Gene Symbol:	HSPA1B ( FLJ54328,HSP70-1B,HSP70-2,HSPA1A )
Gene Full Name:	heat shock 70kDa protein 1B
Band:	6p21.33
Quick Links	Entrez ID:3304; OMIM: 603012; Uniprot ID:HSP71_HUMAN; ENSEMBL ID: ENSG00000204388; HGNC ID: 5233
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa03040	Spliceosome
hsa04141	Protein processing in endoplasmic reticulum
hsa04144	Endocytosis
hsa05145	Toxoplasmosis
hsa04612	Antigen processing and presentation

Desease ID	Desease Name
1832	Congenital abnormality
1856	Obesity
1870	Drug abuse
1904	Diabetes mellitus
1918	Atherosclerosis
1932	Pancreatitis
1998	Enteritis
2028	Nasopharyngeal cancer
2074	Asthma
2094	Ulcerative colitis

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of HSPA1B mRNA	affects expression	18281256
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein]	decreases reaction\|increases expression	17046822
D000082	Acetaminophen	Acetaminophen affects the expression of HSPA1B mRNA	affects expression	15606129
D000082	Acetaminophen	Acetaminophen results in increased expression of HSPA1B mRNA	increases expression	11264010
D000082	Acetaminophen	Acetaminophen affects the expression of HSPA1B mRNA	affects expression	18246545
D000082	Acetaminophen	Acetaminophen results in increased expression of HSPA1B mRNA	increases expression	17202762
D024502	alpha-Tocopherol	alpha-Tocopherol results in increased expression of HSPA1B mRNA	increases expression	16908007
C103505	AM 251	AM 251 results in decreased expression of HSPA1B mRNA	decreases expression	16500647
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HSPA1B mRNA	affects expression	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of HSPA1B mRNA	increases expression	19194377
D001151	Arsenic	Arsenic results in decreased expression of HSPA1B mRNA	decreases expression	16835338
D001151	Arsenic	Arsenic results in decreased expression of HSPA1B mRNA	decreases expression	19654921
C006632	arsenic trioxide	arsenic trioxide affects the expression of HSPA1B mRNA	affects expression	17530438
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSPA1B mRNA	increases expression	19417148
C015001	arsenite	[arsenite co-treated with Benzo(a)pyrene] results in increased expression of HSPA1B mRNA	affects cotreatment\|increases expression	15894712
C015001	arsenite	arsenite results in increased expression of HSPA1B mRNA	increases expression	15894712
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in increased expression of HSPA1B mRNA	increases expression	18687144
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of HSPA1B mRNA	increases expression	19737606
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSPA1B mRNA	increases expression	20106945
D001564	Benzo(a)pyrene	[arsenite co-treated with Benzo(a)pyrene] results in increased expression of HSPA1B mRNA	affects cotreatment\|increases expression	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSPA1B mRNA	decreases expression	20127859
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSPA1B mRNA	increases expression	15894712
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HSPA1B mRNA	increases expression	20382639
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA1B protein	increases expression	15525353
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Estradiol results in increased expression of HSPA1B mRNA]	decreases reaction\|increases expression	12927369
C070515	bisindolylmaleimide I	bisindolylmaleimide I promotes the reaction [bisphenol A results in increased expression of HSPA1B mRNA]	increases expression\|increases reaction	12927369
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in increased expression of HSPA1B mRNA	increases expression	12927369
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of HSPA1B mRNA	increases expression	15912405
C006780	bisphenol A	bisindolylmaleimide I promotes the reaction [bisphenol A results in increased expression of HSPA1B mRNA]	increases expression\|increases reaction	12927369
C006780	bisphenol A	bisphenol A results in increased expression of HSPA1B mRNA	increases expression	12927369
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSPA1B mRNA]	decreases reaction\|increases expression	12927369
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of HSPA1B mRNA	increases expression	12414654
D002104	Cadmium	Cadmium results in increased expression of HSPA1B mRNA	increases expression	21172416
D002104	Cadmium	Cadmium results in increased expression of HSPA1B mRNA	increases expression	12653483
D002104	Cadmium	HSF1 protein affects the reaction [Cadmium results in increased expression of HSPA1B protein]	affects reaction\|increases expression	16282982
