AutismKB 2.0

Annotation Detail for HSP90AA1


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Basic Information Top
Gene Symbol:HSP90AA1 ( FLJ31884,HSP86,HSP89A,HSP90A,HSP90N,HSPC1,HSPCA,HSPCAL1,HSPCAL4,HSPN,Hsp89,Hsp90,LAP2 )
Gene Full Name: heat shock protein 90kDa alpha (cytosolic), class A member 1
Band: 14q32.31
Quick LinksEntrez ID:3320; OMIM: 140571; Uniprot ID:HS90A_HUMAN; ENSEMBL ID: ENSG00000080824; HGNC ID: 5253
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04141Protein processing in endoplasmic reticulum
hsa04621NOD-like receptor signaling pathway
hsa04612Antigen processing and presentation
hsa05215Prostate cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Metabolism of nitric oxide
Cell Cycle, Mitotic
Axon guidance
Pathway IDPathway Name
200122Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
200136ErbB receptor signaling network
200019Signaling events mediated by HDAC Class II
200151VEGFR1 specific signals
200061LKB1 signaling events
200099IL2 signaling events mediated by PI3K
200098Class I PI3K signaling events
200072Regulation of Telomerase
200077Glucocorticoid receptor regulatory network
200169Class I PI3K signaling events mediated by Akt
200161Signaling events mediated by VEGFR1 and VEGFR2
200045Validated targets of C-MYC transcriptional activation
200109Integrins in angiogenesis
200102Regulation of Androgen receptor activity
No data
Pathway IDPathway Name
500689vRNP Assembly
500849eNOS activation
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1720Fanconi's anemia
1740Alzheimer's disease
1850Herpes
1934Cancer
1986Eating disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in increased expression of HSP90AA1 mRNAincreases expression 15375163
C112765 17-(allylamino)-17-demethoxygeldanamycin 17-(allylamino)-17-demethoxygeldanamycin results in decreased expression of HSP90AA1 proteindecreases expression 18830594
C112765 17-(allylamino)-17-demethoxygeldanamycin 17-(allylamino)-17-demethoxygeldanamycin results in decreased activity of HSP90AA1 proteindecreases activity 17308081
17157164
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HSP90AA1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of HSP90AA1 mRNAincreases expression 19417177
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HSP90AA1 mRNAaffects expression 21346803
C024709 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to HSP90AA1 proteinaffects binding 16533022
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of HSP90AA1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of HSP90AA1 mRNAdecreases expression 12958071
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of HSP90AA1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HSP90AA1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of HSP90AA1 mRNAincreases expression 12958197
11743745
D000082 Acetaminophen PPARA protein affects the reaction [Acetaminophen results in increased expression of HSP90AA1 mRNA]affects reaction|increases expression 12958197
D000082 Acetaminophen PTGS2 protein affects the reaction [Acetaminophen results in increased expression of HSP90AA1 mRNA]affects reaction|increases expression 11743745
D000082 Acetaminophen Acetaminophen results in increased expression of HSP90AA1 mRNAincreases expression 17202762
C109238 acyline acyline results in increased expression of HSP90AA1 mRNAincreases expression 17510436
C000188 alachlor alachlor results in increased expression of HSP90AA1 mRNA alternative formincreases expression 8792849
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HSP90AA1 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine affects the expression of HSP90AA1 mRNAaffects expression 12558987
C006632 arsenic trioxide arsenic trioxide results in increased expression of HSP90AA1 mRNAincreases expression 18081892
20458559
19417148
C006632 arsenic trioxide arsenic trioxide results in increased expression of HSP90AA1 proteinincreases expression 19364129
18081892
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HSP90AA1 mRNAincreases expression 18061397
C110172 BHTOH-QM BHTOH-QM binds to HSP90AA1 proteinaffects binding 16533022
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 mRNA]decreases reaction|increases expression 12927369
C070515 bisindolylmaleimide I bisindolylmaleimide I results in increased expression of HSP90AA1 mRNAincreases expression 12927369
C006780 bisphenol A bisindolylmaleimide I inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 mRNA]decreases reaction|increases expression 12927369
C006780 bisphenol A bisphenol A results in increased expression of and affects the localization of HSP90AA1 proteinaffects localization|increases expression 11568360
C006780 bisphenol A bisphenol A results in increased expression of HSP90AA1 mRNAincreases expression 12927369
C006780 bisphenol A fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 protein]decreases reaction|increases expression 11568360
C006780 bisphenol A bisphenol A results in increased expression of HSP90AA1 proteinincreases expression 15229138
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of HSP90AA1 mRNAincreases expression 15336504
D002104 Cadmium Cadmium results in increased expression of HSP90AA1 mRNAincreases expression 11985888
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of HSP90AA1 mRNAincreases expression 11985888
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of HSP90AA1 mRNAdecreases expression 12760830
C099555 CD 437 CD 437 results in decreased expression of HSP90AA1 mRNAdecreases expression 12958071
D002706 Chlordan Chlordan results in increased expression of HSP90AA1 mRNA alternative formincreases expression 8792849
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of HSP90AA1 mRNA alternative formincreases expression 8792849
D003375 Coumestrol Coumestrol results in increased expression of HSP90AA1 proteinincreases expression 15229138
C402665 CP 31398 CP 31398 results in increased expression of HSP90AA1 mRNAincreases expression 15155752
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of HSP90AA1 mRNAdecreases expression 11906922
D016572 Cyclosporine Cyclosporine results in increased expression of HSP90AA1 mRNAincreases expression 20106945
C014347 decitabine decitabine results in decreased expression of HSP90AA1 proteindecreases expression 19294695
C014347 decitabine [trichostatin A co-treated with decitabine] results in decreased expression of HSP90AA1 proteinaffects cotreatment|decreases expression 19294695
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSP90AA1 mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of HSP90AA1 mRNAincreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of HSP90AA1 proteinincreases expression 15229138
D004317 Doxorubicin Doxorubicin results in increased expression of HSP90AA1 mRNAincreases expression 17680992
D004317 Doxorubicin Doxorubicin promotes the reaction [HSP90AA1 protein binds to ERBB2 protein]affects binding|increases reaction 17308081
D004317 Doxorubicin Doxorubicin results in increased expression of HSP90AA1 proteinincreases expression 17308081
D004732 Endrin Endrin results in increased expression of HSP90AA1 mRNA alternative formincreases expression 8792849
D004958 Estradiol Estradiol results in increased expression of HSP90AA1 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of and affects the localization of HSP90AA1 proteinaffects localization|increases expression 11568360
D004958 Estradiol Estradiol results in increased expression of HSP90AA1 mRNAincreases expression 12927369
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of HSP90AA1 protein]decreases reaction|increases expression 11568360
D000431 Ethanol Ethanol results in increased expression of HSP90AA1 mRNAincreases expression 17189318
D000431 Ethanol HSF1 protein affects the reaction [Ethanol results in increased expression of HSP90AA1 mRNA]affects reaction|increases expression 17189318
D000431 Ethanol Ethanol results in decreased expression of HSP90AA1 mRNAdecreases expression 16098508
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HSP90AA1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HSP90AA1 mRNAincreases expression 16174780
19400957
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSP90AA1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HSP90AA1 mRNAincreases expression 17108234
19400957
16174780
D005284 Fenthion Fenthion results in increased expression of HSP90AA1 mRNA alternative formincreases expression 8792849
