AutismKB 2.0

Annotation Detail for HTR2A


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Basic Information Top
Gene Symbol:HTR2A ( 5-HT2A,HTR2 )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 2A
Band: 13q14.2
Quick LinksEntrez ID:3356; OMIM: 182135; Uniprot ID:5HT2A_HUMAN; ENSEMBL ID: ENSG00000102468; HGNC ID: 5293
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04540Gap junction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P043745HT2 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1784Choriocarcinoma
1811Drug-Induced dyskinesia
1836Panic disorder
1856Obesity
1907Depression
1954Stroke
2006Anorexia nervosa
2091Hypertension
2045Bipolar disorder
2053Colon cancer
2124Autistic disorder
2185Obsessive-compulsive disorder
2198Psychotic disorder
2216Chronic fatigue syndrome
2220Dermatitis
2221Behavior disease
Desease Name
obsessive compulsive disorder
bipolar disorder
cognitive function
food and alcohol intake
cholesterol, HDL
psychiatric status
glucose
seasonal affective disorder
CARDIOVASCULAR
CHEMDEPENDENCY
leptin
ADHD
clozapine response
Alzheimer's disease
attention deficit disorder
unipolar disorder
PSYCH
therapeutic response
Tourette syndrome
delusions hallucinations psychoses
PHARMACOGENOMIC
lipids
aura
response to antidepressants
migraine with aura
harm avoidance
impulse behavior
anxiety disorder
hypertension
aggressive behavior
attention-deficit hyperactivity disorder
behavior problems
suicide
anorexia nervosa
antidepressant medication intolerance.
depressive disorder, major
IMMUNE
personality disorders
alcohol abuse
impulsive behavior
NEUROLOGICAL
eating disorders
tardive dyskinesia
alcohol dependence
risperidone treatment response
schizophrenia
METABOLIC
major depression
psychosis
obesity
suicidal behavior in depressed patients.
depression
bulimia
insulin
Irritable Bowel Syndrome
psychoses
major depressive disorder
panic disorder
bulimia nervosa
schizophrenia weight gain
response to clozapine
No data
Desease Name
Alcohol dependence, susceptibility to
Schizophrenia, susceptibility to
Anorexia nervosa, susceptibility to
Obsessive-compulsive disorder, susceptibility to
Seasonal affective disorder, susceptibility to
Major depressive disorder, response to citalopram therapy in
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C015068 1-(3-chlorophenyl)piperazine 1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2A proteinaffects binding|increases activity 16314884
C015068 1-(3-chlorophenyl)piperazine HTR2A gene SNP results in increased susceptibility to 1-(3-chlorophenyl)piperazineincreases response to substance 16314884
C015068 1-(3-chlorophenyl)piperazine HTR2A protein affects the susceptibility to 1-(3-chlorophenyl)piperazineaffects response to substance 16314884
C118559 1-bromopropane 1-bromopropane results in decreased expression of HTR2A mRNAdecreases expression 19576243
C015952 4-iodo-2,5-dimethoxyphenylisopropylamine 4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A proteinaffects binding|increases activity 16314884
C015952 4-iodo-2,5-dimethoxyphenylisopropylamine HTR2A gene SNP results in decreased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylaminedecreases response to substance 16314884
C015952 4-iodo-2,5-dimethoxyphenylisopropylamine HTR2A protein affects the susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamineaffects response to substance 16314884
C015952 4-iodo-2,5-dimethoxyphenylisopropylamine 4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A proteinaffects binding|increases activity 12482207
C095512 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]affects binding|decreases activity|decreases reaction|increases expression|increases phosphorylation 18976543
C095512 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[MDL 100907 binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]affects binding|decreases activity|decreases reaction|increases expression|increases phosphorylation 18976543
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HTR2A mRNAaffects expression 16483693
C094645 aripiprazole aripiprazole binds to and results in increased activity of HTR2A proteinaffects binding|increases activity 16314884
C094645 aripiprazole aripiprazole inhibits the reaction [Ketanserin binds to HTR2A protein]affects binding|decreases reaction 16314884
C094645 aripiprazole HTR2A gene SNP results in decreased susceptibility to aripiprazoledecreases response to substance 16314884
C094645 aripiprazole HTR2A protein affects the susceptibility to aripiprazoleaffects response to substance 16314884
C094645 aripiprazole aripiprazole binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 17069544
D002118 Calcium HTR2A protein promotes the reaction [[Freund's Adjuvant results in increased activity of TRPV1 protein] which results in increased transport of Calcium]increases activity|increases reaction|increases transport 16901936
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of HTR2A mRNAincreases expression 16644059
12832660
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of HTR2Aincreases expression 17035140
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of HTR2A mRNAincreases expression 17452286
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of HTR2A mRNA alternative formincreases expression 17452286
D003024 Clozapine Clozapine analog binds to HTR2A proteinaffects binding 11997696
D003024 Clozapine Clozapine binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 20521326
16314884
