorouracil 8.4019084572 18396642 16951190 16424979 19015929 17522103 17172411 15786421 18567086 17498489
MESH:D013274 Stomach Neoplasms Methylnitrosourea 8.4016257854 15930296 18593901
MESH:D013274 Stomach Neoplasms S 1 (combination) 8.4018553229 16557585 18506536
MESH:D013276 Stomach Ulcer Acetylcysteine 3.3417918041
MESH:D020521 Stroke Vitamin E 2.9016517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.8016321402
MESH:D013398 Sudden Infant Death Iron 4.6816640825
MESH:D015173 Supratentorial Neoplasms Vincristine 5.1112837982
MESH:D013736 Testicular Neoplasms Cisplatin 3.9215464296 17225452
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 9.7715790496
MESH:D013953 Thymus Neoplasms Methylnitrosourea 9.7711418001
OMIM:188470 THYROID CARCINOMA, FOLLICULAR marker/mechanism
MESH:D013964 Thyroid Neoplasms marker/mechanism 3078959
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.6519014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.6517909728 16010429
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 8.657505956 3078959
MESH:D013978 Tibial Fractures Estradiol 3.9119048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.1416785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 4.7015735609 18041664 17979512 18305452
MESH:D014062 Tongue Neoplasms Fluorouracil 7.7416280240
MESH:D014062 Tongue Neoplasms resveratrol 7.7416227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.2015213294
MESH:D014202 Tremor Lead 4.7221145352
MESH:D014376 Tuberculosis Iron 3.5616597321
MESH:D001749 Urinary Bladder Neoplasms marker/mechanism 15958052
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 29.3116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 29.3116049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 29.311399818 15289314 15867355
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 29.3112973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 29.3117053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 29.3112973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 29.3117653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 29.3116720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 29.3111723127 16712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Vehicle Emissions 29.3111144890
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 9.4510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 9.4510091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 17.1416803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 17.1416803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 17.1417473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 17.1411813266
MESH:D014594 Uterine Neoplasms resveratrol 3.4117044934
MESH:D014625 Vaginal Neoplasms Cisplatin 3.8615577323
MESH:D014652 Vascular Diseases sodium arsenite 3.6617056641
MESH:D019043 Vascular Neoplasms Urethane 5.1310620525
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 7.8717678736 16364871 17334414 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 7.8717488730
MESH:D014839 Vomiting Cisplatin 3.9411897121
MESH:D014947 Wounds and Injuries Estrogens 7.5011172683
MESH:D014947 Wounds and Injuries Nitrofurazone 7.5018440737 18222664
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:05219 Bladder cancer
KEGG:04062 Chemokine signaling pathway
KEGG:05220 Chronic myeloid leukemia
KEGG:04144 Endocytosis
KEGG:05213 Endometrial cancer
KEGG:04012 ErbB signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04510 Focal adhesion
KEGG:04540 Gap junction
KEGG:05214 Glioma
KEGG:04912 GnRH signaling pathway
REACT:604 Hemostasis
KEGG:05160 Hepatitis C
KEGG:04910 Insulin signaling pathway
KEGG:04730 Long-term depression
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04916 Melanogenesis
KEGG:05218 Melanoma
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04722 Neurotrophin signaling pathway
KEGG:05223 Non-small cell lung cancer
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
REACT:9417 Signaling by EGFR
REACT:498 Signaling by Insulin receptor
REACT:16888 Signaling by PDGF
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
KEGG:04660 T cell receptor signaling pathway
KEGG:05216 Thyroid cancer
KEGG:04530 Tight junction
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29444
    • No data
    Releated disease ID Related disease Name
    PA152208657Cardio-facio-cutaneous Syndrome
    PA142297362Costello Syndrome
    PA445062Neoplasms
    PA445123Noonan Syndrome
    Releated drug ID Related drug Name
    PA448497aspirin
    PA151917011valinomycin
    PA451123progesterone
    PA450631nifedipine
    PA449167cyclosporine
    PA451578tacrolimus
    PA450191lecithin
    PA448948chloroquine
    PA164747225l-citrulline
    PA10804imatinib
    PA164743471adenosine triphosphate
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02210 - Hexane-1,6-Diol
    DB03226 - Trifluoroethanol
    DB04137 - Guanosine-5'-Triphosphate
    DB04315 - Guanosine-5'-Diphosphate
    DB04402 - 2-Propanol, Isopropanol Solvents
    DB08751 - N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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