C020326 ferric nitrilotriacetate ferric nitrilotriacetate results in increased expression of HSP90AA1 mRNAincreases expression 10854235
C070081 fulvestrant fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 protein]decreases reaction|increases expression 11568360
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of HSP90AA1 protein]decreases reaction|increases expression 11568360
C106014 gedunin gedunin results in decreased activity of HSP90AA1 proteindecreases activity 17010675
C001277 geldanamycin geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]affects binding|decreases reaction 17223712
C001277 geldanamycin geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]affects binding|decreases reaction 12775586
D019833 Genistein Genistein results in increased expression of HSP90AA1 proteinincreases expression 15229138
C013038 hydroxyhydroquinone hydroxyhydroquinone results in increased expression of HSP90AA1 mRNAincreases expression 17572062
C075954 indolo(3,2-b)carbazole indolo(3,2-b)carbazole results in increased expression of HSP90AA1 mRNAincreases expression 18061397
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSP90AA1 mRNAaffects cotreatment|decreases expression 18544905
D008628 Mercury Mercury results in increased expression of HSP90AA1 mRNAincreases expression 16823088
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of HSP90AA1 mRNAincreases expression 16966085
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to HSP90AA1 protein]affects binding|increases reaction 17220478
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of HSP90AA1 mRNAincreases expression 20024957
D009151 Mustard Gas Mustard Gas results in increased expression of HSP90AA1 mRNAincreases expression 15674843
C017557 nickel subsulfide nickel subsulfide results in decreased expression of HSP90AA1 mRNAdecreases expression 12760830
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of HSP90AA1 mRNAincreases expression 17616710
D010416 Pentachlorophenol Pentachlorophenol results in increased expression of HSP90AA1 mRNAincreases expression 18486366
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of HSP90AA1 mRNAdecreases expression 17616710
C006253 pirinixic acid pirinixic acid results in increased expression of HSP90AA1 mRNAincreases expression 20059764
15375163
18301758
C006253 pirinixic acid pirinixic acid results in increased expression of HSP90AA1 proteinincreases expression 20059764
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of HSP90AA1 mRNA]affects reaction|increases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of HSP90AA1 protein]increases expression|increases reaction 20059764
D010936 Plant Extracts Plant Extracts affects the expression of HSP90AA1 mRNAaffects expression 12878215
D010936 Plant Extracts Plant Extracts results in increased expression of HSP90AA1 mRNAincreases expression 18061397
D011374 Progesterone Progesterone affects the expression of HSP90AA1 mRNAaffects expression 17251523
C031280 pyrazole pyrazole results in increased expression of HSP90AA1 mRNAincreases expression 17945193
C009131 pyrimidin-2-one beta-ribofuranoside pyrimidin-2-one beta-ribofuranoside results in decreased expression of HSP90AA1 proteindecreases expression 18830594
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of HSP90AA1 mRNAincreases expression 16678137
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of HSP90AA1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of HSP90AA1 mRNAdecreases expression 19244175
D019821 Simvastatin Simvastatin results in increased expression of HSP90AA1 proteinincreases expression 16375908
C017947 sodium arsenite sodium arsenite results in increased expression of HSP90AA1 mRNAincreases expression 12760830
C017947 sodium arsenite sodium arsenite results in increased expression of HSP90AA1 mRNAincreases expression 16014739
C017947 sodium arsenite sodium arsenite results in increased expression of HSP90AA1 mRNAincreases expression 16815819
C016104 sodium bichromate sodium bichromate results in decreased expression of HSP90AA1 mRNAdecreases expression 12760830
C016766 sulforafan sulforafan inhibits the reaction [HSP90AA1 protein binds to AR protein]affects binding|decreases reaction 19805354
C016766 sulforafan sulforafan results in increased acetylation of HSP90AA1 proteinincreases acetylation 19805354
D013629 Tamoxifen Tamoxifen affects the expression of HSP90AA1 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen results in increased expression of HSP90AA1 mRNAincreases expression 19400957
D013629 Tamoxifen Tamoxifen results in increased expression of HSP90AA1 mRNAincreases expression 19400957
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HSP90AA1 mRNAincreases expression 18061397
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSP90AA1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HSP90AA1 mRNAincreases expression 17942748
D013853 Thioacetamide Thioacetamide results in increased expression of HSP90AA1 mRNAincreases expression 16297948
D013874 Thiopental Thiopental results in increased expression of HSP90AA1 mRNAincreases expression 18218830
C012589 trichostatin A trichostatin A affects the expression of HSP90AA1 proteinaffects expression 19294695
C012589 trichostatin A [trichostatin A co-treated with decitabine] results in decreased expression of HSP90AA1 proteinaffects cotreatment|decreases expression 19294695
C050414 tripterine tripterine results in decreased activity of HSP90AA1 proteindecreases activity 17010675
C025643 vinclozolin vinclozolin affects the expression of HSP90AA1 mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of HSP90AA1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of HSP90AA1 mRNAdecreases expression 19244175
D015032 Zinc Zinc results in decreased expression of HSP90AA1 mRNAdecreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of HSP90AA1 mRNAdecreases expression 17074742
D015054 Zymosan Zymosan results in increased expression of HSP90AA1 mRNAincreases expression 19061961
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.8014745880
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 14.517525203
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 14.517525203
MESH:D000014 Abnormalities, Drug-Induced Ethanol 14.5118926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.5114514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 13.6318287403
MESH:D000138 Acidosis Ethanol 13.6311192467
MESH:D000138 Acidosis Zinc Sulfate 13.637265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.2017505938
MESH:D000169 Acrodermatitis Zinc 4.6716889938 17190629 17202136
MESH:D055371 Acute Lung Injury pirinixic acid 2.4418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 13.7211798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.7220127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 13.7217418594
MESH:D000230 Adenocarcinoma Estradiol 13.7211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.7214692618
MESH:D000230 Adenocarcinoma Genistein 13.7211473722
MESH:D000236 Adenoma Benzo(a)pyrene 5.056695378
MESH:D000236 Adenoma Diethylnitrosamine 5.0510737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 13.0617162532 19052882 16434500 17620307 18056438 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 13.0616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 13.0616835633
MESH:D011125 Adenomatous Polyposis Coli sulforafan 4.6217942926
MESH:D000310 Adrenal Gland Neoplasms Pentachlorophenol 10.8210696769
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 10.8215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.1516712894 17306315
MESH:D000382 Agricultural Workers' Diseases alachlor 6.8914769641 11874814
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 6.8916611668 17119214 11874814
MESH:D000419 Albuminuria Doxorubicin 3.8421441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.5715451039 15451040
MESH:D000544 Alzheimer Disease Plant Extracts 3.8916962711
MESH:D000544 Alzheimer Disease Zinc 3.8916325427 16410023 17119284 16580781
MESH:D000686 Amyloidosis Diethylstilbestrol 3.7815469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.8511748828
MESH:D000740 Anemia Zymosan 6.8518664788
MESH:D000755 Anemia, Sickle Cell Zinc 4.2016916123
MESH:D000799 Angioedema Acetaminophen 3.1010982225
MESH:D000853 Anophthalmos Ethanol 4.1015513904
MESH:D000860 Anoxia Zinc Sulfate 4.297265320
MESH:D001008 Anxiety Disorders Ethanol 7.0211141031