D003024 Clozapine Clozapine binds to HTR2A proteinaffects binding 16983399
11997696
D003024 Clozapine Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]affects binding|decreases reaction 16314884
D003024 Clozapine HTR2A gene SNP results in increased susceptibility to Clozapineincreases response to substance 16314884
D003024 Clozapine HTR2A protein affects the susceptibility to Clozapineaffects response to substance 16314884
D003024 Clozapine Clozapine results in increased expression of HTR2A mRNAincreases expression 15542763
D003024 Clozapine alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]affects binding|decreases activity|decreases reaction|increases expression|increases phosphorylation 18976543
D003024 Clozapine Clozapine binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 18976543
D003024 Clozapine [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 proteinaffects binding|decreases activity|increases phosphorylation 18976543
D003024 Clozapine [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 proteinaffects binding|decreases activity|increases expression|increases phosphorylation 18976543
D003024 Clozapine Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]decreases activity|increases reaction 15380371
D003024 Clozapine Clozapine results in decreased activity of HTR2A proteindecreases activity 15380371
D003024 Clozapine Clozapine results in decreased expression of HTR2A mRNAdecreases expression 17868938
14751426
D003024 Clozapine Clozapine results in decreased expression of HTR2A proteindecreases expression 14751426
C079149 clozapine N-oxide clozapine N-oxide results in decreased expression of HTR2A proteindecreases expression 14751426
D003345 Corticosterone Corticosterone results in increased expression of HTR2A mRNAincreases expression 15755911
D003976 Diazinon Diazinon promotes the reaction [Ketanserin binds to HTR2A protein]affects binding|increases reaction 17035140
D003976 Diazinon Diazinon results in increased expression of HTR2A mRNAincreases expression 17452286
D003976 Diazinon Diazinon results in increased expression of HTR2A proteinincreases expression 17035140
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of HTR2A mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of HTR2A mRNA]decreases reaction|increases expression 17942915
D004130 N,N-Dimethyltryptamine HTR2A gene SNP results in decreased susceptibility to N,N-Dimethyltryptaminedecreases response to substance 16314884
D004130 N,N-Dimethyltryptamine HTR2A protein affects the susceptibility to N,N-Dimethyltryptamineaffects response to substance 16314884
D004130 N,N-Dimethyltryptamine N,N-Dimethyltryptamine binds to and results in increased activity of HTR2A proteinaffects binding|increases activity 16314884
C074283 estradiol 3-benzoate estradiol 3-benzoate results in increased expression of HTR2A mRNAincreases expression 17398000
C074283 estradiol 3-benzoate estradiol 3-benzoate results in increased expression of HTR2A proteinincreases expression 17398000
C074283 estradiol 3-benzoate Raloxifene inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A mRNA]decreases reaction|increases expression 17398000
C074283 estradiol 3-benzoate Raloxifene inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A protein]decreases reaction|increases expression 17398000
D004958 Estradiol [Estradiol co-treated with Sertraline] affects the expression of HTR2A mRNAaffects cotreatment|affects expression 18650020
D004958 Estradiol Estradiol promotes the reaction [Sertraline results in increased expression of HTR2A mRNA]increases expression|increases reaction 18650020
D016666 Fluvoxamine HTR2A gene SNP affects the susceptibility to Fluvoxamineaffects response to substance 12607287
D005620 Freund's Adjuvant Freund's Adjuvant results in increased expression of HTR2A mRNAincreases expression 16901936
D005620 Freund's Adjuvant HTR2A protein promotes the reaction [[Freund's Adjuvant results in increased activity of TRPV1 protein] which results in increased transport of Calcium]increases activity|increases reaction|increases transport 16901936
D006220 Haloperidol [Phencyclidine co-treated with Haloperidol] affects the activity of HTR2A proteinaffects activity|affects cotreatment 15380371
D012701 Serotonin HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]affects reaction|increases activity 18621911
D012701 Serotonin Ketanserin inhibits the reaction [HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]]affects reaction|decreases reaction|increases activity 18621911
D012701 Serotonin HTR2A gene SNP results in decreased susceptibility to Serotonindecreases response to substance 16314884
D012701 Serotonin HTR2A protein affects the susceptibility to Serotoninaffects response to substance 16314884
D012701 Serotonin Serotonin binds to and results in increased activity of HTR2A proteinaffects binding|increases activity 16314884
D012701 Serotonin HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]affects phosphorylation|affects reaction 11880652
D007650 Ketanserin Ketanserin inhibits the reaction [HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]]affects reaction|decreases reaction|increases activity 18621911
D007650 Ketanserin aripiprazole inhibits the reaction [Ketanserin binds to HTR2A protein]affects binding|decreases reaction 16314884
D007650 Ketanserin Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]affects binding|decreases reaction 16314884
D007650 Ketanserin Ketanserin binds to HTR2A proteinaffects binding 2891550
