AutismKB 2.0

Annotation Detail for HSD11B2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HSD11B2 ( AME,AME1,HSD11K,HSD2,SDR9C3 )
Gene Full Name: hydroxysteroid (11-beta) dehydrogenase 2
Band: 16q22.1
Quick LinksEntrez ID:3291; OMIM: 218030; Uniprot ID:DHI2_HUMAN; ENSEMBL ID: ENSG00000176387; HGNC ID: 5209
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00140Steroid hormone biosynthesis
hsa04960Aldosterone-regulated sodium reabsorption
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1731Growth retardation
1738Cushing syndrome
1766Renal Cell cancer
1781Rheumatoid arthritis
1822Infectious lung disease
1832Congenital abnormality
1856Obesity
1859Ovarian cancer
1904Diabetes mellitus
1944Breast cancer
1962Respiratory distress syndrome
2091Hypertension
2053Colon cancer
2116Adrenal gland tumor
2169Pituitary tumor
2245Fetal disease
Desease Name
CARDIOVASCULAR
diabetes, type 1
nephropathy, diabetic
hypertension
IMMUNE
No data
Desease Name
Apparent mineralocorticoid excess, hypertension due to
Hypertension, mild low-renin
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C036837 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 proteinaffects cotreatment|decreases expression 18032417
C036837 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 proteinincreases activity 18032417
C036837 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]decreases reaction|increases activity 18032417
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HSD11B2 mRNAaffects expression 21346803
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone [Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNAaffects cotreatment|increases expression 20146248
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone Grape Seed Proanthocyanidins inhibits the reaction [[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNA]affects cotreatment|decreases reaction|increases expression 20146248
D000082 Acetaminophen Acetaminophen affects the expression of HSD11B2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HSD11B2 mRNAaffects expression 16483693
D001280 Atrazine Atrazine results in increased expression of HSD11B2 mRNAincreases expression 18461179
D001280 Atrazine NR5A1 protein promotes the reaction [Atrazine results in increased expression of HSD11B2 mRNA]increases expression|increases reaction 18461179
D001280 Atrazine SGK1 protein affects the reaction [Atrazine results in increased expression of HSD11B2 mRNA]affects reaction|increases expression 18461179
C006680 baicalein 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [baicalein results in increased activity of HSD11B2 protein]decreases reaction|increases activity 18032417
C006680 baicalein baicalein results in increased activity of HSD11B2 proteinincreases activity 18032417
D001564 Benzo(a)pyrene [Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNAaffects cotreatment|increases expression 20146248
D001564 Benzo(a)pyrene Grape Seed Proanthocyanidins inhibits the reaction [[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNA]affects cotreatment|decreases reaction|increases expression 20146248
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Progesterone results in increased expression of HSD11B2 mRNA]decreases reaction|increases expression 15857753
C006780 bisphenol A bisphenol A results in increased expression of HSD11B2 mRNAincreases expression 12075121
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of HSD11B2 mRNAincreases expression 17961207
D002229 Carbenoxolone Carbenoxolone results in decreased activity of HSD11B2 proteindecreases activity 16857225
D002229 Carbenoxolone Carbenoxolone results in decreased activity of HSD11B2 proteindecreases activity 15743993
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of HSD11B2 proteindecreases expression 16192424
D002395 Catecholamines Catecholamines results in increased expression of HSD11B2 mRNAincreases expression 15855228
D003348 Cortisone HSD11B2 protein affects the metabolism of Cortisoneaffects metabolic processing 15743993
D003348 Cortisone HSD11B2 protein results in increased chemical synthesis of Cortisoneincreases chemical synthesis 17515840
C014347 decitabine decitabine results in increased expression of HSD11B2 mRNAincreases expression 15489962
C014347 decitabine decitabine results in increased expression of HSD11B2 mRNAincreases expression 15489962
D003907 Dexamethasone Dexamethasone results in increased expression of HSD11B2 mRNAincreases expression 15679045
D003907 Dexamethasone Dexamethasone results in increased expression of HSD11B2 proteinincreases expression 15679045
D003907 Dexamethasone HSD11B2 protein results in increased oxidation of Dexamethasoneincreases oxidation 16857225
D003907 Dexamethasone Thiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Dexamethasone]decreases reaction|increases oxidation 16857225
D003907 Dexamethasone HSD11B2 protein results in increased oxidation of Dexamethasoneincreases oxidation 16857225
D004041 Dietary Fats Dietary Fats results in decreased expression of HSD11B2 mRNAdecreases expression 18042831
D004229 Dithiothreitol Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]decreases activity|decreases reaction 12901862
D004958 Estradiol Estradiol results in decreased expression of HSD11B2 proteindecreases expression 17515840
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HSD11B2 mRNAaffects expression 16872691
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HSD11B2 mRNAincreases expression 15576828
12075121
16140622
15834898
12655037
D005480 Flurbiprofen Flurbiprofen results in increased expression of HSD11B2 mRNAincreases expression 16949054
D019833 Genistein Genistein results in increased expression of HSD11B2 mRNAincreases expression 12075121
D005938 Glucocorticoids HSD11B2 protein affects the metabolism of and results in decreased activity of Glucocorticoidsaffects metabolic processing|decreases activity 15974890
D005938 Glucocorticoids HSD11B2 protein affects the metabolism of Glucocorticoidsaffects metabolic processing 12943734
D005947 Glucose Glucose results in decreased expression of HSD11B2 mRNAdecreases expression 15017115