MESH:D001008 Anxiety Disorders vinclozolin 7.0219015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.3619183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 7.8015014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 7.8011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 9.5815885639
MESH:D001169 Arthritis, Experimental Plant Extracts 9.5814686799
MESH:D001169 Arthritis, Experimental Zymosan 9.5817659584 15142272 15944321 16872482 15188379
MESH:D001249 Asthma Mustard Gas 4.2310378619
MESH:D001249 Asthma Zinc 4.2317085522
MESH:D050197 Atherosclerosis Cadmium 3.1715687053
MESH:D001284 Atrophy fulvestrant 4.1511514358
MESH:D001321 Autistic Disorder Acetaminophen 2.1718445737
MESH:D001321 Autistic Disorder Mercury 2.1717497416
MESH:D001327 Autoimmune Diseases Mercury 9.0616634805
MESH:D001327 Autoimmune Diseases sulforafan 9.0619761891
MESH:D001768 Blister Mustard Gas 4.4219167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.5616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.5619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.5612125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 16.5619483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.0415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.2515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 3.9514601052
MESH:D001862 Bone Resorption bisphenol A 3.2011985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.5917868700
MESH:D001930 Brain Injuries Progesterone 8.6715665606 15380490 15845082
MESH:D001930 Brain Injuries Zinc 8.6717109824
MESH:D002545 Brain Ischemia Plant Extracts 4.0016041641
MESH:D001932 Brain Neoplasms Doxorubicin 3.1717150277
MESH:D001943 Breast Neoplasms marker/mechanism 20562527
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 9.2817474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 9.2817123778
MESH:D001943 Breast Neoplasms Cyclophosphamide 9.2817388661 12006526 18234424 18323546 11325840 15093573 15136595 17020986 16978400
MESH:D001943 Breast Neoplasms decitabine 9.2818320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 9.2817474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 9.2817129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 9.2818628466 18382427 19526202 15692762 16096432 11325840 18695136 17983394 16264153 17426702 15136595 15993339 15939500 16322301 15668708 16826403 15634643 15567936 18234424 16595493 16935488 17369602 16115903 15994142
MESH:D001943 Breast Neoplasms Estradiol 9.2817289903 17018787 12948864 18497071 16675129 17261762 19861407 14630087
MESH:D001943 Breast Neoplasms fulvestrant 9.2818984771
MESH:D001943 Breast Neoplasms Genistein 9.2817200150 16873071 16541309
MESH:D001943 Breast Neoplasms Progesterone 9.2816175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 9.2818629630 21138602 18855134 17261762 11161223 20390343 15668708 20065188 20135344 19487384 18815881 21152245 19189212 19066611 15565566 19288272 19189210 19059307 16202921 16818667 18351453 19244106 19084267 19103187 19221464 16273361 20544844 17049068 17893378 16873071 19142967 19410462 19011961 19200415 19115204 20859285 19155303 18997820 18425577 18821012 19289846 17440819 18984771 17242785 20005174
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.2820435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.4215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.2317687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.6511589617
MESH:D002056 Burns Ethanol 3.9416374292
MESH:D002057 Burns, Chemical Plant Extracts 4.599625245
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7316111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.2216050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.0616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.2116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.7919066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 33.6916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 33.6916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 33.693084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 33.6915073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 33.6919701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 33.6918506893 18056438 17761372 16540662 16288022 19418558 17138121 16807293 17055752 19822196 19539802 18494052 17978847 18978308 10672840 3581430 19052882 11831363 20214788 16698587 16502159 18665156 16569478 10737359 17173139 21159647 18393292 18785209 18788625 17428255 16328049 20727157 19919837 17162532 3084413 19383236 19701751 20084675 19208518 19394651 16878318 16681979 20514400 16830150 18210153 20101231 19171122 19107877 16935385 18971187 19519916 16779866 20512989 18691550 20524982 20432363 19335982 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 33.6916924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 33.6916234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 33.6916924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 33.6915289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 33.6916924424
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 33.6918834353
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 33.6917306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 33.6916924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 33.6917997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.2517123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.1616152834
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.1319014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 8.7116201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 8.7116201981 1485588
MESH:D002292 Carcinoma, Renal Cell ferric nitrilotriacetate 8.718340253
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.4712490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 11.2620419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 11.2619215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 11.266189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 11.2618572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 11.2616543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 2.9717572228
MESH:D006332 Cardiomegaly Ethanol 8.8519332462
MESH:D006332 Cardiomegaly Plant Extracts 8.8517645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 8.8516120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.0115792986 16731534 17928571 15476868 15811867 16952015 16278810 16109756 17924179 17329180 17007740 17519947 16612575 16269455 17382496 17351982 17974986 18627295 16242529 16364871 16455267 17308081 16651473 15505089 17131338
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.1116243910 17334414
MESH:D002311 Cardiomyopathy, Dilated Mercury 5.1110334427
MESH:D002318 Cardiovascular Diseases Genistein 5.7916332659
MESH:D002318 Cardiovascular Diseases Zinc 5.7916936243
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 9.7914694615
MESH:D002386 Cataract Acetaminophen 9.7910977129
MESH:D002386 Cataract Simvastatin 9.7912518039
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 23.586135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 23.5817332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 23.5812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 23.5817174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 23.5818566989
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 23.5819716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 23.5820056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 12.4819052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 12.4816835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 12.4818291259
MESH:D002779 Cholestasis Cyclosporine 10.0419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.0417681005 11677210 16105132 17333356 16919318 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 10.0419176532
MESH:D002971 Cleft Lip Ethanol 3.1515513904
MESH:D002972 Cleft Palate Ethanol 4.7115513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.7116354765 8697196 15668235 15340226 12621046
MESH:D003092 Colitis Selenium 3.0717936198
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.3420423518
MESH:D003110 Colonic Neoplasms 17-(allylamino)-17-demethoxygeldanamycin 4.9215993848
MESH:D003110 Colonic Neoplasms decitabine 4.9217616700
MESH:D003110 Colonic Neoplasms Genistein 4.9217182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.9320501625
