AutismKB 2.0

Annotation Detail for APOA1


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Basic Information Top
Gene Symbol:APOA1 ( MGC117399 )
Gene Full Name: apolipoprotein A-I
Band: 11q23.3
Quick LinksEntrez ID:335; OMIM: 107680; Uniprot ID:APOA1_HUMAN; ENSEMBL ID: ENSG00000118137; HGNC ID: 600
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03320PPAR signaling pathway
Pathway IDPathway Name
Transmembrane transport of small molecules
Hemostasis
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200073FOXA2 and FOXA3 transcription factor networks
No data
Pathway IDPathway Name
500331ABC-family proteins mediated transport
500795Lipoprotein metabolism
500797HDL-mediated lipid transport
500796Chylomicron-mediated lipid transport
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1712Yersinia infection
1740Alzheimer's disease
1767Immunologic deficiency syndrome
1781Rheumatoid arthritis
1837Polyneuropathy
1870Drug abuse
1904Diabetes mellitus
1924Gallbladder disease
1963Amyloidosis
1981Metastatic cancer to brain
1992Aortic valve disease
2007Liver tumor
2022Liver cancer
2049Hyperuricemia
2053Colon cancer
2066Lung cancer
2069Schizophrenia
2070Cholelithiasis
2097Hyperlipidemia
2099Hepatitis B
2118Adenovirus infection
2236Cardiovascular disease
Desease Name
hypercholesterolemia
HDL cholesterol
cholesterol cholesterol, HDL cholesterol, LDL lipoprotein triglycerides
stroke, hemorrhagic
cholesterol, HDL
coronary atherosclerosis
Atherosclerosis
atherosclerosis, coronary
cerebral infarct
CARDIOVASCULAR
reduced expression of the apolipoprotein A-I gene and resolution of disputed paternity
myocardial infarct
cholesterol, LDL
Alzheimer's disease
Lp(a)
cardiac and cutaneous amyloidosis
stroke, ischemic
lipids
plasma high density lipoprotein cholesterol and apolipoprotein AI
multiple sclerosis
lipoprotein
decreased production rate of apolipoprotein A-I
cardiovascular
IMMUNE
NEUROLOGICAL
hyperlipidemia
METABOLIC
brain aneurysm
LDL cholesterol
triglycerides
reduced HDL cholesterol and LpA-I
premature coronary artery disease and familial hypoalphalipoproteinemia
cholesterol, total
familial combined hyperlipidaemia.
apolipoprotein A-I levels
diabetes, type 2
hyperalphalipoproteinemia
carotid atherosclerosis
elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations
elevated serum apolipoprotein AI levels
gallstones
Desease Name
HDL cholesterol
Cholesterol, total
Triglycerides
LDL cholesterol
Desease Name
Corneal clouding, autosomal recessive
Amyloidosis, 3 or more types
Hypoalphalipoproteinemia
ApoA-I and apoC-III deficiency, combined
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C060229 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
C038237 1-oleoyl-2-acetylglycerol 1-oleoyl-2-acetylglycerol inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
C046728 2,2'-azobis(2-amidinopropane) 2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 proteinincreases oxidation 12576517
C046728 2,2'-azobis(2-amidinopropane) [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]affects cotreatment|decreases reaction|increases oxidation 12576517
C046728 2,2'-azobis(2-amidinopropane) Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]decreases reaction|increases oxidation 12576517
C046728 2,2'-azobis(2-amidinopropane) Pentetic Acid inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]decreases reaction|increases oxidation 12576517
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene results in decreased expression of APOA1 mRNAdecreases expression 16917068
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of APOA1 mRNAaffects expression 21346803
C076996 27-hydroxycholesterol 27-hydroxycholesterol promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|increases reaction|increases secretion 20083572
C076996 27-hydroxycholesterol 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]affects cotreatment|increases reaction|increases secretion 20083572
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal binds to APOA1 proteinaffects binding 18778096
C041594 4-nonylphenol 4-nonylphenol affects the expression of APOA1 mRNAaffects expression 15792627
C418762 9,12-dioxo-10-dodecenoic acid 9,12-dioxo-10-dodecenoic acid binds to APOA1 proteinaffects binding 18778096
C119006 9-hydroxy-12-oxo-10(E)-dodecenoic acid 9-hydroxy-12-oxo-10(E)-dodecenoic acid binds to APOA1 proteinaffects binding 18778096
D000082 Acetaminophen Acetaminophen affects the expression of APOA1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen affects the expression of APOA1 proteinaffects expression 16099942
D000171 Acrolein Acrolein affects the metabolism of APOA1 proteinaffects metabolic processing 16126721
16037261
D000171 Acrolein [Acrolein affects the metabolism of APOA1 protein] which results in decreased secretion of Cholesterolaffects metabolic processing|decreases secretion 16126721
D000171 Acrolein Acrolein inhibits the reaction [APOA1 protein affects the transport of Cholesterol]affects transport|decreases reaction 16037261
C038518 acrylodan acrylodan binds to APOA1 proteinaffects binding 11087425
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of APOA1 proteinaffects expression 20106945
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
D016718 Arachidonic Acid Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D016718 Arachidonic Acid Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of APOA1 mRNAaffects cotreatment|increases expression 16532367
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of APOA1 mRNAincreases expression 20440473
C532858 biotinylated linoleoylglycerylphosphatidylcholine biotinylated linoleoylglycerylphosphatidylcholine binds to APOA1 proteinaffects binding 18778096
C006780 bisphenol A bisphenol A results in decreased expression of APOA1 mRNAdecreases expression 17912697
16835292
C006780 bisphenol A bisphenol A results in increased expression of APOA1 mRNAincreases expression 18418863
C006780 bisphenol A bisphenol A results in increased expression of APOA1 proteinincreases expression 18418863
C053342 brevetoxin brevetoxin analog results in decreased expression of APOA1 mRNAdecreases expression 14529743
D002084 Butylated Hydroxytoluene [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]affects cotreatment|decreases reaction|increases oxidation 12576517
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]decreases reaction|increases oxidation 12576517
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of APOA1 mRNAincreases expression 15816358
D002251 Carbon Tetrachloride Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of APOA1 mRNA]decreases reaction|increases expression 15816358
D002635 Chenodeoxycholic Acid Chenodeoxycholic Acid results in decreased expression of APOA1 proteindecreases expression 19445040
D002784 Cholesterol 1-oleoyl-2-acetylglycerol inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D002784 Cholesterol [Acrolein affects the metabolism of APOA1 protein] which results in decreased secretion of Cholesterolaffects metabolic processing|decreases secretion 16126721
D002784 Cholesterol Acrolein inhibits the reaction [APOA1 protein affects the transport of Cholesterol]affects transport|decreases reaction 16037261
D002784 Cholesterol APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]affects reaction|increases transport 16118212
D002784 Cholesterol APOA1 protein promotes the reaction [ABCA1 protein results in increased export of Cholesterol]increases export|increases reaction 15983222
D002784 Cholesterol APOA1 protein results in increased secretion of Cholesterolincreases secretion 20056921
12531903
D002784 Cholesterol Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D002784 Cholesterol CYP27A1 protein promotes the reaction [APOA1 protein results in increased secretion of Cholesterol]increases reaction|increases secretion 12531903