D006034 Glycyrrhetinic Acid Glycyrrhetinic Acid results in decreased activity of HSD11B2 proteindecreases activity 16061069
D019695 Glycyrrhizic Acid Glycyrrhizic Acid results in decreased expression of HSD11B2 mRNAdecreases expression 10474021
11798659
C511402 Grape Seed Proanthocyanidins Grape Seed Proanthocyanidins inhibits the reaction [[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNA]affects cotreatment|decreases reaction|increases expression 20146248
D007975 Leukotriene B4 [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 proteinaffects cotreatment|decreases expression 18032417
D007975 Leukotriene B4 Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]decreases reaction|increases activity 18032417
D007975 Leukotriene B4 Leukotriene B4 inhibits the reaction [Nordihydroguaiaretic Acid results in increased activity of HSD11B2 protein]decreases reaction|increases activity 18032417
D007975 Leukotriene B4 Leukotriene B4 results in decreased activity of HSD11B2 proteindecreases activity 18032417
10377029
D007975 Leukotriene B4 Leukotriene B4 results in decreased expression of HSD11B2 mRNAdecreases expression 18032417
D007975 Leukotriene B4 [Nordihydroguaiaretic Acid co-treated with Leukotriene B4] results in decreased expression of HSD11B2 proteinaffects cotreatment|decreases expression 18032417
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [baicalein results in increased activity of HSD11B2 protein]decreases reaction|increases activity 18032417
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Nordihydroguaiaretic Acid results in increased activity of HSD11B2 protein]decreases reaction|increases activity 18032417
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Nordihydroguaiaretic Acid results in increased expression of HSD11B2 mRNA]decreases reaction|increases expression 18032417
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid results in decreased activity of HSD11B2 proteindecreases activity 18032417
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid results in decreased expression of HSD11B2 mRNAdecreases expression 18032417
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Mifepristone inhibits the reaction [12-Hydroxy-5,8,10,14-eicosatetraenoic Acid results in decreased activity of HSD11B2 protein]decreases activity|decreases reaction 18032417
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid [Nordihydroguaiaretic Acid co-treated with 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] results in decreased expression of HSD11B2 proteinaffects cotreatment|decreases expression 18032417
D006854 Hydrocortisone Hydrocortisone results in increased expression of HSD11B2 mRNAincreases expression 15961419
15855228
D006854 Hydrocortisone HSD11B2 protein affects the metabolism of Hydrocortisoneaffects metabolic processing 15743993
D006854 Hydrocortisone HSD11B2 protein results in increased oxidation of Hydrocortisoneincreases oxidation 17515840
D007213 Indomethacin Indomethacin results in decreased activity of HSD11B2 proteindecreases activity 10377029
D008797 Metyrapone Metyrapone results in increased expression of HSD11B2 mRNAincreases expression 15265784
D015735 Mifepristone Mifepristone inhibits the reaction [12-Hydroxy-5,8,10,14-eicosatetraenoic Acid results in decreased activity of HSD11B2 protein]decreases activity|decreases reaction 18032417
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]decreases activity|decreases reaction 18032417
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in decreased expression of HSD11B2 mRNA]decreases expression|decreases reaction 18032417
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in decreased expression of HSD11B2 protein]decreases expression|decreases reaction 18032417
D015735 Mifepristone Mifepristone results in increased expression of HSD11B2 mRNAincreases expression 18032417
D015735 Mifepristone Mifepristone results in increased expression of HSD11B2 proteinincreases expression 18032417
D015735 Mifepristone Nordihydroguaiaretic Acid promotes the reaction [Mifepristone results in increased activity of HSD11B2 protein]increases activity|increases reaction 18032417
D009637 Nordihydroguaiaretic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Nordihydroguaiaretic Acid results in increased activity of HSD11B2 protein]decreases reaction|increases activity 18032417
D009637 Nordihydroguaiaretic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Nordihydroguaiaretic Acid results in increased expression of HSD11B2 mRNA]decreases reaction|increases expression 18032417
D009637 Nordihydroguaiaretic Acid Leukotriene B4 inhibits the reaction [Nordihydroguaiaretic Acid results in increased activity of HSD11B2 protein]decreases reaction|increases activity 18032417
D009637 Nordihydroguaiaretic Acid [Nordihydroguaiaretic Acid co-treated with 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] results in decreased expression of HSD11B2 proteinaffects cotreatment|decreases expression 18032417
D009637 Nordihydroguaiaretic Acid [Nordihydroguaiaretic Acid co-treated with Leukotriene B4] results in decreased expression of HSD11B2 proteinaffects cotreatment|decreases expression 18032417
D009637 Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]decreases activity|decreases reaction 18032417
D009637 Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid promotes the reaction [Mifepristone results in increased activity of HSD11B2 protein]increases activity|increases reaction 18032417
D009637 Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid results in increased activity of HSD11B2 proteinincreases activity 10377029
18032417
D009637 Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid results in increased expression of HSD11B2 mRNAincreases expression 18032417
C041786 palm oil palm oil results in decreased expression of HSD11B2 mRNAdecreases expression 18042831
D011342 Procainamide Procainamide results in increased expression of HSD11B2 mRNAincreases expression 15489962
D011342 Procainamide Procainamide results in increased expression of HSD11B2 mRNAincreases expression 15489962
