AutismKB 2.0

Annotation Detail for HTR1D


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Basic Information Top
Gene Symbol:HTR1D ( 5-HT1D,HT1DA,HTR1DA,HTRL,RDC4 )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 1D
Band: 1p36.12
Quick LinksEntrez ID:3352; OMIM: 182133; Uniprot ID:5HT1D_HUMAN; ENSEMBL ID: ENSG00000179546; HGNC ID: 5289
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P043735HT1 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2006Anorexia nervosa
2190Attention deficit hyperactivity disorder
Desease Name
attention deficit hyperactivity disorder behavior disorder
PSYCH
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of HTR1D mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HTR1D mRNAaffects expression 16483693
C108532 BRL 15572 BRL 15572 binds to and results in increased activity of HTR1D proteinaffects binding|increases activity 9303567
D002211 Capsaicin HTR1D protein inhibits the reaction [Capsaicin results in increased expression of FOS protein]decreases reaction|increases expression 12110114
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of HTR1D mRNAincreases expression 11566570
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of HTR1D mRNAincreases expression 16644059
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of HTR1D mRNAincreases expression 18835401
D003024 Clozapine Clozapine results in decreased expression of HTR1D mRNAdecreases expression 16715494
D003976 Diazinon Diazinon results in decreased expression of HTR1D mRNAdecreases expression 18835401
D004026 Dieldrin Dieldrin affects the expression of HTR1D mRNAaffects expression 18835401
C115647 eletriptan eletriptan binds to and results in increased activity of HTR1D proteinaffects binding|increases activity 11301495
D006220 Haloperidol Haloperidol results in decreased expression of HTR1D mRNAdecreases expression 16715494
D012701 Serotonin HTR1D gene polymorphism affects the abundance of Serotoninaffects abundance 17203304
C108531 N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide binds to and results in increased activity of HTR1D proteinaffects binding|increases activity 9303567
D009532 Nickel Nickel affects the expression of HTR1D mRNAaffects expression 18835401
C006253 pirinixic acid pirinixic acid results in decreased expression of HTR1D mRNAdecreases expression 17950772
C025299 polyphenols polyphenols results in decreased expression of HTR1D mRNAdecreases expression 16293270
D018170 Sumatriptan Sumatriptan binds to and results in increased activity of HTR1D proteinaffects binding|increases activity 11301495
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 4.5218926900
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D058186 Acute Kidney Injury Capsaicin 4.5218460982
MESH:D055371 Acute Lung Injury Nickel 9.1816166738
MESH:D055371 Acute Lung Injury pirinixic acid 9.1818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4716434500
MESH:D000380 Agranulocytosis Clozapine 5.0414617031 12649775 16160616
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.1417119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.1416487989
MESH:D000505 Alopecia Capsaicin 4.7117569567
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001321 Autistic Disorder marker/mechanism 19038234
MESH:D001321 Autistic Disorder Acetaminophen 2.4018445737
MESH:D001321 Autistic Disorder Haloperidol 2.4018080171 19368416
MESH:D001321 Autistic Disorder Serotonin 2.4019221690 15132762 17157402 18405062 18361446 8570775 18062943
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1319483382
MESH:D001919 Bradycardia Capsaicin 11.2218207255
MESH:D001919 Bradycardia Serotonin 11.228112388
MESH:D002545 Brain Ischemia Capsaicin 4.9619211983
MESH:D001943 Breast Neoplasms Dieldrin 2.9615770527 11859874
MESH:D001943 Breast Neoplasms Nickel 2.9615986119
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7718705752 15700767 3786805 16227642 16192424 15673190 16124888 15721981 16097048 16050911 16011737 10355542
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.833084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.8318788625
MESH:D002375 Catalepsy Haloperidol 4.901977408 15215559
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002659 Child Development Disorders, Pervasive Serotonin 4.1621254450
MESH:D002779 Cholestasis pirinixic acid 2.8119176532
MESH:D021081 Chronobiology Disorders Serotonin 6.6917157402
MESH:D003072 Cognition Disorders Clozapine 4.9517123785
MESH:D003110 Colonic Neoplasms polyphenols 2.6716293270
MESH:D003371 Cough Capsaicin 5.1810350223
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.8220210726