16314884
D007650 Ketanserin quetiapine inhibits the reaction [Ketanserin binds to HTR2A protein]affects binding|decreases reaction 16314884
D007650 Ketanserin Spiperone inhibits the reaction [Ketanserin binds to HTR2A protein]affects binding|decreases reaction 2891550
D007650 Ketanserin ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein]affects binding|decreases reaction 16314884
D007650 Ketanserin Ketanserin binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 10978843
D007650 Ketanserin Diazinon promotes the reaction [Ketanserin binds to HTR2A protein]affects binding|increases reaction 17035140
D007650 Ketanserin Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]decreases reaction|increases activity 18417104
D007650 Ketanserin Ketanserin binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 15542624
C079049 MDL 100907 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[MDL 100907 binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]affects binding|decreases activity|decreases reaction|increases expression|increases phosphorylation 18976543
C079049 MDL 100907 MDL 100907 binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 18976543
C079049 MDL 100907 [MDL 100907 binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 proteinaffects binding|decreases activity|increases phosphorylation 18976543
C079049 MDL 100907 [[MDL 100907 binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 proteinaffects binding|decreases activity|increases expression|increases phosphorylation 18976543
D008803 Mianserin Mianserin binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 10978843
D009532 Nickel Nickel results in decreased expression of HTR2A mRNAdecreases expression 18835401
C058272 norclozapine norclozapine results in decreased expression of HTR2A mRNAdecreases expression 14751426
C058272 norclozapine norclozapine results in decreased expression of HTR2A proteindecreases expression 14751426
C076029 olanzapine olanzapine binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 20521326
C076029 olanzapine olanzapine binds to HTR2A proteinaffects binding 16983399
C076029 olanzapine olanzapine binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 18976543
C076029 olanzapine [olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 proteinaffects binding|decreases activity|increases phosphorylation 18976543
C076029 olanzapine [[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 proteinaffects binding|decreases activity|increases expression|increases phosphorylation 18976543
D010269 Paraquat Paraquat results in decreased expression of HTR2A mRNAdecreases expression 17077588
D010278 Parathion Parathion results in decreased expression of HTR2A proteindecreases expression 17035140
D017374 Paroxetine HTR2A gene polymorphism affects the susceptibility to Paroxetineaffects response to substance 17503984
D010622 Phencyclidine Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]decreases activity|increases reaction 15380371
D010622 Phencyclidine [Phencyclidine co-treated with Haloperidol] affects the activity of HTR2A proteinaffects activity|affects cotreatment 15380371
D010622 Phencyclidine Phencyclidine results in decreased activity of HTR2A proteindecreases activity 15380371
C069541 quetiapine quetiapine inhibits the reaction [Ketanserin binds to HTR2A protein]affects binding|decreases reaction 16314884
D020849 Raloxifene Raloxifene affects the expression of HTR2A mRNAaffects expression 14699072
D020849 Raloxifene Raloxifene inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A mRNA]decreases reaction|increases expression 17398000
D020849 Raloxifene Raloxifene inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A protein]decreases reaction|increases expression 17398000
D018967 Risperidone HTR2A gene SNP results in increased susceptibility to Risperidoneincreases response to substance 16314884
D018967 Risperidone HTR2A protein affects the susceptibility to Risperidoneaffects response to substance 16314884
D018967 Risperidone Risperidone binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 16314884
D018967 Risperidone Risperidone binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 16948927
D016713 Ritanserin Ritanserin binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 19228979
D020280 Sertraline [Estradiol co-treated with Sertraline] affects the expression of HTR2A mRNAaffects cotreatment|affects expression 18650020
D020280 Sertraline Estradiol promotes the reaction [Sertraline results in increased expression of HTR2A mRNA]increases expression|increases reaction 18650020
D020280 Sertraline Sertraline results in increased expression of HTR2A mRNAincreases expression 18650020
D013134 Spiperone Spiperone inhibits the reaction [Ketanserin binds to HTR2A protein]affects binding|decreases reaction 2891550
D013629 Tamoxifen Tamoxifen affects the expression of HTR2A mRNAaffects expression 14699072
D014147 Tramadol Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]decreases reaction|increases activity 18417104
D014147 Tramadol Tramadol results in increased activity of HTR2A proteinincreases activity 18417104
D014147 Tramadol Tramadol results in increased expression of HTR2A mRNAincreases expression 18417104
D014196 Trazodone Trazodone binds to and results in decreased activity of HTR2A proteinaffects binding|decreases activity 19623435
19711746
C030820 tryptamine HTR2A gene SNP results in decreased susceptibility to tryptaminedecreases response to substance 16314884
