AutismKB 2.0

Annotation Detail for PRMT2


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Basic Information Top
Gene Symbol:PRMT2 ( HRMT1L1,MGC111373 )
Gene Full Name: protein arginine methyltransferase 2
Band: 21q22.3
Quick LinksEntrez ID:3275; OMIM: 601961; Uniprot ID:ANM2_HUMAN; ENSEMBL ID: ENSG00000160310; HGNC ID: 5186
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PRMT2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PRMT2 mRNAdecreases expression 18648102
C464660 6-ethylchenodeoxycholic acid 6-ethylchenodeoxycholic acid promotes the reaction [PRMT2 protein binds to NR0B2 promoter]affects binding|increases reaction 15911693
D000082 Acetaminophen Acetaminophen affects the expression of PRMT2 mRNAaffects expression 17562736
D001104 Arbutin Arbutin results in decreased expression of PRMT2 mRNAdecreases expression 17103032
D016572 Cyclosporine Cyclosporine results in increased expression of PRMT2 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of PRMT2 mRNAincreases expression 16002434
C011890 kojic acid kojic acid results in decreased expression of PRMT2 mRNAdecreases expression 16595896
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of PRMT2 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of PRMT2 mRNAincreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of PRMT2 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of PRMT2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001943 Breast Neoplasms Calcitriol 2.5911237771
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.647296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.643084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6611237771
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.957505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9512371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.309022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.3019486331
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.018970840 18759878 2524372 12868966 14531868 11298694 8156756 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.3518692083 7440962 18648102 11289319 18289764 6679447 9653073 6482804 9022650 9328219 16192314 8291058 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3519164858 18071297 15619225 14986274 12392966 16227642 16485898 16177239 12594235 10915739 11421492 19416960 2444490 11834606 15968718 12540782 11743745 16109766 19420014 11461765 18713872 10663392 17522070 12153990 17562736 16081117 10774834 14725611 16393943 12958197 19923254 16781746 19370779 11529661 11739529 19739265 11287661 17906064 19085960 12705907 14550746
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3515131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1315138306
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005234 Fatty Liver Cyclosporine 3.0319224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 10.5515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.5518776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 10.5512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.226582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental 6-ethylchenodeoxycholic acid 3.3315980055 15860571
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.3316169303
MESH:D008107 Liver Diseases Acetaminophen 1.6619460945 16610002 19014921 11587558 12969438 16611625 19784758 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.52598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.5218544905
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.436482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3612479363 15754350 16644109 18247401 16289102
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3615084515
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.016587162 1399818 6582329 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.218074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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