AutismKB 2.0

Annotation Detail for HTR1A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HTR1A ( 5-HT1A,5HT1a,ADRB2RL1,ADRBRL1 )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 1A
Band: 5q12.3
Quick LinksEntrez ID:3350; OMIM: 109760; Uniprot ID:5HT1A_HUMAN; ENSEMBL ID: ENSG00000178394; HGNC ID: 5286
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P043735HT1 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1799Epilepsy
1836Panic disorder
1866Sudden infant death syndrome
1904Diabetes mellitus
1907Depression
1909Migraine
1954Stroke
2091Hypertension
2100Hepatitis C
2134Amyotrophic lateral sclerosis
2220Dermatitis
2221Behavior disease
Desease Name
Macular Degeneration
PSYCH
PHARMACOGENOMIC
migraine migraine with aura
depression, interferon-induced
depressive disorder, major
personality disorders
NEUROLOGICAL
methamphetamine induced psychosis
VISION
depression
panic disorder
schizophrenia weight gain
Desease Name
Body mass index
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C118559 1-bromopropane 1-bromopropane results in decreased expression of HTR1A mRNAdecreases expression 19576243
C010654 (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A proteinaffects binding 2891550
C010654 (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein]affects binding|decreases reaction 2891550
D000639 Amitriptyline Amitriptyline results in increased expression of HTR1A proteinincreases expression 1589591
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HTR1A mRNAaffects expression 16483693
D045930 Anabolic Agents Anabolic Agents results in decreased expression of HTR1A proteindecreases expression 16914188
C094645 aripiprazole aripiprazole binds to and results in increased activity of HTR1A proteinaffects binding|increases activity 17069544
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HTR1A mRNAdecreases expression 19428949
D002749 Chlorprothixene Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein]affects binding|decreases reaction 2891550
D004390 Chlorpyrifos Chlorpyrifos affects the expression of HTR1A mRNAaffects expression 18835401
17452286
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of HTR1Aincreases expression 17035140
D003474 Curcumin Curcumin affects the expression of HTR1A mRNAaffects expression 17617388
D003891 Desipramine Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]decreases expression|decreases reaction 15885359
D003891 Desipramine Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]decreases expression|decreases reaction 15885359
D003891 Desipramine Desipramine results in increased expression of HTR1A proteinincreases expression 1589591
D003976 Diazinon Diazinon promotes the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]affects binding|increases reaction 17035140
D003976 Diazinon Diazinon results in increased expression of HTR1A proteinincreases expression 17035140
D004026 Dieldrin Dieldrin results in decreased expression of HTR1A mRNAdecreases expression 18835401
D004316 Doxepin Doxepin results in increased expression of HTR1A proteinincreases expression 1589591
D004958 Estradiol [Estradiol co-treated with Sertraline] affects the expression of HTR1A mRNAaffects cotreatment|affects expression 18650020
D005473 Fluoxetine Fluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]decreases expression|decreases reaction 15885359
D005473 Fluoxetine Fluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]decreases expression|decreases reaction 15885359
C119994 GR 46611 GR 46611 binds to HTR1A proteinaffects binding 15152026
D012701 Serotonin Serotonin binds to and affects the activity of HTR1A proteinaffects activity|affects binding 17202474
D007099 Imipramine Imipramine affects the expression of HTR1A mRNAaffects expression 17617388
D003189 p-Methoxy-N-methylphenethylamine p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A proteinincreases activity 16415902
C521676 N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine binds to and results in increased activity of HTR1A proteinaffects binding|increases activity 19695244