C030820 tryptamine HTR2A protein affects the susceptibility to tryptamineaffects response to substance 16314884
C030820 tryptamine tryptamine binds to and results in increased activity of HTR2A proteinaffects binding|increases activity 16314884
C092292 ziprasidone ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein]affects binding|decreases reaction 16314884
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1014745880
MESH:D000138 Acidosis Ammonium Chloride 3.1218287403
MESH:D055371 Acute Lung Injury Nickel 4.1816166738
MESH:D000230 Adenocarcinoma Estradiol 1.9811473722
MESH:D000236 Adenoma Diethylnitrosamine 2.5910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.4617162532 19061943 18056438 17620307 16434500 19052882
MESH:D000380 Agranulocytosis Clozapine 4.6212649775 16160616 14617031
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 16.9111874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 16.9116487989
MESH:D000382 Agricultural Workers' Diseases Paraquat 16.9111874814
MESH:D000382 Agricultural Workers' Diseases Parathion 16.9117119214 11874814
MESH:D000419 Albuminuria Raloxifene 4.1717308373 17451421
MESH:D000437 Alcoholism marker/mechanism
MESH:D000544 Alzheimer Disease 1-(3-chlorophenyl)piperazine 6.531912105
MESH:D000544 Alzheimer Disease Raloxifene 6.5315800139
MESH:D000544 Alzheimer Disease Trazodone 6.5316856516 17897735
MESH:D000856 Anorexia Nervosa marker/mechanism
MESH:D001008 Anxiety Disorders Sertraline 4.7518822694
MESH:D020817 Asperger Syndrome aripiprazole 10.5519519261
MESH:D020817 Asperger Syndrome Risperidone 10.5516401163
MESH:D001289 Attention Deficit Disorder with Hyperactivity aripiprazole 8.3817069544
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 8.3818349709
MESH:D001321 Autistic Disorder marker/mechanism 17280648
MESH:D001321 Autistic Disorder aripiprazole 6.8017069544
MESH:D001321 Autistic Disorder Fluvoxamine 6.8012607287 18775368 19232924
MESH:D001321 Autistic Disorder Haloperidol 6.8018080171 19368416
MESH:D001321 Autistic Disorder olanzapine 6.8018685284 17069543
MESH:D001321 Autistic Disorder Risperidone 6.8019368416 17929164 18026891 18775368 16379507 17019624 17069546 15543515 19013209 19232924 16239862 18349709 16948927 15930063 15492353 15994720 16730335 18080171 18278980 16601648 19154706
MESH:D001321 Autistic Disorder Serotonin 6.8019221690 18405062 18361446 8570775 17157402 15132762 18062943
MESH:D001321 Autistic Disorder Sertraline 6.8018775368
MESH:D001321 Autistic Disorder ziprasidone 6.8018315450
MESH:D001714 Bipolar Disorder marker/mechanism 14708030
MESH:D001714 Bipolar Disorder Risperidone 4.2819154706 18278980
MESH:D001862 Bone Resorption Freund's Adjuvant 4.7316769263
MESH:D001919 Bradycardia Serotonin 5.038112388
MESH:D001930 Brain Injuries Raloxifene 4.0416580743
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.7217474063
MESH:D001943 Breast Neoplasms Estradiol 2.7217289903 16675129 12948864 17018787 18497071 17261762 14630087 19861407
MESH:D001943 Breast Neoplasms Nickel 2.7215986119
MESH:D001943 Breast Neoplasms Parathion 2.7212762645
MESH:D001943 Breast Neoplasms Raloxifene 2.7215758505 17595753 16912660 17952589 15572757 17440819 17893378 17049068 16837676 17261762 17242785 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 2.7219200415 19011961 18984771 19155303 21152245 18815881 19410462 15668708 16273361 15565566 18821012 17893378 19289846 18629630 17049068 18855134 19066611 19189210 19244106 20544844 19059307 19221464 21138602 19142967 17242785 19084267 16818667 19189212 20390343 16202921 19103187 19115204 20859285 18351453 16873071 11161223 17440819 20135344 19288272 20065188 20005174 19487384 18997820 18425577 17261762
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3516097048 15721981 16192424 15673190 3786805 15700767 18705752 16227642 10355542 16124888 16050911 16011737
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0719066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 5.8718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 5.8717162532 16935385 20512989 19171122 19822196 19052882 19418558 19701751 19519916 18393292 17428255 3084413 10737359 18788625 18665156 17055752 16779866 17978847 18971187 16878318 16698587 16569478 18785209 19539802 21159647 18210153 16681979 20727157 18691550 16288022 18056438 17761372 20084675 20514400 20524982 20214788 18494052 16328049 20432363 10672840 16807293 18506893 18978308 19208518 11831363 19919837 19383236 16502159 19107877 16540662 19394651 17173139 20935162 17138121 16830150 20007298 20101231 3581430 19335982
MESH:D006528 Carcinoma, Hepatocellular Estradiol 5.8716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 5.8716924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.2317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.2317572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.1415775269
MESH:D002375 Catalepsy Haloperidol 4.471977408 15215559
MESH:D002389 Catatonia olanzapine 5.8018071103 16772815
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 5.6717174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.6718566989
MESH:D002637 Chest Pain Trazodone 5.5715238202
MESH:D002659 Child Development Disorders, Pervasive aripiprazole 6.6519519261
MESH:D002659 Child Development Disorders, Pervasive Serotonin 6.6521254450
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.3119052882
MESH:D021081 Chronobiology Disorders Serotonin 6.2417157402
MESH:D003072 Cognition Disorders Clozapine 10.2417123785