MESH:D015179 Colorectal Neoplasms decitabine 2.9318981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9318802399 18259882
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 12.0715095906
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 12.0715095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 12.0714669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.4912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.9710525206
MESH:D019465 Craniofacial Abnormalities Ethanol 5.9715513904 19302082 11873399 15451039 10194807 11198716 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.9715322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.9719769572
MESH:D019465 Craniofacial Abnormalities Zinc 5.9719302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 9.0512952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 9.0514966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 8.5218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 8.5218551238
MESH:D003550 Cystic Fibrosis Simvastatin 4.3119747007
MESH:D003556 Cystitis Cyclophosphamide 4.2418433785 18295254 18372110 11948286 16413132 18483878 12388444 16989017 15643279 17010015 10498854 16651033 18093676 18710439 16614059 12161096 15276878 10700343 12913760 17979934
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.4115213294
MESH:D003704 Dementia Methylmercury Compounds 4.3316140633
MESH:D003711 Demyelinating Diseases Tamoxifen 3.6419031437
MESH:D017449 Dermatitis, Allergic Contact alachlor 5.418428444
MESH:D017449 Dermatitis, Allergic Contact Mercury 5.4116823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.0318249437
MESH:D018500 Diabetes Insipidus, Nephrogenic 17-(allylamino)-17-demethoxygeldanamycin 5.5318854434
MESH:D003920 Diabetes Mellitus Zinc 3.5816479319
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.4615331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 2.9418772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 5.6320387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 5.6316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 5.6317107852
MESH:D003928 Diabetic Nephropathies Estradiol 11.4519279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 11.4519706694
MESH:D003928 Diabetic Nephropathies Tamoxifen 11.4519279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.7817187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 29.7521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 29.7518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 29.7521346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 29.7521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 29.7517562736 12958197 18713872 14725611 12153990 12705907 19164858 15968718 11529661 17522070 19420014 16781746 11743745 16081117 11739529 16227642 19923254 16109766 19370779 18071297 2444490 10915739 16485898 19416960 10663392 17906064 16393943 19085960 12540782 14986274 12594235 19739265 12392966 16177239 10774834 11421492 15619225 11461765 14550746 11287661 11834606
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 29.7519107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 29.7517416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 29.7511566570
MESH:D056486 Drug-Induced Liver Injury pyrazole 29.7512499123
MESH:D056486 Drug-Induced Liver Injury Selenium 29.7515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 29.7520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 29.7512963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.3519426721
MESH:D004362 Drug Toxicity Doxorubicin 6.2218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.2211462148
MESH:C538011 Eales disease Vitamin E 3.969068938
MESH:D004487 Edema bisindolylmaleimide I 18.638273558
MESH:D004487 Edema Mustard Gas 18.6311402378 9260866 11428631 11428647
MESH:D004487 Edema pirinixic acid 18.6312083418
MESH:D004487 Edema Plant Extracts 18.6312787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 18.6311000095 12711302
MESH:D004487 Edema Zymosan 18.637907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.1615322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 11.3112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 11.3117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 11.3119031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 11.5519294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 11.5519294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 9.4616402032
MESH:D004714 Endometrial Hyperplasia Genistein 9.4616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 17.8615700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 17.8617359293
MESH:D016889 Endometrial Neoplasms Estradiol 17.8618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 17.8611473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 17.8617893378 20544844 16202921 19155303
MESH:D004715 Endometriosis Progesterone 6.7916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 6.7910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 11.5818037988
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 11.5815268973
MESH:D004802 Eosinophilia Cyclophosphamide 3.5111006010
MESH:D004827 Epilepsy Plant Extracts 3.3019439326 19700373
MESH:D004890 Erythema Mustard Gas 4.429357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.3716302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 11.0312903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 11.0316530937
MESH:D004938 Esophageal Neoplasms Ethanol 11.0316704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 11.0315547733 16704527 15264214 15150132 16510608 16805852 15878914 15623463 15547721
MESH:D004938 Esophageal Neoplasms Zinc 11.0316543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.4411564622
MESH:D005218 Fat Necrosis Thioacetamide 4.9716456712
MESH:D005234 Fatty Liver arsenic trioxide 31.8015073043
MESH:D005234 Fatty Liver Cyclosporine 31.8019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 31.8021071580 20387270
MESH:D005234 Fatty Liver Ethanol 31.8016409862 18620774 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 31.8015345470
MESH:D005234 Fatty Liver pirinixic acid 31.8020131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 31.8015975614
MESH:D005234 Fatty Liver Tamoxifen 31.8014986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 4.9217920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.5615751030 16513791 16534752 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.5616709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.5616946407 15513904 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.7411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.7914745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.0119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.0119069698
MESH:D005355 Fibrosis Cyclosporine 6.1312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 6.1320067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.5616904648
MESH:D005756 Gastritis Acetaminophen 14.7616983495
MESH:D005756 Gastritis Ethanol 14.7615046732
MESH:D005756 Gastritis Zinc 14.7617241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.2016973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.5516417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.3816452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.3816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.488708960
MESH:D005909 Glioblastoma Doxorubicin 9.0417150277
MESH:D005909 Glioblastoma Genistein 9.0416598420
MESH:D005909 Glioblastoma trichostatin A 9.0418801729
MESH:D018316 Gliosarcoma Cyclophosphamide 4.7811389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.8510696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.3216376943 11014644 15172196
MESH:D006130 Growth Disorders Zinc 3.4517217573
MESH:D006258 Head and Neck Neoplasms decitabine 6.1919215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 6.1915692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 8.5220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 8.5211294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 8.5216080930
MESH:D006331 Heart Diseases Doxorubicin 2.9514766674 17888722 18006777 16330681 16244372 16707910 17875725 12587719 16495754 16244371 16879835 18674790 16144979
MESH:D006333 Heart Failure Doxorubicin 16.9217481944
MESH:D006333 Heart Failure pirinixic acid 16.9220558911
MESH:D006333 Heart Failure Plant Extracts 16.9218097624