D002784 Cholesterol fingolimod promotes the reaction [APOA1 protein results in increased secretion of Cholesterol]increases reaction|increases secretion 20056921
D002784 Cholesterol Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D002784 Cholesterol mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]affects reaction|decreases reaction|increases export 16118212
D002784 Cholesterol Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D002784 Cholesterol palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D002784 Cholesterol PLD2 protein affects the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]affects reaction|increases export 16118212
D002784 Cholesterol PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]affects reaction|decreases reaction|increases export 16118212
D002784 Cholesterol 27-hydroxycholesterol promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|increases reaction|increases secretion 20083572
D002784 Cholesterol 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]affects cotreatment|increases reaction|increases secretion 20083572
D002784 Cholesterol [Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterolaffects cotreatment|increases secretion 20083572
D002784 Cholesterol Cholesterol results in decreased expression of APOA1 proteindecreases expression 16115471
D002784 Cholesterol Probucol inhibits the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|decreases reaction|increases secretion 20083572
D002784 Cholesterol Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]affects cotreatment|decreases reaction|increases reaction|increases secretion 20083572
D002784 Cholesterol STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|increases reaction|increases secretion 20083572
D002784 Cholesterol [TO-901317 co-treated with APOA1 protein] results in increased secretion of Cholesterolaffects cotreatment|increases secretion 20083572
D002784 Cholesterol TO-901317 promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|increases reaction|increases secretion 20083572
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APOA1 mRNAaffects cotreatment|increases expression 19509184
D008076 Cholesterol, HDL Fatty Acids, Unsaturated affects the reaction [APOA1 promoter SNP affects the abundance of Cholesterol, HDL]affects abundance|affects reaction 11756058
D008076 Cholesterol, HDL PON1 protein binds to [APOA1 protein binds to Cholesterol, HDL]affects binding 16128586
C017133 chromous chloride chromous chloride affects the expression of APOA1 mRNAaffects expression 12679171
D016572 Cyclosporine Cyclosporine results in decreased expression of APOA1 mRNAdecreases expression 20106945
C017160 cypermethrin cypermethrin results in increased expression of APOA1 mRNAincreases expression 9650644
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of APOA1 mRNAdecreases expression 18709148
D003907 Dexamethasone Dexamethasone affects the expression of APOA1 mRNAaffects expression 15102944
D003994 Bucladesine 27-hydroxycholesterol promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|increases reaction|increases secretion 20083572
D003994 Bucladesine 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]affects cotreatment|increases reaction|increases secretion 20083572
D003994 Bucladesine [Bucladesine co-treated with APOA1 protein] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 20083572
D003994 Bucladesine [Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterolaffects cotreatment|increases secretion 20083572
D003994 Bucladesine Probucol inhibits the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|decreases reaction|increases secretion 20083572
D003994 Bucladesine Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]affects cotreatment|decreases reaction|increases reaction|increases secretion 20083572
D003994 Bucladesine STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased expression of ABCA1 mRNA]affects cotreatment|increases expression|increases reaction 20083572
D003994 Bucladesine STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|increases reaction|increases secretion 20083572
D003994 Bucladesine TO-901317 promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|increases reaction|increases secretion 20083572
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APOA1 mRNAaffects cotreatment|increases expression 19509184
D004052 Diethylnitrosamine [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of APOA1 proteinaffects cotreatment|increases expression 20935162
C056213 dioleoyl ethylene glycol dioleoyl ethylene glycol inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of APOA1 mRNAaffects cotreatment|increases expression 16532367
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]decreases expression|decreases reaction 16297877
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal results in increased expression of APOA1 mRNAincreases expression 16297877
D004365 Drugs, Chinese Herbal PPARA protein affects the reaction [Drugs, Chinese Herbal inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
D004365 Drugs, Chinese Herbal PPARA protein affects the reaction [Drugs, Chinese Herbal results in increased expression of APOA1 mRNA]affects reaction|increases expression 16297877
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of APOA1 mRNAdecreases expression 17912697
16835292
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of APOA1 mRNAdecreases expression 17606305
16872691
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APOA1 mRNAaffects cotreatment|increases expression 17942748
D005231 Fatty Acids, Unsaturated Fatty Acids, Unsaturated affects the reaction [APOA1 promoter SNP affects the abundance of Cholesterol, HDL]affects abundance|affects reaction 11756058
D011345 Fenofibrate Fenofibrate results in decreased expression of APOA1 proteindecreases expression 19445040
C098720 fingolimod fingolimod promotes the reaction [APOA1 protein results in increased secretion of Cholesterol]increases reaction|increases secretion 20056921
D005419 Flavonoids Flavonoids results in decreased expression of APOA1 mRNAdecreases expression 18035473
D005485 Flutamide Flutamide results in decreased expression of APOA1 mRNAdecreases expression 16835292
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APOA1 mRNAaffects cotreatment|increases expression 19509184
D005632 Fructose Fructose results in increased expression of APOA1 mRNAincreases expression 9322794
D005632 Fructose Fructose results in increased expression of APOA1 proteinincreases expression 9322794
C055328 ginsenoside Rf ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]decreases expression|decreases reaction 16297877
C055328 ginsenoside Rf ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 protein]decreases expression|decreases reaction 16297877
C055328 ginsenoside Rf ginsenoside Rf results in decreased expression of APOA1 proteindecreases expression 16297877
C055328 ginsenoside Rf PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
D036145 Ginsenosides Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]decreases expression|decreases reaction 16297877
D036145 Ginsenosides Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOA1 protein]decreases expression|decreases reaction 16297877
D036145 Ginsenosides Ginsenosides results in decreased expression of APOA1 proteindecreases expression 16297877
D036145 Ginsenosides Ginsenosides results in increased expression of APOA1 mRNAincreases expression 16297877
D036145 Ginsenosides PPARA protein affects the reaction [Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
D036145 Ginsenosides PPARA protein affects the reaction [Ginsenosides results in increased expression of APOA1 mRNA]affects reaction|increases expression 16297877
D005947 Glucose Glucose results in decreased expression of APOA1 mRNAdecreases expression 9668074
D005947 Glucose Glucose results in increased expression of APOA1 mRNAincreases expression 9322794