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of HSPA1B protein	decreases expression	15338365
D002259	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA1B mRNA	decreases expression	16039398
D002336	Carnosine	Carnosine results in increased expression of HSPA1B protein	increases expression	16984587
D002738	Chloroquine	Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein]	decreases reaction\|increases expression	17046822
D003042	Cocaine	Cocaine affects the expression of HSPA1B mRNA	affects expression	15681117
C030123	coumarin	coumarin results in increased expression of HSPA1B mRNA	increases expression	18480146
C402665	CP 31398	CP 31398 results in increased expression of HSPA1B mRNA	increases expression	15155752
C408982	CPG-oligonucleotide	Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein]	decreases reaction\|increases expression	17046822
C408982	CPG-oligonucleotide	CPG-oligonucleotide promotes the reaction [[TLR9 co-treated with MYD88] results in increased expression of HSPA1B protein]	affects cotreatment\|increases expression\|increases reaction	17046822
C408982	CPG-oligonucleotide	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein]	decreases reaction\|increases expression	17046822
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in increased expression of HSPA1B protein	increases expression	17046822
C408982	CPG-oligonucleotide	Quercetin inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein]	decreases reaction\|increases expression	17046822
D003520	Cyclophosphamide	Cyclophosphamide affects the expression of HSPA1B mRNA	affects expression	18246545
D016572	Cyclosporine	Cyclosporine results in increased expression of HSPA1B mRNA	increases expression	20106945
D013759	Tetrahydrocannabinol	Tetrahydrocannabinol results in decreased expression of HSPA1B mRNA	decreases expression	16039398
D003907	Dexamethasone	Dexamethasone results in increased expression of HSPA1B mRNA	increases expression	17998272
D016190	Carboplatin	Carboplatin results in increased expression of HSPA1B mRNA	increases expression	18172885
D002945	Cisplatin	Cisplatin results in increased expression of HSPA1B mRNA	increases expression	18172885
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in increased expression of HSPA1B mRNA	increases expression	17490981
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of HSPA1B mRNA	increases expression	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of HSPA1B mRNA]	decreases reaction\|increases expression	17942915
D004178	Diquat	Diquat results in increased expression of HSPA1B mRNA	increases expression	21172416
D004391	Dust	Dust results in increased expression of HSPA1B mRNA	increases expression	17805423
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of HSPA1B mRNA	decreases expression	18851785
D004958	Estradiol	Estradiol results in increased expression of HSPA1B mRNA	increases expression	20106945
D004958	Estradiol	bisindolylmaleimide I inhibits the reaction [Estradiol results in increased expression of HSPA1B mRNA]	decreases reaction\|increases expression	12927369
D004958	Estradiol	Estradiol results in increased expression of HSPA1B mRNA	increases expression	12927369
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of HSPA1B mRNA]	decreases reaction\|increases expression	12927369
D005472	Fluorouracil	Fluorouracil results in decreased expression of HSPA1B protein	decreases expression	15352031
D005472	Fluorouracil	HSPA1B protein affects the susceptibility to Fluorouracil	affects response to substance	15352031
D005632	Fructose	Fructose results in increased expression of HSPA1B mRNA	increases expression	15150374
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSPA1B mRNA]	decreases reaction\|increases expression	12927369
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of HSPA1B mRNA]	decreases reaction\|increases expression	12927369
C106014	gedunin	gedunin results in increased expression of HSPA1B mRNA	increases expression	17010675
D019833	Genistein	Genistein results in increased expression of HSPA1B mRNA	increases expression	17341692
D005839	Gentamicins	Gentamicins results in increased expression of HSPA1B mRNA	increases expression	18172885
C031049	geranylgeranylacetone	[Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA	affects cotreatment\|increases expression	15340226
C031049	geranylgeranylacetone	[Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein	affects cotreatment\|increases expression	15340226
D006851	Hydrochloric Acid	HSPA1B protein affects the susceptibility to Hydrochloric Acid	affects response to substance	15338365