D011374 Progesterone benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Progesterone results in increased expression of HSD11B2 mRNA]decreases reaction|increases expression 15857753
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]decreases activity|decreases reaction 18032417
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in decreased expression of HSD11B2 mRNA]decreases expression|decreases reaction 18032417
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in decreased expression of HSD11B2 protein]decreases expression|decreases reaction 18032417
D011374 Progesterone Nordihydroguaiaretic Acid inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]decreases activity|decreases reaction 18032417
D011374 Progesterone Progesterone results in decreased activity of HSD11B2 proteindecreases activity 18032417
D011374 Progesterone Progesterone results in decreased expression of HSD11B2 mRNAdecreases expression 18032417
18070364
D011374 Progesterone Progesterone results in decreased expression of HSD11B2 proteindecreases expression 18032417
D011374 Progesterone Progesterone results in increased expression of HSD11B2 mRNAincreases expression 15857753
D015232 Dinoprostone Dinoprostone results in decreased activity of HSD11B2 proteindecreases activity 10377029
D015237 Dinoprost Dinoprost results in decreased activity of HSD11B2 proteindecreases activity 10377029
D011794 Quercetin Quercetin results in decreased expression of HSD11B2 proteindecreases expression 18095365
D012643 Selenium [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of HSD11B2 mRNAaffects cotreatment|decreases expression 11444866
C009277 sodium arsenate sodium arsenate results in decreased expression of HSD11B2 mRNAdecreases expression 16882884
C009277 sodium arsenate sodium arsenate results in decreased expression of HSD11B2 mRNAdecreases expression 12727804
C017947 sodium arsenite sodium arsenite results in decreased expression of HSD11B2 mRNAdecreases expression 12727804
D012965 Sodium Chloride Sodium Chloride results in decreased activity of HSD11B2 proteindecreases activity 12943734
D012965 Sodium Chloride Sodium Chloride results in decreased expression of HSD11B2 mRNAdecreases expression 12943734
D014284 Triiodothyronine Triiodothyronine results in increased expression of HSD11B2 mRNAincreases expression 15961419
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HSD11B2 mRNAdecreases expression 16443690
D013893 Thiram Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]decreases activity|decreases reaction 12901862
D013893 Thiram Thiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Dexamethasone]decreases reaction|increases oxidation 16857225
D013893 Thiram Thiram results in decreased activity of HSD11B2 proteindecreases activity 12901862
16857225
D014303 Trinitrotoluene Trinitrotoluene affects the expression of HSD11B2 mRNAaffects expression 21346803
D014810 Vitamin E [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of HSD11B2 mRNAaffects cotreatment|decreases expression 11444866
C063449 zileuton zileuton results in increased activity of HSD11B2 proteinincreases activity 10377029
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.8015322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 6.807525203
MESH:D000138 Acidosis Ammonium Chloride 3.0218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 10.2817505938
MESH:D000152 Acne Vulgaris zileuton 10.2820436887
MESH:D055371 Acute Lung Injury zileuton 4.5017118201
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.7320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 11.7311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.7314692618
MESH:D000230 Adenocarcinoma Genistein 11.7311473722
MESH:D000230 Adenocarcinoma Indomethacin 11.7316537180
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 9.4316176798
MESH:D000236 Adenoma Benzo(a)pyrene 9.436695378
MESH:D000236 Adenoma Indomethacin 9.4311497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.8416835633
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 13.9217942926
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 13.9210680582
MESH:D011125 Adenomatous Polyposis Coli Leukotriene B4 13.9217942926
MESH:D000303 Adrenal Cortex Diseases Catecholamines 6.776895166
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3516712894 17306315
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.7011874814
MESH:D016301 Alveolar Bone Loss Indomethacin 4.8217225004
MESH:D000544 Alzheimer Disease Indomethacin 2.5717627676 15579461
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4811748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7617084956
MESH:D000799 Angioedema Acetaminophen 3.3010982225
MESH:D001014 Aortic Aneurysm Dinoprostone 10.5110231640
MESH:D001014 Aortic Aneurysm Indomethacin 10.5110231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 17.0919183758
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 17.0910388637
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 17.0910388637
MESH:D001161 Arteriosclerosis Dietary Fats 8.1715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.1711256880
MESH:D018771 Arthralgia Indomethacin 4.622160914
MESH:D001168 Arthritis Leukotriene B4 5.6311006272
MESH:D001169 Arthritis, Experimental Dexamethasone 6.2117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.2115885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.6811248219
MESH:D001249 Asthma Leukotriene B4 5.3511006272 19667530
MESH:D001249 Asthma zileuton 5.358598621 19214143 10764316 17944539 20332717 10181070 9620945
MESH:D001250 Asthma, Exercise-Induced Leukotriene B4 10.4619667531
MESH:D001250 Asthma, Exercise-Induced zileuton 10.4610984370
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4415336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4918445737
MESH:D001327 Autoimmune Diseases Quercetin 3.8819761891
MESH:D001477 Bartter Syndrome Dinoprostone 10.9515976003
MESH:D001477 Bartter Syndrome Indomethacin 10.9510684365
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.5712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4015746008
MESH:D001862 Bone Resorption bisphenol A 3.3811985600