D009277 Nandrolone [testosterone 17 beta-cypionate co-treated with Nandrolone co-treated with testosterone undecanoate] results in decreased expression of HTR1A proteinaffects cotreatment|decreases expression 16914188
D017371 8-Hydroxy-2-(di-n-propylamino)tetralin 8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A proteinaffects binding|increases activity 15893579
15798786
D017371 8-Hydroxy-2-(di-n-propylamino)tetralin Diazinon promotes the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]affects binding|increases reaction 17035140
D017371 8-Hydroxy-2-(di-n-propylamino)tetralin Parathion inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]affects binding|decreases reaction 17035140
D017371 8-Hydroxy-2-(di-n-propylamino)tetralin 8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A proteinaffects binding|increases activity 16914188
D010278 Parathion Parathion inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]affects binding|decreases reaction 17035140
D010278 Parathion Parathion results in decreased expression of HTR1A proteindecreases expression 17035140
D010869 Pindolol Pindolol binds to and results in decreased activity of HTR1A proteinaffects binding|decreases activity 15542624
D020280 Sertraline [Estradiol co-treated with Sertraline] affects the expression of HTR1A mRNAaffects cotreatment|affects expression 18650020
D020280 Sertraline Sertraline results in increased expression of HTR1A mRNAincreases expression 18650020
D014284 Triiodothyronine Triiodothyronine results in increased expression of HTR1A mRNAincreases expression 17403546
D013974 Thyroxine Thyroxine results in increased expression of HTR1A mRNAincreases expression 17403546
C518393 technetium 99m tricarbonyl 4-((2-methoxyphenyl)piperazin-1-yl)dithioformate technetium 99m tricarbonyl 4-((2-methoxyphenyl)piperazin-1-yl)dithioformate binds to HTR1A proteinaffects binding 17074495
C016131 testosterone 17 beta-cypionate [testosterone 17 beta-cypionate co-treated with Nandrolone co-treated with testosterone undecanoate] results in decreased expression of HTR1A proteinaffects cotreatment|decreases expression 16914188
C010792 testosterone undecanoate [testosterone 17 beta-cypionate co-treated with Nandrolone co-treated with testosterone undecanoate] results in decreased expression of HTR1A proteinaffects cotreatment|decreases expression 16914188
D014196 Trazodone Trazodone results in decreased expression of HTR1A proteindecreases expression 12127910
D014196 Trazodone Trazodone results in increased expression of HTR1A proteinincreases expression 1589591
D014196 Trazodone Trazodone binds to HTR1A proteinaffects binding 19711746
C090413 WAY 100635 WAY 100635 binds to and results in decreased activity of HTR1A proteinaffects binding|decreases activity 15136721
16415089
C090413 WAY 100635 [WAY 100635 binds to and results in decreased activity of HTR1A protein] which results in increased activity of DDC proteinaffects binding|decreases activity|increases activity 16415089
C090413 WAY 100635 WAY 100635 binds to and results in decreased activity of HTR1A proteinaffects binding|decreases activity 19695244
C090413 WAY 100635 WAY 100635 binds to and results in decreased activity of HTR1A proteinaffects binding|decreases activity 15542624
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.9920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 3.9911473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.476695378
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 12.8411874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 12.8416487989
MESH:D000382 Agricultural Workers' Diseases Parathion 12.8411874814 17119214
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7517887948
MESH:D000544 Alzheimer Disease Curcumin 4.6315590663
MESH:D000544 Alzheimer Disease Trazodone 4.6317897735 16856516
MESH:D001008 Anxiety Disorders Fluoxetine 9.0418083778