D005947 Glucose Glucose results in increased expression of APOA1 proteinincreases expression 9322794
D005990 Glycerol Glycerol analog promotes the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]increases expression|increases reaction 19013290
D018684 Glycine Agents Glycine Agents results in increased expression of APOA1 mRNAincreases expression 16532367
C010972 glycolaldehyde glycolaldehyde inhibits the reaction [ABCA1 protein binds to APOA1 protein]affects binding|decreases reaction 15983222
D006037 Glyoxal Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]affects binding|decreases reaction 15983222
C412815 GW 4064 GW 4064 results in decreased expression of APOA1 proteindecreases expression 19445040
C453899 GW 7647 GW 7647 results in increased expression of APOA1 proteinincreases expression 19445040
C051140 iron(II)-ascorbic acid complex iron(II)-ascorbic acid complex results in decreased expression of APOA1 proteindecreases expression 10898742
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of APOA1 mRNAaffects cotreatment|increases expression 16532367
C060893 L 663536 L 663536 inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]decreases expression|decreases reaction 19883121
C060893 L 663536 L 663536 results in decreased expression of APOA1 proteindecreases expression 19883121
C099406 L 742694 L 742694 affects the expression of APOA1 mRNAaffects expression 15102944
C037500 mastoparan mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]affects reaction|decreases reaction|increases export 16118212
C003297 nandrolone decanoate nandrolone decanoate results in decreased expression of APOA1 proteindecreases expression 16153628
D019829 Nevirapine Nevirapine results in increased expression of APOA1 proteinincreases expression 19667106
D005996 Nitroglycerin Nitroglycerin results in decreased expression of APOA1 mRNAdecreases expression 12102619
D019787 Linoleic Acid Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D019787 Linoleic Acid Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D019787 Linoleic Acid PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]affects reaction|decreases reaction|increases export 16118212
D019301 Oleic Acid Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D019301 Oleic Acid Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
C008757 palmitoleic acid palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
C008757 palmitoleic acid palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D004369 Pentetic Acid [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]affects cotreatment|decreases reaction|increases oxidation 12576517
D004369 Pentetic Acid Pentetic Acid inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]decreases reaction|increases oxidation 12576517
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of APOA1 mRNAdecreases expression 17681415
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of APOA1 mRNAdecreases expression 18709148
D010634 Phenobarbital Phenobarbital affects the expression of APOA1 proteinaffects expression 16099942
D010634 Phenobarbital [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of APOA1 proteinaffects cotreatment|increases expression 20935162
D010672 Phenytoin Phenytoin results in increased expression of APOA1 mRNAincreases expression 15136057
D010716 Phosphatidylinositols 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
D010716 Phosphatidylinositols anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
D010716 Phosphatidylinositols dioleoyl ethylene glycol inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
D010716 Phosphatidylinositols Glycerol analog promotes the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]increases expression|increases reaction 19013290
D010716 Phosphatidylinositols MAPK1 protein affects the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]affects reaction|increases expression 19013290
D010716 Phosphatidylinositols MAPK3 protein affects the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]affects reaction|increases expression 19013290
D010716 Phosphatidylinositols Phosphatidylinositols results in decreased degradation of APOA1 proteindecreases degradation 19013290
D010716 Phosphatidylinositols Phosphatidylinositols results in increased expression of APOA1 proteinincreases expression 19013290
D010716 Phosphatidylinositols sulindac sulfide inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
D010716 Phosphatidylinositols tricyclodecane-9-yl-xanthogenate inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
D010716 Phosphatidylinositols U 0126 inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
D010743 Phospholipids APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]affects reaction|increases transport 16118212
D010743 Phospholipids Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D010743 Phospholipids Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D010743 Phospholipids Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D010743 Phospholipids palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
C006253 pirinixic acid [pirinixic acid co-treated with SB 203580] inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]affects cotreatment|decreases expression|decreases reaction 19883121
C006253 pirinixic acid [pirinixic acid co-treated with U 0126] inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]affects cotreatment|decreases expression|decreases reaction 19883121
C006253 pirinixic acid pirinixic acid results in decreased expression of APOA1 proteindecreases expression 19883121
C006253 pirinixic acid pirinixic acid results in increased expression of APOA1 mRNAincreases expression 19883121
C006253 pirinixic acid pirinixic acid results in increased expression of APOA1 proteinincreases expression 19445040
C006253 pirinixic acid Drugs, Chinese Herbal inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]decreases expression|decreases reaction 16297877
C006253 pirinixic acid ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]decreases expression|decreases reaction 16297877
C006253 pirinixic acid ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 protein]decreases expression|decreases reaction 16297877
C006253 pirinixic acid Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]decreases expression|decreases reaction 16297877
C006253 pirinixic acid Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOA1 protein]decreases expression|decreases reaction 16297877
C006253 pirinixic acid pirinixic acid results in decreased expression of APOA1 mRNAdecreases expression 16297877
C006253 pirinixic acid pirinixic acid results in decreased expression of APOA1 proteindecreases expression 16297877
C006253 pirinixic acid PPARA protein affects the reaction [Drugs, Chinese Herbal inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
C006253 pirinixic acid PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
C006253 pirinixic acid PPARA protein affects the reaction [Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
C006253 pirinixic acid pirinixic acid affects the expression of APOA1 proteinaffects expression 16099942
D011341 Probucol Probucol inhibits the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|decreases reaction|increases secretion 20083572
D011341 Probucol Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]affects cotreatment|decreases reaction|increases reaction|increases secretion 20083572
D015232 Dinoprostone Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of APOA1 mRNA]decreases reaction|increases expression 15816358
C009159 rapeseed oil rapeseed oil affects the expression of APOA1 mRNAaffects expression 16177195
C093642 SB 203580 [pirinixic acid co-treated with SB 203580] inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]affects cotreatment|decreases expression|decreases reaction 19883121