MESH:D001929 Brain Edema Indomethacin 11.0511481608
MESH:D001929 Brain Edema zileuton 11.0519309543
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7917868700
MESH:D001930 Brain Injuries Progesterone 3.7315665606 15380490 15845082
MESH:D002545 Brain Ischemia Indomethacin 3.8812524144
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.0520146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 10.0520146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 10.0517123778
MESH:D001943 Breast Neoplasms decitabine 10.0518320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 10.0520435547
MESH:D001943 Breast Neoplasms Estradiol 10.0517289903 17018787 12948864 18497071 19861407 16675129 14630087 17261762
MESH:D001943 Breast Neoplasms Genistein 10.0516873071 17200150 16541309
MESH:D001943 Breast Neoplasms Grape Seed Proanthocyanidins 10.0520146248
MESH:D001943 Breast Neoplasms Indomethacin 10.0517401462
MESH:D001943 Breast Neoplasms Nordihydroguaiaretic Acid 10.0518418215
MESH:D001943 Breast Neoplasms Progesterone 10.0516175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 10.0518628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.0520435547
MESH:D016535 Bronchial Hyperreactivity Leukotriene B4 8.1212794006 12654629
MESH:D016535 Bronchial Hyperreactivity zileuton 8.1212654629 12388339 12794006
MESH:D002056 Burns Indomethacin 4.1810459503
MESH:D002100 Cachexia Indomethacin 4.4711239499 16537180 15141370 15625704
MESH:D002105 Cadmium Poisoning Quercetin 5.0016962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.1916192424 15721981 3786805 15700767 16050911 10355542 16097048 15673190 18705752 16227642 16124888 16011737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.1916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3716835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 14.9016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.903084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.9018788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.9016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 14.9016924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 14.9016391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 14.9012508355 19519916
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 14.9017306315 15276417 16507464
MESH:D002278 Carcinoma in Situ bisphenol A 4.4517123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.1911053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8118791128 14736730 11352223
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4317234771
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1017341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.2520419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 9.2519215824
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 9.2512636206 15482327
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.2518572023
MESH:D006332 Cardiomegaly Quercetin 5.7419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.7418670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 2.9316332659
MESH:D002386 Cataract Acetaminophen 6.3910977129
MESH:D002386 Cataract Trinitrotoluene 6.3915817613 14694615
MESH:D002471 Cell Transformation, Neoplastic Dinoprost 13.0716192471
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 13.0716192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.0718566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 13.0720056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D002764 Cholecystitis Indomethacin 4.6211181007
MESH:D002779 Cholestasis Ethinyl Estradiol 2.4716919318 11677210 17681005 15861022 16105132 17333356 17110522
MESH:D002972 Cleft Palate Hydrocortisone 5.4715826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4715668235 8697196 12621046 15340226 16354765
MESH:D003092 Colitis Selenium 3.2617936198
MESH:D003110 Colonic Neoplasms decitabine 15.2517616700
MESH:D003110 Colonic Neoplasms Dexamethasone 15.2515824018
MESH:D003110 Colonic Neoplasms Genistein 15.2517182828
MESH:D003110 Colonic Neoplasms Indomethacin 15.2515936596 11260862 15637740 15963497 15786552 15625704
MESH:D003110 Colonic Neoplasms Nordihydroguaiaretic Acid 15.2515936596
MESH:D003110 Colonic Neoplasms Quercetin 15.2517148506 15741050 19056647 11134977 19440933 17191121 16640504
MESH:D003110 Colonic Neoplasms zileuton 15.2518927292
MESH:D015179 Colorectal Neoplasms decitabine 3.2118981723
MESH:D015179 Colorectal Neoplasms Indomethacin 3.2117054584 12606626 18059344 11197048
MESH:D015179 Colorectal Neoplasms Quercetin 3.2118852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.7614669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 7.7615095906
MESH:D018352 Coronavirus Infections Indomethacin 5.1717302372
OMIM:218030 CORTISOL 11-BETA-KETOREDUCTASE DEFICIENCY marker/mechanism
MESH:D019465 Craniofacial Abnormalities Dexamethasone 8.4417728286
MESH:D019465 Craniofacial Abnormalities Glucocorticoids 8.4418281261
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 8.4417728286
MESH:D019465 Craniofacial Abnormalities sodium arsenate 8.4410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.4410048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 8.4419769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.4818551238
MESH:D003490 Cyanosis Trinitrotoluene 9.4818551238
MESH:D003665 Decompression Sickness zileuton 5.6818309904
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9112438553
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.3019496084
MESH:D003922 Diabetes Mellitus, Type 1 marker/mechanism 16616286
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 3.7916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.7917107852
MESH:D003928 Diabetic Nephropathies Estradiol 2.9619279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9717187935
MESH:D003967 Diarrhea Dexamethasone 14.907237001
MESH:D003967 Diarrhea Dinoprostone 14.9010446763 7237001 11488427
MESH:D003967 Diarrhea Hydrocortisone 14.907237001
