AutismKB 2.0

Annotation Detail for HSD3B2


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Basic Information Top
Gene Symbol:HSD3B2 ( HSD3B,HSDB,SDR11E2 )
Gene Full Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Band: 1p12
Quick LinksEntrez ID:3284; OMIM: 201810; Uniprot ID:3BHS2_HUMAN; ENSEMBL ID: ENSG00000203859; HGNC ID: 5218
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-381glucocorticoid biosynthesis
PWY66-378androgen biosynthesis
PWY66-382mineralocorticoid biosynthesis
Pathway IDPathway Name
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of lipid/glycolipid metabolism
H00216Congenital adrenal hyperplasia
Genetic disorders
Desease IDDesease Name
1831Prostate cancer
1832Congenital abnormality
Desease Name
Hirsutism
CANCER
pubarche
hereditary and sporadic prostate cancer susceptibility.
No data
Desease Name
3-beta-hydroxysteroid dehydrogenase, type II, deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in decreased expression of HSD3B2 mRNAdecreases expression 15302862
C120129 2,2',3,4',5',6-hexachlorobiphenyl 2,2',3,4',5',6-hexachlorobiphenyl metabolite inhibits the reaction [2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of HSD3B2 mRNA]decreases reaction|increases expression 16216300
C120129 2,2',3,4',5',6-hexachlorobiphenyl 2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of HSD3B2 mRNAincreases expression 16216300
C009828 2,4,5,2',5'-pentachlorobiphenyl 2,4,5,2',5'-pentachlorobiphenyl metabolite results in increased expression of HSD3B2 mRNAincreases expression 16216300
C009828 2,4,5,2',5'-pentachlorobiphenyl 2,4,5,2',5'-pentachlorobiphenyl results in increased expression of HSD3B2 mRNAincreases expression 16216300
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD3B2 mRNAincreases expression 16216300
C008636 4-nitro-3-cresol [4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of HSD3B2 proteinaffects cotreatment|decreases expression 18336853
D000082 Acetaminophen Acetaminophen affects the expression of HSD3B2 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of HSD3B2 mRNAdecreases expression 11264010
C430898 AGN 194204 AGN 194204 results in decreased expression of HSD3B2 mRNAdecreases expression 15302862
D015124 8-Bromo Cyclic Adenosine Monophosphate [4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of HSD3B2 proteinaffects cotreatment|decreases expression 18336853
D002220 Carbamazepine Carbamazepine results in decreased activity of HSD3B2 proteindecreases activity 15730543
C023386 chlorinated dibenzofurans [polychlorodibenzo-4-dioxin co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with chlorinated dibenzofurans] results in decreased expression of HSD3B2 mRNAaffects cotreatment|decreases expression 16650473
C023386 chlorinated dibenzofurans [Polycyclic Hydrocarbons, Aromatic co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with chlorinated dibenzofurans] results in decreased expression of HSD3B2 mRNAaffects cotreatment|decreases expression 16650473
C029010 cinnamic acid cinnamic acid analog results in decreased activity of HSD3B2 proteindecreases activity 15072549
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B2 mRNAaffects cotreatment|decreases expression 18313992
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal results in increased expression of HSD3B2 mRNAincreases expression 14711788
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of HSD3B2 mRNAdecreases expression 12655037
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HSD3B2 mRNAincreases expression 12075121
C026098 etiracetam etiracetam results in decreased expression of HSD3B2 mRNAdecreases expression 19566492
D005576 Forskolin Forskolin results in increased expression of HSD3B2 mRNAincreases expression 17080404
D005576 Forskolin Lindane inhibits the reaction [Forskolin results in increased expression of HSD3B2 mRNA]decreases reaction|increases expression 17080404
D005938 Glucocorticoids HSD3B2 protein affects the chemical synthesis of Glucocorticoidsaffects chemical synthesis 15208301
D055768 Halogenated Diphenyl Ethers Halogenated Diphenyl Ethers metabolite results in increased expression of HSD3B2 mRNAincreases expression 18313098
D006843 Hydrocarbons, Chlorinated [polychlorodibenzo-4-dioxin co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with chlorinated dibenzofurans] results in decreased expression of HSD3B2 mRNAaffects cotreatment|decreases expression 16650473
D006843 Hydrocarbons, Chlorinated [Polycyclic Hydrocarbons, Aromatic co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with chlorinated dibenzofurans] results in decreased expression of HSD3B2 mRNAaffects cotreatment|decreases expression 16650473
C047781 lamotrigine lamotrigine results in decreased activity of HSD3B2 proteindecreases activity 15730543
D001556 Lindane Lindane inhibits the reaction [Forskolin results in increased expression of HSD3B2 mRNA]decreases reaction|increases expression 17080404
