AutismKB 2.0

Annotation Detail for HTR1B


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Basic Information Top
Gene Symbol:HTR1B ( 5-HT1B,5-HT1DB,HTR1D2,HTR1DB,S12 )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 1B
Band: 6q14.1
Quick LinksEntrez ID:3351; OMIM: 182131; Uniprot ID:5HT1B_HUMAN; ENSEMBL ID: ENSG00000135312; HGNC ID: 5287
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P043735HT1 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1870Drug abuse
1907Depression
2091Hypertension
2045Bipolar disorder
2221Behavior disease
Desease Name
bipolar disorder
CHEMDEPENDENCY
ADHD
PSYCH
alcoholism
body mass
migraine migraine with aura
schizoaffective disorder
obsessive-compulsive disorder
aggressive behavior
attention-deficit hyperactivity disorder
suicide
NEUROLOGICAL
attention deficit hyperactivity disorder
alcohol dependence
minimum lifetime body mass index
METABOLIC
major depression
self-harm behavior
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C117663 1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine 1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine binds to HTR1B proteinaffects binding 11888550
C117663 1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine 1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine binds to HTR1B proteinaffects binding 11888550
C065046 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one binds to HTR1B proteinaffects binding 11888550
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HTR1B mRNAdecreases expression 18648102
C047087 5-carboxamidotryptamine 5-carboxamidotryptamine binds to HTR1B proteinaffects binding 11888550
C047087 5-carboxamidotryptamine 5-carboxamidotryptamine binds to HTR1B proteinaffects binding 11888550
C025145 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole binds to HTR1B proteinaffects binding 11888550
C025145 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole binds to HTR1B proteinaffects binding 11888550
C100822 alniditan alniditan binds to HTR1B proteinaffects binding 11888550
C100822 alniditan alniditan binds to HTR1B proteinaffects binding 11888550
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HTR1B mRNAaffects expression 16483693
D045930 Anabolic Agents Anabolic Agents affects the expression of HTR1B proteinaffects expression 17201468
C075631 anpirtoline anpirtoline binds to HTR1B proteinaffects binding 11888550
C075631 anpirtoline anpirtoline binds to HTR1B proteinaffects binding 11888550
C101699 BMS 181101 BMS 181101 binds to HTR1B proteinaffects binding 11888550
C101699 BMS 181101 BMS 181101 binds to HTR1B proteinaffects binding 11888550
C108532 BRL 15572 BRL 15572 binds to and results in increased activity of HTR1B proteinaffects binding|increases activity 9303567
D002211 Capsaicin HTR1B protein promotes the reaction [F 11356 results in decreased susceptibility to Capsaicin]decreases response to substance|increases reaction 16880765
D002211 Capsaicin HTR1B protein inhibits the reaction [Capsaicin results in increased expression of FOS protein]decreases reaction|increases expression 12110114
C052561 CGS 12066B CGS 12066B binds to HTR1B proteinaffects binding 11888550
C052561 CGS 12066B CGS 12066B binds to HTR1B proteinaffects binding 11888550
D004390 Chlorpyrifos Chlorpyrifos affects the expression of HTR1B mRNAaffects expression 18835401
C047975 cyanopindolol cyanopindolol binds to HTR1B proteinaffects binding 11888550
C047975 cyanopindolol cyanopindolol binds to HTR1B proteinaffects binding 11888550
D003976 Diazinon Diazinon results in increased expression of HTR1B mRNAincreases expression 17452286
C036042 dicyclohexyl phthalate dicyclohexyl phthalate results in increased expression of HTR1B mRNAincreases expression 15620428
C514241 dihydroethidine dihydroethidine binds to HTR1B proteinaffects binding 11888550
C514241 dihydroethidine dihydroethidine binds to HTR1B proteinaffects binding 11888550
C115647 eletriptan eletriptan binds to and results in increased activity of HTR1B proteinaffects binding|increases activity 11301495