MESH:D003967 Diarrhea Indomethacin 14.907907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.8018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.8016485898 19416960 15619225 12958197 17562736 17522070 19370779 10663392 19923254 18071297 2444490 16109766 14550746 12705907 18713872 11834606 16393943 11287661 12594235 19085960 11739529 11421492 11743745 10915739 19164858 16177239 12540782 14725611 12153990 11461765 11529661 16081117 10774834 16781746 12392966 14986274 19420014 17906064 19739265 15968718 16227642
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 18.8015027814 15968718 19336974 16227642 6623471 2869522 6884620 19085960 7179309 17522070 10092053 4309450 7120509 10915739 3786805 9327722 11566570 21278145 15998439 16177239 3732212 7440962
MESH:D056486 Drug-Induced Liver Injury Selenium 18.8015131321
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 18.8018186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.8020420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 18.8021346803 18551238
MESH:D056486 Drug-Induced Liver Injury zileuton 18.8017944539
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 11.5119426721
MESH:D056487 Drug-Induced Liver Injury, Chronic Glycyrrhizic Acid 11.5119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3611462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6118446180 17190690 18043480 16326151 12774134 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.6311535926 11595431 17329845 17151854 17045617 17202747 11991626 16699067 17351913 11595415 10671773
MESH:D050171 Dyslipidemias Dietary Fats 3.0618367378
MESH:C538011 Eales disease Vitamin E 4.169068938
MESH:D004485 Eczema Dexamethasone 3.9512438553
MESH:D004487 Edema 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone 16.687812673
MESH:D004487 Edema Dexamethasone 16.6819703484
MESH:D004487 Edema Indomethacin 16.688985016 16100529 19703484 7907874 7990266 10653021 8273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.6811000095 12711302
MESH:D004487 Edema zileuton 16.6819703484 9831321 7990266 11698051 17118201 7812673 8273558
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.3512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.3517692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5719294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.0516402032
MESH:D016889 Endometrial Neoplasms Estradiol 6.2911473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 6.2911473722
MESH:D004715 Endometriosis Indomethacin 18.0215652904
MESH:D004715 Endometriosis Mifepristone 18.0216134523
MESH:D004715 Endometriosis Progesterone 18.0216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 18.029294722 10568697
MESH:D019446 Endotoxemia Indomethacin 9.2218509659
MESH:D019446 Endotoxemia zileuton 9.2215328337
MESH:D004751 Enteritis Indomethacin 4.2016328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4617980183
MESH:D004802 Eosinophilia Indomethacin 7.7611298111
MESH:D004802 Eosinophilia zileuton 7.7610764316 8621850
MESH:D004892 Erythema Multiforme Thiram 6.1016750123
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.0616530937
MESH:D004938 Esophageal Neoplasms Indomethacin 4.0611005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 10.3419224547 12631006 16239168 15959796 61145 12795759 16045604 17595544
MESH:D005234 Fatty Liver Dietary Fats 10.3419551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 10.3415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9311858732
MESH:D005334 Fever Dinoprost 12.9311852909
MESH:D005334 Fever Dinoprostone 12.9311852909 16997862
MESH:D005334 Fever Indomethacin 12.9310431976 11852909 17627676
MESH:D005354 Fibrosarcoma Indomethacin 4.3610962813
MESH:D005355 Fibrosis baicalein 27.7519474275
MESH:D005355 Fibrosis Carbon Tetrachloride 27.7518705752
MESH:D005355 Fibrosis Dietary Fats 27.7518296743
MESH:D005355 Fibrosis Indomethacin 27.7517994277
MESH:D005355 Fibrosis Quercetin 27.7519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 27.7520067830
MESH:D005499 Folliculitis Indomethacin 4.6211298111
MESH:D005596 Fractures, Closed zileuton 5.3119544365
MESH:D005756 Gastritis Acetaminophen 9.3316983495
MESH:D005756 Gastritis Indomethacin 9.3315046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1416452187
MESH:D005909 Glioblastoma baicalein 14.0719804834
MESH:D005909 Glioblastoma Genistein 14.0716598420
MESH:D005909 Glioblastoma Indomethacin 14.0712870263
MESH:D005909 Glioblastoma Quercetin 14.0719804834
MESH:D005910 Glioma Indomethacin 5.5118371953 16487511
MESH:D005910 Glioma Quercetin 5.5117643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8511849393
MESH:D018149 Glucose Intolerance sodium arsenate 4.5819446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006073 Gout Indomethacin 4.8111248219
MESH:D006258 Head and Neck Neoplasms decitabine 6.7819215824
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.7815482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.3220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.3211294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 9.3216080930
MESH:D006331 Heart Diseases Grape Seed Proanthocyanidins 4.6412587719
MESH:D006333 Heart Failure Selenium 2.7317162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8511000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.0915633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.0919900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1715135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.7215340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 11.7215817613
MESH:D006529 Hepatomegaly zileuton 11.728661344
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.257520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.2516863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.4815709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.7112676792
MESH:D019584 Hot Flashes Estradiol 8.2317088409
MESH:D019584 Hot Flashes Vitamin E 8.2314716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5016959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 10.7816870215
MESH:D006930 Hyperalgesia Dinoprostone 10.7816793879
MESH:D006930 Hyperalgesia Indomethacin 10.7812727271
MESH:D034321 Hyperamylasemia Indomethacin 5.1717883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.1121332399