MESH:D001008 Anxiety Disorders Sertraline 9.0418822694
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7619183758
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6616807698
MESH:D020817 Asperger Syndrome aripiprazole 5.9419519261
MESH:D050197 Atherosclerosis Curcumin 3.1318704882
MESH:D001289 Attention Deficit Disorder with Hyperactivity aripiprazole 5.2917069544
MESH:D001321 Autistic Disorder aripiprazole 2.8917069544
MESH:D001321 Autistic Disorder Fluoxetine 2.8919232924 18775368
MESH:D001321 Autistic Disorder Serotonin 2.8919221690 15132762 18361446 18062943 17157402 8570775 18405062
MESH:D001321 Autistic Disorder Sertraline 2.8918775368
MESH:D001327 Autoimmune Diseases Curcumin 4.1719761891
MESH:D001919 Bradycardia Serotonin 5.158112388
MESH:D002545 Brain Ischemia Curcumin 4.0116770732
MESH:D001932 Brain Neoplasms Curcumin 3.6617596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2820146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 2.2816243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Dieldrin 2.2811859874 15770527
MESH:D001943 Breast Neoplasms Estradiol 2.2818497071 12948864 17261762 17289903 17018787 16675129 14630087 19861407
MESH:D001943 Breast Neoplasms Parathion 2.2812762645
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1416111702
MESH:D002277 Carcinoma Curcumin 3.5818593918
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7316924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8618414057
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4020419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.4018462866
MESH:D006332 Cardiomegaly Thyroxine 3.9218093424
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.5518566989
MESH:D002637 Chest Pain Trazodone 5.6915238202
MESH:D002659 Child Development Disorders, Pervasive aripiprazole 6.8319519261
MESH:D002659 Child Development Disorders, Pervasive Serotonin 6.8321254450
MESH:D021081 Chronobiology Disorders Serotonin 6.3617157402
MESH:D003092 Colitis Curcumin 3.8616804969 18200517 16782535
MESH:D003103 Coloboma Curcumin 4.2618809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4516340194 19359593
MESH:D003128 Coma Trazodone 5.8010836866
MESH:D016510 Corneal Neovascularization Curcumin 4.5818497527
MESH:D003704 Dementia Trazodone 5.1412587811 11575062
MESH:D003866 Depressive Disorder Amitriptyline 32.5415014590 18083778
MESH:D003866 Depressive Disorder Desipramine 32.543690436 15014590
MESH:D003866 Depressive Disorder Doxepin 32.5415014590
MESH:D003866 Depressive Disorder Fluoxetine 32.5415014590
MESH:D003866 Depressive Disorder Imipramine 32.5420305041
MESH:D003866 Depressive Disorder Sertraline 32.5415014590 18822694 20305041
MESH:D003866 Depressive Disorder Trazodone 32.5420305041 18083778 4066620 15014590 19623435 3378227 3690436
MESH:D003865 Depressive Disorder, Major Sertraline 9.9816968574
MESH:D003865 Depressive Disorder, Major Trazodone 9.9816968574
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.6218403477
MESH:D003928 Diabetic Nephropathies Curcumin 8.1318204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.1319279558
MESH:D003967 Diarrhea Serotonin 4.4711488427 8112388 10446763
MESH:D004381 Duodenal Ulcer Curcumin 3.7417351913
MESH:D004409 Dyskinesia, Drug-Induced 8-Hydroxy-2-(di-n-propylamino)tetralin 18.3615893579
MESH:D004409 Dyskinesia, Drug-Induced Desipramine 18.363690436
MESH:D004409 Dyskinesia, Drug-Induced Trazodone 18.363690436
MESH:D004417 Dyspnea Diazinon 4.4716487989
MESH:D004421 Dystonia Trazodone 5.343700695
MESH:D004487 Edema Amitriptyline 18.7312798668
MESH:D004487 Edema Fluoxetine 18.7312798668
MESH:D004487 Edema Imipramine 18.7312798668
MESH:D004487 Edema Serotonin 18.7318841975
MESH:D004487 Edema Trazodone 18.7312798668
MESH:D016889 Endometrial Neoplasms Estradiol 2.7719148513 11473722 18566989
MESH:D007172 Erectile Dysfunction Trazodone 5.177604472
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9316530937
MESH:D020329 Essential Tremor Trazodone 5.783296121