C017947 sodium arsenite sodium arsenite results in decreased expression of APOA1 mRNAdecreases expression 17450228
C025462 sulindac sulfide sulindac sulfide inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
D013629 Tamoxifen Tamoxifen results in increased expression of APOA1 mRNAincreases expression 16835292
D013656 Taurocholic Acid Taurocholic Acid results in decreased expression of APOA1 proteindecreases expression 19445040
C003377 taxifolin taxifolin results in increased expression of APOA1 proteinincreases expression 11108730
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APOA1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of APOA1 mRNAdecreases expression 15800033
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of APOA1 mRNAdecreases expression 15703262
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of APOA1 mRNAincreases expression 16267337
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of APOA1 mRNAincreases expression 16497791
15644576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of APOA1 proteinincreases expression 16497791
C423915 TO-901317 TO-901317 inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]decreases expression|decreases reaction 19883121
C423915 TO-901317 TO-901317 results in decreased expression of APOA1 proteindecreases expression 19883121
C423915 TO-901317 [TO-901317 co-treated with APOA1 protein] results in increased secretion of Cholesterolaffects cotreatment|increases secretion 20083572
C423915 TO-901317 TO-901317 promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]affects cotreatment|increases reaction|increases secretion 20083572
C066340 tolcapone tolcapone binds to APOA1 proteinaffects binding 19783845
C046498 tricyclodecane-9-yl-xanthogenate tricyclodecane-9-yl-xanthogenate inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
C113580 U 0126 [pirinixic acid co-treated with U 0126] inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]affects cotreatment|decreases expression|decreases reaction 19883121
C113580 U 0126 U 0126 inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein]decreases reaction|increases expression 19013290
D015032 Zinc Zinc results in decreased expression of APOA1 proteindecreases expression 12679171
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.7314745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.776195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 9.773425630 10563481 9677735 8986270 6195326 9118846
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.7714514962 11752688 15322242
MESH:D000038 Abscess Drugs, Chinese Herbal 5.5015043669
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.1317505938
MESH:D000168 Acrocephalosyndactylia U 0126 4.7017694057
MESH:D000169 Acrodermatitis Zinc 4.6017202136 17190629 16889938
MESH:D055371 Acute Lung Injury Acrolein 6.8321297076 20525806
MESH:D055371 Acute Lung Injury pirinixic acid 6.8318653653
MESH:D000230 Adenocarcinoma marker/mechanism 15378696
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.2420464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.2414692618
MESH:D000236 Adenoma Benzo(a)pyrene 4.886695378
MESH:D000236 Adenoma Diethylnitrosamine 4.8810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.3617162532 19052882 18056438 16434500 17620307 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.3617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.3616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.3616835633
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 4.3217942926
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 3.8815276417
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 4.9817302879
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.0916712894 17306315
MESH:D000382 Agricultural Workers' Diseases Atrazine 6.7311874814
MESH:D000382 Agricultural Workers' Diseases cypermethrin 6.7316487989
MESH:D017109 Akathisia, Drug-Induced tolcapone 5.4811080934
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 12.3414523054 20157255
MESH:D000544 Alzheimer Disease Acrolein 12.3417570602 14715435 15207723
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 12.3420157255
MESH:D000544 Alzheimer Disease sulindac sulfide 12.3418759972
MESH:D000544 Alzheimer Disease tolcapone 12.3420150427
MESH:D000544 Alzheimer Disease Zinc 12.3416580781 17119284 16325427 16410023
MESH:C538249 Amyloidosis, familial visceral marker/mechanism
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.5510965797
MESH:D000740 Anemia Drugs, Chinese Herbal 6.6915504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.6911748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.1416916123
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 4.6111477813
MESH:D000799 Angioedema Acetaminophen 3.0310982225
MESH:D000860 Anoxia Oleic Acid 5.1015090967
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.1515043669
MESH:D001014 Aortic Aneurysm Dinoprostone 4.8410231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 9.3919183758
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 9.3910388637
MESH:D001161 Arteriosclerosis Acrolein 18.1015014928
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 18.1015552841
MESH:D001161 Arteriosclerosis Dietary Fats 18.1015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 18.1011256880
MESH:D001169 Arthritis, Experimental Dexamethasone 5.5417659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 5.5415885639
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 4.9519655406
MESH:D001249 Asthma Zinc 2.6617085522
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 15.0111166758 9059518
MESH:D050197 Atherosclerosis Acrolein 15.0117363696 16126721 16037261
MESH:D050197 Atherosclerosis Cholesterol 15.0116632123
MESH:D050197 Atherosclerosis fingolimod 15.0120056921
MESH:D050197 Atherosclerosis Phenytoin 15.0115136057
MESH:D001321 Autistic Disorder Acetaminophen 2.2718445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2718582451
MESH:D001321 Autistic Disorder Linoleic Acid 2.2718582451
MESH:D001477 Bartter Syndrome Dinoprostone 4.9615976003
MESH:D001778 Blood Coagulation Disorders pirinixic acid 6.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 6.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.9815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.2015746008
MESH:D001862 Bone Resorption bisphenol A 7.4311985600
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 7.439881647
MESH:D001930 Brain Injuries Zinc 3.9117109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3620146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.3617123778
MESH:D001943 Breast Neoplasms Dietary Fats 2.3620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3617474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.3620544844 20005174 15668708 18425577 15565566 17242785 19155303 19059307 18629630 18855134 20135344 19142967 18351453 19103187 19115204 18984771 11161223 16273361 17049068 19289846 16873071 16202921 21138602 19288272 19189210 20065188 18821012 19244106 19084267 17261762 20859285 20390343 19221464 19410462 21152245 16818667 17893378 19011961 19066611 19200415 19487384 17440819 18815881 18997820 19189212
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.0015721981 16097048 16227642 16124888 10355542 18705752 15673190 16011737 16050911 16192424 3786805 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.1516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.7219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 18.3316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.3316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.333084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 18.3321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 18.3319418558
