Annotation Detail for HRH1
Basic Information Top
| Gene Symbol: | HRH1 ( H1-R,hisH1 ) |
|---|---|
| Gene Full Name: | histamine receptor H1 |
| Band: | 3p25.3 |
| Quick Links | Entrez ID:3269; OMIM: 600167; Uniprot ID:HRH1_HUMAN; ENSEMBL ID: ENSG00000196639; HGNC ID: 5182 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04020 | Calcium signaling pathway |
| Pathway ID | Pathway Name |
|---|---|
| Signaling by GPCR |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| P04385 | Histamine H1 receptor mediated signaling pathway |
| P00026 | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway |
| Pathway ID | Pathway Name |
|---|---|
| 500416 | Histamine receptors |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C070379 | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein] | decreases reaction|increases activity | 18508907 |
| C084981 | 1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene | 1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 10661506 |
| C084981 | 1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene | [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein] promotes the reaction [TH protein results in increased chemical synthesis of Dopamine] | affects binding|increases activity|increases chemical synthesis|increases reaction | 10661506 |
| C006183 | 2-(2-aminoethyl)pyridine | 2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 9657254 |
| C006183 | 2-(2-aminoethyl)pyridine | HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA] | increases expression|increases reaction | 9657254 |
| C006183 | 2-(2-aminoethyl)pyridine | 2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 16143415 |
| C029345 | 2-(2-aminoethyl)thiazole | 2-(2-aminoethyl)thiazole binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 12065605 |
| C026259 | 2-methylhistamine | 2-methylhistamine binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 12065605 |
| C528564 | 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid | 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 18298128 |
| C528564 | 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid | 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 18298128 |
| C009505 | 4,4'-diaminodiphenylmethane | 4,4'-diaminodiphenylmethane results in decreased expression of HRH1 mRNA | decreases expression | 18648102 |
| C081972 | 6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide | 6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 11238657 |
| C081972 | 6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide | [6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium | affects binding|increases abundance|increases activity | 11238657 |
| C081972 | 6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide | HRH1 protein promotes the reaction [6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide results in increased expression of GUSB protein] | increases expression|increases reaction | 11238657 |
| C081972 | 6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide | HRH1 protein promotes the reaction [6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide results in increased expression of IL6 protein] | increases expression|increases reaction | 11238657 |
| D000242 | Cyclic AMP | 1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]] | decreases abundance|decreases reaction|increases reaction | 2419744 |
| D000242 | Cyclic AMP | HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP] | decreases abundance|increases reaction | 2419744 |
| D000242 | Cyclic AMP | Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]] | decreases abundance|decreases reaction|increases reaction | 2419744 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of HRH1 mRNA | affects expression | 16483693 |
| D017638 | Asbestos, Crocidolite | Asbestos, Crocidolite results in increased expression of HRH1 mRNA | increases expression | 18687144 |
| D016589 | Astemizole | Astemizole binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7612054 |
| D016589 | Astemizole | Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] | affects cotreatment|decreases activity|decreases reaction | 12147327 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of HRH1 mRNA | decreases expression | 20064835 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HRH1 mRNA | decreases expression | 20382639 |
| D001621 | Betahistine | Betahistine binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 16143415 |
| D002104 | Cadmium | Cadmium results in decreased expression of HRH1 mRNA | decreases expression | 16263506 |
| D002118 | Calcium | HRH1 protein affects the reaction [GNA11 protein inhibits the reaction [Pyrilamine results in decreased abundance of Calcium]] | affects reaction|decreases abundance|decreases reaction | 15192105 |
| D002118 | Calcium | [6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium | affects binding|increases abundance|increases activity | 11238657 |
| D002118 | Calcium | fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium] | affects binding|decreases reaction|increases abundance|increases activity | 11238657 |
| D002118 | Calcium | [Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium | increases abundance|increases activity | 11238657 |
| D002118 | Calcium | HRH1 protein promotes the reaction [Histamine results in increased export of Calcium] | increases export|increases reaction | 2419744 |
| D002118 | Calcium | HRH1 protein results in increased abundance of Calcium | increases abundance | 19443731 |
| D002118 | Calcium | Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium] | decreases reaction|increases abundance|increases activity | 11527950 |
| D002118 | Calcium | Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]] | decreases reaction|increases export|increases reaction | 2419744 |
| D017332 | Cetirizine | Cetirizine analog binds to HRH1 protein | affects binding | 15482930 |
| D017332 | Cetirizine | Cetirizine binds to HRH1 protein | affects binding | 15482930 |
| D002744 | Chlorpheniramine | Chlorpheniramine inhibits the reaction [mizolastine binds to HRH1 protein] | affects binding|decreases reaction | 7612054 |
| D002744 | Chlorpheniramine | Chlorpheniramine binds to and affects the activity of HRH1 protein | affects activity|affects binding | 17496723 |
| D002744 | Chlorpheniramine | Chlorpheniramine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 11432448 |
| D002744 | Chlorpheniramine | Chlorpheniramine results in decreased activity of HRH1 protein | decreases activity | 8111568 |
| D002744 | Chlorpheniramine | Chlorpheniramine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 16143415 |
| D002744 | Chlorpheniramine | Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 18360087 15054595 19075512 |
| D002927 | Cimetidine | Cimetidine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 6869119 15159029 |
| D002927 | Cimetidine | Cimetidine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 15159029 6869119 |
| D003024 | Clozapine | Clozapine binds to HRH1 protein | affects binding | 16983399 |
| D016572 | Cyclosporine | Cyclosporine results in increased expression of HRH1 mRNA | increases expression | 20106945 |
| D003533 | Cyproheptadine | Cyproheptadine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7612054 |
| D003533 | Cyproheptadine | Cyproheptadine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7650688 |
| C121345 | desloratadine | desloratadine binds to HRH1 protein | affects binding | 15482930 |
| D003907 | Dexamethasone | Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 15513549 18360087 15054595 |
| C118996 | dimethylhistaprodifen | dimethylhistaprodifen binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 12669185 |