MESH:D005234 Fatty Liver Curcumin 3.4119297423
MESH:D005355 Fibrosis Curcumin 3.6718705752
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3818462866
MESH:D005909 Glioblastoma Curcumin 3.2717596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.4418829502 18462866
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.4820471113
MESH:D006505 Hepatitis Diazinon 4.2716487989
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7217701891
MESH:D006558 Herpes Genitalis Estradiol 4.7015709030
MESH:D006561 Herpes Simplex Chlorprothixene 5.791682908
MESH:D019584 Hot Flashes Estradiol 15.5117088409
MESH:D019584 Hot Flashes Fluoxetine 15.5114716179
MESH:D019584 Hot Flashes Trazodone 15.5119711746
MESH:D006816 Huntington Disease Sertraline 5.7018403212
MESH:D006930 Hyperalgesia Trazodone 4.6212790215
MESH:D006937 Hypercholesterolemia Curcumin 3.7618704882
MESH:D007024 Hypotension, Orthostatic Trazodone 5.6915811171
MESH:D007247 Infertility, Female Dieldrin 4.6410630421
MESH:D007248 Infertility, Male Diazinon 6.9712948887 16466525
MESH:D007248 Infertility, Male Parathion 6.9716029889
MESH:D007249 Inflammation Amitriptyline 14.1512798668
MESH:D007249 Inflammation Curcumin 14.1517151092 18403477 16956363
MESH:D007249 Inflammation Fluoxetine 14.1512798668
MESH:D007249 Inflammation Imipramine 14.1512798668
MESH:D007249 Inflammation Trazodone 14.1512798668
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0818200517 18596194
MESH:D007333 Insulin Resistance Estradiol 2.7616393666 16627594
MESH:D007414 Intestinal Neoplasms Curcumin 3.9410783313
MESH:D007674 Kidney Diseases Estradiol 2.4015618244
MESH:D007680 Kidney Neoplasms Estradiol 2.7215610895
MESH:D007889 Leiomyoma Curcumin 4.2718555241
MESH:D007938 Leukemia Curcumin 3.0818462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.9116106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.4516106398
MESH:D008064 Lipidoses Amitriptyline 17.1117567588 15342952
MESH:D008064 Lipidoses Fluoxetine 17.1115342952 17567588
MESH:D008064 Lipidoses Imipramine 17.1115342952 17567588
MESH:D008064 Lipidoses Sertraline 17.1117567588
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.5318705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5314659978 14716833
MESH:D008107 Liver Diseases Chlorpyrifos 4.3315991261
MESH:D008107 Liver Diseases Curcumin 4.3316956363
MESH:D017114 Liver Failure, Acute Trazodone 5.1319857765
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5120195826 21137059
MESH:D008113 Liver Neoplasms Dieldrin 4.519539021 8742319
MESH:D008133 Long QT Syndrome Trazodone 4.7118167038
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4618569708 20135361 18816296 17053015 20464547 18520028 20869020 20064080 6695378
MESH:D008175 Lung Neoplasms Curcumin 2.4616243823 19359593 18462866
MESH:D008223 Lymphoma Curcumin 3.3618462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3816173963
MESH:D016778 Malaria, Falciparum Chlorprothixene 6.0116882315
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.3611807958 11408345 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.1519453300
MESH:D008545 Melanoma Curcumin 2.3717885582 18462866
MESH:D008569 Memory Disorders Curcumin 3.8517263510
MESH:D001523 Mental Disorders Amitriptyline 43.0516856516
MESH:D001523 Mental Disorders aripiprazole 43.0516856516
MESH:D001523 Mental Disorders Chlorprothixene 43.0516856516
MESH:D001523 Mental Disorders Desipramine 43.0516856516
MESH:D001523 Mental Disorders Doxepin 43.0516856516
MESH:D001523 Mental Disorders Fluoxetine 43.0516856516
MESH:D001523 Mental Disorders Imipramine 43.0516856516
MESH:D001523 Mental Disorders Sertraline 43.0516856516
MESH:D001523 Mental Disorders Trazodone 43.0516856516
MESH:D008607 Mental Retardation aripiprazole 4.7116891339 17069544
MESH:D008881 Migraine Disorders Amitriptyline 4.5618803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9416381670
MESH:D009069 Movement Disorders Trazodone 5.464066620
MESH:D009101 Multiple Myeloma Curcumin 3.2919372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.5917962980