MESH:D003072 Cognition Disorders Raloxifene 10.2415800139
MESH:D003128 Coma Trazodone 5.6810836866
MESH:D019465 Craniofacial Abnormalities Mianserin 4.2810978843
MESH:D019465 Craniofacial Abnormalities Ritanserin 4.2810978843 14991402
MESH:D016757 Death, Sudden, Cardiac Haloperidol 10.1020210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 10.1020210726
MESH:D003704 Dementia Haloperidol 14.6311575062
MESH:D003704 Dementia Risperidone 14.6311575062
MESH:D003704 Dementia Trazodone 14.6312587811 11575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9319031437
MESH:D003866 Depressive Disorder Fluvoxamine 20.8219571598
MESH:D003866 Depressive Disorder Mianserin 20.8218083778
MESH:D003866 Depressive Disorder Paroxetine 20.8215014590 17072103
MESH:D003866 Depressive Disorder Sertraline 20.8220305041 15014590 18822694
MESH:D003866 Depressive Disorder Trazodone 20.824066620 3378227 19623435 3690436 20305041 15014590 18083778
MESH:D003865 Depressive Disorder, Major marker/mechanism
MESH:D003865 Depressive Disorder, Major Fluvoxamine 20.6417474826
MESH:D003865 Depressive Disorder, Major Raloxifene 20.6417474826
MESH:D003865 Depressive Disorder, Major Sertraline 20.6416968574
MESH:D003865 Depressive Disorder, Major Trazodone 20.6416968574
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.5419470301 17100760 17244072
MESH:D003877 Dermatitis, Contact Nickel 4.232952479
MESH:D002658 Developmental Disabilities olanzapine 4.3917069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.2816402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2820387270
MESH:D003928 Diabetic Nephropathies Estradiol 12.8719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 12.8715920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.8719279558
MESH:D003967 Diarrhea Serotonin 4.3611488427 8112388 10446763
MESH:D006970 Disorders of Excessive Somnolence Clozapine 12.9415331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 12.9416379507
MESH:D053207 Diurnal Enuresis Risperidone 6.2217822346
MESH:D004314 Down Syndrome Risperidone 4.7418349709
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.4415027814 16177239 6884620 17522070 10092053 7440962 3786805 9327722 6623471 21278145 7120509 4309450 3732212 15968718 11566570 19085960 15998439 16227642 7179309 2869522 19336974 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.4419107877
MESH:D004409 Dyskinesia, Drug-Induced Trazodone 5.483690436
MESH:D020820 Dyskinesias marker/mechanism 11526996
MESH:D050171 Dyslipidemias Clozapine 3.8616402076
MESH:D004417 Dyspnea Diazinon 4.3516487989
MESH:D004421 Dystonia Trazodone 5.233700695
MESH:D004487 Edema Raloxifene 9.7415860553
MESH:D004487 Edema Serotonin 9.7418841975
MESH:D004487 Edema Trazodone 9.7412798668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 7.8515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.8519031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.4118566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.4116202921 20544844 19155303 17893378
MESH:D007172 Erectile Dysfunction Trazodone 5.067604472
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6616302075
MESH:D020329 Essential Tremor Trazodone 5.673296121
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.5712631006 61145 12795759 19224547 15959796 16239168 17595544 16045604
MESH:D005234 Fatty Liver Diethylnitrosamine 15.5720387270 21071580
MESH:D005234 Fatty Liver Raloxifene 15.5717473493
MESH:D005234 Fatty Liver Tamoxifen 15.5714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9616709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.0318705752
MESH:D005911 Gliosis Paraquat 4.7111124998
MESH:D006330 Heart Defects, Congenital Ritanserin 5.0714991402
MESH:D006331 Heart Diseases Raloxifene 3.2311110106
MESH:D018883 Heat Stroke Ketanserin 6.7216205318
MESH:D006505 Hepatitis Carbon Tetrachloride 8.2219900420 19110552
MESH:D006505 Hepatitis Diazinon 8.2216487989
MESH:D006558 Herpes Genitalis Estradiol 4.5815709030
MESH:D015658 HIV Infections Nickel 3.5817263646
MESH:D019584 Hot Flashes Estradiol 14.9017088409
MESH:D019584 Hot Flashes Paroxetine 14.9014716179
MESH:D019584 Hot Flashes Trazodone 14.9019711746
MESH:D006816 Huntington Disease Sertraline 5.5918403212
MESH:D006930 Hyperalgesia Freund's Adjuvant 7.8116769263
MESH:D006930 Hyperalgesia Trazodone 7.8112790215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0916899240
MESH:D006943 Hyperglycemia Risperidone 4.7818278980
MESH:D006948 Hyperkinesis Clozapine 4.4716046005
MESH:D006963 Hyperphagia olanzapine 5.7917933447
MESH:D006973 Hypertension Raloxifene 2.6915787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6615338365
MESH:D007024 Hypotension, Orthostatic Trazodone 5.5715811171
MESH:D007248 Infertility, Male Diazinon 9.8712948887 16466525
MESH:D007248 Infertility, Male Paraquat 9.874850670
MESH:D007248 Infertility, Male Parathion 9.8716029889
MESH:D007249 Inflammation Diethylnitrosamine 13.3518785209
MESH:D007249 Inflammation Freund's Adjuvant 13.3516793879
MESH:D007249 Inflammation Nickel 13.3516166738
MESH:D007249 Inflammation Tamoxifen 13.3519457130
MESH:D007249 Inflammation Trazodone 13.3512798668
MESH:D007333 Insulin Resistance Estradiol 2.6716627594 16393666
MESH:D007674 Kidney Diseases Estradiol 2.3315618244
MESH:D007680 Kidney Neoplasms Estradiol 6.2015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.2018625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.5916316344
MESH:D007889 Leiomyoma Raloxifene 4.0916973256