| D004155 | Diphenhydramine | Diphenhydramine binds to and affects the activity of HRH1 protein | affects activity|affects binding | 17496723 |
| D004155 | Diphenhydramine | Diphenhydramine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 2419744 9609743 |
| D004155 | Diphenhydramine | Diphenhydramine binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 1912125 |
| D004155 | Diphenhydramine | Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 2419744 1912125 |
| D004155 | Diphenhydramine | HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to IL8 protein] | decreases response to substance|increases reaction | 7522859 |
| C009871 | diphenylpyraline | diphenylpyraline binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 1912125 |
| C009871 | diphenylpyraline | diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 1912125 |
| D004298 | Dopamine | [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein] promotes the reaction [TH protein results in increased chemical synthesis of Dopamine] | affects binding|increases activity|increases chemical synthesis|increases reaction | 10661506 |
| C121361 | efletirizine | efletirizine analog binds to HRH1 protein | affects binding | 15482930 |
| C043345 | emedastine | emedastine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 2883850 |
| D004726 | Endosulfan | Endosulfan results in increased expression of HRH1 mRNA | increases expression | 16263506 |
| C053090 | epinastine | epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 19075512 |
| C053090 | epinastine | epinastine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7650688 |
| C093230 | fexofenadine | fexofenadine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 11238657 |
| C093230 | fexofenadine | fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium] | affects binding|decreases reaction|increases abundance|increases activity | 11238657 |
| C093230 | fexofenadine | fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein] | affects binding|decreases reaction|increases activity|increases expression | 11238657 |
| C093230 | fexofenadine | fexofenadine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 17133778 |
| D006160 | Guanosine Triphosphate | Guanosine Triphosphate affects the reaction [Histamine binds to and results in increased activity of HRH1 protein] | affects binding|affects reaction|increases activity | 12669185 |
| D006160 | Guanosine Triphosphate | Guanosine Triphosphate affects the reaction [histaprodifen binds to and results in increased activity of HRH1 protein] | affects binding|affects reaction|increases activity | 12669185 |
| D006160 | Guanosine Triphosphate | Guanosine Triphosphate affects the reaction [methylhistaprodifen binds to and results in increased activity of HRH1 protein] | affects binding|affects reaction|increases activity | 12669185 |
| D006160 | Guanosine Triphosphate | Guanosine Triphosphate analog inhibits the reaction [Histamine binds to HRH1 protein] | affects binding|decreases reaction | 3728201 |
| D006160 | Guanosine Triphosphate | Guanosine Triphosphate inhibits the reaction [Histamine binds to HRH1 protein] | affects binding|decreases reaction | 3728201 |
| D006160 | Guanosine Triphosphate | Magnesium inhibits the reaction [Guanosine Triphosphate inhibits the reaction [Histamine binds to HRH1 protein]] | affects binding|decreases reaction | 3728201 |
| D006160 | Guanosine Triphosphate | Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]] | affects binding|affects reaction|decreases reaction | 2419744 |
| D006632 | Histamine | Guanosine Triphosphate affects the reaction [Histamine binds to and results in increased activity of HRH1 protein] | affects binding|affects reaction|increases activity | 12669185 |
| D006632 | Histamine | Guanosine Triphosphate analog inhibits the reaction [Histamine binds to HRH1 protein] | affects binding|decreases reaction | 3728201 |
| D006632 | Histamine | Guanosine Triphosphate inhibits the reaction [Histamine binds to HRH1 protein] | affects binding|decreases reaction | 3728201 |
| D006632 | Histamine | Histamine binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 12669185 |
| D006632 | Histamine | Histamine binds to HRH1 protein | affects binding | 3728201 |
| D006632 | Histamine | Magnesium inhibits the reaction [Guanosine Triphosphate inhibits the reaction [Histamine binds to HRH1 protein]] | affects binding|decreases reaction | 3728201 |
| D006632 | Histamine | Triprolidine inhibits the reaction [Histamine results in increased activity of HRH1 protein] | decreases reaction|increases activity | 12669185 |
| D006632 | Histamine | 1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]] | decreases abundance|decreases reaction|increases reaction | 2419744 |
| D006632 | Histamine | Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] | affects cotreatment|decreases activity|decreases reaction | 12147327 |
| D006632 | Histamine | fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium] | affects binding|decreases reaction|increases abundance|increases activity | 11238657 |
| D006632 | Histamine | fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein] | affects binding|decreases reaction|increases activity|increases expression | 11238657 |
| D006632 | Histamine | Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]] | affects binding|affects reaction|decreases reaction | 2419744 |
| D006632 | Histamine | Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 2419744 |
| D006632 | Histamine | Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein] | affects cotreatment|decreases activity | 12147327 |
| D006632 | Histamine | Histamine results in increased activity of HRH1 protein | increases activity | 11238657 |
| D006632 | Histamine | [Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium | increases abundance|increases activity | 11238657 |
| D006632 | Histamine | HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP] | decreases abundance|increases reaction | 2419744 |
| D006632 | Histamine | HRH1 protein promotes the reaction [Histamine results in increased export of Calcium] | increases export|increases reaction | 2419744 |
| D006632 | Histamine | HRH1 protein promotes the reaction [Histamine results in increased expression of GUSB protein] | increases expression|increases reaction | 11238657 |
| D006632 | Histamine | HRH1 protein promotes the reaction [Histamine results in increased expression of IL6 protein] | increases expression|increases reaction | 11238657 |
| D006632 | Histamine | HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols] | increases metabolic processing|increases reaction | 2419744 |
| D006632 | Histamine | Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein] | affects binding|decreases reaction|increases activity | 11306145 |
| D006632 | Histamine | [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein | affects binding|decreases expression|decreases reaction|increases activity | 11306145 |
| D006632 | Histamine | [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein | affects binding|decreases expression|decreases reaction|increases activity | 11306145 |
| D006632 | Histamine | Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium] | decreases reaction|increases abundance|increases activity | 11527950 |
| D006632 | Histamine | Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]] | decreases abundance|decreases reaction|increases reaction | 2419744 |
| D006632 | Histamine | Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]] | decreases reaction|increases export|increases reaction | 2419744 |