MESH:D006940 Hyperemia Indomethacin 4.4712524144
MESH:D006943 Hyperglycemia Quercetin 3.5711834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 7.7021332399
MESH:D006949 Hyperlipidemias Indomethacin 7.7017546600
MESH:D006973 Hypertension Dexamethasone 10.5317042910
MESH:D006973 Hypertension Quercetin 10.5318356687
MESH:D006973 Hypertension Sodium Chloride 10.5311507004
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.5318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5615338365
MESH:D006976 Hypertension, Pulmonary zileuton 4.2714726295
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2816569931 16945680
MESH:D007077 Ileal Diseases Indomethacin 4.4818306037 10574470
MESH:D007079 Ileitis Indomethacin 4.8110651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.8216133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.1015869954
MESH:D020244 Infarction, Middle Cerebral Artery zileuton 10.1019309543
MESH:D007246 Infertility Thiram 5.326420938
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9712013081
MESH:D007248 Infertility, Male Atrazine 17.1912948887
MESH:D007248 Infertility, Male decitabine 17.1917581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 17.1917937319
MESH:D007248 Infertility, Male sodium arsenite 17.1912646999 15346721
MESH:D007248 Infertility, Male Trinitrotoluene 17.1912150543
MESH:D007249 Inflammation Dexamethasone 19.5811099482 8960868
MESH:D007249 Inflammation Dietary Fats 19.5820412841
MESH:D007249 Inflammation Flurbiprofen 19.5811099482
MESH:D007249 Inflammation Indomethacin 19.5812568917 7812673 3291741
MESH:D007249 Inflammation Progesterone 19.5815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.5812878042 12200463
MESH:D007249 Inflammation zileuton 19.587812673 9831321 8621850 18309904 17118201 18295198 18059327 8960868
MESH:D015212 Inflammatory Bowel Diseases Leukotriene B4 6.5511006272
MESH:D015212 Inflammatory Bowel Diseases zileuton 6.5515339030
MESH:D007251 Influenza, Human Nordihydroguaiaretic Acid 22.2018473937
MESH:D007251 Influenza, Human Quercetin 22.2016624496
MESH:D007251 Influenza, Human Selenium 22.2016624496
MESH:D007251 Influenza, Human Vitamin E 22.2016624496
MESH:D007333 Insulin Resistance bisphenol A 10.2616393666
MESH:D007333 Insulin Resistance Dietary Fats 10.2611836018 18457598
MESH:D007333 Insulin Resistance Estradiol 10.2616627594 16393666
MESH:D007410 Intestinal Diseases Indomethacin 3.8011855677 11713966 17994277 15831440 18236018 17329856 15610444 10210152 11686837
MESH:D019586 Intracranial Hypertension Indomethacin 4.8215241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8516580747
MESH:D007579 Jejunal Diseases Indomethacin 4.4810574470 18306037 16133968
MESH:D007627 Keloid Quercetin 4.4317086741
MESH:D007674 Kidney Diseases Acetaminophen 28.1612587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 28.1616962696
MESH:D007674 Kidney Diseases Estradiol 28.1615618244
MESH:D007674 Kidney Diseases Grape Seed Proanthocyanidins 28.1612587719
MESH:D007674 Kidney Diseases Indomethacin 28.1617190690
MESH:D007674 Kidney Diseases Quercetin 28.1616962696
MESH:D007674 Kidney Diseases sodium arsenite 28.1620008137
MESH:D007674 Kidney Diseases Vitamin E 28.1612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.4016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 5.9116705839
MESH:D007680 Kidney Neoplasms Estradiol 5.9115610895
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 7.5811703811 12228301 10320625
MESH:D016773 Leishmaniasis, Cutaneous Sodium Chloride 7.589499605
MESH:D007938 Leukemia decitabine 8.8819235587 18980019
MESH:D007938 Leukemia Genistein 8.8818980019 17468513
MESH:D007938 Leukemia Quercetin 8.8817468513
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.7016572323 10785260 15631656
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive zileuton 7.7019503090 19823023
MESH:D007951 Leukemia, Myeloid decitabine 3.5219117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.7618206229 17679729 18704418 19010910 19387464 18460780
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.7618360721
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.9118055864
MESH:D007964 Leukocytosis Indomethacin 4.8216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1717980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1711479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.5721278145 16943688 17334410 11408273 17174718 17157831 16221502 16239168 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 5.5718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 13.8914512876 17714472 14620537 12898905 12649538 12632514 17698563 17805973 18006644 17922224 17869086 18412020 12389079 18251166 15370692 15338365 12445418 16638106 15925388 16248980 18472094 18277467 16136751 18210741 18054572 17708605 17481882 18395914 18339082 15818738 18263696 14716496 15052691 15931870 18420326 15730626 17766677 18472332 15876570 18376398 18418968 12546737 12741479 12666154 16116963 17823541 17944888 15673190 10355542 14748882 16027843 16015684 18279442 17557913 15959796 17761835 15650968 16011737 15996030 17976157 14724832 17525996 20821823 16192424 15362042 12958196 17565644 18187930 12609069 18481824 15893842 16097048 18705752 18429990 18156304 12632512 18166357 17640975 15057751 18395095 15123356 12667390 14716833 18317297 11481614 12586293 17900296 12445421 13678700 18205269 17721639 16033810 17631135
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 13.8916718785
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 13.8915816358
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 13.8914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 13.8917823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 13.8918194892
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 13.8912741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 13.8912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 13.8916169303
MESH:D008107 Liver Diseases Acetaminophen 8.0919784758 16611625 19014921 11587558 12969438 12587719 19460945 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.0916964402 15830285 15720792 17285989 16246199
MESH:D008107 Liver Diseases Dinoprostone 8.0915816358
MESH:D008107 Liver Diseases Grape Seed Proanthocyanidins 8.0912587719
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.8516899240 14706259
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 18.2815890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.2821137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.2819294768
MESH:D008113 Liver Neoplasms Glycyrrhizic Acid 18.2819426721
MESH:D008113 Liver Neoplasms Quercetin 18.2818980244
MESH:D008113 Liver Neoplasms sodium arsenite 18.2815276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.2816984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 7.8212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 7.8219519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 7.8212151625
MESH:D008171 Lung Diseases Grape Seed Proanthocyanidins 10.4112587719
MESH:D008171 Lung Diseases sodium arsenite 10.4119095001
MESH:D008171 Lung Diseases Vitamin E 10.4116863852
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 11.4118813816 14755239 16061637 18508827 17139156 19931552 15172992 15893417 16401635 9255578 12438228
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.4120464547 20135361 18816296 17053015 18569708 20064080 18520028 20869020 6695378
MESH:D008175 Lung Neoplasms Dexamethasone 11.4111195469 15824018
MESH:D008175 Lung Neoplasms Indomethacin 11.4111053908 11497255 16537180
MESH:D008175 Lung Neoplasms Quercetin 11.4116280456
MESH:D008175 Lung Neoplasms sodium arsenite 11.4115276417 17077188 17306315 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.4119555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 11.4111062179
MESH:D008223 Lymphoma decitabine 3.0319470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.3211807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 11.3214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 11.3217203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 11.3215318939
MESH:D020149 Manganese Poisoning Estradiol 3.9319453300
MESH:D008545 Melanoma decitabine 4.5916505122 17785578
MESH:D008545 Melanoma Glucose 4.5914993021
MESH:D008545 Melanoma sodium arsenite 4.5916487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0419513568
MESH:D008654 Mesothelioma Atrazine 5.651916698
MESH:D008654 Mesothelioma Selenium 5.6515107826
MESH:D008881 Migraine Disorders Indomethacin 3.2911903285
MESH:D020326 Migraine without Aura Dinoprostone 4.7511304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.2716381670
MESH:D009062 Mouth Neoplasms Indomethacin 7.2712636206
MESH:D009101 Multiple Myeloma decitabine 6.2218172295
MESH:D009101 Multiple Myeloma Dexamethasone 6.2215867202 15744524 16118317
MESH:D009135 Muscular Diseases Glucocorticoids 5.3815946989
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.3718186108
MESH:D009190 Myelodysplastic Syndromes decitabine 6.5519157545 16882708 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.559809623
MESH:D009203 Myocardial Infarction Genistein 5.1517141266
MESH:D009203 Myocardial Infarction Quercetin 5.1519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.8716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 11.8717141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 11.8719207477
MESH:D009298 Nasal Polyps zileuton 5.6810665187
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.9018551238
MESH:D009336 Necrosis Trinitrotoluene 8.9018551238
MESH:D009362 Neoplasm Metastasis Indomethacin 2.9316537180 11239499 11053908
MESH:D009369 Neoplasms Benzo(a)pyrene 9.4911141357
MESH:D009369 Neoplasms decitabine 9.4919470736 19116145 17925555
MESH:D009369 Neoplasms Quercetin 9.4915185748
MESH:D009369 Neoplasms sodium arsenite 9.4911559025
MESH:D009374 Neoplasms, Experimental Indomethacin 7.5415625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.5420056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2017289903
MESH:D009421 Nervous System Malformations bisphenol A 19.2611399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 19.2616427766 11399458
MESH:D009421 Nervous System Malformations Genistein 19.2616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 19.2614600291
MESH:D009436 Neural Tube Defects sodium arsenate 6.4310525206 19446573 11749123 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 6.4312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.9418514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 6.9412349958
MESH:D020078 Neurogenic Inflammation Quercetin 3.8717929310
MESH:D009503 Neutropenia Leukotriene B4 4.848305713
MESH:D009765 Obesity Dietary Fats 2.1417217161 21332399 19632207 18457598 20518802 18674790 11836018 16723640 20132043
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.626374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.6712819281 16049721
MESH:D009784 Occupational Diseases Trinitrotoluene 7.6714694615 17852074 12819281
MESH:D010003 Osteoarthritis Indomethacin 3.337009135
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 5.9318500342
MESH:D010009 Osteochondrodysplasias Thiram 5.1115899490 17954590 15518828
MESH:D010024 Osteoporosis Genistein 2.9119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 8.4916169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.4919495926
MESH:D010049 Ovarian Diseases bisphenol A 4.4511985600
MESH:D010051 Ovarian Neoplasms decitabine 19.8319331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 19.8319401270
MESH:D010051 Ovarian Neoplasms Genistein 19.8319005980
MESH:D010051 Ovarian Neoplasms Mifepristone 19.8316525653
MESH:D010051 Ovarian Neoplasms Progesterone 19.8316525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 19.8319005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 19.8315276417 17306315
MESH:D010146 Pain Acetaminophen 8.9416870215
MESH:D010146 Pain Indomethacin 8.943291741 17627676 17440234 13679232
MESH:D010146 Pain zileuton 8.9415935457
MESH:D010149 Pain, Postoperative Indomethacin 4.1312538197 18702446
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 7.5212384795
MESH:D010190 Pancreatic Neoplasms decitabine 7.5219294695