MESH:D006333 Heart Failure Selenium 16.9217162251
MESH:D006333 Heart Failure Zinc 16.9217162251
MESH:D006335 Heart Injuries Zinc 5.0217074742
MESH:D016481 Helicobacter Infections Zinc 3.8517241300
MESH:D006394 Hemangiosarcoma Doxorubicin 7.4515692506
MESH:D006394 Hemangiosarcoma Pentachlorophenol 7.4515200160
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.6915720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.5711918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.6711000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 3.9118665440 17276928 15929193
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 4.7914986274
MESH:D006505 Hepatitis Thioacetamide 7.5816456712
MESH:D006505 Hepatitis Zymosan 7.5819110552
MESH:D006527 Hepatolenticular Degeneration Zinc 8.9417276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 8.9417063115
MESH:D006529 Hepatomegaly pirinixic acid 5.9119772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 5.9116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.3916490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.2815709030
MESH:D006561 Herpes Simplex Plant Extracts 3.9010715843
MESH:D015658 HIV Infections marker/mechanism 12878215
MESH:D015658 HIV Infections Plant Extracts 3.2512878215
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.7716135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 8.7718501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 8.7712676792
MESH:D019584 Hot Flashes Estradiol 12.8517088409
MESH:D019584 Hot Flashes Plant Extracts 12.8514716179 16566672 17454163
MESH:D019584 Hot Flashes Vitamin E 12.8514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3018606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 5.8416870215
MESH:D006930 Hyperalgesia Ethanol 5.8418783367
MESH:D006943 Hyperglycemia pirinixic acid 2.5420558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 3.8416484555
MESH:D006949 Hyperlipidemias Plant Extracts 3.8015268973 15975614
MESH:D006938 Hyperlipoproteinemia Type II Simvastatin 4.6116238680
MESH:D006965 Hyperplasia Diethylstilbestrol 3.7212960047 14722030
MESH:D006973 Hypertension Cyclosporine 3.8010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 3.8018670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 8.8616002989
MESH:D007021 Hypospadias Ethinyl Estradiol 8.8616945680 16569931
MESH:D007022 Hypotension Zinc Sulfate 3.807265320
MESH:D007154 Immune System Diseases Cyclophosphamide 4.5816076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.6915869954
MESH:D007246 Infertility Diethylstilbestrol 3.6615036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.7812013081
MESH:D007248 Infertility, Male alachlor 32.6612948887 17049205 16466525
MESH:D007248 Infertility, Male Chlordan 32.669432128
MESH:D007248 Infertility, Male Coumestrol 32.6616892005
MESH:D007248 Infertility, Male Cyclophosphamide 32.667193160 16517039
MESH:D007248 Infertility, Male decitabine 32.6617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 32.6617937319
MESH:D007248 Infertility, Male fulvestrant 32.6611514358
MESH:D007248 Infertility, Male sodium arsenite 32.6615346721 12646999
MESH:D007248 Infertility, Male vinclozolin 32.6616467254
MESH:D007249 Inflammation bisindolylmaleimide I 20.918273558
MESH:D007249 Inflammation Diethylnitrosamine 20.9118785209
MESH:D007249 Inflammation Mustard Gas 20.919260866 11402378 17524151 11428631 8975870 11428647 11428620 9357497 16001271
MESH:D007249 Inflammation Plant Extracts 20.9112787963 19332304 15997105 16366677
MESH:D007249 Inflammation Progesterone 20.9115869954
MESH:D007249 Inflammation Tamoxifen 20.9119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.9112878042 12200463
MESH:D007249 Inflammation Zymosan 20.9111289658 8014878
MESH:D007251 Influenza, Human Selenium 8.4816624496
MESH:D007251 Influenza, Human Vitamin E 8.4816624496
MESH:D007333 Insulin Resistance bisphenol A 9.3016393666
MESH:D007333 Insulin Resistance Estradiol 9.3016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 9.3016306350
MESH:D007414 Intestinal Neoplasms Plant Extracts 3.9712351151 12584176 12628509
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.1017553498
MESH:D007511 Ischemia Zinc 3.9216584753
MESH:D007569 Jaw Abnormalities Ethanol 7.9115513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.9116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.6915604871
MESH:D007674 Kidney Diseases Acetaminophen 38.5715629191 12587719
MESH:D007674 Kidney Diseases Cadmium 38.5716962696 16226777 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 38.5716962696
MESH:D007674 Kidney Diseases Cyclosporine 38.578314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 38.5715369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 38.5715618244
MESH:D007674 Kidney Diseases ferric nitrilotriacetate 38.5718617210 15834431
MESH:D007674 Kidney Diseases Mercury 38.5717934191
MESH:D007674 Kidney Diseases sodium arsenite 38.5720008137
MESH:D007674 Kidney Diseases Vitamin E 38.5712488133
MESH:D007674 Kidney Diseases Zinc 38.5716960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 12.9416707910
MESH:D007676 Kidney Failure, Chronic Selenium 12.9416518626
MESH:D007676 Kidney Failure, Chronic Zinc 12.9416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 25.7716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 25.7716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 25.7712371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 25.7715003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 25.7715610895
MESH:D007680 Kidney Neoplasms ferric nitrilotriacetate 25.779667754 18055543
MESH:D007680 Kidney Neoplasms Tamoxifen 25.7718625569
MESH:D007859 Learning Disorders Diethylstilbestrol 7.4217184923
MESH:D007859 Learning Disorders Ethanol 7.4215451040
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.6615237267
MESH:D007938 Leukemia alachlor 15.2014769641
MESH:D007938 Leukemia arsenic trioxide 15.2015070760
MESH:D007938 Leukemia Cyclophosphamide 15.2010602166
MESH:D007938 Leukemia decitabine 15.2019235587 18980019
MESH:D007938 Leukemia Genistein 15.2017468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.4116085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.1317658394 17802794 17296974 18587576 18172266 17008537
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.1317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.5716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 6.7214633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 6.7210373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 7.3819077051
MESH:D007951 Leukemia, Myeloid decitabine 7.3818454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.0920471514 16467208 17050201 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.0919010910 19387464 18460780 18206229 17679729 18704418
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 5.0918206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.7118055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.7019642359 16331271 16891316 12679006 16112521 15748426 15213294 11161223 16823087 12018890 17107899 17217047 9834237 16966277 19075265 15622746 11468182 19225113 17649720 17869043 19035177 15336539 17712046 16330433 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.6516882451
MESH:D007970 Leukopenia Cyclophosphamide 4.2311830472 10052129
MESH:D007984 Leydig Cell Tumor vinclozolin 4.0016417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.2617676605
MESH:D008064 Lipidoses Tamoxifen 2.6117567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 8.5418665156 18407596 18522880 19638242 20032147
MESH:D008103 Liver Cirrhosis Ethanol 8.5415289165
MESH:D008103 Liver Cirrhosis Plant Extracts 8.5417157831
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.3618295389
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 15.0016439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 15.0014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 15.0018166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 15.0017823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 15.0015474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 15.0015479170