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 18.3318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.3316830150 19519916 16935385 19394651 16569478 19701751 18788625 20524982 20214788 18210153 19539802 16807293 10672840 20935162 19919837 17428255 18978308 18393292 20727157 19052882 16502159 20084675 17173139 17761372 17138121 18785209 16328049 3084413 20514400 18506893 16698587 21159647 17978847 18971187 16540662 20512989 19171122 19418558 16288022 10737359 19208518 18665156 16878318 19822196 17055752 20007298 3581430 19335982 19107877 19383236 20101231 17162532 16681979 18691550 16779866 11831363 18056438 20432363 18494052
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 18.3317173139 1701930 6705139 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.3316507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 18.3316924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.1917123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.1112391285
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.7120419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.7118572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.7116543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 2.9117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 1.8718850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.0816936243
MESH:D002386 Cataract Acetaminophen 2.0610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.856135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.8512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.8517174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 14.8516192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.8520056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 9.084080065
MESH:D002493 Central Nervous System Diseases Phenytoin 9.084080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.0319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.0316835633
MESH:D002779 Cholestasis Cyclosporine 9.7119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 9.7117681005 15861022 17333356 16105132 17110522 11677210 16919318
MESH:D002779 Cholestasis pirinixic acid 9.7119176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.0711748493
MESH:D002971 Cleft Lip Phenytoin 3.672227380
MESH:D002972 Cleft Palate Phenytoin 4.7710789828 2227380 1687470 6856622 3877104 6862529
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.7712621046 15668235 15340226 16354765 8697196
MESH:D003103 Coloboma Phenytoin 4.429212184
MESH:D003110 Colonic Neoplasms Dexamethasone 2.3315824018
MESH:D015179 Colorectal Neoplasms Acrolein 2.9317597105
MESH:D000013 Congenital Abnormalities Phenytoin 7.0910627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.0914669216 17141729
MESH:D003327 Coronary Disease Fructose 3.9118504504
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.3317728286
MESH:D019465 Craniofacial Abnormalities Phenytoin 4.338986270 19952982 9212184
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.3310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 4.3319302082
MESH:D003490 Cyanosis 2,4-dinitrotoluene 8.3018551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 8.3018551238
MESH:D003556 Cystitis Acrolein 4.5812161096
MESH:D003711 Demyelinating Diseases Tamoxifen 3.5819031437
MESH:D003715 Dengue 27-hydroxycholesterol 4.8819427377
MESH:D003866 Depressive Disorder tolcapone 3.707768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 4.2110440460
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.6912438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 1.9918249437
MESH:D003920 Diabetes Mellitus Zinc 3.5216479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 3.8318603373
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.3816616286
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 5.5620387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 5.5618603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 5.5617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 2.7919279558
MESH:D003967 Diarrhea Dexamethasone 6.077237001
MESH:D003967 Diarrhea Dinoprostone 6.0711488427 7237001 10446763
OMIM:607208 DRAVET SYNDROME Phenytoin 4.6111748493
MESH:D003875 Drug Eruptions Phenytoin 4.7215024534
MESH:D056486 Drug-Induced Liver Injury marker/mechanism 16099942
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.3018713872 16109766 10663392 12705907 11739529 19085960 11743745 18071297 12540782 11461765 15619225 16177239 14550746 16081117 10915739 19416960 12153990 16227642 12594235 11834606 11287661 12958197 19739265 16781746 19420014 14725611 19164858 14986274 11529661 11421492 17906064 2444490 19923254 15968718 12392966 10774834 17562736 19370779 16485898 16393943 17522070
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 19.3015998439 10092053 4309450 6884620 3732212 2869522 3786805 21278145 11566570 10915739 6623471 7440962 17522070 19085960 19336974 15968718 15027814 16177239 7120509 9327722 16227642 7179309
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 19.3019107877
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 19.3015027814
MESH:D056486 Drug-Induced Liver Injury Nevirapine 19.3014986274
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.3020420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 19.3016604736 19783845
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.2819426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.1411462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 4.5911455177
MESH:D050171 Dyslipidemias Dietary Fats 6.9018367378
MESH:D050171 Dyslipidemias Fenofibrate 6.9016707586
MESH:D004417 Dyspnea cypermethrin 4.5816487989
MESH:D004421 Dystonia Phenobarbital 3.261851702
MESH:D004485 Eczema Dexamethasone 3.7012438553
MESH:D004487 Edema Arachidonic Acid 17.869831321 15177302 16716910 11698051 7990266 9599246
MESH:D004487 Edema Dexamethasone 17.8619703484
MESH:D004487 Edema L 663536 17.867990266
MESH:D004487 Edema perfluorooctanoic acid 17.8612083418 17259670
MESH:D004487 Edema pirinixic acid 17.8612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.8612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.0915322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 15.8317410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.8312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 15.8317654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.8319031437
MESH:D016889 Endometrial Neoplasms Fenofibrate 5.8916569247
MESH:D016889 Endometrial Neoplasms Tamoxifen 5.8919155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.3210568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.4320235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.426251365 1399206
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.333659116
MESH:D004828 Epilepsies, Partial Phenobarbital 7.6611558140 3922381
MESH:D004828 Epilepsies, Partial Phenytoin 7.6611558140 17116037
MESH:D004827 Epilepsy Phenobarbital 5.4220417680
MESH:D004827 Epilepsy Phenytoin 5.42821787 11434505 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 2.866401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.087750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 9.087750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.213659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 8.213659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.3016302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 3.6816530937
MESH:D004938 Esophageal Neoplasms Zinc 3.6816543248
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.1319578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.3811564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 30.7512631006 16239168 19224547 17595544 61145 12795759 16045604 15959796
MESH:D005234 Fatty Liver Cyclosporine 30.7519224547
MESH:D005234 Fatty Liver Dietary Fats 30.7518296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 30.7521071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 30.7515345470
MESH:D005234 Fatty Liver Fructose 30.7519196556 18395287 18641190
MESH:D005234 Fatty Liver pirinixic acid 30.7520131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 30.7519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.6916709447
MESH:D005313 Fetal Death Phenytoin 8.1510627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 8.1511858732
MESH:D005334 Fever Arachidonic Acid 7.5211852909
MESH:D005334 Fever Dinoprostone 7.5216997862 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.7314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.3819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 19.5818705752
MESH:D005355 Fibrosis Cyclosporine 19.5812639820 12168785
MESH:D005355 Fibrosis Dietary Fats 19.5818296743
MESH:D005355 Fibrosis Fructose 19.5818504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.5820067830
MESH:D005756 Gastritis Acetaminophen 8.4716983495
MESH:D005756 Gastritis Zinc 8.4717241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 3.8816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 10.268708960
MESH:D005885 Gingival Hyperplasia Phenytoin 10.269029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.4216390469 14659971
MESH:D018149 Glucose Intolerance Fructose 4.5819165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.7810696789
MESH:D006130 Growth Disorders Zinc 3.4017217573
MESH:D006261 Headache Nitroglycerin 4.3811284996 11554966
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 4.8120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 4.8110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 5.3220558911
MESH:D006333 Heart Failure Zinc 5.3217162251
MESH:D006335 Heart Injuries Zinc 4.9517074742
MESH:D016481 Helicobacter Infections Zinc 3.7917241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.6111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 11.6419900420 19110552
MESH:D006505 Hepatitis cypermethrin 11.6416487989
MESH:D006505 Hepatitis Drugs, Chinese Herbal 11.6418339527
MESH:D006527 Hepatolenticular Degeneration Zinc 3.9117276780
MESH:D006529 Hepatomegaly perfluorooctanoic acid 14.363609246
MESH:D006529 Hepatomegaly Phenobarbital 14.3616109766
MESH:D006529 Hepatomegaly pirinixic acid 14.3619772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.3616120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.727520565
MESH:D015658 HIV Infections Nevirapine 4.4111141242
MESH:D006689 Hodgkin Disease sodium arsenite 2.5012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.238697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 9.4816870215
MESH:D006930 Hyperalgesia Dinoprostone 9.4816793879
MESH:D006930 Hyperalgesia perfluorooctanoic acid 9.4812083418
MESH:D017588 Hyperandrogenism Flutamide 4.6515356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.7316899240
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 16.0917873880
MESH:D006937 Hypercholesterolemia Cholesterol 16.0916933029
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 16.0910876104
MESH:D006937 Hypercholesterolemia Dietary Fats 16.0921332399
MESH:D006943 Hyperglycemia pirinixic acid 2.4820558911
MESH:D020138 Hyperhomocysteinemia Phenytoin 3.9810459572
MESH:D006946 Hyperinsulinism Fructose 4.2218563319 15752949 19008412 14757778 18360027
MESH:D006949 Hyperlipidemias Dietary Fats 7.1021332399
MESH:D006949 Hyperlipidemias Fructose 7.1015752949
MESH:D006951 Hyperlipoproteinemias Fatty Acids, Unsaturated 5.4618435438
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 3.8117604070
MESH:D006973 Hypertension Cyclosporine 9.1810903974
MESH:D006973 Hypertension Dexamethasone 9.1817042910
MESH:D006973 Hypertension Fructose 9.1814568997 16843071 14633139 14573337 19008412
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.1818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.3115338365
MESH:D006976 Hypertension, Pulmonary L 663536 4.5714726295
MESH:D015228 Hypertriglyceridemia Fructose 4.3719342510 19799862
MESH:D052456 Hypoalphalipoproteinemias marker/mechanism
MESH:D007021 Hypospadias Ethinyl Estradiol 3.0316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.7212013081
MESH:D007248 Infertility, Male Atrazine 7.9412948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.9417937319
MESH:D007248 Infertility, Male sodium arsenite 7.9412646999 15346721
MESH:D007249 Inflammation Arachidonic Acid 20.0615177302 9831321 17371808
MESH:D007249 Inflammation Dexamethasone 20.0611099482 8960868
MESH:D007249 Inflammation Dietary Fats 20.0620412841
MESH:D007249 Inflammation Diethylnitrosamine 20.0618785209
MESH:D007249 Inflammation Flavonoids 20.0617296493
MESH:D007249 Inflammation perfluorooctanoic acid 20.0612083418
MESH:D007249 Inflammation Tamoxifen 20.0619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.0612878042 12200463
MESH:D007299 Insect Bites and Stings cypermethrin 5.1615189238
MESH:D007333 Insulin Resistance bisphenol A 12.9916393666
MESH:D007333 Insulin Resistance Dietary Fats 12.9911836018 18457598
MESH:D007333 Insulin Resistance Fructose 12.9919799862 19586609 14757778 18981581 19008412 18563319 19342510 14633139 17133782 14573337 18057795
MESH:D007333 Insulin Resistance pirinixic acid 12.9916306350
MESH:D007511 Ischemia Zinc 3.8516584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.6116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.6315604871
MESH:D007674 Kidney Diseases Acetaminophen 13.5312587719 15629191
MESH:D007674 Kidney Diseases Acrolein 13.5312488133
MESH:D007674 Kidney Diseases Cyclosporine 13.5318776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 13.5320008137
MESH:D007674 Kidney Diseases Zinc 13.5316960431
MESH:D007676 Kidney Failure, Chronic Zinc 3.7016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.2816705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.2816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 12.2818625569
MESH:D007859 Learning Disorders Cholesterol 4.3217134702
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.5215802533
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 9.4916972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 9.4916972261
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.438812269
MESH:D008064 Lipidoses Tamoxifen 2.5517567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 15.3516943688 17157831 16221502 21278145 11408273 11903743 17334410 17174718 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 15.3518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 15.3518665156 20032147 19638242 18522880 18407596
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 15.3517163593
MESH:D008103 Liver Cirrhosis Phenobarbital 15.3521047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.3118251166 14724832 17761835 15959796 15818738 18166357 18472094 17944888 12649538 18156304 17869086 18481824 17631135 18429990 16638106 16027843 15996030 18420326 15123356 15876570 15730626 17640975 16136751 12445421 12546737 12609069 18210741 18395095 12741479 12667390 12632512 17525996 12898905 18418968 18376398 16033810 18395914 11481614 15673190 15057751 16192424 18705752 17766677 17976157 15362042 16097048 17805973 20821823 17714472 16011737 15338365 17900296 17481882 13678700 12586293 18205269 18187930 18279442 18277467 14716833 18339082 17721639 18472332 10355542 12958196 12666154 16248980 18263696 12632514 18054572 17557913 15650968 14748882 17565644 17708605 15925388 18412020 18006644 17698563 14716496 15893842 14620537 17922224 15931870 15370692 18317297 14512876 16015684 12445418 16116963 17823541 15052691 12389079
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 10.3116718785
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 10.3115816358
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 10.3115641146 15744066 15339415 15754396 18371158 17881167 17666798 12632512 17036385 18606216 15818738 16610055 18237412 18567088 17629604 15849816 15383259 15763062 15864749 17348192
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 10.3115474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.3115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.3118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.3112878042
MESH:D008107 Liver Diseases Acetaminophen 17.7419460945 16611625 19014921 16610002 12969438 19784758 11587558 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 17.7415830285 16246199 16964402 17285989 15720792
MESH:D008107 Liver Diseases cypermethrin 17.7415991261
MESH:D008107 Liver Diseases Diethylnitrosamine 17.7417034775
MESH:D008107 Liver Diseases Dinoprostone 17.7415816358
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 17.7417207593
MESH:D008107 Liver Diseases Phenobarbital 17.7419363144
MESH:D008107 Liver Diseases Phenytoin 17.7414986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.0617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.0616899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 44.287678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 44.2815890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 44.2821137059 20195826
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 44.2818177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 44.2819294768
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 44.2818709148
MESH:D008113 Liver Neoplasms Diethylnitrosamine 44.2810737359 18977376 20492335 12112319 20405173 21071580 19812893 19294768 19638242 20101389 19499222 20583210 20452335 19996281 19256749 21167192 18754104 21278145 9163691 19642983 18644402 19690152 21047994 19255062 19090486 19426721 2422723 19254457 19551842 12771043 19850985 18648771 20434301 15175105 16942905 2862719 18978307 20137499 20118626 19427195 20501860 19833225 19073162 15885732
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 44.2818339527
MESH:D008113 Liver Neoplasms Fenofibrate 44.2818978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 44.2818709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 44.2819073162 19482888 8742319 15975961 21047994 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 44.2816377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 44.2815276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 44.2816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 44.2816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 27.472876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 27.478603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 27.4715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 27.478603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 27.473124819 18079962 2563599 18775883 19126423 18164116 17854601 18253720 21159647 18544905 17174075 17942915 19004024 18282651 18093689 9362446 16842330 18308698 19519916 19539802 16267830 19009564
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 27.4718253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 27.471399818 6150874 18308698 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Probucol 27.4712014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 27.4712151625
MESH:D008171 Lung Diseases Acrolein 5.8811504702
MESH:D008171 Lung Diseases sodium arsenite 5.8819095001
MESH:D055370 Lung Injury Oleic Acid 4.5815090967
MESH:D008175 Lung Neoplasms marker/mechanism 19180532
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.2314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.2318816296 17053015 18569708 20135361 20464547 6695378 18520028 20869020 20064080
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 14.2311696405 11246140 19359593 18597497 19925653 16337739 15390079
MESH:D008175 Lung Neoplasms Dexamethasone 14.2315824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.2320970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 14.2318339527
MESH:D008175 Lung Neoplasms L 663536 14.2315899809
MESH:D008175 Lung Neoplasms sodium arsenite 14.2315276417 19931552 17077188 16712894 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 14.2318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.2311884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 2.9719428831
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 12.921500032
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 12.9216457693
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 12.9214758024
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.9216827153 11731420 19196723 19196722 14580682
MESH:D008325 Mammary Neoplasms, Experimental Zinc 12.9212773700
MESH:D020149 Manganese Poisoning Tamoxifen 3.7319453300
MESH:D008545 Melanoma Glucose 4.0214993021
MESH:D008545 Melanoma sodium arsenite 4.0219082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.0219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.3815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 8.3919513568
MESH:D008546 Melanoma, Experimental Acrolein 8.3910803710
MESH:D008607 Mental Retardation Phenytoin 3.339212184
MESH:D008654 Mesothelioma Atrazine 3.141916698
MESH:D024821 Metabolic Syndrome X Fructose 4.1419165636 17098227 17261469 18497449 16815490
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 3.9716801185
MESH:D008708 Methemoglobinemia Nitroglycerin 4.003537620
MESH:D020326 Migraine without Aura Dinoprostone 8.6811304026
MESH:D020326 Migraine without Aura Nitroglycerin 8.6814659530
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.5516381670
MESH:D009101 Multiple Myeloma Dexamethasone 2.9116118317 15744524 15867202
MESH:D009135 Muscular Diseases pirinixic acid 2.7316239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.029809623
MESH:D009203 Myocardial Infarction Nitroglycerin 4.6414729435
MESH:D009203 Myocardial Infarction pirinixic acid 4.6419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.3612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.3116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 9.8417484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 9.8417484760
MESH:D009224 Myotonia Congenita Phenytoin 4.611896199
MESH:D009336 Necrosis 2,4-dinitrotoluene 7.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 7.7018551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.399029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.3919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1819410462
MESH:D009369 Neoplasms Acrolein 8.0417329238
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0411141357
MESH:D009369 Neoplasms pirinixic acid 8.0417405874
MESH:D009369 Neoplasms sodium arsenite 8.0411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 2.9020056578
MESH:D009376 Neoplasms, Hormone-Dependent Nevirapine 8.7419152342
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.7419196722 19189210 19200415
MESH:D009393 Nephritis Acrolein 5.4712653641
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.6317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.6018481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 7.0616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.0614600291
MESH:D009436 Neural Tube Defects Phenytoin 5.809118846
MESH:D009436 Neural Tube Defects sodium arsenite 5.8012854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 10.2718514411
MESH:D019636 Neurodegenerative Diseases Acrolein 10.2711342003
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 10.2720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.3020387270
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 9.7520557099 9802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 9.759802331
MESH:D009765 Obesity Dietary Fats 5.8419632207 20518802 21332399 17217161 16723640 18457598 11836018 18674790 20132043
MESH:D009765 Obesity Fructose 5.8418585860 17707055
MESH:D009765 Obesity pirinixic acid 5.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 6.5412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 6.5416049721
