AutismKB 2.0

Annotation Detail for HES1


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Basic Information Top
Gene Symbol:HES1 ( FLJ20408,HES-1,HHL,HRY,bHLHb39 )
Gene Full Name: hairy and enhancer of split 1, (Drosophila)
Band: 3q29
Quick LinksEntrez ID:3280; OMIM: 139605; Uniprot ID:HES1_HUMAN; ENSEMBL ID: ENSG00000114315; HGNC ID: 5192
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04950Maturity onset diabetes of the young
hsa04330Notch signaling pathway
Pathway IDPathway Name
Regulation of beta-cell development
Pathway IDPathway Name
200130C-MYB transcription factor network
200116ATF-2 transcription factor network
200196Notch-mediated HES/HEY network
Pathway IDPathway Name
P00045Notch signaling pathway
Pathway IDPathway Name
500520Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1720Fanconi's anemia
1779Cervical cancer
1944Breast cancer
1976Squamous cell cancer
Desease Name
PSYCH
attention deficit hyperactivity disorder
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HES1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HES1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HES1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of HES1 mRNAdecreases expression 20458559
C015001 arsenite arsenite results in decreased expression of HES1 mRNAdecreases expression 18633435
C015001 arsenite [arsenite results in decreased expression of JAG1 protein] which results in decreased expression of HES1 mRNAdecreases expression 18633435
C015001 arsenite tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of HES1 mRNA]decreases expression|decreases reaction 18633435
C006680 baicalein baicalein results in increased expression of HES1 mRNAincreases expression 19160421
C006680 baicalein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA]decreases reaction|increases expression 19160421
C038044 baicalin baicalin results in increased expression of HES1 mRNAincreases expression 19160421
C038044 baicalin N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]decreases reaction|increases expression 19160421
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HES1 mRNAincreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HES1 mRNAincreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of HES1 mRNAincreases expression 16902998
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of HES1 mRNAincreases expression 17553608
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of HES1 mRNAincreases expression 15336504
D002118 Calcium Calcium affects the expression of HES1 mRNAaffects expression 15913539
D003907 Dexamethasone Dexamethasone results in decreased expression of HES1 mRNAdecreases expression 12782123
D004041 Dietary Fats Dietary Fats results in increased expression of HES1 mRNAincreases expression 18042831
D005419 Flavonoids Flavonoids results in decreased expression of HES1 mRNAdecreases expression 18035473
D005472 Fluorouracil Fluorouracil results in increased activity of HES1 proteinincreases activity 19147571
C013038 hydroxyhydroquinone hydroxyhydroquinone results in increased expression of HES1 mRNAincreases expression 17572062
C051890 irinotecan irinotecan results in increased activity of HES1 proteinincreases activity 19147571
D007657 Ketone Bodies Ketone Bodies results in decreased expression of HES1 mRNAdecreases expression 16807920
D009534 Niclosamide Niclosamide results in decreased expression of HES1 proteindecreases expression 19160421
C007350 nitrofen nitrofen results in increased expression of HES1 mRNAincreases expression 17618886
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA]decreases reaction|increases expression 19160421
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]decreases reaction|increases expression 19160421
C030110 oxaliplatin oxaliplatin results in increased activity of HES1 proteinincreases activity 19147571
C030110 oxaliplatin oxaliplatin results in increased expression of HES1 proteinincreases expression 19147571
C041786 palm oil palm oil results in increased expression of HES1 mRNAincreases expression 18042831
D019800 Phenol Phenol results in increased expression of HES1 mRNAincreases expression 17547211
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HES1 mRNAaffects binding|increases activity|increases expression 19710929
C059514 resveratrol resveratrol results in decreased expression of HES1 mRNAdecreases expression 17868649
C009166 retinol acetate retinol acetate results in increased expression of HES1 mRNAincreases expression 16772331
C488333 Ro 65-7199 Ro 65-7199 affects the expression of HES1 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of HES1 mRNAaffects expression 14610520
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of HES1 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in decreased expression of HES1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HES1 mRNAincreases expression 14722248
20106945
16697128
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HES1 proteinincreases expression 14722248
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of HES1 mRNA]decreases expression|decreases reaction 18633435
C025643 vinclozolin vinclozolin affects the expression of HES1 mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of HES1 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of HES1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1918287403