MESH:D008064 Lipidoses Clozapine 11.5517567588
MESH:D008064 Lipidoses Sertraline 11.5517567588
MESH:D008064 Lipidoses Tamoxifen 11.5517567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.7616943688 11903743 11408273 16221502 17157831 17174718 17334410 16239168 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.7620032147 18407596 18665156 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.1514620537 17900296 12632514 14724832 18277467 18481824 18472332 11481614 17698563 16033810 17823541 18705752 17761835 17944888 18395914 16097048 17805973 15057751 15370692 18166357 16248980 20821823 18006644 18395095 18412020 18205269 17714472 13678700 18376398 15876570 14716496 17640975 16136751 12445421 14512876 17976157 15931870 18317297 14748882 12667390 17708605 17525996 12649538 16192424 16638106 12632512 18210741 16011737 17922224 18418968 15730626 18263696 12546737 14716833 12666154 16116963 17557913 18156304 18054572 15996030 15818738 18429990 15338365 17766677 12445418 15959796 12898905 16027843 18472094 12586293 17869086 12958196 15925388 15052691 15673190 15362042 12389079 12741479 17481882 18279442 18251166 18339082 16015684 17721639 10355542 18187930 15893842 15650968 18420326 17565644 17631135 15123356 12609069
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.1514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.1518564211
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.8916964402 16246199 15720792 17285989 15830285
MESH:D008107 Liver Diseases Chlorpyrifos 5.8915991261
MESH:D008107 Liver Diseases Diethylnitrosamine 5.8917034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9314706259 16899240
MESH:D017114 Liver Failure, Acute Trazodone 8.9319857765
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 6.3919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 6.3920405173 19638242 20501860 20452335 19551842 18644402 19256749 12112319 9163691 18977376 19850985 21278145 20434301 18754104 19642983 19690152 19073162 19812893 19090486 19426721 20492335 19499222 19255062 20101389 21167192 19294768 10737359 15175105 15885732 18648771 2862719 12771043 19996281 20137499 18978307 19254457 21071580 19427195 20118626 21047994 20583210 19833225 2422723 16942905
MESH:D008113 Liver Neoplasms Tamoxifen 6.3916684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.0212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.023124819 16267830 19126423 18544905 18093689 18079962 2563599 19009564 17854601 18775883 19519916 19539802 18308698 16842330 9362446 18282651 18253720 18164116 19004024 17942915 21159647 17174075
MESH:D008133 Long QT Syndrome olanzapine 8.0820210726
MESH:D008133 Long QT Syndrome Trazodone 8.0818167038
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2920970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Tamoxifen 2.2918625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3219428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 11.9912807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.9911408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 11.9915375486
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.9916827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.1419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.1419453300
MESH:D008545 Melanoma Tamoxifen 1.8212393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7415990972
MESH:D001523 Mental Disorders aripiprazole 58.0716856516
MESH:D001523 Mental Disorders Clozapine 58.0716856516
MESH:D001523 Mental Disorders Fluvoxamine 58.0716856516
MESH:D001523 Mental Disorders Haloperidol 58.0716856516
MESH:D001523 Mental Disorders Mianserin 58.0716856516
MESH:D001523 Mental Disorders olanzapine 58.0716856516
MESH:D001523 Mental Disorders Paroxetine 58.0716856516
MESH:D001523 Mental Disorders quetiapine 58.0716856516
MESH:D001523 Mental Disorders Risperidone 58.0716596465 16856516
MESH:D001523 Mental Disorders Sertraline 58.0716856516
MESH:D001523 Mental Disorders Trazodone 58.0716856516
MESH:D001523 Mental Disorders ziprasidone 58.0716856516
MESH:D008607 Mental Retardation aripiprazole 6.5416891339 17069544
MESH:D008607 Mental Retardation Risperidone 6.5418349709
MESH:D008659 Metabolic Diseases marker/mechanism 19142110
MESH:D008659 Metabolic Diseases olanzapine 4.9919142110
MESH:D024821 Metabolic Syndrome X Clozapine 8.9819142101
MESH:D024821 Metabolic Syndrome X Risperidone 8.9819142101
MESH:D008881 Migraine Disorders marker/mechanism 12482207
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1015863610
MESH:D019964 Mood Disorders Risperidone 5.4017019624
MESH:D009069 Movement Disorders Trazodone 5.354066620
MESH:D009101 Multiple Myeloma Raloxifene 3.1216497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9416810080
MESH:D009232 Myxoma Raloxifene 5.1016343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.093581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.0919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3619410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5519189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2917289903
MESH:D009410 Nerve Degeneration Paraquat 3.3816893418
MESH:D009421 Nervous System Malformations Estradiol 3.2316427766 11399458
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 2.9820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6620387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.8615081274
MESH:D053206 Nocturnal Enuresis Risperidone 5.8817822346
MESH:D009765 Obesity marker/mechanism 17097612
