AutismKB 2.0

Annotation Detail for HSPB2


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Basic Information Top
Gene Symbol:HSPB2 ( HSP27,Hs.78846,LOH11CR1K,MGC133245,MKBP )
Gene Full Name: heat shock 27kDa protein 2
Band: 11q23.1
Quick LinksEntrez ID:3316; OMIM: 602179; Uniprot ID:HSPB2_HUMAN; ENSEMBL ID: ENSG00000170276; HGNC ID: 5247
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00056VEGF signaling pathway
P00005Angiogenesis
No data
Related Diseases/Disorders Top
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Desease IDDesease Name
1740Alzheimer's disease
1904Diabetes mellitus
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of HSPB2 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HSPB2 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of HSPB2 mRNAincreases expression 12558987
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of HSPB2 proteinincreases expression 12558987
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HSPB2 mRNAaffects cotreatment|increases expression 18164116
C099952 bifenthrin bifenthrin results in decreased expression of HSPB2 proteindecreases expression 16271832
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of HSPB2 mRNAdecreases expression 15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of HSPB2 mRNAincreases expression 14729362
15003993
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HSPB2 mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of HSPB2 mRNAaffects expression 17484886
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HSPB2 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HSPB2 mRNAaffects cotreatment|decreases expression 20360939
D005472 Fluorouracil Fluorouracil results in increased phosphorylation of HSPB2 proteinincreases phosphorylation 18757417
D005472 Fluorouracil SB 203580 inhibits the reaction [Fluorouracil results in increased phosphorylation of HSPB2 protein]decreases reaction|increases phosphorylation 18757417
C011994 pirimicarb pirimicarb results in decreased expression of HSPB2 proteindecreases expression 16271832
C093642 SB 203580 SB 203580 inhibits the reaction [Fluorouracil results in increased phosphorylation of HSPB2 protein]decreases reaction|increases phosphorylation 18757417
D012643 Selenium Selenium results in decreased expression of HSPB2 mRNAdecreases expression 18997278
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Fluorouracil 2.4417638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.493712494
MESH:D000236 Adenoma beta-Naphthoflavone 11.4919389873
MESH:D000236 Adenoma Diethylnitrosamine 11.4910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0217162532 19052882 16434500 19061943 18056438 17620307
MESH:D000740 Anemia Fluorouracil 3.7916511603 17963324 15504547
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1511289319 1440618
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2417474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.2418357371 16595493 18608205 16557594 16110121 19217205 15136595
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8816227642 16097048 15721981 10355542 15700767 16050911 15673190 16011737 18705752 3786805 16124888 16192424
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 3.6317121937
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.697296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6920084675 16328049 19394651 19919837 20935162 17978847 17428255 18788625 19519916 16878318 20524982 17761372 18785209 17055752 16807293 16935385 19107877 18506893 19383236 20514400 18665156 16502159 16698587 19701751 10737359 16288022 19335982 19171122 19418558 20214788 3581430 19539802 16540662 16569478 20512989 19208518 18978308 19052882 21159647 20727157 16779866 17138121 11831363 18210153 20432363 18393292 18494052 10672840 20007298 16830150 18056438 17173139 18691550 3084413 16681979 17162532 20101231 18971187 19822196
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.6918930000 17045692 16799960 16332177 17088986 17971768
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.617296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6118695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5116280240 16757204 18986760 17066447
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.877505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.872727394 17174075 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.219022650 19486331
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2415001691 17725105 16510598 17287894 18772588 17172411 16340194 17016597 17018589 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018288408 16282729 18949393 18383874 17016601 17401013 17094418 17454858 17594712 16524972 17255274 18802399 16391804 18509181 15289873 16331619 14970324 15148649 18448328 16303861 20501625 17695437
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9018759878 11906362 12868966 2524372 8156756 14531868 8970840 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.199022650 18289764 7440962 18692083 8291058 9653073 9328219 18648102 6679447 6482804 11289319 1440618 16192314
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.192869522 4309450 15998439 21278145 6884620 7440962 11566570 10915739 3786805 9327722 10092053 16227642 19336974 16177239 7179309 15968718 7120509 19085960 15027814 17522070 6623471 3732212
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.1919107877
MESH:D056486 Drug-Induced Liver Injury Selenium 9.1915131321
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.593581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5916785472 15173087 16481741 16337965 17638652
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1012795759 19224547 15959796 16045604 12631006 61145 17595544 16239168
MESH:D005234 Fatty Liver Diethylnitrosamine 8.1020387270 21071580
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5618705752
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4415102660 15162350 18337622
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.546705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.5419110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007249 Inflammation Diethylnitrosamine 2.4118785209
MESH:D007251 Influenza, Human Selenium 4.3316624496
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6610783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.5915369732
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.716582329
MESH:D007680 Kidney Neoplasms Fluorouracil 7.7116985049
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.0416766008
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7511408273 11903743 16943688 16239168 17157831 21278145 16221502 17174718 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7520032147 18407596 18522880 19638242 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.249327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518210741 18156304 17823541 15362042 17869086 17976157 17698563 18395095 15370692 12632512 18054572 18418968 18006644 12609069 14716496 12667390 17481882 12741479 15925388 20821823 15818738 17525996 18472332 18420326 17557913 12445421 12546737 17640975 16248980 18166357 17708605 15876570 12666154 11481614 17761835 16027843 16015684 18429990 12632514 12586293 17922224 17766677 17805973 18481824 12445418 12958196 16638106 15959796 12898905 18263696 15673190 14716833 18251166 18339082 18472094 16192424 18376398 17900296 18395914 15057751 15931870 18705752 16136751 16097048 12389079 15123356 14512876 17721639 18277467 10355542 14620537 16033810 12649538 18279442 15730626 15996030 17714472 18187930 15338365 17631135 14748882 13678700 18412020 18205269 17565644 14724832 15893842 16011737 18317297 17944888 15052691 15650968 16116963
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1317285989 15720792 16964402 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1317034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7714706259 16899240
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 10.9921295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.9919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.9919255062 12112319 2862719 19426721 20434301 18754104 19850985 19690152 19551842 19499222 2422723 18644402 19090486 15175105 19427195 19294768 21167192 19638242 21047994 20101389 19073162 19254457 16942905 20452335 15885732 19812893 20583210 12771043 20501860 19996281 19833225 18648771 19642983 21278145 21071580 20137499 18978307 18977376 20118626 9163691 20405173 19256749 20492335 10737359
MESH:D008113 Liver Neoplasms Fluorouracil 10.9916603448 17045692 15113037 18383874
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.571399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.5718164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.5712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5721159647 19009564 17174075 18775883 18308698 18544905 17854601 18079962 18282651 16267830 19519916 19539802 2563599 18253720 3124819 17942915 16842330 18164116 9362446 19004024 18093689 19126423
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5620970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 2.5615246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D009041 Motion Sickness Dextroamphetamine 5.651613127
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6916757204 18986760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.803581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.803581430 9029167
MESH:D009369 Neoplasms Fluorouracil 2.6418600527 16928823 18239605
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.506482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4116540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4116929163 19003803 15113037 16500647
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4019082440 18626508
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0815538739 18722050 18286688 16160472
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.728532709
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5118456281
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5119015929 18396642 16951190 17522103 18567086 16424979 15786421 17498489 19084572 17172411
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.336582329 6587162 3712494 7505956 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.337505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0616280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.308074119
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9516803524
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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