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of HSPA1B mRNA	increases expression	12414654
C013038	hydroxyhydroquinone	hydroxyhydroquinone results in increased expression of HSPA1B mRNA	increases expression	17572062
C002950	methylformamide	methylformamide affects the expression of HSPA1B mRNA	affects expression	17040096
C002950	methylformamide	methylformamide analog affects the expression of HSPA1B mRNA	affects expression	17040096
D009544	Niflumic Acid	Niflumic Acid affects the expression of HSPA1B protein	affects expression	16184763
D009828	Oleanolic Acid	Oleanolic Acid results in increased expression of HSPA1B mRNA	increases expression	18706400
C042763	olive oil	olive oil analog affects the expression of HSPA1B mRNA	affects expression	17349074
D010634	Phenobarbital	Phenobarbital results in increased expression of HSPA1B mRNA	increases expression	19270015
C006253	pirinixic acid	pirinixic acid results in decreased expression of HSPA1B mRNA	decreases expression	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of HSPA1B mRNA	increases expression	16985257 20059764 18301758 15375163
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of HSPA1B mRNA]	increases expression\|increases reaction	20059764
C061957	polaprezinc	polaprezinc results in increased expression of HSPA1B protein	increases expression	16984587
D011374	Progesterone	Progesterone results in increased expression of HSPA1B mRNA	increases expression	18037150
D011374	Progesterone	Progesterone affects the expression of HSPA1B mRNA	affects expression	17251523
C031280	pyrazole	pyrazole results in increased expression of HSPA1B mRNA	increases expression	17945193
D011794	Quercetin	Quercetin results in decreased expression of HSPA1B protein	decreases expression	17234771 15221776
D011794	Quercetin	Quercetin inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein]	decreases reaction\|increases expression	17046822
D011794	Quercetin	Quercetin results in decreased expression of HSPA1B mRNA	decreases expression	17349211
D020849	Raloxifene	ESR1 protein affects the reaction [Raloxifene results in decreased expression of HSPA1B mRNA]	affects reaction\|decreases expression	14699072
D020849	Raloxifene	Raloxifene affects the expression of HSPA1B mRNA	affects expression	14699072
C059514	resveratrol	resveratrol results in increased expression of HSPA1B mRNA	increases expression	17956190
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of HSPA1B mRNA	increases expression	16678137
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of HSPA1B protein	increases expression	16678137
C515055	S-(dimethylarsino)-glutathione	S-(dimethylarsino)-glutathione results in increased expression of HSPA1B mRNA	increases expression	19417148
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPA1B mRNA	increases expression	17682005 16322246 15327774 18812580
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPA1B protein	increases expression	11353140
D012980	Sodium Salicylate	Sodium Salicylate affects the expression of HSPA1B protein	affects expression	16184763
C025462	sulindac sulfide	sulindac sulfide results in increased expression of HSPA1B mRNA	increases expression	16184548
C004648	testosterone enanthate	testosterone enanthate affects the expression of HSPA1B mRNA	affects expression	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSPA1B mRNA	affects expression	18691609
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA	affects cotreatment\|increases expression	15340226
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein	affects cotreatment\|increases expression	15340226
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSPA1B mRNA	increases expression	15340226 17035482
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSPA1B protein	increases expression	15340226
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSPA1B protein	decreases expression	16548065
D013849	Thimerosal	Thimerosal results in increased expression of HSPA1B mRNA	increases expression	16870260
C050414	tripterine	tripterine results in increased expression of HSPA1B mRNA	increases expression	17010675
D014415	Tunicamycin	Tunicamycin results in decreased expression of HSPA1B mRNA	decreases expression	17127020
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of HSPA1B mRNA	increases expression	19465080
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of HSPA1B mRNA	increases expression	12414654
D015032	Zinc	HSPA1B gene SNP affects the abundance of Zinc	affects abundance	16513158
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of HSPA1B protein	increases expression	16984587