MESH:D058186 Acute Kidney Injury resveratrol 3.5316538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.7818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.5019825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.5020127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 6.5017638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.086695378
MESH:D000236 Adenoma resveratrol 6.0815688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.6816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6816835633
MESH:D000544 Alzheimer Disease resveratrol 2.4916162502 16183991
MESH:D000740 Anemia Fluorouracil 7.6317963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.6311748828
MESH:D000799 Angioedema Acetaminophen 3.4710982225
MESH:D001008 Anxiety Disorders vinclozolin 3.3519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7119183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.5315238619
MESH:D001169 Arthritis, Experimental Dexamethasone 6.9217659584
MESH:D001169 Arthritis, Experimental resveratrol 6.9217115116
MESH:D050197 Atherosclerosis resveratrol 3.0617967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.3816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.3819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.3812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5315746008
MESH:D001859 Bone Neoplasms Phenol 4.8710556009
MESH:D001862 Bone Resorption bisphenol A 3.5411985600
MESH:D001913 Bowen's Disease Phenol 5.3819293009
MESH:D002545 Brain Ischemia resveratrol 3.9217600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.7620146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.7617123778
MESH:D001943 Breast Neoplasms Dietary Fats 2.7620435547
MESH:D001943 Breast Neoplasms Fluorouracil 2.7616557594 19217205 18357371 16110121 18608205 15136595 16595493
MESH:D001943 Breast Neoplasms resveratrol 2.7616393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.7620435547
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.6012794006
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9911589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.5716050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2916051944
MESH:D002277 Carcinoma Fluorouracil 7.2317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.2316835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.1516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.153084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.1511135700 16217749 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.1517971768 17045692 18930000 16332177 16799960 17088986
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.1519321006 16227395
MESH:D002278 Carcinoma in Situ bisphenol A 4.6217123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2216675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5019014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8418695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.8920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 6.8916757204 17066447 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell resveratrol 6.8916227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1618850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.2215458977
MESH:D002386 Cataract Acetaminophen 2.3610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 5.816135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 5.8120889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8516835633
MESH:D002779 Cholestasis pirinixic acid 2.5619176532
MESH:D016770 Ciliophora Infections Niclosamide 5.3612113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9515668235 15340226 12621046 8697196 16354765
MESH:D003092 Colitis resveratrol 8.4616474422
MESH:D003092 Colitis Selenium 8.4617936198
MESH:D003110 Colonic Neoplasms marker/mechanism 19147571
MESH:D003110 Colonic Neoplasms arsenite 13.0815037631
MESH:D003110 Colonic Neoplasms Dexamethasone 13.0815824018
MESH:D003110 Colonic Neoplasms Fluorouracil 13.0817018589 16510598 17169374 17725105 17016597 15001691 18772588 17172411 17287894 16340194
MESH:D003110 Colonic Neoplasms irinotecan 13.0817725105 17287894
MESH:D003110 Colonic Neoplasms oxaliplatin 13.0816510598 16004971 16024531
MESH:D003110 Colonic Neoplasms resveratrol 13.0816338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.0520501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.0518509181 17255274 16331619 17094418 17695437 18448328 16282729 16391804 20501625 17016601 15148649 18288408 17454858 18949393 18383874 17594712 18802399 14970324 16303861 17401013 16524972 15289873
MESH:D015179 Colorectal Neoplasms irinotecan 6.0517159606 16303861 18259882 17454858 16391804 15273666 18509181
MESH:D015179 Colorectal Neoplasms oxaliplatin 6.0518448328 17401013 17594712 18509181 17255274 17695437
MESH:D015179 Colorectal Neoplasms resveratrol 6.0516550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7517141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.5116507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.8410525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.8417728286
MESH:D019465 Craniofacial Abnormalities nitrofen 6.8411405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.8410048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 6.8419769572
MESH:D003456 Cryptorchidism vinclozolin 3.9914966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.6618551238