| D006632 | Histamine | Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]] | decreases reaction|increases metabolic processing|increases reaction | 2419744 |
| D006632 | Histamine | Histamine binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 16143415 15167971 |
| D006632 | Histamine | [Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein | affects binding|increases activity|increases expression | 15167971 |
| D006632 | Histamine | Histamine results in increased activity of HRH1 protein | increases activity | 16354729 |
| D006632 | Histamine | [Histamine results in increased activity of HRH1 protein] which affects the transport of Potassium | affects transport|increases activity | 16354729 |
| D006632 | Histamine | Histamine results in increased expression of HRH1 mRNA | increases expression | 18360087 |
| D006632 | Histamine | Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] | affects binding|decreases reaction|increases activity|increases expression | 15167971 |
| D006632 | Histamine | Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 18360087 |
| D006632 | Histamine | Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] | affects binding|decreases reaction|increases activity|increases expression | 15167971 |
| C087869 | histamine trifluoromethyl-toluidide | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein] | decreases reaction|increases activity | 18508907 |
| C087869 | histamine trifluoromethyl-toluidide | histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein | increases activity | 18508907 |
| C087869 | histamine trifluoromethyl-toluidide | Terfenadine inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein] | decreases reaction|increases activity | 18508907 |
| C087869 | histamine trifluoromethyl-toluidide | W 7 inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein] | decreases reaction|increases activity | 18508907 |
| C087869 | histamine trifluoromethyl-toluidide | histamine trifluoromethyl-toluidide analog results in increased activity of HRH1 protein | increases activity | 16354729 |
| C087869 | histamine trifluoromethyl-toluidide | [histamine trifluoromethyl-toluidide analog results in increased activity of HRH1 protein] which affects the transport of Potassium | affects transport|increases activity | 16354729 |
| C118994 | histaprodifen | Guanosine Triphosphate affects the reaction [histaprodifen binds to and results in increased activity of HRH1 protein] | affects binding|affects reaction|increases activity | 12669185 |
| C118994 | histaprodifen | histaprodifen binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 12669185 |
| C118994 | histaprodifen | Triprolidine inhibits the reaction [histaprodifen results in increased activity of HRH1 protein] | decreases reaction|increases activity | 12669185 |
| C118994 | histaprodifen | histaprodifen binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 15167971 |
| C118994 | histaprodifen | [histaprodifen binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein | affects binding|increases activity|increases expression | 15167971 |
| D015056 | 1-Methyl-3-isobutylxanthine | 1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]] | decreases abundance|decreases reaction|increases reaction | 2419744 |
| D007665 | Ketotifen | Ketotifen binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 16117696 |
| D007665 | Ketotifen | Ketotifen results in decreased activity of HRH1 protein | decreases activity | 16386349 |
| D017336 | Loratadine | Loratadine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7612054 |
| D017336 | Loratadine | Loratadine inhibits the reaction [mizolastine binds to HRH1 protein] | affects binding|decreases reaction | 7612054 |
| D017336 | Loratadine | Loratadine analog binds to HRH1 protein | affects binding | 15482930 |
| D017336 | Loratadine | Loratadine binds to HRH1 protein | affects binding | 15482930 |
| D008274 | Magnesium | Magnesium inhibits the reaction [Guanosine Triphosphate inhibits the reaction [Histamine binds to HRH1 protein]] | affects binding|decreases reaction | 3728201 |
| C088248 | mepifiline | mepifiline binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 12100006 |
| C006069 | mequitazine | mequitazine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7612054 |
| C006069 | mequitazine | mequitazine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7650688 |
| C118995 | methylhistaprodifen | Guanosine Triphosphate affects the reaction [methylhistaprodifen binds to and results in increased activity of HRH1 protein] | affects binding|affects reaction|increases activity | 12669185 |
| C118995 | methylhistaprodifen | methylhistaprodifen binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 12669185 |
| C118995 | methylhistaprodifen | Triprolidine inhibits the reaction [methylhistaprodifen results in increased activity of HRH1 protein] | decreases reaction|increases activity | 12669185 |
| D008803 | Mianserin | Mianserin binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7650688 |
| C076170 | mizolastine | Chlorpheniramine inhibits the reaction [mizolastine binds to HRH1 protein] | affects binding|decreases reaction | 7612054 |
| C076170 | mizolastine | Loratadine inhibits the reaction [mizolastine binds to HRH1 protein] | affects binding|decreases reaction | 7612054 |
| C076170 | mizolastine | mizolastine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7612054 |
| C076170 | mizolastine | mizolastine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 7612054 |
| C076170 | mizolastine | Pyrilamine inhibits the reaction [mizolastine binds to HRH1 protein] | affects binding|decreases reaction | 7612054 |
| C076170 | mizolastine | Terfenadine inhibits the reaction [mizolastine binds to HRH1 protein] | affects binding|decreases reaction | 7612054 |
| C076029 | olanzapine | olanzapine binds to HRH1 protein | affects binding | 16983399 |
| C074921 | olopatadine | olopatadine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 18360087 19075512 |
| C005430 | phenindamine | phenindamine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7650688 |
| D010716 | Phosphatidylinositols | HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols] | increases metabolic processing|increases reaction | 2419744 |
| D010716 | Phosphatidylinositols | Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]] | decreases reaction|increases metabolic processing|increases reaction | 2419744 |
| D011188 | Potassium | [Histamine results in increased activity of HRH1 protein] which affects the transport of Potassium | affects transport|increases activity | 16354729 |
| D011188 | Potassium | [histamine trifluoromethyl-toluidide analog results in increased activity of HRH1 protein] which affects the transport of Potassium | affects transport|increases activity | 16354729 |
| D011398 | Promethazine | Promethazine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 15159029 6869119 |
| D011398 | Promethazine | Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 6869119 15159029 |
| D011398 | Promethazine | Promethazine binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 1912125 |
| D011398 | Promethazine | Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 1912125 |
| D011398 | Promethazine | Promethazine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 19703484 |
| D011738 | Pyrilamine | Cimetidine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 6869119 15159029 |
| D011738 | Pyrilamine | Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 6869119 15159029 |
| D011738 | Pyrilamine | Pyrilamine binds to HRH1 protein | affects binding | 6869119 3728201 15159029 |
| D011738 | Pyrilamine | Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 6869119 15159029 |