MESH:D009765 Obesity Clozapine 4.9718515891 19142110
MESH:D009765 Obesity olanzapine 4.9718515891
MESH:D009771 Obsessive-Compulsive Disorder marker/mechanism
MESH:D009771 Obsessive-Compulsive Disorder Paroxetine 5.6617503984
MESH:D053578 Opsoclonus-Myoclonus Syndrome Trazodone 6.011318289
MESH:D010024 Osteoporosis Calcium 6.5917882678
MESH:D010024 Osteoporosis Raloxifene 6.5919059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8217823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 2.0719401270
MESH:D010146 Pain Tramadol 7.1018204346
MESH:D010146 Pain Trazodone 7.1012790215 12798668
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.2616540662
MESH:D010300 Parkinson Disease Paraquat 2.6412911755 16140633 15451049 15824117 11445065 11124998 11181820 16510128
MESH:D010302 Parkinson Disease, Secondary Paraquat 10.0616190885
MESH:D010302 Parkinson Disease, Secondary Trazodone 10.063378227
MESH:D011014 Pneumonia Paraquat 4.0112504350
MESH:D011041 Poisoning Diazinon 3.9517603234
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.182563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4920887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.7516740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7515731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7515067354
MESH:D011595 Psychomotor Agitation Haloperidol 10.3811575062
MESH:D011595 Psychomotor Agitation olanzapine 10.3818685284
MESH:D011618 Psychotic Disorders marker/mechanism 14708030
MESH:D011618 Psychotic Disorders aripiprazole 13.0816891339
MESH:D011618 Psychotic Disorders Clozapine 13.0815331141
MESH:D011618 Psychotic Disorders Haloperidol 13.0811575062
MESH:D011657 Pulmonary Eosinophilia Trazodone 5.688520792
MESH:D011658 Pulmonary Fibrosis Paraquat 2.7316324872 17997886
MESH:D011693 Purpura Raloxifene 5.1015770314
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.5011700416
MESH:D012131 Respiratory Insufficiency Trazodone 5.358520792
MESH:D012135 Respiratory Sounds Chlorpyrifos 13.8717119214 16611668 11874814
MESH:D012135 Respiratory Sounds Paraquat 13.8711874814
MESH:D012135 Respiratory Sounds Parathion 13.8711874814 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 9.7716611668 17119214
MESH:D012140 Respiratory Tract Diseases Parathion 9.7717119214
MESH:D012162 Retinal Degeneration Paraquat 3.5416458197
MESH:D012559 Schizophrenia marker/mechanism 18513383 14708030
MESH:D012559 Schizophrenia aripiprazole 15.2416891339
MESH:D012559 Schizophrenia Clozapine 15.2417726453 19369910 20107430 20168265 18855531 20521320 20580759 17667964 20452607 18806925 20521326 16141801 11763009 17123785 11151749
MESH:D012559 Schizophrenia Haloperidol 15.2420107430 19369910 1830565 18513383
MESH:D012559 Schizophrenia norclozapine 15.2411151749
MESH:D012559 Schizophrenia olanzapine 15.2417726453 20107430 20521326
MESH:D012559 Schizophrenia Risperidone 15.2419154706 18278980 20107430
MESH:D012559 Schizophrenia Trazodone 15.247868106
MESH:D020230 Serotonin Syndrome Trazodone 5.688704074 7854515 9050436
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.646418539
MESH:D012892 Sleep Deprivation Trazodone 5.8119798453
MESH:D012893 Sleep Disorders Risperidone 10.1418278980
MESH:D012893 Sleep Disorders Trazodone 10.1419395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Trazodone 4.9917225163 15062207 15341891
MESH:D013088 Spermatocele Tamoxifen 3.8416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6019457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D020521 Stroke Raloxifene 8.1216837676
MESH:D020521 Stroke Trazodone 8.12810300
MESH:D013375 Substance Withdrawal Syndrome Mianserin 9.8412749364
MESH:D013375 Substance Withdrawal Syndrome Trazodone 9.8412749364 393279
MESH:D017180 Tachycardia, Ventricular Haloperidol 27.8820210726
MESH:D017180 Tachycardia, Ventricular olanzapine 27.8820210726
MESH:D017180 Tachycardia, Ventricular Risperidone 27.8820210726
MESH:D017180 Tachycardia, Ventricular Trazodone 27.882424891
MESH:D017180 Tachycardia, Ventricular ziprasidone 27.8820210726
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.657505956
MESH:D013978 Tibial Fractures Estradiol 12.2119048282
MESH:D013978 Tibial Fractures Raloxifene 12.2119048282
MESH:D005879 Tourette Syndrome Risperidone 5.5119154706
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 4.6017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.6016712894 8653321 17572228
MESH:D014570 Urologic Diseases Diazinon 4.8316487989
MESH:D054556 Venous Thromboembolism Raloxifene 4.7616837676
MESH:D018879 Ventricular Premature Complexes Trazodone 6.372424891
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1016343187
MESH:D015430 Weight Gain Clozapine 14.4720564506 20107430 16402076 17502770 16141801 20521320
MESH:D015430 Weight Gain olanzapine 14.4717933447 19434072 20107430
MESH:D015430 Weight Gain Risperidone 14.4716379507 20564506
MESH:D015431 Weight Loss Clozapine 4.6317933447
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04540 Gap junction
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA193
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    PA447207Depressive Disorder
    PA445876Tobacco Use Disorder
    PA128406954Weight gain
    PA447216Schizophrenia
    PA447198Autistic Disorder
    PA447278Depression
    PA447321Depressive Disorder, Major
    PA447218Sexual Dysfunctions, Psychological
    Releated drug ID Related drug Name
    PA10026aripiprazole
    PA449690fluvoxamine
    PA451333sertraline
    PA450626nicotine