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 15.0018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 15.0012878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 15.0016097051 16126171 12085344 15078482 12679928 18031379 15288473 11682029 10677585 15474484 17355460 15316131 16098781 15158331 18416461 16343077 11481614 17292413 15334695 15288472 18606216 15095483 16489207 18032466 17050028 15716488 12557150 17629604 18615449 18458672 18263696 18295389 14739098 16248980 16511523 18380797 12531686 11172339 18395095 15465738 17127702 12175628 12891558 15075984 15362042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 15.0016169303
MESH:D008107 Liver Diseases Acetaminophen 9.7319784758 16610002 19460945 16611625 19014921 12587719 12969438 11587558
MESH:D008107 Liver Diseases Chlorpyrifos 9.7315991261
MESH:D008107 Liver Diseases Diethylnitrosamine 9.7317034775
MESH:D008107 Liver Diseases Plant Extracts 9.7317034775
MESH:D008107 Liver Diseases Thioacetamide 9.7318374380 15158337 16337175
MESH:D008108 Liver Diseases, Alcoholic Ethanol 3.9417207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 7.4916871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 7.4912479984 15633222 15313186 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 34.007678174
MESH:D008113 Liver Neoplasms arsenic trioxide 34.0014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 34.0021137059 20195826
MESH:D008113 Liver Neoplasms Chlordan 34.002422723
MESH:D008113 Liver Neoplasms Diethylnitrosamine 34.0020405173 18977376 19256749 20101389 19833225 18648771 2862719 12112319 21071580 12771043 18978307 18754104 16942905 20137499 20118626 19254457 19255062 15175105 19642983 19294768 19996281 19426721 21167192 18644402 19551842 19690152 15885732 19638242 20583210 19499222 2422723 19812893 19427195 21278145 20434301 20452335 19073162 9163691 19090486 20492335 10737359 19850985 21047994 20501860
MESH:D008113 Liver Neoplasms Diethylstilbestrol 34.0015890375 16712894
MESH:D008113 Liver Neoplasms Pentachlorophenol 34.0010696769
MESH:D008113 Liver Neoplasms pirinixic acid 34.0020007298 16377806 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 34.0019168119
MESH:D008113 Liver Neoplasms sodium arsenite 34.0016712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 34.0016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 34.0016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 16.892876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.8920377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.8918164116 19009564 3124819 16267830 19004024 19539802 2563599 18544905 17854601 18079962 9362446 18775883 21159647 17174075 17942915 18308698 19519916 16842330 18282651 18253720 19126423 18093689
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 16.8917085340 16842330
MESH:D008114 Liver Neoplasms, Experimental kojic acid 16.8918544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.8912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.7715213294
MESH:D008171 Lung Diseases Mustard Gas 9.3018161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 9.3019095001
MESH:D008171 Lung Diseases Vitamin E 9.3016863852
MESH:D008175 Lung Neoplasms arsenic trioxide 14.7119825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.7118520028 20464547 6695378 18816296 20135361 18569708 20869020 20064080 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.7120970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 14.7117418594 6189445
MESH:D008175 Lung Neoplasms Mustard Gas 14.713148597 8781369
MESH:D008175 Lung Neoplasms Plant Extracts 14.7120869020
MESH:D008175 Lung Neoplasms sodium arsenite 14.7116712894 19931552 17306315 17077188 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 14.7118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.7111884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 14.7111062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.4115166399
MESH:D008223 Lymphoma Cyclophosphamide 17.6312854902
MESH:D008223 Lymphoma decitabine 17.6319470736
MESH:D008223 Lymphoma Diethylstilbestrol 17.6315700306
MESH:D008223 Lymphoma Doxorubicin 17.6316098063
MESH:D008223 Lymphoma Pentachlorophenol 17.6312669308
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 3.9216675587
MESH:D017728 Lymphoma, Large-Cell, Anaplastic marker/mechanism 17157164
MESH:D017728 Lymphoma, Large-Cell, Anaplastic 17-(allylamino)-17-demethoxygeldanamycin 5.8817157164
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 6.9511911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 6.9517654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 3.8515621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.7716002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.0319428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 20.6915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 20.6911807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 20.6914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 20.6917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 20.6915318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 20.6911731420 19196723 14580682 19196722 16827153
MESH:D008325 Mammary Neoplasms, Experimental Zinc 20.6912773700
MESH:D020149 Manganese Poisoning Estradiol 10.1719453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.1719453300
MESH:D008545 Melanoma decitabine 9.9616505122 17785578
MESH:D008545 Melanoma Doxorubicin 9.9616827129
MESH:D008545 Melanoma pyrimidin-2-one beta-ribofuranoside 9.9616505122
MESH:D008545 Melanoma sodium arsenite 9.9616487513 19082730
MESH:D008545 Melanoma Tamoxifen 9.9619393235 12393984
MESH:D008545 Melanoma trichostatin A 9.9616505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.4515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 8.4619513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 8.4616388313
MESH:D008569 Memory Disorders Ethanol 7.7215451040 18411066
MESH:D008569 Memory Disorders Methylmercury Compounds 7.7218436314
MESH:D008654 Mesothelioma Doxorubicin 5.0917638057
MESH:D008654 Mesothelioma Selenium 5.0915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.0416801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.8315792986
MESH:D009041 Motion Sickness Dextroamphetamine 4.771613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.6116381670
MESH:D009069 Movement Disorders Methylmercury Compounds 4.6418436314
MESH:D052016 Mucositis Doxorubicin 4.0617415656
MESH:D009101 Multiple Myeloma alachlor 12.8314769641
MESH:D009101 Multiple Myeloma arsenic trioxide 12.8311468182 19417148 14977855 19549372 15949261
MESH:D009101 Multiple Myeloma decitabine 12.8318172295
MESH:D009101 Multiple Myeloma trichostatin A 12.8318172295
MESH:D009102 Multiple Organ Failure Zymosan 4.5310890648 15241586 12879239 10479408 15213630 18160304 15259001 12130978 17724436 15834315
MESH:D009135 Muscular Diseases pirinixic acid 2.7916239165
MESH:D009175 Mycoplasma Infections Thiopental 5.8810773494
MESH:D009182 Mycosis Fungoides arsenic trioxide 3.9218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 5.9316105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 5.9319157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Doxorubicin 7.3119429709 15857846
MESH:D009203 Myocardial Infarction Genistein 7.3117141266
MESH:D009203 Myocardial Infarction pirinixic acid 7.3119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.4212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 10.7916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 10.7917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 10.7916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 7.9218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 7.9218551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.2616624393
MESH:D009362 Neoplasm Metastasis marker/mechanism 20562527
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 7.413581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 7.4118259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 7.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.3011141357
MESH:D009369 Neoplasms Cyclophosphamide 14.3018854779
MESH:D009369 Neoplasms decitabine 14.3019116145 19470736 17925555
MESH:D009369 Neoplasms Diethylstilbestrol 14.3015313581
MESH:D009369 Neoplasms pirinixic acid 14.3017405874
MESH:D009369 Neoplasms sodium arsenite 14.3011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 2.9620056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.2619196722 19189210 19200415
MESH:D018301 Neoplasms, Mesothelial Pentachlorophenol 5.9110696769
MESH:D009389 Neovascularization, Pathologic Estradiol 3.0117289903