MESH:D003704 Dementia Haloperidol 4.5611575062
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.9417244072 17100760 19470301
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003877 Dermatitis, Contact Nickel 4.622952479
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9716402076
MESH:D003967 Diarrhea Serotonin 4.7510446763 11488427 8112388
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5515331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2514725611 15619225 16081117 17562736 17522070 16393943 16781746 19370779 16177239 18713872 17906064 16485898 19085960 11529661 12705907 12392966 11421492 12153990 16227642 19420014 19739265 19164858 16109766 12594235 19416960 10663392 10915739 19923254 11461765 10774834 15968718 2444490 18071297 14550746 11287661 12540782 12958197 11743745 11834606 11739529 14986274
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.253786805 2869522 7120509 16227642 19336974 10915739 15998439 21278145 3732212 4309450 15027814 17522070 10092053 19085960 11566570 9327722 6884620 7440962 6623471 15968718 7179309 16177239
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.2519370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004381 Duodenal Ulcer Capsaicin 4.6711535926 10671773
MESH:D050171 Dyslipidemias Clozapine 4.1716402076
MESH:D004417 Dyspnea Diazinon 4.8016487989
MESH:D004487 Edema pirinixic acid 7.2512083418
MESH:D004487 Edema Serotonin 7.2518841975
MESH:D004935 Esophageal Diseases Capsaicin 5.7019566590
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.6116045604 12631006 61145 12795759 16239168 19224547 17595544 15959796
MESH:D005234 Fatty Liver pirinixic acid 7.6119236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 3.4418705752
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005909 Glioblastoma Capsaicin 4.1018405923
MESH:D006261 Headache Sumatriptan 6.2815240983
MESH:D006356 Heartburn Capsaicin 5.7019566590
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006505 Hepatitis Carbon Tetrachloride 9.5619900420 19110552
MESH:D006505 Hepatitis Diazinon 9.5616487989
MESH:D006529 Hepatomegaly pirinixic acid 2.9818467677 16221962 19176532 19772884
MESH:D015658 HIV Infections Nickel 3.8017263646
MESH:D012001 Hyperacusis Sumatriptan 7.0815240983
MESH:D006930 Hyperalgesia Acetaminophen 7.9816870215
MESH:D006930 Hyperalgesia Capsaicin 7.9817434803 17043245
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006948 Hyperkinesis Clozapine 4.9016046005
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0715338365
MESH:D007247 Infertility, Female Dieldrin 4.9210630421
MESH:D007248 Infertility, Male Diazinon 3.8116466525 12948887
MESH:D007249 Inflammation Capsaicin 8.6716956363
MESH:D007249 Inflammation Nickel 8.6716166738
MESH:D007249 Inflammation polyphenols 8.6716366677
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.1915629191 12587719
MESH:D008064 Lipidoses Clozapine 3.9417567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8016943688 17157831 11408273 21278145 16221502 16239168 17174718 17334410 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3112898905 15730626 12546737 12649538 18412020 14620537 17714472 18006644 18251166 15818738 17557913 17805973 18376398 17761835 18395914 15925388 15057751 12632514 17976157 17698563 15959796 18472332 16116963 12389079 17631135 16638106 16033810 17823541 17721639 12666154 18279442 15370692 12586293 17708605 15996030 14512876 18481824 15338365 18166357 17869086 12958196 18472094 14724832 14716496 10355542 17922224 18187930 14748882 12741479 16136751 17766677 17481882 20821823 15673190 18418968 16248980 18317297 12445418 18429990 16015684 18156304 18054572 17944888 18277467 17525996 18210741 18420326 15931870 15362042 18339082 12667390 16192424 17565644 16011737 12445421 18395095 18205269 14716833 15052691 16097048 15876570 12609069 17640975 15893842 13678700 11481614 18263696 15123356 16027843 12632512 18705752 15650968 17900296
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3115474484
MESH:D008107 Liver Diseases Acetaminophen 12.5216610002 19460945 11587558 19014921 12587719 19784758 12969438 16611625
MESH:D008107 Liver Diseases Capsaicin 12.5216956363
MESH:D008107 Liver Diseases Carbon Tetrachloride 12.5216246199 16964402 15830285 17285989 15720792
MESH:D008107 Liver Diseases Chlorpyrifos 12.5215991261
MESH:D008107 Liver Diseases polyphenols 12.5216698588
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.3516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.3514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.5119294768
MESH:D008113 Liver Neoplasms Dieldrin 7.518742319 9539021