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 5.6618500342
MESH:D010018 Osteomalacia Phenobarbital 9.4217016548
MESH:D010018 Osteomalacia Phenytoin 9.4217016548
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 8.3016397352
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 8.3016548355
MESH:D010049 Ovarian Diseases bisphenol A 4.1911985600
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.1715276417 17306315
MESH:D010051 Ovarian Neoplasms U 0126 4.1716211241
MESH:D010146 Pain 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 7.7818987195
MESH:D010146 Pain Acetaminophen 7.7816870215
MESH:D010146 Pain Phenytoin 7.7815215642
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 6.6816540662
MESH:D010190 Pancreatic Neoplasms L 663536 6.6812384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 6.6816965848
MESH:D010195 Pancreatitis Taurocholic Acid 4.4920035747
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.9411578682
MESH:D010300 Parkinson Disease Acrolein 9.3617690948
MESH:D010300 Parkinson Disease Atrazine 9.3617218051
MESH:D010300 Parkinson Disease Cholesterol, Dietary 9.3619014385
MESH:D010300 Parkinson Disease tolcapone 9.3618328768 9305320 20334432 9591521 8635184 16758261 1977408 20216409 19578428 8739811 11746615 10651109 11432539 19783845 11586115 17089403 11793426 9333106 9708959 7566641 9754991
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.4312520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 10.7611550810
MESH:D010787 Photosensitivity Disorders Acrolein 10.7611550810
MESH:D011014 Pneumonia Butylated Hydroxytoluene 4.3711893704
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.2815356085
MESH:D017689 Polydactyly Phenytoin 4.359212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 11.2812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 11.282563599
MESH:D011230 Precancerous Conditions Phenobarbital 11.282563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.0421297632
MESH:D011225 Pre-Eclampsia Zinc 3.5317114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 11.7410548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 11.7417132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.7411399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.4820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9416740699
MESH:D011471 Prostatic Neoplasms Flutamide 1.943169114
MESH:D011471 Prostatic Neoplasms Nevirapine 1.9419152342
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9416039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9415067354
MESH:D011471 Prostatic Neoplasms Zinc 1.9416700911 16517595 12429649 16606632
MESH:D011537 Pruritus Ethinyl Estradiol 7.4615861022 16919318
MESH:D011537 Pruritus L 663536 7.4617827870
MESH:D019310 Pseudolymphoma Phenobarbital 9.8612752131
MESH:D019310 Pseudolymphoma Phenytoin 9.8612752131 8603615 1419762
MESH:D011565 Psoriasis Cyclosporine 1.8816882103
MESH:D011629 Puberty, Precocious bisphenol A 3.9910548101
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 5.5815466366
MESH:D011654 Pulmonary Edema Oleic Acid 4.9915090967
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 3.3516987627
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.1515043669
MESH:D051437 Renal Insufficiency Acrolein 4.2312732208
MESH:D015427 Reperfusion Injury pirinixic acid 1.9319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.3418379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Oleic Acid 7.3418549715
MESH:D012135 Respiratory Sounds Atrazine 3.7411874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.0718990726
MESH:D012162 Retinal Degeneration Zinc 3.5016584753
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 4.4615015336
MESH:D012640 Seizures 2,4-dinitrotoluene 9.3318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.3318551238
MESH:D012640 Seizures Phenobarbital 9.3311442880 16876388 3137016 4039156
MESH:D012640 Seizures Phenytoin 9.3316876388 3691417 10029267 15946322 9844417 11044598 19919933 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.026407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8410029692 19755658
MESH:D012878 Skin Neoplasms Glucose 9.8414993021
MESH:D012878 Skin Neoplasms sodium arsenite 9.8419524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8416192470
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.2311254748
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 5.5719812052
MESH:D013088 Spermatocele Ethinyl Estradiol 8.8616709447
MESH:D013088 Spermatocele Tamoxifen 8.8616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.2419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.1512854658
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.3720235791
MESH:D013272 Stomach Diseases Dexamethasone 3.5315472012
MESH:D013274 Stomach Neoplasms marker/mechanism 15378696
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.832093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.8318456281
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 2.8318339527
MESH:D013276 Stomach Ulcer Dexamethasone 2.8115138204
MESH:D020521 Stroke Acrolein 3.9016269634
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 4.9517634840
MESH:D019966 Substance-Related Disorders bisphenol A 3.1916684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.4715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.0912697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 5.087505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 5.081399818
MESH:D014062 Tongue Neoplasms Zinc 3.6916543248
MESH:D014376 Tuberculosis Chenodeoxycholic Acid 4.4816040207
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.1319578428
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.5316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.5316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.5317053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.5317306315 11723127 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.538653321 16712894 17572228
MESH:D014570 Urologic Diseases cypermethrin 5.0516487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 9.3410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 9.3410091137
MESH:D014581 Urticaria Acetaminophen 2.2510982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.0611813266
MESH:D014591 Uterine Diseases bisphenol A 4.1914652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.1714692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 7.1718645019
MESH:D014605 Uveitis Cyclosporine 9.071336536
MESH:D014605 Uveitis Dexamethasone 9.071336536
MESH:D014652 Vascular Diseases sodium arsenite 3.6317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.7812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.8114671159 15869587
MESH:D014820 Vitiligo tolcapone 4.4310573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.4315886252
MESH:D015430 Weight Gain Dietary Fats 3.0516723640
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 3.8716313111
MESH:D014985 Xerophthalmia Cyclosporine 3.6317120751
Pathway ID Pathway Name
KEGG:05143 African trypanosomiasis
KEGG:04975 Fat digestion and absorption
REACT:604 Hemostasis
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:03320 PPAR signaling pathway
REACT:15518 Transmembrane transport of small molecules
KEGG:04977 Vitamin digestion and absorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA49
    • No data
    Releated disease ID Related disease Name
    PA446120Hypertriglyceridemia
    PA443635Cardiovascular Diseases
    PA447230HIV
    PA446213HIV Infections
    PA444528Hyperlipidemias
    Releated drug ID Related drug Name
    PA449594fenofibrate
    PA145007158torcetrapib
    PA133950441hmg coa reductase inhibitors
    PA451260ritonavir
    PA451627testosterone
    PA450952phospholipids
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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