MESH:D007644 Darier Disease Fluorouracil 4.4216733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7615213294
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0712438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2518249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.4716873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5817107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.6616286809
MESH:D003967 Diarrhea Dexamethasone 3.367237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 7.9518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.9511739529 17906064 14550746 11421492 10663392 12705907 12153990 17522070 15619225 19739265 12594235 11287661 16485898 16081117 17562736 10915739 10774834 15968718 11743745 16781746 19420014 18071297 19164858 14725611 19370779 11461765 12392966 19416960 16393943 16109766 19923254 16227642 2444490 11834606 18713872 14986274 12540782 12958197 11529661 19085960 16177239
MESH:D056486 Drug-Induced Liver Injury Selenium 7.9515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.9520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1918367378
MESH:C538011 Eales disease Vitamin E 4.339068938
MESH:D004485 Eczema Dexamethasone 4.1112438553
MESH:D004487 Edema Dexamethasone 13.7819703484
MESH:D004487 Edema pirinixic acid 13.7812083418
MESH:D004487 Edema resveratrol 13.788985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.7812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5315322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.6817872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.719294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4917923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.5120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.5112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.5116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.5116337965 17638652 15173087 16481741 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7411564622
MESH:D005234 Fatty Liver arsenic trioxide 16.1215073043
MESH:D005234 Fatty Liver arsenite 16.1218296743
MESH:D005234 Fatty Liver Dietary Fats 16.1219551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 16.1219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1011858732
MESH:D005355 Fibrosis arsenite 24.0018296743
MESH:D005355 Fibrosis baicalein 24.0019474275
MESH:D005355 Fibrosis baicalin 24.0019474275
MESH:D005355 Fibrosis Dietary Fats 24.0018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.0020067830
MESH:D005393 Fish Diseases Niclosamide 5.3212113305
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9116904648
MESH:D005756 Gastritis Acetaminophen 3.3016983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5716973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9316417039
MESH:D005909 Glioblastoma baicalein 4.6019804834
MESH:D005910 Glioma Fluorouracil 2.7216145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2210696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1415102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.3920471113
MESH:D006330 Heart Defects, Congenital nitrofen 14.3916080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.3911294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 14.3916080930
MESH:D006333 Heart Failure pirinixic acid 6.1920558911
MESH:D006333 Heart Failure Selenium 6.1917162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0111000095
MESH:D006529 Hepatomegaly pirinixic acid 7.0716221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.0715340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 8.957520565
MESH:D006548 Hernia, Diaphragmatic nitrofen 8.9518958481 12746050 17245593 9575882 11588001 10646786 15578192 10898222 12904592 10370017 16720372 11685700 11409163 15707848 16490937 16863852 12759764 10541330 11057544 17270546 12505043 16292651 10898224 9476886 7520565 18280291 15756563 7576705 15088113 11051153 8863223 9473106 10693666 17618886 15793718 10359170 11076806 15764645 15185205 16080930 10370016 7760232 12194112 12021965 18280292 9859898 15136996 9698600 12407540 16473863 11329586 12547725 11584395
MESH:D006548 Hernia, Diaphragmatic Vitamin E 8.9516490937 16863852
MESH:D006561 Herpes Simplex resveratrol 3.8116876885
MESH:D019584 Hot Flashes Vitamin E 3.6014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6718606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.0916870215
MESH:D006930 Hyperalgesia oxaliplatin 7.0917418472
MESH:D006937 Hypercholesterolemia Dietary Fats 8.1321332399
MESH:D006937 Hypercholesterolemia resveratrol 8.1317188708
MESH:D006943 Hyperglycemia pirinixic acid 2.8720558911
MESH:D006949 Hyperlipidemias Dietary Fats 8.1721332399
MESH:D006949 Hyperlipidemias resveratrol 8.1716873680
MESH:D006973 Hypertension Dexamethasone 4.7617042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7618850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9817488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.2917600658
MESH:D007248 Infertility, Male vinclozolin 2.8016467254
MESH:D007249 Inflammation Dexamethasone 13.778960868 11099482
MESH:D007249 Inflammation Dietary Fats 13.7720412841
MESH:D007249 Inflammation Flavonoids 13.7717296493
MESH:D007249 Inflammation resveratrol 13.7716366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.7712200463 12878042