D001556 Lindane Lindane results in decreased expression of HSD3B2 mRNAdecreases expression 17080404
D008901 Mineralocorticoids HSD3B2 protein affects the chemical synthesis of Mineralocorticoidsaffects chemical synthesis 15208301
C093973 PD 98059 PD 98059 results in increased expression of HSD3B2 mRNAincreases expression 17138841
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of HSD3B2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of HSD3B2 mRNAdecreases expression 19482888
C060836 pioglitazone pioglitazone results in decreased activity of HSD3B2 proteindecreases activity 15072549
17138841
C060836 pioglitazone pioglitazone results in decreased expression of HSD3B2 mRNAdecreases expression 17138841
C006253 pirinixic acid pirinixic acid results in decreased expression of HSD3B2 mRNAdecreases expression 20059764
15302862
18445702
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of HSD3B2 mRNA]decreases expression|increases reaction 20059764
D011078 Polychlorinated Biphenyls [polychlorodibenzo-4-dioxin co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with chlorinated dibenzofurans] results in decreased expression of HSD3B2 mRNAaffects cotreatment|decreases expression 16650473
D011078 Polychlorinated Biphenyls [Polycyclic Hydrocarbons, Aromatic co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with chlorinated dibenzofurans] results in decreased expression of HSD3B2 mRNAaffects cotreatment|decreases expression 16650473
C008954 polychlorodibenzo-4-dioxin [polychlorodibenzo-4-dioxin co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with chlorinated dibenzofurans] results in decreased expression of HSD3B2 mRNAaffects cotreatment|decreases expression 16650473
D011084 Polycyclic Hydrocarbons, Aromatic [Polycyclic Hydrocarbons, Aromatic co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with chlorinated dibenzofurans] results in decreased expression of HSD3B2 mRNAaffects cotreatment|decreases expression 16650473
C045362 prochloraz prochloraz results in decreased activity of HSD3B2 proteindecreases activity 19733639
C045362 prochloraz prochloraz results in decreased expression of HSD3B2 mRNAdecreases expression 19733639
C045950 propiconazole propiconazole results in decreased expression of HSD3B2 mRNAdecreases expression 19363144
C031280 pyrazole pyrazole results in decreased expression of HSD3B2 mRNAdecreases expression 17945193
C089730 rosiglitazone rosiglitazone results in decreased activity of HSD3B2 proteindecreases activity 15072549
D012643 Selenium Selenium deficiency results in increased expression of HSD3B2 mRNAincreases expression 16170372
D012643 Selenium Selenium results in increased expression of HSD3B2 mRNAincreases expression 16170372
C446685 systhane systhane results in decreased expression of HSD3B2 mRNAdecreases expression 16730040
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of HSD3B2 mRNAaffects binding|decreases expression 16214954
D013752 Tetracycline Tetracycline results in increased expression of HSD3B2 mRNAincreases expression 16917069
C423915 TO-901317 TO-901317 results in decreased expression of HSD3B2 mRNAdecreases expression 15302862
C052342 topiramate topiramate results in decreased activity of HSD3B2 proteindecreases activity 15730543
C032910 triadimefon triadimefon results in decreased expression of HSD3B2 mRNAdecreases expression 19363144
C057693 troglitazone troglitazone results in decreased activity of HSD3B2 proteindecreases activity 15072549
D014635 Valproic Acid Valproic Acid results in decreased activity of HSD3B2 proteindecreases activity 15730543
D014635 Valproic Acid Valproic Acid results in decreased expression of HSD3B2 mRNAdecreases expression 19566492
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B2 mRNAaffects cotreatment|decreases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 16.668986270
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 16.666195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.6615322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 16.668875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5219490988
MESH:D000038 Abscess Drugs, Chinese Herbal 5.8515043669
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4817505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.389612607
MESH:D055371 Acute Lung Injury pirinixic acid 2.7018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.6914692618
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 21.1916628245
MESH:D018248 Adenoma, Liver Cell Phenobarbital 21.1917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.1916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.1916835633
MESH:C538236 Adrenal hyperplasia 2 marker/mechanism
MESH:D000382 Agricultural Workers' Diseases Lindane 3.9312661182
MESH:D000437 Alcoholism topiramate 4.6817925516 19331489 18552399
MESH:D000544 Alzheimer Disease rosiglitazone 2.7519621015
MESH:D000550 Amblyopia Valproic Acid 4.7717688650
MESH:D000740 Anemia Drugs, Chinese Herbal 7.7317963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7311748828