C120143 F 11356 HTR1B protein promotes the reaction [F 11356 results in decreased susceptibility to Capsaicin]decreases response to substance|increases reaction 16880765
D005473 Fluoxetine Fluoxetine results in decreased expression of HTR1B mRNAdecreases expression 10861803
C090701 GR 127935 GR 127935 binds to HTR1B proteinaffects binding 11888550
C090701 GR 127935 GR 127935 binds to HTR1B proteinaffects binding 11888550
C119994 GR 46611 GR 46611 binds to HTR1B proteinaffects binding 11888550
C119994 GR 46611 GR 46611 binds to HTR1B proteinaffects binding 11888550
D012701 Serotonin Serotonin binds to HTR1B proteinaffects binding 11888550
D012701 Serotonin Serotonin binds to and affects the activity of HTR1B proteinaffects activity|affects binding 17202474
D012701 Serotonin Serotonin binds to HTR1B proteinaffects binding 11888550
C085632 L 694247 L 694247 binds to HTR1B proteinaffects binding 11888550
C085632 L 694247 L 694247 binds to HTR1B proteinaffects binding 11888550
D008711 Metergoline Metergoline binds to HTR1B proteinaffects binding 11888550
D008711 Metergoline Metergoline binds to HTR1B proteinaffects binding 11888550
D008719 Methiothepin Methiothepin binds to HTR1B proteinaffects binding 11888550
D008719 Methiothepin Methiothepin binds to HTR1B proteinaffects binding 11888550
C030589 methylmercury cysteine methylmercury cysteine results in decreased expression of HTR1B mRNAdecreases expression 19465457
D008784 Methysergide Methysergide binds to HTR1B proteinaffects binding 11888550
D008784 Methysergide Methysergide binds to HTR1B proteinaffects binding 11888550
C478959 N-(1-(2,3-dihydro(1,4)dioxin-5-yl)piperidi-4-yl)indan-2-ylamine N-(1-(2,3-dihydro(1,4)dioxin-5-yl)piperidi-4-yl)indan-2-ylamine binds to HTR1B proteinaffects binding 11888550
C478959 N-(1-(2,3-dihydro(1,4)dioxin-5-yl)piperidi-4-yl)indan-2-ylamine N-(1-(2,3-dihydro(1,4)dioxin-5-yl)piperidi-4-yl)indan-2-ylamine binds to HTR1B proteinaffects binding 11888550
C108531 N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide binds to and results in increased activity of HTR1B proteinaffects binding|increases activity 9303567
C107225 N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-3-methyl-4-(4-pyridyl)benzamide N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-3-methyl-4-(4-pyridyl)benzamide binds to HTR1B proteinaffects binding 11888550
D017374 Paroxetine Paroxetine results in decreased expression of HTR1B mRNAdecreases expression 10861803
D010869 Pindolol Pindolol binds to HTR1B proteinaffects binding 11888550
D010869 Pindolol Pindolol binds to HTR1B proteinaffects binding 11888550
D010869 Pindolol Pindolol binds to and results in decreased activity of HTR1B proteinaffects binding|decreases activity 15542624
C112854 PNU 109291 PNU 109291 binds to HTR1B proteinaffects binding 11888550
D011433 Propranolol Propranolol binds to HTR1B proteinaffects binding 11888550
D011433 Propranolol Propranolol binds to HTR1B proteinaffects binding 11888550
D016713 Ritanserin Ritanserin binds to HTR1B proteinaffects binding 11888550
C108518 SB 22489G SB 22489G binds to HTR1B proteinaffects binding 11888550
C108518 SB 22489G SB 22489G binds to HTR1B proteinaffects binding 11888550
D018170 Sumatriptan Sumatriptan binds to HTR1B proteinaffects binding 11888550
D018170 Sumatriptan Sumatriptan binds to and results in increased activity of HTR1B proteinaffects binding|increases activity 11301495
D018170 Sumatriptan Sumatriptan binds to HTR1B proteinaffects binding 11888550
C005632 tertatolol tertatolol binds to HTR1B proteinaffects binding 11888550
C090413 WAY 100635 WAY 100635 binds to and results in decreased activity of HTR1B proteinaffects binding|decreases activity 15542624
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 4.1018926900
MESH:D000138 Acidosis Ammonium Chloride 3.1318287403
MESH:D058186 Acute Kidney Injury Capsaicin 4.1618460982
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.503712494
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 7.7516611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 7.7516487989
MESH:D000505 Alopecia Capsaicin 4.3917569567