MESH:D010190 Pancreatic Neoplasms Quercetin 7.5216965848
MESH:D010195 Pancreatitis Indomethacin 3.4315028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1911578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1716537180
MESH:D010300 Parkinson Disease Atrazine 3.0617218051
MESH:D020734 Parkinsonian Disorders Indomethacin 3.6512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1711903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7012520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6111148446
MESH:D010518 Periodontitis Indomethacin 4.3717225004
MESH:D010538 Peritonitis zileuton 4.7317371808
MESH:D010954 Plasmacytoma Selenium 4.3415087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0518163543
MESH:D011230 Precancerous Conditions Quercetin 3.5319056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2221297632
MESH:D047928 Premature Birth Indomethacin 4.6017000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 7.7310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.7311222880 11118676 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.2017616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.9520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.9520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2216740699
MESH:D011471 Prostatic Neoplasms Estradiol 3.2216740699
MESH:D011471 Prostatic Neoplasms Flurbiprofen 3.2217409433
MESH:D011471 Prostatic Neoplasms Genistein 3.2215378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Nordihydroguaiaretic Acid 3.2218491370
MESH:D011471 Prostatic Neoplasms Quercetin 3.2214715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2216039940
MESH:D011471 Prostatic Neoplasms Thiram 3.2219789329
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2215084515
MESH:D011507 Proteinuria Indomethacin 3.6711849393
MESH:D011537 Pruritus Ethinyl Estradiol 8.1315861022 16919318
MESH:D011537 Pruritus zileuton 8.1319657356 17827870
MESH:D011565 Psoriasis Leukotriene B4 4.1211006272
MESH:D011629 Puberty, Precocious bisphenol A 4.2510548101
MESH:D011654 Pulmonary Edema zileuton 4.8818309904
MESH:D015427 Reperfusion Injury zileuton 3.989865762 15266012
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.5311700416 18379247
MESH:D012135 Respiratory Sounds Atrazine 4.0011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012208 Rhabdomyosarcoma decitabine 3.9119155313
MESH:D012220 Rhinitis zileuton 4.3820332717
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6418045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.0016862918
MESH:D012640 Seizures 2,4-dinitrotoluene 4.9618551238
MESH:D012640 Seizures Trinitrotoluene 4.9618551238
MESH:D012852 Sinusitis zileuton 4.9810665187
MESH:D012871 Skin Diseases Vitamin E 2.2818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.2919755658 10029692
MESH:D012878 Skin Neoplasms Glucose 11.2914993021
MESH:D012878 Skin Neoplasms sodium arsenite 11.2919524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.2916192470
MESH:D020181 Sleep Apnea, Obstructive zileuton 5.3219118273
MESH:D013088 Spermatocele Ethinyl Estradiol 3.3916709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.6316503802 15862959
MESH:D013119 Spinal Cord Injuries zileuton 9.6318059327
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3812854658
MESH:D013158 Splenic Diseases Grape Seed Proanthocyanidins 5.9512587719
MESH:D013163 Splenomegaly Trinitrotoluene 4.6815817613
MESH:D013272 Stomach Diseases Dexamethasone 8.5915472012
MESH:D013272 Stomach Diseases Indomethacin 8.5918209964 10215738 16184426 15038085 16280098 15472012 16113693 10486359 10192188 17160473 17638125 17207306 18545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.2520155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 4.2519037991
MESH:D013274 Stomach Neoplasms Indomethacin 4.2515609394
MESH:D013274 Stomach Neoplasms Sodium Chloride 4.2516646055
MESH:D013276 Stomach Ulcer Dexamethasone 6.0015138204
MESH:D013276 Stomach Ulcer Indomethacin 6.0018543354 18726076 10878458 16934674 16397915 11595415 17918041 14567935 16631530 18181030 10423059 12498302 17895592 11523592 16150113 18237397 11906479 16252198 1323529 18299717 12077510 18087811 15138204 11145282 15104355 12467913 17135157 11595431 17977527 16169175 17627676 12500499 10750652 15255614 18431645 18193104 16755016 17657623 12787963 18209962 17654042 11729361
MESH:D020521 Stroke Vitamin E 3.0916517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.4516684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3512697716
MESH:D013964 Thyroid Neoplasms decitabine 6.1317967635
MESH:D013964 Thyroid Neoplasms Indomethacin 6.1311352223 14736730 18791128
MESH:D013978 Tibial Fractures Estradiol 4.1419048282
MESH:D014456 Ulcer Indomethacin 4.3617380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 13.2316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.2317053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 13.2317616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 13.2316720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.2311723127 17306315 16452187 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.7810091137
MESH:D014581 Urticaria Acetaminophen 2.4910982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.3011813266
MESH:D014591 Uterine Diseases bisphenol A 4.4614652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.7914692618
MESH:D014604 Uveal Neoplasms decitabine 4.3617785578
MESH:D014605 Uveitis Dexamethasone 4.271336536
MESH:D014652 Vascular Diseases sodium arsenite 3.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0615869587 14671159
MESH:D014839 Vomiting Indomethacin 4.2011897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7015886252
MESH:D015430 Weight Gain Dietary Fats 3.2816723640
Pathway ID Pathway Name
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:01100 Metabolic pathways
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29477
    • No data
    No data
    Releated drug ID Related drug Name
    PA10432thiazide derivatives
    PA450218levonorgestrel
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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