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 4.9511477813
MESH:D000799 Angioedema Acetaminophen 3.3810982225
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.5015043669
MESH:D001008 Anxiety Disorders etiracetam 8.3519265183
MESH:D001008 Anxiety Disorders Valproic Acid 8.3517497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3815885639
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 5.3019655406
MESH:D001321 Autistic Disorder Acetaminophen 2.6318445737
MESH:D001321 Autistic Disorder etiracetam 2.6319232924 19265183
MESH:D001321 Autistic Disorder pioglitazone 2.6317207275
MESH:D001321 Autistic Disorder Valproic Acid 2.6320603192 18775368 17507914 19460635 18985861 19232924 15238991 18177632 18558336 16609825 18316065 18396377 17688650 17157402 18940202
MESH:D001714 Bipolar Disorder Carbamazepine 10.8520046352 17594078
MESH:D001714 Bipolar Disorder etiracetam 10.8519265183
MESH:D001714 Bipolar Disorder Valproic Acid 10.8520046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.4219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.0315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.038888407
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 4.429881647
MESH:D001943 Breast Neoplasms Lindane 2.4414688026
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4420435547
MESH:D002277 Carcinoma Hydrocarbons, Chlorinated 7.6812024805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6816835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 19363144
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.623084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.6220935162 17173139 1701930 6705139 20007298
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1118670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.3110977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.814080065
MESH:D002659 Child Development Disorders, Pervasive topiramate 5.8115650499
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 5.8120734317
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 8.5416628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.6211677210 17681005 17333356 16105132 15861022 16919318 17110522
MESH:D002779 Cholestasis pirinixic acid 6.6219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4712621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate triadimefon 5.4716781842
MESH:D003092 Colitis Selenium 3.3417936198
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7215531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6817141729 14669216
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 8.6717686920
MESH:D019465 Craniofacial Abnormalities Carbamazepine 8.679014606
MESH:D019465 Craniofacial Abnormalities Glucocorticoids 8.6718281261
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.6720055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities triadimefon 8.6715834900 16875885
MESH:D019465 Craniofacial Abnormalities Valproic Acid 8.6716575769 17688650 8888407
MESH:D003550 Cystic Fibrosis pioglitazone 4.5319747007
MESH:D003704 Dementia Polychlorinated Biphenyls 4.3016140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2018249437
MESH:D003920 Diabetes Mellitus rosiglitazone 3.9217446233
MESH:D003924 Diabetes Mellitus, Type 2 pioglitazone 12.2916023994 12642470
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 12.2912642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 12.2917107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 12.2916979414
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 12.2916023994
MESH:D003925 Diabetic Angiopathies troglitazone 5.1912601628
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.0011748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.1216538176 15057820 16538175 20216337
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 22.8216081117 11743745 14986274 16393943 11834606 19420014 11421492 11739529 11287661 18713872 17522070 12153990 12705907 12540782 18071297 10663392 16227642 19164858 17906064 16485898 19085960 11529661 19739265 12594235 19416960 19370779 16781746 14550746 16109766 19923254 12958197 2444490 10915739 17562736 16177239 12392966 11461765 15619225 15968718 10774834 14725611
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 22.8217465707
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 22.8215027814
MESH:D056486 Drug-Induced Liver Injury pyrazole 22.8212499123
MESH:D056486 Drug-Induced Liver Injury Selenium 22.8215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 22.8220420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 22.8217522070
MESH:D056486 Drug-Induced Liver Injury troglitazone 22.8214986274
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 22.821733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6319426721
MESH:D004362 Drug Toxicity Carbamazepine 16.9320216337
MESH:D004362 Drug Toxicity Lamivudine 16.9315040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 16.9311462148