MESH:D009401 Nephrosis Doxorubicin 4.0516636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.6917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.2018481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.2015640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 23.4116427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 23.4111399458
MESH:D009421 Nervous System Malformations Estradiol 23.4111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 23.4116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 23.4114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 5.6110525206
MESH:D009436 Neural Tube Defects sodium arsenite 5.6112854658
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.4717168769
MESH:D009447 Neuroblastoma Cyclophosphamide 5.768761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 5.7615555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.1518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.1520387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.1612837982 8761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.3720387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.6415081274
MESH:D009503 Neutropenia Cyclophosphamide 7.288291058
MESH:D009503 Neutropenia Mustard Gas 7.287688884 16761898
MESH:D009669 Nose Neoplasms alachlor 4.1016178123 16698726 14563481 11127290 15580706
MESH:D009765 Obesity pirinixic acid 3.9220558911
MESH:D009765 Obesity Plant Extracts 3.9219056576 20132043
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 11.4316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 11.4316049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 11.4314694615
MESH:D009845 Oligospermia Cyclophosphamide 3.9816517039
MESH:D010024 Osteoporosis Genistein 2.7719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.4116169203
MESH:D012516 Osteosarcoma Doxorubicin 3.5115930896
MESH:D010049 Ovarian Diseases bisphenol A 4.2511985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 21.7616624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms CD 437 21.7617474084
MESH:D010051 Ovarian Neoplasms decitabine 21.7619331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 21.7619401270
MESH:D010051 Ovarian Neoplasms Genistein 21.7619005980
MESH:D010051 Ovarian Neoplasms Progesterone 21.7617393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 21.7617306315 15276417
MESH:D010051 Ovarian Neoplasms trichostatin A 21.7619331143
MESH:D010146 Pain Acetaminophen 4.8716870215
MESH:D010146 Pain Cyclophosphamide 4.8712161096 18093676
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 16.1415580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 16.1411332152
MESH:D010190 Pancreatic Neoplasms decitabine 16.1419294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 16.1416540662
MESH:D010190 Pancreatic Neoplasms Ethanol 16.1412384795
MESH:D010190 Pancreatic Neoplasms trichostatin A 16.1419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0011578682
MESH:D010212 Papilloma Plant Extracts 3.7915173996 16517061
MESH:D010235 Paraganglioma arsenic trioxide 3.4819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5012520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.6515687053
MESH:D010538 Peritonitis Zymosan 4.1718557954 17371808 15259001 11985352 19088179 15979727 19641140 18760300 17826846 14761945 18977430
MESH:D003557 Phyllodes Tumor Doxorubicin 4.4117983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.4214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 3.9516977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.1415087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.4117638057
MESH:D011041 Poisoning Mustard Gas 3.1315727166
MESH:D011085 Polycystic Ovary Syndrome Simvastatin 4.6917105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.8618163543
MESH:D011230 Precancerous Conditions Cyclosporine 6.8512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 6.852563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.3421297632
MESH:D011225 Pre-Eclampsia Zinc 3.5917114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 22.7910548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 22.7917184923
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 22.7918436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 22.7911896295 11399792 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 22.7919015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 10.0517616702
MESH:D055728 Primary Myelofibrosis trichostatin A 10.0517616702
MESH:D011469 Prostatic Diseases vinclozolin 4.2018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.3420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.3420887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 7.6819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 7.6817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 7.6816740699
MESH:D011471 Prostatic Neoplasms Cadmium 7.6817075824
MESH:D011471 Prostatic Neoplasms Coumestrol 7.6816921512
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 7.6817136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 7.6815846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 7.6815749863 18437689 16868541 16729912 16888761 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 7.6816740699
MESH:D011471 Prostatic Neoplasms Genistein 7.6815378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Plant Extracts 7.6814666653 17804756
MESH:D011471 Prostatic Neoplasms sodium arsenite 7.6816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 7.6815067354
MESH:D011471 Prostatic Neoplasms trichostatin A 7.6819789329 18798265
MESH:D011471 Prostatic Neoplasms Vitamin E 7.6815084515
MESH:D011471 Prostatic Neoplasms Zinc 7.6816700911 12429649 16606632 16517595
MESH:D011472 Prostatitis vinclozolin 4.2018629315
MESH:D011537 Pruritus Ethinyl Estradiol 7.1116919318 15861022
MESH:D011537 Pruritus Mustard Gas 7.1118058305
MESH:D011565 Psoriasis Cyclosporine 1.9216882103
MESH:D011629 Puberty, Precocious bisphenol A 4.0510548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 4.8416636934
MESH:D011658 Pulmonary Fibrosis Mustard Gas 4.8417894541 17720292 17266442 10334151 17620002
MESH:D051437 Renal Insufficiency Doxorubicin 3.5117922066
MESH:D015427 Reperfusion Injury pirinixic acid 1.9819058328
MESH:D012135 Respiratory Sounds alachlor 7.9011874814
MESH:D012135 Respiratory Sounds Chlorpyrifos 7.9011874814 16611668 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.1418990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.1516611668 17119214
MESH:D012162 Retinal Degeneration Zinc 3.5516584753
MESH:D012208 Rhabdomyosarcoma decitabine 3.7219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.5418045962
MESH:D012509 Sarcoma Doxorubicin 3.3516767912 18313854 15625365 15675481 17710206 17203757
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 7.9616646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 7.9616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.0617846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.1416636934
MESH:D012640 Seizures 2,4-dinitrotoluene 6.8118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.8118551238
MESH:D012640 Seizures Ethanol 6.819754883
MESH:D018805 Sepsis Zymosan 4.0311441115
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.346418539
MESH:D012871 Skin Diseases monomethylarsonous acid 6.5517431481
MESH:D012871 Skin Diseases Mustard Gas 6.5512880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin E 6.5518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.1719755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 17.1715692506
MESH:D012878 Skin Neoplasms Plant Extracts 17.1715173996 16517061
MESH:D012878 Skin Neoplasms sodium arsenite 17.1719524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 17.178532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.1716192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.8515625365 17203757 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 15.8316002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 15.8316709447
MESH:D013088 Spermatocele Tamoxifen 15.8316709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.7816517039
MESH:D013119 Spinal Cord Injuries Progesterone 8.4415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.4419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.2112854658
MESH:D013160 Splenic Neoplasms Pentachlorophenol 5.5610696769
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.7517007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.7520155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 6.7519037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.7518456281