MESH:D007251 Influenza, Human resveratrol 16.4516624496
MESH:D007251 Influenza, Human Selenium 16.4516624496
MESH:D007251 Influenza, Human Vitamin E 16.4516624496
MESH:D007333 Insulin Resistance bisphenol A 10.9316393666
MESH:D007333 Insulin Resistance Dietary Fats 10.9311836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 10.9316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0116580747
MESH:D055623 Keratosis, Actinic Phenol 6.0719293009
MESH:D007674 Kidney Diseases Acetaminophen 5.2515629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 5.2512488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.5616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.5016705839
MESH:D007680 Kidney Neoplasms Fluorouracil 6.5016985049
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.6716316344
MESH:D007938 Leukemia arsenic trioxide 2.6515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0716467208 17050201 16968895 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.9811468182 12679006 19035177 15336539 16112521 16330433 12712474 15748426 17649720 16331271 17712046 17869043 15213294 15622746 16891316 16966277 19642359 19075265 9834237 11161223 17107899 17217047 16823087 12018890 19225113
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.9816087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0016882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3616417039
MESH:D008103 Liver Cirrhosis arsenite 6.1618296743
MESH:D008103 Liver Cirrhosis Dietary Fats 6.1618296743
MESH:D008106 Liver Cirrhosis, Experimental baicalin 6.2118187930
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.2116718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.2116169303
MESH:D008107 Liver Diseases Acetaminophen 1.5416610002 12969438 12587719 19784758 11587558 19460945 16611625 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9216871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.617678174
MESH:D008113 Liver Neoplasms arsenic trioxide 19.6114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.6121137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 19.6117045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 19.6120007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 19.6119812893 19073162 19321006 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.6116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 8.452876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 8.4520377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.4512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0715213294
MESH:D008171 Lung Diseases nitrofen 7.0717245593 16863852 9614859 9859898
MESH:D008171 Lung Diseases Vitamin E 7.0716863852
MESH:D008175 Lung Neoplasms arsenic trioxide 9.8911798837 19825857
MESH:D008175 Lung Neoplasms arsenite 9.8916809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 9.8918816296 17053015 18569708 20064080 20464547 6695378 20135361 18520028 20869020
MESH:D008175 Lung Neoplasms Dexamethasone 9.8911195469 15824018
MESH:D008175 Lung Neoplasms Fluorouracil 9.8915246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.8919555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 9.8911062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4215086387
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.5714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.8815688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.448985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.4415318939
MESH:D008545 Melanoma resveratrol 2.3217992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2119513568
MESH:D008654 Mesothelioma Selenium 2.6415107826
MESH:D008659 Metabolic Diseases resveratrol 4.0517112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.6016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.6016757204 18986760
MESH:D052016 Mucositis irinotecan 4.6417159606
MESH:D009101 Multiple Myeloma arsenic trioxide 10.6819417148 14977855 15949261 11468182 19549372
MESH:D009101 Multiple Myeloma Dexamethasone 10.6815744524 15867202 16118317
MESH:D009101 Multiple Myeloma resveratrol 10.6817935668 16490592 14749477 17049120 17164350 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5017962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1516239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.8516882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.859809623
MESH:D009203 Myocardial Infarction pirinixic acid 5.2019151258
MESH:D009203 Myocardial Infarction resveratrol 5.2017188708 16456233 16525036 17125593 16317513 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.0517125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.0512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6716411023
MESH:D009205 Myocarditis resveratrol 4.3917322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.497678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6116624393
MESH:D009362 Neoplasm Metastasis irinotecan 3.0218259882
MESH:D009369 Neoplasms Benzo(a)pyrene 7.1211141357
MESH:D009369 Neoplasms Fluorouracil 7.1218600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 7.1217405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.658985016
MESH:D009389 Neovascularization, Pathologic arsenite 4.0515738583
MESH:D009421 Nervous System Malformations bisphenol A 8.4216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4214600291