MESH:D004362 Drug Toxicity Zidovudine 16.9315040536
MESH:D004421 Dystonia Phenobarbital 9.041851702
MESH:D004421 Dystonia Valproic Acid 9.041851702
MESH:D004487 Edema pirinixic acid 9.1512083418
MESH:D004487 Edema rosiglitazone 9.1512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.1512711302 11000095
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 10.8817686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8815322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 7.9617654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.9612538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6310568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 10.6418855540 19915237 20485159 16538176 16415921
MESH:D004816 Epidermal Necrolysis, Toxic lamotrigine 10.6420235791
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 22.7617275665
MESH:D004831 Epilepsies, Myoclonic lamotrigine 22.7617275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 22.763659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 22.7617275665 3659116
MESH:D004828 Epilepsies, Partial Carbamazepine 26.6217116037 16628512 15008574
MESH:D004828 Epilepsies, Partial etiracetam 26.6219265183
MESH:D004828 Epilepsies, Partial lamotrigine 26.6217116037
MESH:D004828 Epilepsies, Partial Phenobarbital 26.623922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 26.623922381 16628512
MESH:D004827 Epilepsy Carbamazepine 18.1419439326 7988514 17178248 17465707 20417680 18234410 9014606 821787 19700373 19620853
MESH:D004827 Epilepsy lamotrigine 18.1419668019
MESH:D004827 Epilepsy Phenobarbital 18.1420417680
MESH:D004827 Epilepsy topiramate 18.1419148780
MESH:D004827 Epilepsy Valproic Acid 18.1418234410 20417680
MESH:D004832 Epilepsy, Absence etiracetam 12.9219265183
MESH:D004832 Epilepsy, Absence Phenobarbital 12.926401628
MESH:D004832 Epilepsy, Absence Valproic Acid 12.926426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 16.867750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 16.867750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 16.867750514
MESH:D004833 Epilepsy, Temporal Lobe lamotrigine 13.3516499746
MESH:D004833 Epilepsy, Temporal Lobe topiramate 13.3516499746
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 21.7815276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic etiracetam 21.7819265183
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 21.783659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 21.783659116
MESH:C535500 Epileptic encephalopathy, Lennox-Gastaut type etiracetam 6.3619265183
MESH:D004916 Erythromelalgia Carbamazepine 5.2719549232
MESH:D005076 Exanthema Carbamazepine 5.0120485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.4715345470
MESH:D005234 Fatty Liver pirinixic acid 25.4720131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 25.4719196556
MESH:D005234 Fatty Liver Tetracycline 25.4716917069 19224547
MESH:D005234 Fatty Liver Valproic Acid 25.4719224547 14986274
MESH:D005234 Fatty Liver Zidovudine 25.4718299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.4216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.708888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.5120067830
MESH:D005756 Gastritis Acetaminophen 3.2116983495
MESH:D005923 Glomerulosclerosis, Focal Segmental pioglitazone 4.8816687628
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1310696789
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 10.1120471113 17686920
MESH:D006330 Heart Defects, Congenital polychlorodibenzo-4-dioxin 10.1111294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.1110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 5.9920558911
MESH:D006333 Heart Failure Selenium 5.9917162251
MESH:D006402 Hematologic Diseases Zidovudine 4.2912579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9311000095
MESH:D006505 Hepatitis Drugs, Chinese Herbal 4.3818339527
MESH:D006509 Hepatitis B Lamivudine 4.6917703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.6915631357 16476009 12044531 15274664 15309715
MESH:D006529 Hepatomegaly Phenobarbital 28.0316109766
MESH:D006529 Hepatomegaly pirinixic acid 28.0319176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly propiconazole 28.0317178689 17178688
MESH:D006529 Hepatomegaly systhane 28.0317178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 28.0315340226 16120746 12621046
MESH:D006529 Hepatomegaly triadimefon 28.0317178688 17178689
MESH:D015658 HIV Infections Lamivudine 6.2211141242 9296927 17530837 20032539
MESH:D015658 HIV Infections Zidovudine 6.2217358032 11363243 11698656 20032539 11141242
MESH:D006849 Hydrocephalus Valproic Acid 4.4117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5815340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.7016870215
MESH:D006930 Hyperalgesia rosiglitazone 6.7012083418
MESH:D006943 Hyperglycemia pirinixic acid 2.7920558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.3410459572
MESH:D006965 Hyperplasia Carbamazepine 4.7718773962