MESH:D009175 Mycoplasma Infections Chlorprothixene 6.5010773494
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0316810080
MESH:D009207 Myoclonus Fluoxetine 5.558041377
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0618495463
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8411141357
MESH:D009369 Neoplasms Dieldrin 4.848820588
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2012497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4117289903
MESH:D009421 Nervous System Malformations Estradiol 3.3416427766 11399458
MESH:D009423 Nervous System Neoplasms Curcumin 5.3018462866
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.9515081274
MESH:D009765 Obesity Curcumin 2.6719297423
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.1520418887
MESH:D053578 Opsoclonus-Myoclonus Syndrome Trazodone 6.131318289
MESH:D010024 Osteoporosis Curcumin 3.2718719352
MESH:D010051 Ovarian Neoplasms Curcumin 4.6218462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 4.6219401270
MESH:D010146 Pain Amitriptyline 14.2812798668
MESH:D010146 Pain Fluoxetine 14.2812798668
MESH:D010146 Pain Imipramine 14.2812798668
MESH:D010146 Pain Trazodone 14.2812798668 12790215
MESH:D010190 Pancreatic Neoplasms Curcumin 2.8219196508 17440100 19401701
MESH:D010300 Parkinson Disease Desipramine 5.9410965161
MESH:D010300 Parkinson Disease Dieldrin 5.9417291500 16112328 11181820 16809432 11445065
MESH:D010302 Parkinson Disease, Secondary Trazodone 5.423378227
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.688041377
MESH:D011041 Poisoning Diazinon 4.0617603234
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6817292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.6811398177 18769126 18156803 18226269 12497104 15129424 10851300
MESH:D011471 Prostatic Neoplasms Estradiol 2.6816740699
MESH:D011618 Psychotic Disorders aripiprazole 9.5016891339
MESH:D011618 Psychotic Disorders Chlorprothixene 9.5019708200 16882315
MESH:D011656 Pulmonary Emphysema Curcumin 4.2519168576
MESH:D011657 Pulmonary Eosinophilia Trazodone 5.808520792
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7310666014 18379247
MESH:D012131 Respiratory Insufficiency Trazodone 5.468520792
MESH:D012135 Respiratory Sounds Chlorpyrifos 9.3411874814 16611668 17119214
MESH:D012135 Respiratory Sounds Parathion 9.3411874814 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 10.1716611668 17119214
MESH:D012140 Respiratory Tract Diseases Parathion 10.1717119214
MESH:D012509 Sarcoma Curcumin 3.8418462866
MESH:D012559 Schizophrenia aripiprazole 6.0116891339
MESH:D012559 Schizophrenia Chlorprothixene 6.011830565
MESH:D012559 Schizophrenia Trazodone 6.017868106
MESH:D018805 Sepsis Curcumin 3.8118389075
MESH:D020230 Serotonin Syndrome Fluoxetine 12.188704074
MESH:D020230 Serotonin Syndrome Trazodone 12.187854515 8704074 9050436
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.766418539
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.2219755658 10029692
MESH:D012892 Sleep Deprivation Imipramine 12.7619798453
MESH:D012892 Sleep Deprivation Trazodone 12.7619798453
MESH:D012893 Sleep Disorders Trazodone 5.3319395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 15.2115341891
MESH:D007319 Sleep Initiation and Maintenance Disorders Doxepin 15.2115341891
MESH:D007319 Sleep Initiation and Maintenance Disorders Trazodone 15.2117225163 15341891 15062207
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D013276 Stomach Ulcer Curcumin 3.2216631530 19188055
MESH:D020521 Stroke Trazodone 4.84810300
MESH:D013375 Substance Withdrawal Syndrome Trazodone 5.1312749364 393279
MESH:D017180 Tachycardia, Ventricular Trazodone 5.252424891
MESH:D013959 Thyroid Diseases Thyroxine 5.3119910387
MESH:D013978 Tibial Fractures Estradiol 4.3519048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.7517053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 4.7518593936
MESH:D014565 Urogenital Neoplasms Curcumin 4.9418462866