MESH:D001008 Anxiety Disorders Fluoxetine 4.5918083778
MESH:D001321 Autistic Disorder marker/mechanism 19038234
MESH:D001321 Autistic Disorder Fluoxetine 2.6818775368 19232924
MESH:D001321 Autistic Disorder Propranolol 2.6818766980
MESH:D001321 Autistic Disorder Serotonin 2.6818405062 19221690 15132762 18361446 8570775 17157402 18062943
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5811289319 1440618
MESH:D001919 Bradycardia Capsaicin 15.5018207255
MESH:D001919 Bradycardia Propranolol 15.506740701
MESH:D001919 Bradycardia Serotonin 15.508112388
MESH:D002545 Brain Ischemia Capsaicin 4.5419211983
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.703581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.467296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.477505956
MESH:D002659 Child Development Disorders, Pervasive Serotonin 4.0021254450
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.8319486331 9022650
MESH:D021081 Chronobiology Disorders Serotonin 6.2517157402
MESH:D003371 Cough Capsaicin 4.7410350223
MESH:D019465 Craniofacial Abnormalities Ritanserin 4.2214991402 10978843
MESH:D003866 Depressive Disorder Fluoxetine 7.9215014590
MESH:D003866 Depressive Disorder Paroxetine 7.9217072103 15014590
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.4118759878 8970840 12868966 14531868 8156756 2524372 11298694 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.103621924 2952479
MESH:D003967 Diarrhea Serotonin 4.378112388 11488427 10446763
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.8516192314 18692083 9022650 18289764 11289319 18648102 7440962 9653073 6679447 6482804 8291058 9328219 1440618
MESH:D004381 Duodenal Ulcer Capsaicin 4.2911535926 10671773
MESH:D004417 Dyspnea Diazinon 4.3616487989
MESH:D004487 Edema Fluoxetine 10.0912798668
MESH:D004487 Edema Methysergide 10.097990266
MESH:D004487 Edema Serotonin 10.0918841975
MESH:D004935 Esophageal Diseases Capsaicin 5.2719566590
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 1.993581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.586705139
MESH:D005909 Glioblastoma Capsaicin 3.8418405923
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.647505956
MESH:D006261 Headache Sumatriptan 5.8415240983
MESH:D006356 Heartburn Capsaicin 5.2719566590
MESH:D006330 Heart Defects, Congenital Ritanserin 5.0814991402
MESH:D006333 Heart Failure Propranolol 4.3520082655
MESH:D006349 Heart Valve Diseases Methysergide 6.4011104741
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.236705139
MESH:D006505 Hepatitis Diazinon 8.2316487989
MESH:D006529 Hepatomegaly Propranolol 4.6716371745
MESH:D019584 Hot Flashes Fluoxetine 9.8814716179
MESH:D019584 Hot Flashes Paroxetine 9.8814716179
MESH:D012001 Hyperacusis Sumatriptan 6.6415240983
MESH:D006930 Hyperalgesia Capsaicin 8.1117043245 17434803
MESH:D006930 Hyperalgesia Methysergide 8.1112727271
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5215034207
MESH:D007022 Hypotension Propranolol 4.796740701
MESH:D007248 Infertility, Male Diazinon 3.5416466525 12948887
MESH:D007249 Inflammation Capsaicin 5.2916956363
MESH:D007249 Inflammation Fluoxetine 5.2912798668
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.589022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.626582329
MESH:D008064 Lipidoses Fluoxetine 4.3415342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9215034207 9327722
MESH:D008107 Liver Diseases Capsaicin 4.4416956363
MESH:D008107 Liver Diseases Chlorpyrifos 4.4415991261
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.271399818 598648 6587162 3712494
MESH:D001523 Mental Disorders Fluoxetine 7.6616856516
MESH:D001523 Mental Disorders Paroxetine 7.6616856516
MESH:D008881 Migraine Disorders Sumatriptan 5.0815689192 15240983
MESH:D009101 Multiple Myeloma Capsaicin 3.8517505005
MESH:D009207 Myoclonus Fluoxetine 5.458041377
MESH:D009325 Nausea Sumatriptan 6.1015240983
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.293581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.636679447
MESH:D020078 Neurogenic Inflammation Capsaicin 4.6917961222