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.1817937319
MESH:D007249 Inflammation pioglitazone 7.1416908763
MESH:D007249 Inflammation rosiglitazone 7.1412083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.1412200463 12878042
MESH:D007251 Influenza, Human Selenium 3.7316624496
MESH:D007333 Insulin Resistance pirinixic acid 6.4916306350
MESH:D007333 Insulin Resistance rosiglitazone 6.4916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.9716580747
MESH:D007569 Jaw Abnormalities triadimefon 8.9715992940 15834900
MESH:D007674 Kidney Diseases Acetaminophen 1.9415629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 3.4816518626
MESH:D007680 Kidney Neoplasms Zidovudine 3.4212579204
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.6816085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.7215802533
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.0120370541
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 4.7816972261
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0716294345 17596541
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 6.2117163593
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2121047994
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 6.0418567088 18371158 12632512 15763062 15744066 15339415 16610055 17629604 15754396 18606216 15383259 17881167 17036385 15818738 18237412 15849816 15864749 15641146 17348192 17666798
MESH:D008106 Liver Cirrhosis, Experimental pioglitazone 6.0416484506 15052691
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.0415474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 6.0415980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.0412878042
MESH:D008107 Liver Diseases Acetaminophen 14.0816610002 19014921 16611625 19460945 11587558 12969438 12587719 19784758
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 14.0817207593
MESH:D008107 Liver Diseases Lindane 14.081715830
MESH:D008107 Liver Diseases Phenobarbital 14.0819363144
MESH:D008107 Liver Diseases propiconazole 14.0819363144
MESH:D008107 Liver Diseases triadimefon 14.0819363144
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8417185352 16871587
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 15.5118339527
MESH:D008113 Liver Neoplasms Phenobarbital 15.5121047994 19812893 8742319 19073162 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 15.5120007298 16377806 15890375
MESH:D008113 Liver Neoplasms propiconazole 15.5119028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.5116984957
MESH:D008113 Liver Neoplasms triadimefon 15.5119028983
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.601399818 18308698 17172636 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 19.601423854
MESH:D008114 Liver Neoplasms, Experimental propiconazole 19.6017178689
MESH:D008114 Liver Neoplasms, Experimental systhane 19.6017178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.6012151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 19.6017178689
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8017228818
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 4.4718339527
MESH:D008175 Lung Neoplasms Polycyclic Hydrocarbons, Aromatic 4.4710814675
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.4719555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 4.4718800350
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.4316628512
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 8.5014758024
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 8.5016827153
MESH:D008325 Mammary Neoplasms, Experimental Selenium 8.5015318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1219513568
MESH:D008607 Mental Retardation Carbamazepine 3.569014606
MESH:D008654 Mesothelioma Selenium 2.6015107826
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.0017261469
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.3717358032
MESH:D008881 Migraine Disorders topiramate 6.9618765137 18759728 18803445 16942474
MESH:D008881 Migraine Disorders Valproic Acid 6.9618765137 18803445
MESH:D019964 Mood Disorders etiracetam 5.8919265183
MESH:D009135 Muscular Diseases Glucocorticoids 9.4415946989
MESH:D009135 Muscular Diseases pirinixic acid 9.4416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.628888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.8917596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0217484760
MESH:D020190 Myoclonic Epilepsy, Juvenile etiracetam 5.5419265183
MESH:D009224 Myotonia Congenita Carbamazepine 5.0120399394
MESH:D009369 Neoplasms Lindane 4.4816818664 12807735
MESH:D009369 Neoplasms pirinixic acid 4.4817405874
MESH:D009395 Nephritis, Interstitial Tetracycline 4.329884423
MESH:D009421 Nervous System Malformations Carbamazepine 8.5016990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5014600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.8316359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5018514411
MESH:D009669 Nose Neoplasms Hydrocarbons, Chlorinated 5.2012024805
MESH:D009765 Obesity pirinixic acid 1.6920558911
MESH:D010018 Osteomalacia Carbamazepine 10.5817016548
MESH:D010018 Osteomalacia Phenobarbital 10.5817016548
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 4.5716548355
MESH:D010146 Pain Acetaminophen 5.8016870215
MESH:D010146 Pain Carbamazepine 5.8015215642
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.3216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 10.0411578682
MESH:D016584 Panic Disorder etiracetam 10.0419265183
MESH:D010267 Parapsoriasis Carbamazepine 5.2616538176
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.2216702228
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.4717145499 17679678
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7812520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.9711026799
MESH:D010954 Plasmacytoma Selenium 4.4215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1318163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.242563599
MESH:D011248 Pregnancy Complications Carbamazepine 4.719014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 13.749014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.7411222880 11399792 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 13.7420603192
MESH:D017096 Prion Diseases Tetracycline 4.9610903871
MESH:D011471 Prostatic Neoplasms marker/mechanism 17823934
MESH:D011471 Prostatic Neoplasms AGN 194204 3.1316000583
MESH:D011471 Prostatic Neoplasms Lindane 3.1314688026 12661182
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 3.1315721890
MESH:D011507 Proteinuria pioglitazone 4.7116687628
MESH:D011537 Pruritus Ethinyl Estradiol 2.8616919318 15861022
MESH:D019310 Pseudolymphoma Carbamazepine 18.4912752131 9591791
MESH:D019310 Pseudolymphoma Phenobarbital 18.4912752131
MESH:D019310 Pseudolymphoma Valproic Acid 18.4912752131 11422049
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 5.8816987627
MESH:D011658 Pulmonary Fibrosis troglitazone 5.8818162602
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.5015043669
MESH:D015427 Reperfusion Injury pirinixic acid 2.1519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4118990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.089296927
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.7619155313
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 4.8115015336
MESH:D012559 Schizophrenia Valproic Acid 2.0015737665 19110320
MESH:D012640 Seizures Carbamazepine 23.369046859 16180713 16876388 15946322 9844417 16938433 19414003
MESH:D012640 Seizures etiracetam 23.3611738929 15946322
MESH:D012640 Seizures lamotrigine 23.369844417 16499746
MESH:D012640 Seizures Lindane 23.367539098 15475178 12842176
MESH:D012640 Seizures Phenobarbital 23.363137016 16876388 11442880 4039156
MESH:D012640 Seizures topiramate 23.3616499746
MESH:D012640 Seizures Valproic Acid 23.363137016 11738929 11044598 15475178 1511512 17978042 14763951 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.376407741
OMIM:608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO lamotrigine 6.1520485159 19668019
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.8216192470
MESH:D012893 Sleep Disorders Carbamazepine 4.6719414003
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4816709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.0812833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 10.4416538176 20485159 19694795 16415921 19915237 18855540 15057820
MESH:D013262 Stevens-Johnson Syndrome lamotrigine 10.4420235791
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 3.5018339527
MESH:D013274 Stomach Neoplasms troglitazone 3.5015930296
MESH:D013274 Stomach Neoplasms Zidovudine 3.5017696246
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 5.3017634840
MESH:D013733 Testicular Diseases pyrazole 4.366499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4412697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.441399818
MESH:D013964 Thyroid Neoplasms triadimefon 6.4417178689
MESH:D005879 Tourette Syndrome etiracetam 6.0019265183
MESH:D014178 Translocation, Genetic Valproic Acid 4.7717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.073119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.208888407
MESH:D014581 Urticaria Acetaminophen 2.5610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8714692618
MESH:D014625 Vaginal Neoplasms Zidovudine 4.3212579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1314671159 15869587
MESH:D014839 Vomiting etiracetam 5.7517157078
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7815886252
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 4.1716313111
Pathway ID Pathway Name
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
DB01108 antagonist Trilostane Antiadrenal;Anticorticosteroids
Drugbank ID Action Drug Name Description
DB00603 inhibitor Lunelle Contraceptives;Contraceptives, Oral, Synthetic;Progestins
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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