MESH:D014570 Urologic Diseases Diazinon 4.9516487989
MESH:D018879 Ventricular Premature Complexes Trazodone 6.492424891
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA192
    • No data
    Releated disease ID Related disease Name
    PA447207Depressive Disorder
    PA447321Depressive Disorder, Major
    PA447278Depression
    PA445769Sudden Infant Death
    PA443319Alzheimer Disease
    Releated drug ID Related drug Name
    PA10026aripiprazole
    PA452229antidepressants
    PA449015citalopram
    PA450801paroxetine
    PA448689buspirone
    PA450550morphine
    PA450586naloxone
    PA449690fluvoxamine
    PA449415doxycycline
    PA449673fluoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00216 agonist Eletriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00247 agonist Methysergide Vasoconstrictor Agents;Sympatholytics;Serotonin Antagonists
    DB00248 agonist Cabergoline Antineoplastic Agents;Antiparkinson Agents;Dopamine Agonists
    DB00268 agonist Ropinirole Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00315 agonist Zolmitriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00321 unknown Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00413 unknown Pramipexole Antioxidants;Free Radical Scavengers;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00477 antagonist Chlorpromazine Antiemetics;Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00490 partial agonist Buspirone Anti-anxiety Agents;Serotonin Agonists;Anxiolytics sedatives and hypnotics
    DB00540 antagonist Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00571 other/unknown Propranolol Anti-anxiety Agents;Antihypertensive Agents;Adrenergic Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00589 agonist Lisuride Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Serotonin Agonists
    DB00656 partial agonist Trazodone Anti-anxiety Agents;Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00669 agonist Sumatriptan Vasoconstrictor Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00714 agonist Homeopathic Remedy Thc No. 48 Dps Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00726 antagonist Trimipramine Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00734 antagonist Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00866 antagonist Alprenolol Antihypertensive Agents;Adrenergic beta-Antagonists;Sympatholytics;Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00904 other/unknown Ondansetron Anti-anxiety Agents;Antiemetics;Antipsychotics;Serotonin Antagonists;Antipruritics;Antipsychotic Agents
    DB00952 agonist Naratriptan Vasoconstrictor Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00960 blocker Viskazide 10/50tab Antihypertensive Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Serotonin Antagonists
    DB01049 other Ergoloid mesylate Sympatholytics;Vasodilator Agents;Adrenergic alpha-Antagonists;Nootropic Agents
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01149 antagonist Nefazodone Antidepressants;Analgesics;Antidepressive Agents, Second-Generation;Serotonin Agents
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01238 partial agonist Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01267 antagonist Paliperidone Antipsychotic Agents
    DB01392 partial agonist Yohimbine Mydriatics;Adrenergic alpha-Antagonists
    DB01614 antagonist Acepromazine Dopamine Antagonists;Antipsychotic Agents;Sedatives and Hypnotics
    DB01616 antagonist Alverine Antispasmodics
    DB01618 antagonist Molindone Antipsychotic Agents
    DB01621 antagonist Pipotiazine Phenothiazines;Antipsychotic Agents
    DB01622 antagonist Thioproperazine Phenothiazines;Antipsychotic Agents
    DB05271 - Rotigotine Transdermal Patch Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB08807 - Bopindolol Antihypertensive Agents;Adrenergic beta-Antagonists
    DB08810 agonist Cinitapride Antiemetics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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