    PA10074escitalopram
    PA452229antidepressants
    PA451744trazodone
    PA450688olanzapine
    PA452233antipsychotics
    PA449061clozapine
    PA449673fluoxetine
    PA450801paroxetine
    PA449015citalopram
    PA451257risperidone
    PA164713257Selective serotonin reuptake inhibitors
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00247 antagonist Methysergide Vasoconstrictor Agents;Sympatholytics;Serotonin Antagonists
    DB00248 agonist Cabergoline Antineoplastic Agents;Antiparkinson Agents;Dopamine Agonists
    DB00268 agonist Ropinirole Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00370 antagonist Mirtazapine Histamine H1 Antagonists;Adrenergic alpha-Antagonists;Antidepressive Agents, Tricyclic
    DB00408 antagonist Loxapine Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00409 other/unknown Remoxipride Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00413 unknown Pramipexole Antioxidants;Free Radical Scavengers;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00420 antagonist Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00434 antagonist Cyproheptadine Serotonin Antagonists;Antipruritics;Gastrointestinal Agents;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamine derivatives
    DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00472 antagonist Fluoxetine Selective Serotonin Reuptake Inhibitors (SSRIs);Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00477 antagonist Chlorpromazine Antiemetics;Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00502 other/unknown Haloperidol Antiemetics;Antidyskinetics;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Butyrophenones;Anti-Dyskinesia Agents
    DB00540 antagonist Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00589 agonist Lisuride Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Serotonin Agonists
    DB00604 agonist Cisapride Anti-Ulcer Agents;Gastrointestinal Agents;Serotonin Agonists;Prokinetic Agents
    DB00656 antagonist Trazodone Anti-anxiety Agents;Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00679 antagonist Thioridazine Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00696 agonist Wigraine Tab Vasoconstrictor Agents;Sympatholytics;Adrenergic alpha-Agonists;Analgesics, Non-Narcotic
    DB00714 agonist Homeopathic Remedy Thc No. 48 Dps Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00715 other/unknown Paroxetine Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00726 agonist Trimipramine Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00734 antagonist Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00751 antagonist Epinastine Histamine H1 Antagonists;Antihistamines;Ophthalmics
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB00805 antagonist Minaprine Central Nervous System Agents;Antiparkinson Agents;Antidepressive Agents
    DB00843 other/unknown Donepezil Parasympathomimetics;Cholinesterase Inhibitors;Nootropic Agents
    DB00875 antagonist Flupenthixol Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Thioxanthenes
    DB00924 antagonist Cyclobenzaprine Muscle Relaxants;Skeletal Muscle Relaxants;Antidepressive Agents, Tricyclic;Muscle Relaxants, Central;Tranquilizing Agents
    DB00933 antagonist Mesoridazine Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB01069 antagonist Phenergan VC Expectorant Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Phenothiazine Derivatives
    DB01079 antagonist Tegaserod Gastrointestinal Agents;Serotonin Agonists
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01149 antagonist Nefazodone Antidepressants;Analgesics;Antidepressive Agents, Second-Generation;Serotonin Agents
    DB01151 antagonist Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01238 antagonist Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01239 antagonist Chlorprothixene Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB01242 antagonist Clomipramine Antidepressive Agents, Tricyclic;Serotonin Uptake Inhibitors
    DB01267 antagonist Paliperidone Antipsychotic Agents
    DB01287 agonist Dihydroergotoxine
    DB01392 antagonist Yohimbine Mydriatics;Adrenergic alpha-Antagonists
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB01442 agonist MMDA Psychotropic Drugs
    DB01454 agonist 3,4-Methylenedioxymethamphetamine Adrenergic Uptake Inhibitors;Hallucinogens;Serotonin Agents
    DB01488 - Dimethyltryptamine Serotonin Antagonists;Hallucinogens;Serotonin Agonists
    DB01614 antagonist Acepromazine Dopamine Antagonists;Antipsychotic Agents;Sedatives and Hypnotics
    DB01618 antagonist Molindone Antipsychotic Agents
    DB01621 antagonist Pipotiazine Phenothiazines;Antipsychotic Agents
    DB01622 antagonist Thioproperazine Phenothiazines;Antipsychotic Agents
    DB01623 antagonist Thiothixene Dopamine Antagonists;Antipsychotic Agents;Thioxanthenes
    DB01624 antagonist Zuclopenthixol Dopamine Antagonists;Antipsychotic Agents
    DB04599 - Aniracetam Nootropic Agents;Antidepressive Agents
    DB04842 antagonist Fluspirilene Dopamine Antagonists;Antipsychotic Agents
    DB06144 antagonist Sertindole Neuroleptics;Antipsychotic Agents
    DB06148 antagonist Mianserin Serotonin Antagonists;Histamine H1 Antagonists;Adrenergic alpha-Antagonists;Antidepressive Agents, Second-Generation
    DB06288 antagonist Amisulpride Dopamine Antagonists;Antipsychotic Agents
    DB08810 antagonist Cinitapride Antiemetics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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