MESH:D009436 Neural Tube Defects arsenic trioxide 2.8810525206
MESH:D009447 Neuroblastoma irinotecan 3.298761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3718514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.3717652729
MESH:D017599 Neuroectodermal Tumors irinotecan 4.368761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.0617929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1916436463
MESH:D009765 Obesity Dietary Fats 4.0918674790 16723640 20132043 11836018 17217161 18457598 21332399 19632207 20518802
MESH:D009765 Obesity pirinixic acid 4.0920558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.1216049721
MESH:D010024 Osteoporosis Calcium 3.5517882678
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.9217513867
MESH:D010049 Ovarian Diseases bisphenol A 4.6211985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.2912452020 16624393 19769630
MESH:D010146 Pain Acetaminophen 6.0916870215
MESH:D010146 Pain Phenol 6.0917610455
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 4.8915580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 4.8916929163 15113037 19003803 16500647
MESH:D010235 Paraganglioma arsenic trioxide 3.8219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8712520081
MESH:D010392 Pemphigus Phenol 6.0716522979 17163923
MESH:D010864 Pilonidal Sinus Phenol 6.0719655223 15622588
MESH:D010954 Plasmacytoma Selenium 4.5115087411
MESH:D011041 Poisoning Phenol 4.388825745
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2118163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3421297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 20.2310548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 20.2316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 20.2311222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 20.2318220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.5718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.8820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0419131511
MESH:D011471 Prostatic Neoplasms baicalin 2.0415714805
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0416740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0419082440 18626508
MESH:D011471 Prostatic Neoplasms resveratrol 2.0416731767 17636462 17718901 17804756 17675339 15767336
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0415084515
MESH:D011472 Prostatitis vinclozolin 4.5718629315
MESH:D011629 Puberty, Precocious bisphenol A 4.4210548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7018286688 18722050 16160472 15538739
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.2116325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.9519058328
MESH:D015427 Reperfusion Injury resveratrol 5.9517520802 16314181 15827377 16317513 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6811700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4918990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6116646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3018551238
MESH:D012871 Skin Diseases Vitamin E 2.3418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.0810029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 12.0815837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.088532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.0816192470
MESH:D013088 Spermatocele Phenol 5.2718646496
MESH:D013272 Stomach Diseases Dexamethasone 3.9515472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.4017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.4020155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 4.4017498489 18567086 17172411 17522103 19015929 16424979 19084572 18396642 15786421 16951190
MESH:D013274 Stomach Neoplasms irinotecan 4.4015723263
MESH:D013276 Stomach Ulcer Dexamethasone 3.1715138204
MESH:D020521 Stroke Vitamin E 3.2316517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1616321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.6216684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.8119014326
MESH:D014062 Tongue Neoplasms Fluorouracil 8.9316280240
MESH:D014062 Tongue Neoplasms resveratrol 8.9316227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5915213294
MESH:D014277 Trigeminal Neuralgia Phenol 6.0710223447 16527771
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.4016049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.4020435036 12845720 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.4017053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9510091137
MESH:D014581 Urticaria Acetaminophen 2.6410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.5516803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.5517473185
MESH:D014591 Uterine Diseases bisphenol A 4.6314652134
MESH:D014594 Uterine Neoplasms resveratrol 3.7917044934
MESH:D014605 Uveitis Dexamethasone 4.441336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2212125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.9417488730
MESH:D014860 Warts Phenol 5.7219122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8715886252
MESH:D015430 Weight Gain Dietary Fats 3.4316723640
Pathway ID Pathway Name
KEGG:04950 Maturity onset diabetes of the young
KEGG:04330 Notch signaling pathway
REACT:13698 Regulation of beta-cell development
REACT:13641 Regulation of Beta-Cell Development
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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