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.8715081274
MESH:D009765 Obesity Capsaicin 3.2819056576
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 10.5220418887
MESH:D009771 Obsessive-Compulsive Disorder Paroxetine 10.5217503984
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.056482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.583988306
MESH:D010146 Pain Capsaicin 6.5717434803 17043245 16996476 17084039 18987195 19081190
MESH:D010146 Pain Fluoxetine 6.5712798668
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.077296757
MESH:D020795 Photophobia Sumatriptan 6.6415240983
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.036228378
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.588041377
MESH:D011041 Poisoning Diazinon 3.9617603234
MESH:D011618 Psychotic Disorders marker/mechanism 14708030
MESH:D015427 Reperfusion Injury Capsaicin 3.7418460982 19211983
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.2216611668 17119214 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.4617119214 16611668
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.053692021
MESH:D020230 Serotonin Syndrome Fluoxetine 5.468704074
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.656418539
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.2817997062
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.563712494 6582329 1399818 6587162 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.118074119
MESH:D014570 Urologic Diseases Diazinon 4.8416487989
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29549
    • No data
    Releated disease ID Related disease Name
    PA447278Depression
    PA444460Heroin Dependence
    PA447207Depressive Disorder
    Releated drug ID Related drug Name
    PA452229antidepressants
    PA449015citalopram
    PA452619heroin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00216 agonist Eletriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00248 agonist Cabergoline Antineoplastic Agents;Antiparkinson Agents;Dopamine Agonists
    DB00268 agonist Ropinirole Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00315 agonist Zolmitriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00320 agonist Dihydroergotamine Vasoconstrictor Agents;Analgesics;Sympatholytics;Anti-migraine Agents;Dopamine Agonists;Analgesics, Non-Narcotic
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00413 unknown Pramipexole Antioxidants;Free Radical Scavengers;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00571 other/unknown Propranolol Anti-anxiety Agents;Antihypertensive Agents;Adrenergic Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00589 agonist Lisuride Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Serotonin Agonists
    DB00669 agonist Sumatriptan Vasoconstrictor Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00696 agonist Wigraine Tab Vasoconstrictor Agents;Sympatholytics;Adrenergic alpha-Agonists;Analgesics, Non-Narcotic
    DB00714 agonist Homeopathic Remedy Thc No. 48 Dps Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00904 other/unknown Ondansetron Anti-anxiety Agents;Antiemetics;Antipsychotics;Serotonin Antagonists;Antipruritics;Antipsychotic Agents
    DB00918 agonist Almotriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00952 agonist Naratriptan Vasoconstrictor Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00953 agonist Rizatriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00960 other/unknown Viskazide 10/50tab Antihypertensive Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Serotonin Antagonists
    DB00998 agonist Frovatriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Serotonin Agonists
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 other/unknown Quetiapine Antipsychotics;Antipsychotic Agents
    DB01238 other/unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01392 antagonist Yohimbine Mydriatics;Adrenergic alpha-Antagonists
    DB08807 - Bopindolol Antihypertensive Agents;Adrenergic beta-Antagonists
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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