Pathway ID	Pathway Name
KEGG:04612	Antigen processing and presentation
KEGG:04144	Endocytosis
KEGG:04010	MAPK signaling pathway
KEGG:05162	Measles
REACT:21257	Metabolism of RNA
KEGG:04141	Protein processing in endoplasmic reticulum
KEGG:03040	Spliceosome
KEGG:05145	Toxoplasmosis

Pathway ID	Pathway Name
P00049	Parkinson disease
P00006	Apoptosis signaling pathway

Desease Name
CARDIOVASCULAR
Alzheimer's disease
pancreatitis
CANCER
outcome after severe injury
kidney transplant
urinary tract infection
atherosclerosis, coronary carotid artery damage
RENAL
IMMUNE
NEUROLOGICAL
clozapine-induced agranulocytosis
sepsis
METABOLIC
nasopharyngeal carcinoma
obesity
INFECTION

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced	Phenobarbital	5.90	6195326
MESH:D000014	Abnormalities, Drug-Induced	Tetrachlorodibenzodioxin	5.90	15322242 11752688 14514962
MESH:D000138	Acidosis	Ammonium Chloride	13.73	18287403
MESH:D000138	Acidosis	Hydrochloric Acid	13.73	12771618 19262391 16144966 20872349 15920416 11574821
MESH:D000138	Acidosis	Zinc Sulfate	13.73	7265320
MESH:D000141	Acidosis, Renal Tubular	Hydrochloric Acid	5.05	17183249
MESH:D000142	Acidosis, Respiratory	Hydrochloric Acid	5.07	20597076
MESH:D000169	Acrodermatitis	Zinc	4.67	17190629 16889938 17202136
MESH:D058186	Acute Kidney Injury	Cisplatin	10.80	12690470 15814532 17670903
MESH:D058186	Acute Kidney Injury	Gentamicins	10.80	11274264
MESH:D058186	Acute Kidney Injury	resveratrol	10.80	16538975
MESH:D055371	Acute Lung Injury	Hydrochloric Acid	7.07	19060228 19094174 16759491 11953099 11850527 15970105 19760209
MESH:D055371	Acute Lung Injury	pirinixic acid	7.07	18653653
MESH:D000230	Adenocarcinoma	arsenic trioxide	13.73	11798837 19825857
MESH:D000230	Adenocarcinoma	Benzo(a)pyrene	13.73	20127859 20464547
MESH:D000230	Adenocarcinoma	Cisplatin	13.73	11798837 17638652
MESH:D000230	Adenocarcinoma	Estradiol	13.73	11473722
MESH:D000230	Adenocarcinoma	Fluorouracil	13.73	17638652
MESH:D000230	Adenocarcinoma	Genistein	13.73	11473722
MESH:D000236	Adenoma	Benzo(a)pyrene	12.09	6695378
MESH:D000236	Adenoma	beta-Naphthoflavone	12.09	19389873
MESH:D000236	Adenoma	Diethylnitrosamine	12.09	10737359 6695378
MESH:D000236	Adenoma	resveratrol	12.09	15688382
MESH:D018248	Adenoma, Liver Cell	Diethylnitrosamine	18.89	19052882 18056438 17620307 17162532 19061943 16434500
MESH:D018248	Adenoma, Liver Cell	Phenobarbital	18.89	17620307
MESH:D018248	Adenoma, Liver Cell	pirinixic acid	18.89	16434500
MESH:D018248	Adenoma, Liver Cell	Tetrachlorodibenzodioxin	18.89	16835633
MESH:D000310	Adrenal Gland Neoplasms	sodium arsenite	3.95	15276417
MESH:D018246	Adrenocortical Adenoma	Arsenic	11.31	17306315
MESH:D018246	Adrenocortical Adenoma	sodium arsenite	11.31	16712894 17306315
MESH:D000419	Albuminuria	Raloxifene	3.90	17451421 17308373
MESH:D000544	Alzheimer Disease	Raloxifene	7.53	15800139
MESH:D000544	Alzheimer Disease	resveratrol	7.53	16162502 16183991
MESH:D000544	Alzheimer Disease	sulindac sulfide	7.53	18759972
MESH:D000544	Alzheimer Disease	Zinc	7.53	16325427 16410023 17119284 16580781
MESH:D000690	Amyotrophic Lateral Sclerosis	Tetrahydrocannabinol	4.33	15204022
MESH:D000740	Anemia	Fluorouracil	6.54	17963324 16511603 15504547
MESH:D000740	Anemia	Tetrachlorodibenzodioxin	6.54	11748828
MESH:D000743	Anemia, Hemolytic	Quercetin	3.58	17084956
MESH:D000755	Anemia, Sickle Cell	Zinc	4.20	16916123

AutismKB 2.0

Annotation Detail for HSPA1B

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics