AutismKB 2.0

Annotation Detail for NDST1


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Basic Information Top
Gene Symbol:NDST1 ( HSST,NST1 )
Gene Full Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Band: 5q33.1
Quick LinksEntrez ID:3340; OMIM: 600853; Uniprot ID:NDST1_HUMAN; ENSEMBL ID: ENSG00000070614; HGNC ID: 7680
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6564heparan sulfate biosynthesis
PWY-6558heparan sulfate biosynthesis (late stages)
Pathway IDPathway Name
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate
hsa01100Metabolic pathways
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of NDST1 mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NDST1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NDST1 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NDST1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of NDST1 mRNAincreases expression 20458559
D005419 Flavonoids Flavonoids results in increased expression of NDST1 mRNAincreases expression 18035473
D005492 Folic Acid Folic Acid affects the expression of NDST1 mRNAaffects expression 17320366
C006253 pirinixic acid pirinixic acid results in decreased expression of NDST1 mRNAdecreases expression 17950772
17426115
18445702
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of NDST1 mRNA]decreases expression|increases reaction 17950772
C488333 Ro 65-7199 Ro 65-7199 affects the expression of NDST1 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of NDST1 mRNAaffects expression 14610520
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D058186 Acute Kidney Injury Folic Acid 4.5316316344 16595132 17003819
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3319825857 11798837
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.383712494
MESH:D000236 Adenoma Folic Acid 7.3816963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000544 Alzheimer Disease Folic Acid 3.0817116317
MESH:D001321 Autistic Disorder Folic Acid 2.8221388746
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.6919483382
MESH:D001943 Breast Neoplasms Folic Acid 3.1516777985
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.743581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7416217749 15073043 14691202 11135700 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002318 Cardiovascular Diseases Folic Acid 4.0916755160
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.126135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.127505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.3519486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D002971 Cleft Lip Folic Acid 4.0721254359
MESH:D002972 Cleft Palate Folic Acid 3.6421254359 8946559
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8420501625
MESH:D015179 Colorectal Neoplasms Folic Acid 2.8416963246 17245555 17116713 16985020 17087956
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities marker/mechanism 16020517
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0612868966 8156756 8970840 11906362 11298694 14531868 18759878 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.1716886840
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.0218692083 16192314 8291058 9328219 18289764 6482804 9653073 7440962 1440618 11289319 18648102 9022650 6679447
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D016889 Endometrial Neoplasms Folic Acid 4.1317301261
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.623581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6212903497
MESH:D017889 Exfoliation Syndrome Folic Acid 5.7816504073
MESH:D005124 Eye Abnormalities marker/mechanism 16020517
MESH:D005234 Fatty Liver arsenic trioxide 8.4115073043
MESH:D005234 Fatty Liver pirinixic acid 8.4119236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005756 Gastritis Folic Acid 5.4117171786
MESH:D005901 Glaucoma Folic Acid 5.3016504073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006330 Heart Defects, Congenital Folic Acid 3.8916524890 17286298
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly pirinixic acid 3.2516221962 19772884 18467677 19176532
MESH:D006679 HIV Seropositivity Folic Acid 5.7817209195
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.6816395265 16433478 16755160 16397167 16865747
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007249 Inflammation Flavonoids 2.7417296493
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.946582329
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 19850784 20471514 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3415622746 16966277 12712474 15336539 17869043 11161223 17649720 12679006 16112521 19642359 16891316 16330433 9834237 15748426 17712046 16331271 19035177 17217047 19075265 12018890 15213294 19225113 11468182 17107899 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Folic Acid 3.0816877991
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.817678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8114682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.8120007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.572876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.57598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.5720377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3817718048
MESH:D054220 Malformations of Cortical Development marker/mechanism 16020517
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.9816832597
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2519417148 11468182 14977855 15949261 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1518551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 13.006679447
MESH:D009436 Neural Tube Defects arsenic trioxide 13.0010525206
MESH:D009436 Neural Tube Defects Folic Acid 13.0017438019
MESH:D009503 Neutropenia Folic Acid 4.7216322990
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.544026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4616624393 19769630 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2419131511
MESH:D051437 Renal Insufficiency Folic Acid 5.0415728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012559 Schizophrenia Folic Acid 2.9216641680
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D012871 Skin Diseases Folic Acid 3.2918709164
MESH:D013118 Spinal Cord Diseases Folic Acid 5.7816361298
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.8317007042
MESH:D013274 Stomach Neoplasms Folic Acid 2.8317171786
MESH:D020521 Stroke Folic Acid 4.4916517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.683712494 6587162 7505956 6582329 1399818
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.6819014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.728074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7211780464 12845720 20435036 12973940
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
Pathway ID Pathway Name
KEGG:00534 Glycosaminoglycan biosynthesis - heparan sulfate
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01812 - Adenosine-3'-5'-Diphosphate
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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