MESH:D008113 Liver Neoplasms pirinixic acid 7.5116377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6015583823 12014681
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D001523 Mental Disorders Clozapine 8.3416856516
MESH:D001523 Mental Disorders Haloperidol 8.3416856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3919142101
MESH:D008881 Migraine Disorders Sumatriptan 5.3715689192 15240983
MESH:D009101 Multiple Myeloma Capsaicin 4.1417505005
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009325 Nausea Sumatriptan 6.5315240983
MESH:D009369 Neoplasms Dieldrin 5.268820588
MESH:D009369 Neoplasms pirinixic acid 5.2617405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D020078 Neurogenic Inflammation Capsaicin 5.0717961222
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.1515081274
MESH:D009765 Obesity Capsaicin 7.5919056576
MESH:D009765 Obesity Clozapine 7.5919142110 18515891
MESH:D009765 Obesity pirinixic acid 7.5920558911
MESH:D010146 Pain Acetaminophen 6.9416870215
MESH:D010146 Pain Capsaicin 6.9417084039 17434803 17043245 18987195 16996476 19081190
MESH:D010300 Parkinson Disease Dieldrin 3.5216112328 11181820 11445065 17291500 16809432
MESH:D020795 Photophobia Sumatriptan 7.0815240983
MESH:D011041 Poisoning Diazinon 4.3317603234
MESH:D011595 Psychomotor Agitation Haloperidol 4.9411575062
MESH:D011618 Psychotic Disorders Clozapine 9.1115331141
MESH:D011618 Psychotic Disorders Haloperidol 9.1111575062
MESH:D015427 Reperfusion Injury Capsaicin 6.7919211983 18460982
MESH:D015427 Reperfusion Injury pirinixic acid 6.7919058328
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.6211874814 16611668 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.8917119214 16611668
MESH:D012559 Schizophrenia Clozapine 4.0916141801 20521326 20521320 20452607 18806925 11763009 11151749 17726453 20168265 20107430 17123785 20580759 19369910 18855531 17667964
MESH:D012559 Schizophrenia Haloperidol 4.091830565 19369910 18513383 20107430
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.096418539
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6920210726
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 13.3617997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 13.3617997062
MESH:D014570 Urologic Diseases Diazinon 5.2816487989
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D015430 Weight Gain Clozapine 4.4516402076 20564506 17502770 20521320 20107430 16141801
MESH:D015431 Weight Loss Clozapine 5.0717933447
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29550
    • No data
    No data
    Releated drug ID Related drug Name
    PA451216rabeprazole
    PA451221raloxifene
    PA130413154tegaserod
    PA451975zolmitriptan
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00216 agonist Eletriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00248 agonist Cabergoline Antineoplastic Agents;Antiparkinson Agents;Dopamine Agonists
    DB00268 agonist Ropinirole Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00315 agonist Zolmitriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00320 agonist Dihydroergotamine Vasoconstrictor Agents;Analgesics;Sympatholytics;Anti-migraine Agents;Dopamine Agonists;Analgesics, Non-Narcotic
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00413 unknown Pramipexole Antioxidants;Free Radical Scavengers;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00589 agonist Lisuride Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Serotonin Agonists
    DB00669 agonist Sumatriptan Vasoconstrictor Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00696 agonist Wigraine Tab Vasoconstrictor Agents;Sympatholytics;Adrenergic alpha-Agonists;Analgesics, Non-Narcotic
    DB00714 agonist Homeopathic Remedy Thc No. 48 Dps Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00734 antagonist Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00918 agonist Almotriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00952 agonist Naratriptan Vasoconstrictor Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00953 agonist Rizatriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00998 agonist Frovatriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Serotonin Agonists
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 other/unknown Quetiapine Antipsychotics;Antipsychotic Agents
    DB01238 other/unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01267 antagonist Paliperidone Antipsychotic Agents
    DB01392 antagonist Yohimbine Mydriatics;Adrenergic alpha-Antagonists
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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