MESH:D013274 Stomach Neoplasms Ethanol 6.7518456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 6.7517575124 12958204
MESH:D013276 Stomach Ulcer Ethanol 5.559211565 17918041 17189318 11906479 9562338 16755016
MESH:D013276 Stomach Ulcer Plant Extracts 5.5518237397 17135157 18193104 12787963 15255614
MESH:D020521 Stroke Vitamin E 2.9316517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.2616684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.619754883
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.3212837982
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.7317997062
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 8.4315864552
MESH:D013733 Testicular Diseases pyrazole 8.436499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.9411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.5315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.1612697716
MESH:D013964 Thyroid Neoplasms alachlor 16.398812207
MESH:D013964 Thyroid Neoplasms arsenic trioxide 16.3919014326
MESH:D013964 Thyroid Neoplasms decitabine 16.3917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.397505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 16.3917909728 16010429
MESH:D013978 Tibial Fractures Estradiol 3.9419048282
MESH:D014062 Tongue Neoplasms Zinc 3.7516543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.2315213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 37.7816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 37.7816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 37.7811780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 37.7817053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 37.7816720286
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 37.7814692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 37.7817616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 37.7816712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 37.7817653716
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 37.7820375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 37.7816712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 37.7816712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 9.5610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 9.5610091137
MESH:D014581 Urticaria Acetaminophen 2.3110982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 7.4016175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 7.4011813266
MESH:D014591 Uterine Diseases bisphenol A 11.3314652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.3314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.1615809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.1614692618
MESH:D014604 Uveal Neoplasms decitabine 4.1717785578
MESH:D014605 Uveitis Cyclosporine 9.501336536
MESH:D014605 Uveitis Zymosan 9.5011006244
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.7216513791 16002989
MESH:D014652 Vascular Diseases sodium arsenite 3.6917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.8512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.8714671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.1317334414 17638931 16364871 17678736
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 8.1318097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.5818097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5015886252
MESH:D014947 Wounds and Injuries Plant Extracts 3.6520213670 19894650
MESH:D014985 Xerophthalmia Cyclosporine 3.6917120751
Pathway ID Pathway Name
KEGG:04612 Antigen processing and presentation
REACT:18266 Axon guidance
REACT:152 Cell Cycle, Mitotic
REACT:12508 Metabolism of nitric oxide
KEGG:04621 NOD-like receptor signaling pathway
KEGG:05200 Pathways in cancer
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:05215 Prostate cancer
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29519
    • Releated gene ID Related gene Name
    PA24684AKT1
    PA7360EGFR
    PA27844ERBB2
    PA33148PDGFRB
    Releated disease ID Related disease Name
    PA443450Asthma
    PA443560Breast Neoplasms
    PA443899Diarrhea
    PA443937Drug Toxicity
    PA444153Fatigue
    PA445062Neoplasms
    PA164925725Toxic liver disease
    PA444354Headache
    PA445846Thrombocytopenia
    PA446051Vomiting
    Releated drug ID Related drug Name
    PA448691busulfan
    PA449773glucose
    PA164778686pyruvic acid
    PA161990676tetrahydrobiopterin
    PA448547beclomethasone
    PA164754818betamethasone
    PA448681budesonide
    PA164781399ciclesonide
    PA164776996desonide
    PA449247dexamethasone
    PA449661flunisolide
    PA449686fluticasone propionate
    PA452347glucocorticoids
    PA449905hydrocortisone
    PA450466methylprednisolone
    PA450541mometasone
    PA164777035paramethasone
    PA451096prednisolone
    PA451100prednisone
    PA164752251rimexolone
    PA451749triamcinolone
    PA164744376adenosine monophosphate
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA164743471adenosine triphosphate
    PA152031327geldanamycin
    PA165291491alvespimycin
    PA165291490tanespimycin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00615 other/unknown Rifabutin Anti-Bacterial Agents;Antibiotics, Antitubercular
    DB00716 - Nedocromil Anti-Asthmatic Agents;Anti-inflammatory Agents;Anti-Allergic Agents
    DB02359 - 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine
    DB02424 - Geldanamycin Antiviral Agents;Enzyme Inhibitors;Antibiotics, Antineoplastic;Cysteine Proteinase Inhibitors
    DB02550 - 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
    DB02754 - 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine
    DB02840 - 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid
    DB03080 - 17-Dmag
    DB03093 - 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
    DB03137 - 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine
    DB03431 - Adenosine-5'-Diphosphate
    DB03504 - 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine
    DB03684 - 2-Methyl-2,4-Pentanediol
    DB03749 - 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole
    DB03809 - 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine
    DB03899 - 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine
    DB04054 - 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
    DB04254 - 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine
    DB04505 - 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
    DB04588 - N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
    DB06956 - N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
    DB06957 - 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
    DB06958 - 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE
    DB06961 - 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide
    DB06964 - 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE
    DB06969 - 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
    DB07100 - 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
    DB07317 - (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one
    DB07319 - 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE
    DB07324 - 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE
    DB07325 - N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE
    DB07495 - 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
    DB07502 - 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol
    DB07594 - 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL
    DB07601 - 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol
    DB07877 - 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
    DB08194 - 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine
    DB08197 - (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime
    DB08436 - 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-
    DB08442 - 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol
    DB08443 - 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol
    DB08557 - 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide
    DB08786 - 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine
    DB08787 - 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine
    DB08788 - 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE
    DB08789 - 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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