| D011738 | Pyrilamine | HRH1 protein affects the reaction [GNA11 protein inhibits the reaction [Pyrilamine results in decreased abundance of Calcium]] | affects reaction|decreases abundance|decreases reaction | 15192105 |
| D011738 | Pyrilamine | mizolastine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 7612054 |
| D011738 | Pyrilamine | Pyrilamine binds to and results in decreased activity of [GNA11 protein binds to HRH1 protein] | affects binding|decreases activity | 15192105 |
| D011738 | Pyrilamine | Pyrilamine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7612054 |
| D011738 | Pyrilamine | Pyrilamine inhibits the reaction [mizolastine binds to HRH1 protein] | affects binding|decreases reaction | 7612054 |
| D011738 | Pyrilamine | Pyrilamine results in decreased activity of HRH1 protein | decreases activity | 15192105 |
| D011738 | Pyrilamine | Pyrilamine binds to and affects the activity of HRH1 protein | affects activity|affects binding | 17496723 |
| D011738 | Pyrilamine | Pyrilamine binds to HRH1 protein | affects binding | 17496723 |
| D011738 | Pyrilamine | Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 2419744 1912125 |
| D011738 | Pyrilamine | diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 1912125 |
| D011738 | Pyrilamine | Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]] | affects binding|affects reaction|decreases reaction | 2419744 |
| D011738 | Pyrilamine | Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 2419744 |
| D011738 | Pyrilamine | HRH1 protein promotes the reaction [Pyrilamine results in decreased susceptibility to IL8 protein] | decreases response to substance|increases reaction | 7522859 |
| D011738 | Pyrilamine | Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 1912125 |
| D011738 | Pyrilamine | Pyrilamine binds to HRH1 protein | affects binding | 2419744 1912125 |
| D011738 | Pyrilamine | Pyrilamine results in decreased activity of HRH1 protein | decreases activity | 8111568 |
| D011738 | Pyrilamine | Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 2419744 1912125 |
| D011738 | Pyrilamine | Pyrilamine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 9832392 |
| D011738 | Pyrilamine | Pyrilamine binds to HRH1 protein | affects binding | 15513549 3379823 |
| D011738 | Pyrilamine | Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] | affects binding|decreases reaction|increases activity|increases expression | 15167971 |
| D011738 | Pyrilamine | Toluene 2,4-Diisocyanate promotes the reaction [Pyrilamine binds to HRH1 protein] | affects binding|increases reaction | 15513549 |
| C064758 | Ro 31-8220 | Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 18360087 |
| C090832 | sho-seiryu-to | sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 19050374 |
| D016593 | Terfenadine | Terfenadine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7612054 |
| D016593 | Terfenadine | Terfenadine inhibits the reaction [mizolastine binds to HRH1 protein] | affects binding|decreases reaction | 7612054 |
| D016593 | Terfenadine | Terfenadine inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein] | decreases reaction|increases activity | 18508907 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of HRH1 mRNA | affects expression | 15977195 |
| D014051 | Toluene 2,4-Diisocyanate | Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 15054595 18360087 19075512 |
| D014051 | Toluene 2,4-Diisocyanate | Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 18360087 15513549 15054595 |
| D014051 | Toluene 2,4-Diisocyanate | epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 19075512 |
| D014051 | Toluene 2,4-Diisocyanate | olopatadine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 19075512 18360087 |
| D014051 | Toluene 2,4-Diisocyanate | sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] | decreases reaction|increases expression | 19050374 |
| D014051 | Toluene 2,4-Diisocyanate | Toluene 2,4-Diisocyanate promotes the reaction [Pyrilamine binds to HRH1 protein] | affects binding|increases reaction | 15513549 |
| D014051 | Toluene 2,4-Diisocyanate | Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA | increases expression | 15054595 15513549 19075512 19050374 18360087 |
| D014051 | Toluene 2,4-Diisocyanate | Toluene 2,4-Diisocyanate results in increased expression of HRH1 protein | increases expression | 18360087 |
| D014309 | Tripelennamine | Tripelennamine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 10210152 |
| D014311 | Triprolidine | Triprolidine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 15159029 6869119 3728201 12669185 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [Histamine results in increased activity of HRH1 protein] | decreases reaction|increases activity | 12669185 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [histaprodifen results in increased activity of HRH1 protein] | decreases reaction|increases activity | 12669185 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [methylhistaprodifen results in increased activity of HRH1 protein] | decreases reaction|increases activity | 12669185 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 15159029 6869119 |
| D014311 | Triprolidine | HRH1 protein promotes the reaction [Triprolidine results in decreased susceptibility to IL8 protein] | decreases response to substance|increases reaction | 7522859 |
| D014311 | Triprolidine | Triprolidine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 11527950 2419744 11306145 |
| D014311 | Triprolidine | Triprolidine binds to and results in increased activity of HRH1 protein | affects binding|increases activity | 1912125 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein] | affects binding|decreases reaction|increases activity | 11306145 |
| D014311 | Triprolidine | [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein | affects binding|decreases expression|decreases reaction|increases activity | 11306145 |
| D014311 | Triprolidine | [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein | affects binding|decreases expression|decreases reaction|increases activity | 11306145 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium] | decreases reaction|increases abundance|increases activity | 11527950 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]] | decreases abundance|decreases reaction|increases reaction | 2419744 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]] | decreases reaction|increases export|increases reaction | 2419744 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]] | decreases reaction|increases metabolic processing|increases reaction | 2419744 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein] | affects binding|decreases reaction | 2419744 1912125 |
| D014311 | Triprolidine | Triprolidine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 12714356 |
| D014311 | Triprolidine | Triprolidine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 10661506 16143415 |
| D014311 | Triprolidine | Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] | affects binding|decreases reaction|increases activity|increases expression | 15167971 |
| D014311 | Triprolidine | Triprolidine binds to and results in decreased activity of HRH1 protein | affects binding|decreases activity | 7650688 16354729 |
| C017967 | W 7 | W 7 inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein] | decreases reaction|increases activity | 18508907 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000014 | Abnormalities, Drug-Induced | Tetrachlorodibenzodioxin | 2.23 | 11752688 15322242 14514962 | |
| MESH:D000138 | Acidosis | Ammonium Chloride | 2.93 | 18287403 | |
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 1.80 | 20127859 20464547 | |
| MESH:D000236 | Adenoma | 4,4'-diaminodiphenylmethane | 9.02 | 3712494 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 9.02 | 6695378 | |
| MESH:D000236 | Adenoma | Magnesium | 9.02 | 17823441 | |
| MESH:D018248 | Adenoma, Liver Cell | Tetrachlorodibenzodioxin | 2.75 | 16835633 | |
| MESH:D000380 | Agranulocytosis | Clozapine | 4.44 | 14617031 12649775 16160616 | |
| OMIM:607154 | ALLERGIC RHINITIS | fexofenadine | 14.39 | 16037679 | |
| OMIM:607154 | ALLERGIC RHINITIS | Loratadine | 14.39 | 16527031 | |
| OMIM:607154 | ALLERGIC RHINITIS | Terfenadine | 14.39 | 16037679 | |
| MESH:D000740 | Anemia | Tetrachlorodibenzodioxin | 2.40 | 11748828 | |
| MESH:D000799 | Angioedema | Astemizole | 5.02 | 2883202 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 3.45 | 19183758 | |
| MESH:D001169 | Arthritis, Experimental | Dexamethasone | 3.12 | 17659584 | |
| MESH:D001249 | Asthma | Histamine | 7.05 | 16387687 | |
| MESH:D001249 | Asthma | Loratadine | 7.05 | 9196086 | |
| MESH:D001249 | Asthma | Toluene 2,4-Diisocyanate | 7.05 | 15590891 11467998 17015710 12762349 10934080 12585506 18394133 6091945 170078 11077013 7684630 20032816 15590890 16792590 19187332 6091946 3040596 8156442 11742282 12684321 15855793 10797510 16210060 | |
| MESH:D050197 | Atherosclerosis | Cadmium | 3.24 | 15687053 | |
| MESH:D001321 | Autistic Disorder | Magnesium | 3.17 | 16846101 | |
| MESH:D001321 | Autistic Disorder | olanzapine | 3.17 | 17069543 18685284 | |
| MESH:D001660 | Biliary Tract Diseases | 4,4'-diaminodiphenylmethane | 4.37 | 1440618 11289319 | |
| MESH:D001778 | Blood Coagulation Disorders | Tetrachlorodibenzodioxin | 2.48 | 12125929 | |
| MESH:D001836 | Body Weight Changes | Tetrachlorodibenzodioxin | 3.15 | 15340226 | |
| MESH:D001848 | Bone Diseases, Developmental | Tetrachlorodibenzodioxin | 2.33 | 15746008 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 2.01 | 20146248 17474063 | |
| MESH:D001943 | Breast Neoplasms | Tetrachlorodibenzodioxin | 2.01 | 20435547 | |
| MESH:D001943 | Breast Neoplasms | Toluene 2,4-Diisocyanate | 2.01 | 11921183 | |
| MESH:D016535 | Bronchial Hyperreactivity | Toluene 2,4-Diisocyanate | 4.03 | 15590891 8156442 12507178 | |
| MESH:D001986 | Bronchial Spasm | 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid | 16.66 | 18298128 | |
| MESH:D001986 | Bronchial Spasm | Chlorpheniramine | 16.66 | 11432448 | |
| MESH:D001986 | Bronchial Spasm | Histamine | 16.66 | 18298128 | |
| MESH:D002277 | Carcinoma | Tetrachlorodibenzodioxin | 2.29 | 16835633 | |
| MESH:D006528 | Carcinoma, Hepatocellular | 4,4'-diaminodiphenylmethane | 1.68 | 7296757 3581430 | |
| MESH:D002292 | Carcinoma, Renal Cell | 4,4'-diaminodiphenylmethane | 2.34 | 7296757 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 1.84 | 20419170 | |
| MESH:D006332 | Cardiomegaly | Tetrachlorodibenzodioxin | 1.99 | 16120746 18670907 18850075 | |
| MESH:D002389 | Catatonia | olanzapine | 5.60 | 16772815 18071103 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 4,4'-diaminodiphenylmethane | 12.29 | 7505956 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 12.29 | 20889678 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cadmium | 12.29 | 17332340 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 12.29 | 12371664 | |
| MESH:D018281 | Cholangiocarcinoma | Tetrachlorodibenzodioxin | 2.62 | 16835633 | |
| MESH:D002779 | Cholestasis | 4,4'-diaminodiphenylmethane | 6.26 | 19486331 9022650 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 6.26 | 19486331 | |
| MESH:D002972 | Cleft Palate | Tetrachlorodibenzodioxin | 1.80 | 8697196 12621046 15340226 15668235 16354765 | |
| MESH:D003072 | Cognition Disorders | Clozapine | 4.35 | 17123785 | |
| MESH:D003110 | Colonic Neoplasms | Dexamethasone | 2.37 | 15824018 | |
| MESH:D003111 | Colonic Polyps | Magnesium | 5.45 | 17823441 | |
| MESH:D015179 | Colorectal Neoplasms | Magnesium | 3.45 | 17823441 | |
| MESH:D000013 | Congenital Abnormalities | Tetrachlorodibenzodioxin | 2.52 | 14669216 17141729 | |
| MESH:D019465 | Craniofacial Abnormalities | Dexamethasone | 3.60 | 17728286 | |
| MESH:D019465 | Craniofacial Abnormalities | Mianserin | 3.60 | 10978843 | |
| MESH:D019465 | Craniofacial Abnormalities | Tetrachlorodibenzodioxin | 3.60 | 10048152 20055451 15322242 | |
| MESH:D003490 | Cyanosis | Endosulfan | 4.92 | 7900959 | |
| MESH:D003866 | Depressive Disorder | Mianserin | 5.12 | 18083778 | |
| MESH:D017449 | Dermatitis, Allergic Contact | 4,4'-diaminodiphenylmethane | 8.24 | 11906362 12868966 2524372 8156756 11298694 18759878 8970840 14531868 | |
| MESH:D017449 | Dermatitis, Allergic Contact | Dexamethasone | 8.24 | 12438553 | |
| MESH:D017449 | Dermatitis, Allergic Contact | Toluene 2,4-Diisocyanate | 8.24 | 15491423 18759878 12956900 | |
| MESH:D003876 | Dermatitis, Atopic | fexofenadine | 4.44 | 17133778 | |
| MESH:D003877 | Dermatitis, Contact | 4,4'-diaminodiphenylmethane | 7.65 | 2952479 3621924 | |
| MESH:D003877 | Dermatitis, Contact | Toluene 2,4-Diisocyanate | 7.65 | 17010967 | |
| MESH:D002658 | Developmental Disabilities | Magnesium | 7.59 | 16846101 | |
| MESH:D002658 | Developmental Disabilities | olanzapine | 7.59 | 17069543 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Clozapine | 3.84 | 16402076 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Tetrachlorodibenzodioxin | 3.84 | 17107852 | |
| MESH:D003967 | Diarrhea | Dexamethasone | 3.12 | 7237001 | |
| MESH:D006970 | Disorders of Excessive Somnolence | Clozapine | 4.91 | 15331141 | |
| MESH:D004244 | Dizziness | Astemizole | 5.82 | 3105558 | |
| MESH:D056486 | Drug-Induced Liver Injury | 4,4'-diaminodiphenylmethane | 2.96 | 8291058 1440618 7440962 18692083 11289319 18289764 18648102 9022650 9328219 6482804 16192314 9653073 6679447 | |
| MESH:D056486 | Drug-Induced Liver Injury | Tetrachlorodibenzodioxin | 2.96 | 20420201 | |
| MESH:D004362 | Drug Toxicity | Tetrachlorodibenzodioxin | 2.28 | 11462148 | |
| MESH:D050171 | Dyslipidemias | Clozapine | 3.71 | 16402076 | |
| MESH:D004417 | Dyspnea | Endosulfan | 4.64 | 3388749 7900959 | |
| MESH:D004485 | Eczema | Dexamethasone | 3.86 | 12438553 | |
| MESH:D004487 | Edema | Cimetidine | 15.83 | 19703484 | |
| MESH:D004487 | Edema | Cyproheptadine | 15.83 | 7907874 | |
| MESH:D004487 | Edema | Dexamethasone | 15.83 | 19703484 | |
| MESH:D004487 | Edema | Promethazine | 15.83 | 19703484 | |
| MESH:D004487 | Edema | Tetrachlorodibenzodioxin | 15.83 | 12711302 11000095 | |
| MESH:D004489 | Edema, Cardiac | Tetrachlorodibenzodioxin | 3.26 | 15322242 18230668 16714409 | |
| MESH:D004646 | Emphysema | Endosulfan | 5.91 | 7900959 | |
| MESH:D004715 | Endometriosis | Tetrachlorodibenzodioxin | 2.47 | 9294722 10568697 | |
| MESH:D004802 | Eosinophilia | Astemizole | 26.37 | 1355641 | |
| MESH:D004802 | Eosinophilia | Cetirizine | 26.37 | 12689652 1355641 | |
| MESH:D004802 | Eosinophilia | epinastine | 26.37 | 12689652 | |
| MESH:D004802 | Eosinophilia | Histamine | 26.37 | 12689652 | |
| MESH:D004802 | Eosinophilia | Pyrilamine | 26.37 | 1355641 | |
| MESH:D004802 | Eosinophilia | Toluene 2,4-Diisocyanate | 26.37 | 8156442 | |
| MESH:D004938 | Esophageal Neoplasms | 4,4'-diaminodiphenylmethane | 5.93 | 3581430 | |
| MESH:D004938 | Esophageal Neoplasms | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 5.93 | 20426865 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 5.93 | 16530937 | |
| MESH:D005124 | Eye Abnormalities | Tetrachlorodibenzodioxin | 2.52 | 11564622 | |
| MESH:D005128 | Eye Diseases | Toluene 2,4-Diisocyanate | 5.11 | 18447907 | |
| MESH:D005234 | Fatty Liver | Cyclosporine | 2.30 | 19224547 | |
| MESH:D005313 | Fetal Death | Tetrachlorodibenzodioxin | 2.84 | 11858732 | |
| MESH:D005350 | Fibroma | 4,4'-diaminodiphenylmethane | 4.37 | 6705139 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 6.45 | 12639820 12168785 | |
| MESH:D005355 | Fibrosis | Tetrachlorodibenzodioxin | 6.45 | 20067830 | |
| MESH:D005499 | Folliculitis | Astemizole | 5.27 | 1671328 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 3.58 | 8708960 | |
| MESH:D006042 | Goiter | 4,4'-diaminodiphenylmethane | 3.45 | 7505956 | |
| MESH:D006058 | Gonadal Disorders | Tetrachlorodibenzodioxin | 3.95 | 10696789 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 5.21 | 20471113 | |
| MESH:D006330 | Heart Defects, Congenital | Tetrachlorodibenzodioxin | 5.21 | 10048152 11294989 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 3.79 | 15720958 | |
| MESH:D006470 | Hemorrhage | Endosulfan | 8.55 | 7900959 | |
| MESH:D006470 | Hemorrhage | Tetrachlorodibenzodioxin | 8.55 | 11000095 | |
| MESH:D006505 | Hepatitis | 4,4'-diaminodiphenylmethane | 2.92 | 6705139 | |
| MESH:D006529 | Hepatomegaly | Tetrachlorodibenzodioxin | 2.29 | 15340226 16120746 12621046 | |
| MESH:D006548 | Hernia, Diaphragmatic | Dexamethasone | 2.81 | 7520565 | |
| MESH:D006869 | Hydronephrosis | Tetrachlorodibenzodioxin | 3.40 | 18606429 15340226 16354765 8697196 16959395 | |
| MESH:D006930 | Hyperalgesia | Promethazine | 5.26 | 12727271 | |
| MESH:D006948 | Hyperkinesis | Clozapine | 4.28 | 16046005 | |
| MESH:D006963 | Hyperphagia | olanzapine | 5.60 | 17933447 | |
| MESH:D006965 | Hyperplasia | 4,4'-diaminodiphenylmethane | 3.32 | 15034207 | |
| MESH:D006967 | Hypersensitivity | 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid | 26.54 | 18298128 | |
| MESH:D006967 | Hypersensitivity | fexofenadine | 26.54 | 17910814 | |
| MESH:D006967 | Hypersensitivity | Ketotifen | 26.54 | 16536907 | |
| MESH:D006967 | Hypersensitivity | Promethazine | 26.54 | 16536907 | |
| MESH:D006967 | Hypersensitivity | Terfenadine | 26.54 | 2570798 | |
| MESH:D006967 | Hypersensitivity | Toluene 2,4-Diisocyanate | 26.54 | 11019492 10880147 | |
| MESH:D006973 | Hypertension | Cyclosporine | 6.91 | 10903974 | |
| MESH:D006973 | Hypertension | Dexamethasone | 6.91 | 17042910 | |
| MESH:D006973 | Hypertension | Tetrachlorodibenzodioxin | 6.91 | 18850075 18670907 | |
| MESH:D020514 | Hypokalemic Periodic Paralysis | Potassium | 5.23 | 19822448 | |
| MESH:D007021 | Hypospadias | Loratadine | 5.49 | 16407038 | |
| MESH:D007022 | Hypotension | Dopamine | 4.44 | 6740701 | |
| MESH:D007077 | Ileal Diseases | 1-Methyl-3-isobutylxanthine | 4.80 | 18306037 | |
| MESH:D007248 | Infertility, Male | Endosulfan | 3.86 | 8588293 9432128 | |
| MESH:D007249 | Inflammation | Dexamethasone | 3.89 | 8960868 11099482 | |
| MESH:D007249 | Inflammation | Tetrachlorodibenzodioxin | 3.89 | 12200463 12878042 | |
| MESH:D007565 | Jaundice | 4,4'-diaminodiphenylmethane | 4.37 | 8074119 9022650 | |
| MESH:D007569 | Jaw Abnormalities | Tetrachlorodibenzodioxin | 2.77 | 16580747 | |
| MESH:D007579 | Jejunal Diseases | 1-Methyl-3-isobutylxanthine | 4.80 | 18306037 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 3.79 | 15604871 | |
| MESH:D007674 | Kidney Diseases | Cadmium | 4.96 | 16322080 16962696 16226777 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 4.96 | 8314463 10903974 18776723 | |
| MESH:D007680 | Kidney Neoplasms | 4,4'-diaminodiphenylmethane | 5.55 | 6582329 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 5.55 | 12371664 | |
| MESH:D007683 | Kidney Tubular Necrosis, Acute | Calcium | 4.40 | 16316344 | |
| MESH:D007859 | Learning Disorders | Endosulfan | 4.49 | 8157075 | |
| MESH:D017513 | Lichen Nitidus | Astemizole | 5.82 | 2563723 | |
| MESH:D008064 | Lipidoses | Clozapine | 7.23 | 17567588 | |
| MESH:D008064 | Lipidoses | Loratadine | 7.23 | 17567588 | |
| MESH:D008105 | Liver Cirrhosis, Biliary | 4,4'-diaminodiphenylmethane | 2.77 | 9327722 15034207 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Dexamethasone | 2.22 | 16718785 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tetrachlorodibenzodioxin | 2.22 | 12878042 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 3.41 | 21137059 20195826 | |
| MESH:D008113 | Liver Neoplasms | Tetrachlorodibenzodioxin | 3.41 | 16984957 | |
| MESH:D008114 | Liver Neoplasms, Experimental | 4,4'-diaminodiphenylmethane | 4.34 | 598648 6587162 1399818 3712494 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Tetrachlorodibenzodioxin | 4.34 | 12151625 | |
| MESH:D008133 | Long QT Syndrome | Astemizole | 11.25 | 18472280 11989578 | |
| MESH:D008133 | Long QT Syndrome | olanzapine | 11.25 | 20210726 | |
| MESH:D008133 | Long QT Syndrome | Terfenadine | 11.25 | 8772706 | |
| MESH:D055370 | Lung Injury | Asbestos, Crocidolite | 3.41 | 17365036 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 2.87 | 18816296 20064080 18569708 20869020 20464547 18520028 6695378 20135361 17053015 | |
| MESH:D008175 | Lung Neoplasms | Dexamethasone | 2.87 | 11195469 15824018 | |
| MESH:D008175 | Lung Neoplasms | Tetrachlorodibenzodioxin | 2.87 | 11884234 19555203 | |
| MESH:D008275 | Magnesium Deficiency | Magnesium | 5.81 | 17823441 | |
| MESH:D008288 | Malaria | Astemizole | 4.29 | 16816845 | |
| MESH:D008545 | Melanoma | Histamine | 3.40 | 17709802 | |
| MESH:D001523 | Mental Disorders | Clozapine | 10.05 | 16856516 | |
| MESH:D001523 | Mental Disorders | Mianserin | 10.05 | 16856516 | |
| MESH:D001523 | Mental Disorders | olanzapine | 10.05 | 16856516 | |
| MESH:D008654 | Mesothelioma | Asbestos, Crocidolite | 2.89 | 16166281 16966607 18303189 | |
| MESH:D008659 | Metabolic Diseases | olanzapine | 4.82 | 19142110 | |
| MESH:D024821 | Metabolic Syndrome X | Clozapine | 3.88 | 19142101 | |
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 4.14 | 16801185 | |
| MESH:D008881 | Migraine Disorders | Magnesium | 4.30 | 18803445 | |
| MESH:D020326 | Migraine without Aura | Cyclic AMP | 4.55 | 11304026 | |
| MESH:D009041 | Motion Sickness | Promethazine | 6.37 | 1613127 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 2.69 | 16381670 | |
| MESH:D009101 | Multiple Myeloma | Dexamethasone | 3.04 | 15744524 15867202 16118317 | |
| MESH:D009190 | Myelodysplastic Syndromes | Dexamethasone | 3.15 | 9809623 | |
| MESH:D017202 | Myocardial Ischemia | Tetrachlorodibenzodioxin | 2.51 | 12213967 | |
| MESH:D009362 | Neoplasm Metastasis | 4,4'-diaminodiphenylmethane | 2.18 | 3581430 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 1.86 | 11141357 | |
| MESH:D009374 | Neoplasms, Experimental | Toluene 2,4-Diisocyanate | 4.12 | 1670384 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 3.79 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 2.75 | 19348381 18481113 | |
| MESH:D009421 | Nervous System Malformations | Tetrachlorodibenzodioxin | 2.62 | 14600291 | |
| MESH:D009436 | Neural Tube Defects | 4,4'-diaminodiphenylmethane | 2.48 | 6679447 | |
| MESH:D009759 | Nystagmus, Pathologic | Astemizole | 5.82 | 6135121 | |
| MESH:D009765 | Obesity | Clozapine | 4.72 | 19142110 18515891 | |
| MESH:D009765 | Obesity | olanzapine | 4.72 | 18515891 | |
| MESH:D009784 | Occupational Diseases | 4,4'-diaminodiphenylmethane | 7.52 | 4026338 6482804 | |
| MESH:D009784 | Occupational Diseases | Toluene 2,4-Diisocyanate | 7.52 | 3040596 12585506 18394133 6091945 11077013 6091946 8156442 | |
| MESH:D009902 | Optic Neuritis | 4,4'-diaminodiphenylmethane | 4.37 | 3988306 | |
| MESH:D010024 | Osteoporosis | Calcium | 3.37 | 17882678 | |
| MESH:D010195 | Pancreatitis | Cimetidine | 4.71 | 10484002 | |
| MESH:D010212 | Papilloma | 4,4'-diaminodiphenylmethane | 2.87 | 7296757 | |
| MESH:D010382 | Peliosis Hepatis | Tetrachlorodibenzodioxin | 3.60 | 12520081 | |
| MESH:D016491 | Peripheral Vascular Diseases | Cadmium | 4.75 | 15687053 | |
| MESH:D010787 | Photosensitivity Disorders | 4,4'-diaminodiphenylmethane | 3.82 | 6228378 | |
| MESH:D010995 | Pleural Diseases | Asbestos, Crocidolite | 4.27 | 10923243 | |
| MESH:D011041 | Poisoning | Diphenhydramine | 5.33 | 12460839 | |
| MESH:D017119 | Porphyria Cutanea Tarda | Tetrachlorodibenzodioxin | 2.96 | 18163543 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 2.68 | 12371664 | |
| MESH:D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Dexamethasone | 3.16 | 21297632 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Tetrachlorodibenzodioxin | 2.57 | 11118676 11896295 11399792 11222880 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 3.78 | 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | Cadmium | 3.78 | 17075824 | |
| MESH:D011537 | Pruritus | fexofenadine | 4.98 | 17133778 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 1.97 | 16882103 | |
| MESH:D011595 | Psychomotor Agitation | olanzapine | 4.96 | 18685284 | |
| MESH:D011618 | Psychotic Disorders | Clozapine | 3.71 | 15331141 | |
| MESH:D011657 | Pulmonary Eosinophilia | Toluene 2,4-Diisocyanate | 4.98 | 14606601 | |
| MESH:D011658 | Pulmonary Fibrosis | Asbestos, Crocidolite | 2.75 | 17322281 17365031 17975199 15814490 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Dexamethasone | 3.44 | 11700416 18379247 | |
| MESH:D012130 | Respiratory Hypersensitivity | Toluene 2,4-Diisocyanate | 3.99 | 7692837 20219652 16940033 | |
| MESH:D015619 | Respiratory System Abnormalities | Tetrachlorodibenzodioxin | 3.23 | 18990726 | |
| MESH:D012140 | Respiratory Tract Diseases | Toluene 2,4-Diisocyanate | 4.48 | 18447907 | |
| MESH:D012162 | Retinal Degeneration | 4,4'-diaminodiphenylmethane | 2.89 | 3692021 | |
| MESH:D012220 | Rhinitis | marker/mechanism | 12167471 | ||
| MESH:D012220 | Rhinitis | 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid | 26.27 | 18298128 | |
| MESH:D012220 | Rhinitis | Cetirizine | 26.27 | 12167471 | |
| MESH:D012220 | Rhinitis | epinastine | 26.27 | 12167471 | |
| MESH:D012220 | Rhinitis | Histamine | 26.27 | 12689652 | |
| MESH:D012220 | Rhinitis | sho-seiryu-to | 26.27 | 19050374 | |
| MESH:D012220 | Rhinitis | Toluene 2,4-Diisocyanate | 26.27 | 19050374 | |
| MESH:D012221 | Rhinitis, Allergic, Perennial | Astemizole | 43.31 | 10822083 | |
| MESH:D012221 | Rhinitis, Allergic, Perennial | Chlorpheniramine | 43.31 | 8201490 10822083 | |
| MESH:D012221 | Rhinitis, Allergic, Perennial | epinastine | 43.31 | 10822083 | |
| MESH:D012221 | Rhinitis, Allergic, Perennial | Ketotifen | 43.31 | 10822083 | |
| MESH:D012221 | Rhinitis, Allergic, Perennial | mizolastine | 43.31 | 18020585 | |
| MESH:D012221 | Rhinitis, Allergic, Perennial | Terfenadine | 43.31 | 8201490 | |
| MESH:D012221 | Rhinitis, Allergic, Perennial | Toluene 2,4-Diisocyanate | 43.31 | 12617775 15015336 | |
| MESH:D006255 | Rhinitis, Allergic, Seasonal | Chlorpheniramine | 32.36 | 19075512 | |
| MESH:D006255 | Rhinitis, Allergic, Seasonal | epinastine | 32.36 | 19075512 | |
| MESH:D006255 | Rhinitis, Allergic, Seasonal | mizolastine | 32.36 | 18020585 | |
| MESH:D006255 | Rhinitis, Allergic, Seasonal | olopatadine | 32.36 | 19075512 | |
| MESH:D006255 | Rhinitis, Allergic, Seasonal | Toluene 2,4-Diisocyanate | 32.36 | 19075512 | |
| MESH:D012559 | Schizophrenia | marker/mechanism | 1912125 | ||
| MESH:D012559 | Schizophrenia | Clozapine | 3.90 | 11151749 20107430 19369910 20580759 18806925 20521326 17123785 20452607 20168265 18855531 17667964 17726453 20521320 11763009 16141801 | |
| MESH:D012559 | Schizophrenia | olanzapine | 3.90 | 20521326 17726453 20107430 | |
| MESH:D012640 | Seizures | Endosulfan | 3.64 | 7539098 10698677 | |
| MESH:D012772 | Shock, Septic | Diphenhydramine | 10.08 | 18063050 | |
| MESH:D012772 | Shock, Septic | Triprolidine | 10.08 | 18063050 | |
| MESH:D012852 | Sinusitis | Triprolidine | 5.70 | 7327846 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 4.35 | 19755658 10029692 | |
| MESH:D012878 | Skin Neoplasms | Tetrachlorodibenzodioxin | 4.35 | 16192470 | |
| MESH:D012912 | Sneezing | Chlorpheniramine | 32.36 | 19075512 | |
| MESH:D012912 | Sneezing | epinastine | 32.36 | 19075512 | |
| MESH:D012912 | Sneezing | olopatadine | 32.36 | 19075512 | |
| MESH:D012912 | Sneezing | sho-seiryu-to | 32.36 | 19050374 | |
| MESH:D012912 | Sneezing | Toluene 2,4-Diisocyanate | 32.36 | 19050374 19075512 | |
| MESH:D013272 | Stomach Diseases | Dexamethasone | 3.69 | 15472012 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 1.56 | 2093021 20155912 | |
| MESH:D013276 | Stomach Ulcer | Dexamethasone | 2.95 | 15138204 | |
| MESH:D013375 | Substance Withdrawal Syndrome | Mianserin | 5.61 | 12749364 | |
| MESH:D017180 | Tachycardia, Ventricular | olanzapine | 4.73 | 20210726 | |
| MESH:D013959 | Thyroid Diseases | Tetrachlorodibenzodioxin | 3.26 | 12697716 | |
| MESH:D013964 | Thyroid Neoplasms | 4,4'-diaminodiphenylmethane | 2.40 | 7505956 6582329 1399818 3712494 6587162 | |
| MESH:D016171 | Torsades de Pointes | Astemizole | 9.17 | 8256756 9583453 | |
| MESH:D016171 | Torsades de Pointes | Terfenadine | 9.17 | 8256756 | |
| MESH:D001749 | Urinary Bladder Neoplasms | 4,4'-diaminodiphenylmethane | 4.00 | 8074119 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 4.00 | 17053015 | |
| MESH:D014581 | Urticaria | 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid | 37.93 | 18298128 | |
| MESH:D014581 | Urticaria | Astemizole | 37.93 | 3097109 2568013 1976298 1683191 3080510 3134034 2565098 2568189 2147912 2885854 2883202 2859714 | |
| MESH:D014581 | Urticaria | Cetirizine | 37.93 | 14713918 14512923 2568013 2147912 | |
| MESH:D014581 | Urticaria | Chlorpheniramine | 37.93 | 2569998 | |
| MESH:D014581 | Urticaria | Histamine | 37.93 | 18298128 | |
| MESH:D014581 | Urticaria | Loratadine | 37.93 | 2568013 | |
| MESH:D014581 | Urticaria | mizolastine | 37.93 | 18020585 | |
| MESH:D014581 | Urticaria | Terfenadine | 37.93 | 2885854 2565098 2859714 2569995 2568013 | |
| MESH:D014605 | Uveitis | Cyclosporine | 9.62 | 1336536 | |
| MESH:D014605 | Uveitis | Dexamethasone | 9.62 | 1336536 | |
| MESH:D054079 | Vascular Malformations | Tetrachlorodibenzodioxin | 3.95 | 12125929 | |
| MESH:D014717 | Vertigo | Astemizole | 5.82 | 3105558 | |
| MESH:D019282 | Wasting Syndrome | Tetrachlorodibenzodioxin | 3.60 | 15886252 | |
| MESH:D015430 | Weight Gain | Clozapine | 8.55 | 16141801 20107430 20564506 17502770 20521320 16402076 | |
| MESH:D015430 | Weight Gain | olanzapine | 8.55 | 17933447 20107430 19434072 | |
| MESH:D015431 | Weight Loss | Clozapine | 4.44 | 17933447 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 3.79 | 17120751 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04020 | Calcium signaling pathway |
| KEGG:04080 | Neuroactive ligand-receptor interaction |
| REACT:14797 | Signaling by GPCR |
| No data |
| Releated disease ID | Related disease Name |
|---|---|
| PA444546 | Hypersensitivity |
| PA447216 | Schizophrenia |
| Releated drug ID | Related drug Name |
|---|---|
| PA450688 | olanzapine |
| PA449880 | histamine phosphate |
| PA449061 | clozapine |
| PA448039 | acitretin |
| PA448905 | cetirizine |
| PA449046 | clomifene |
| PA449373 | disopyramide |
| PA449412 | doxorubicin |
| PA450322 | maprotiline |
| PA450522 | mirtazapine |
| PA451952 | zaleplon |
| PA451974 | ziprasidone |
| Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB00245 | other/unknown | Benztropine | Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Parasympatholytics |
| DB00246 | antagonist | Ziprasidone | Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents |
| DB00283 | antagonist | Tavist-D Tablets | Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists |
| DB00321 | antagonist | Triavil Tab | Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic |
| DB00334 | antagonist | Olanzapine | Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors |
| DB00341 | antagonist | Cetirizine | Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating |
| DB00342 | antagonist | Terfenadine | Antiarrhythmic Agents;Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating |
| DB00354 | antagonist | Buclizine | Antiemetics;Antihistamines;Anticholinergic Agents |
| DB00363 | antagonist | Clozapine | Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists |
| DB00366 | antagonist | Tylenol Cold & Flu Nighttime | Hypnotics and Sedatives;Antiemetics;Anti-Allergic Agents;Histamine H1 Antagonists;Antitussive Agents |
| DB00370 | antagonist | Mirtazapine | Histamine H1 Antagonists;Adrenergic alpha-Antagonists;Antidepressive Agents, Tricyclic |
| DB00405 | antagonist | Drixtab Tab | Antihistamines |
| DB00420 | antagonist | Promazine | Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents |
| DB00427 | antagonist | Triprofed Tab | Anti-Allergic Agents;Histamine H1 Antagonists |
| DB00434 | antagonist | Cyproheptadine | Serotonin Antagonists;Antipruritics;Gastrointestinal Agents;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamine derivatives |
| DB00455 | antagonist | Liberator | Antipruritics;Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating |
| DB00458 | antagonist | Imipramine | Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors |
| DB00540 | antagonist | Nortriptyline | Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors |
| DB00557 | antagonist | Hydroxyzine | Antipruritics;Histamine H1 Antagonists;Anxiolytics sedatives and hypnotics |
| DB00568 | antagonist | Cinnarizine | Calcium Channel Blockers;Anti-Allergic Agents;Histamine H1 Antagonists |
| DB00637 | antagonist | Astemizole | Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating |
| DB00656 | antagonist | Trazodone | Anti-anxiety Agents;Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation |
| DB00667 | agonist | Histamine Phosphate | Diagnostic aid;Histamine Agents |
| DB00719 | antagonist | Trinalin Repetabs | Histamine H1 Antagonists |
| DB00726 | antagonist | Trimipramine | Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors |
| DB00734 | antagonist | Risperidone | Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents |
| DB00737 | antagonist | Antivert Tab | Antiemetics;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamines |
| DB00748 | antagonist | Carbinoxamine | Antihistamines |
| DB00751 | antagonist | Epinastine | Histamine H1 Antagonists;Antihistamines;Ophthalmics |
| DB00767 | antagonist | Benzquinamide | Antiemetics;Antipsychotics |
| DB00768 | antagonist | Olopatadine | Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamines;Histamine H1 Antagonists, Non-Sedating |
| DB00777 | antagonist | Propiomazine | Sedatives and Hypnotics |
| DB00792 | antagonist | Tripelennamine | Anti-Allergic Agents;Histamine H1 Antagonists;Ethylenediamine Derivatives |
| DB00797 | agonist | Tolazoline | Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists |
| DB00835 | antagonist | Tantapp Elixir | Anti-Allergic Agents;Histamine H1 Antagonists |
| DB00885 | antagonist | Pemirolast | Antipruritics;Anti-Allergic Agents;Histamine Antagonists;Ophthalmics |
| DB00902 | antagonist | Methdilazine | Antihistamines |
| DB00920 | antagonist | Ketotifen | Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists |
| DB00934 | antagonist | Maprotiline | Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Second-Generation |
| DB00950 | antagonist | Allegra-D | Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating |
| DB00967 | antagonist | Clarinex-D 12 Hour Extended Release Tablets | Cholinergic Antagonists;Antihistamines;Histamine H1 Antagonists, Non-Sedating |
| DB00972 | antagonist | Azelastine | Lipoxygenase Inhibitors;Platelet Aggregation Inhibitors;Bronchodilator Agents;Anti-Allergic Agents;Histamine H1 Antagonists;Histamine H1 Antagonists, Non-Sedating |
| DB00985 | antagonist | Dimenhydrinate | Antiemetics;Histamine H1 Antagonists |
| DB01069 | antagonist | Phenergan VC Expectorant Syrup | Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Phenothiazine Derivatives |
| DB01071 | antagonist | Mequitazine | Bronchodilator Agents;Histamine H1 Antagonists |
| DB01075 | antagonist | Suppress Cough Syr W.Cod.Diphen.Hcl Amm.Chl. | Hypnotics and Sedatives;Antiemetics;Antiparkinson Agents;Antidyskinetics;Antipruritics;Anesthetics;Anti-Allergic Agents;Histamine H1 Antagonists;Anesthetics, Local;Antitussives;Ethanolamine Derivatives |
| DB01084 | antagonist | Emedastine | Anti-Allergic Agents;Histamine H1 Antagonists |
| DB01106 | antagonist | Levocabastine | Histamine H1 Antagonists;Histamine H1 Antagonists, Non-Sedating |
| DB01114 | antagonist | Triaminicol Dm Syrup | Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamines |
| DB01142 | antagonist | Doxepin | Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists |
| DB01146 | antagonist | Vito Bronches Sirop | Antihistamines |
| DB01151 | antagonist | Desipramine | Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors |
| DB01173 | antagonist | Orphenadrine | Skeletal Muscle Relaxants;Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Muscle Relaxants, Central;Parasympatholytics |
| DB01175 | other/unknown | Escitalopram | Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation |
| DB01176 | antagonist | Cyclizine | Antiemetics;Histamine H1 Antagonists;Piperazine Derivatives |
| DB01224 | antagonist | Quetiapine | Antipsychotics;Antipsychotic Agents |
| DB01237 | antagonist | Ambenyl Cough Syrup | Antihistamines |
| DB01238 | unknown | Aripiprazole | Antipsychotics;Antipsychotic Agents |
| DB01239 | antagonist | Chlorprothixene | Antipsychotics;Dopamine Antagonists;Antipsychotic Agents |
| DB01246 | antagonist | Vanectyl-P Tablets | Antipruritics;Phenothiazine Derivatives |
| DB01267 | agonist | Paliperidone | Antipsychotic Agents |
| DB01403 | antagonist | Methotrimeprazine | Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents |
| DB01615 | antagonist | Aceprometazine | Antihistamines;Sedatives and Hypnotics |
| DB01619 | antagonist | Amilon | Histamine H1 Antagonists;Antihistamines |
| DB01620 | antagonist | Visine Advance Allergy | Antipruritic Agents;Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists |
| DB04837 | antagonist | Chlophedianol | Anesthetics, Local;Antihistamines;Antitussive Agents |
| DB04841 | antagonist | Flunarizine | Anticonvulsants;Vasodilator Agents;Calcium Channel Blockers;Histamine H1 Antagonists |
| DB04890 | antagonist | Bepotastine | Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating |
| DB06148 | antagonist | Mianserin | Serotonin Antagonists;Histamine H1 Antagonists;Adrenergic alpha-Antagonists;Antidepressive Agents, Second-Generation |
| DB06691 | antagonist | Mepyramine | Histamine H1 Antagonists;Antihistamines |
| DB06698 | agonist | Betahistine | Antivertigo Agents |
| DB06766 | antagonist | Alcaftadine | Topical;Histamine H1 Antagonists |
| DB08799 | antagonist | Antazoline | Anti-Allergic Agents;Antihistamines;Histamine Antagonists |
| DB08800 | antagonist | Chloropyramine | Anti-Allergic Agents;Antihistamines |
| DB08801 | antagonist | Dimethindene | Antipruritics;Anti-Allergic Agents;Antihistamines;Anticholinergics |
| DB08802 | antagonist | Isothipendyl | Antipruritic Agents;Anti-Allergic Agents;Histamine Antagonists |
| No data |
| No data |
| No data |