AutismKB 2.0

Annotation Detail for HTR2C


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Basic Information Top
Gene Symbol:HTR2C ( 5-HT2C,5-HTR2C,HTR1C )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 2C
Band: Xq23
Quick LinksEntrez ID:3358; OMIM: 312861; Uniprot ID:5HT2C_HUMAN; ENSEMBL ID: ENSG00000147246; HGNC ID: 5295
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04540Gap junction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P043745HT2 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1909Migraine
2006Anorexia nervosa
2091Hypertension
2045Bipolar disorder
2221Behavior disease
Desease Name
weight gain, antipsychotic-induced
personality traits
seasonal affective disorder
clozapine response
weight gain (antipsychotic-drug induced)
PSYCH
Weight Gain
PHARMACOGENOMIC
NEUROLOGICAL
tardive dyskinesia
attention deficit hyperactivity disorder
schizophrenia
METABOLIC
Body Weight
obesity
weight gain, antipsychotic drug-induced
Weight Loss
antipsychotic agent-induced weight gain
schizophrenia weight gain
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C118559 1-bromopropane 1-bromopropane results in increased expression of HTR2C mRNAincreases expression 19576243
C107820 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein]decreases reaction|increases expression 18083778
C107820 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [mirtazapine results in increased expression of HTR2C protein]decreases reaction|increases expression 18083778
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HTR2C proteinaffects expression 20106945
D000639 Amitriptyline Amitriptyline binds to HTR2C proteinaffects binding 18083778
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HTR2C mRNAaffects expression 16483693
D002220 Carbamazepine Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [CQ 32085 binds to HTR2C protein]]affects binding|affects reaction|decreases reaction 19700373
D002220 Carbamazepine Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]decreases expression|decreases reaction 19439326
D002220 Carbamazepine Carbamazepine inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]decreases reaction|increases expression 19700373
D015283 Citalopram Citalopram binds to HTR2C proteinaffects binding 18083778
D002997 Clomipramine Clomipramine binds to HTR2C proteinaffects binding 18083778
D003024 Clozapine Clozapine binds to HTR2C proteinaffects binding 16983399
D003024 Clozapine HTR2C gene polymorphism affects the susceptibility to Clozapineaffects response to substance 19142110
19142101
D003024 Clozapine HTR2C gene SNP affects the susceptibility to Clozapineaffects response to substance 15635667
D003024 Clozapine HTR2C promoter SNP affects the susceptibility to Clozapineaffects response to substance 12668355
D003024 Clozapine HTR2C protein affects the susceptibility to Clozapineaffects response to substance 19142101
D003024 Clozapine Clozapine results in decreased expression of HTR2C mRNAdecreases expression 17868938
C031649 CQ 32085 CQ 32085 binds to HTR2C proteinaffects binding 18083778
C031649 CQ 32085 Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [CQ 32085 binds to HTR2C protein]]affects binding|affects reaction|decreases reaction 19700373
C031649 CQ 32085 CQ 32085 binds to HTR2C proteinaffects binding 19700373
19439326
C031649 CQ 32085 Pilocarpine affects the reaction [CQ 32085 binds to HTR2C protein]affects binding|affects reaction 19439326
19700373
C031649 CQ 32085 Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [CQ 32085 binds to HTR2C protein]]affects binding|affects reaction|decreases reaction 19700373
D016572 Cyclosporine Cyclosporine results in decreased expression of HTR2C mRNAdecreases expression 20106945
D003976 Diazinon Diazinon results in decreased expression of HTR2C mRNAdecreases expression 17452286
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of HTR2C mRNAincreases expression 15620428
D004026 Dieldrin Dieldrin affects the expression of HTR2C mRNAaffects expression 18835401
D004041 Dietary Fats Dietary Fats results in increased expression of HTR2C mRNAincreases expression 18721800
D002117 Calcitriol Calcitriol results in increased expression of HTR2C mRNAincreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Sertraline] affects the expression of HTR2C mRNAaffects cotreatment|affects expression 18650020
D004958 Estradiol Estradiol promotes the reaction [Sertraline results in increased expression of HTR2C mRNA]increases expression|increases reaction 18650020
D004958 Estradiol Estradiol results in increased expression of HTR2C mRNAincreases expression 20068009
D005473 Fluoxetine Fluoxetine binds to HTR2C proteinaffects binding 18083778
D006220 Haloperidol Haloperidol results in decreased expression of HTR2C mRNAdecreases expression 17868938
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of HTR2C mRNAincreases expression 12057914
D008803 Mianserin 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein]decreases reaction|increases expression 18083778
D008803 Mianserin Mianserin binds to and affects the activity of HTR2C proteinaffects activity|affects binding 18083778
D008803 Mianserin Mianserin results in increased expression of HTR2C proteinincreases expression 18083778
D008803 Mianserin Mianserin binds to and results in decreased activity of HTR2C proteinaffects binding|decreases activity 10978843
C035133 mirtazapine 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [mirtazapine results in increased expression of HTR2C protein]decreases reaction|increases expression 18083778
C035133 mirtazapine mirtazapine binds to and affects the activity of HTR2C proteinaffects activity|affects binding 18083778
C035133 mirtazapine mirtazapine results in increased expression of HTR2C proteinincreases expression 18083778
D009151 Mustard Gas Mustard Gas results in increased expression of HTR2C mRNAincreases expression 15674844
C051752 nefazodone nefazodone binds to HTR2C proteinaffects binding 18083778
C058272 norclozapine norclozapine binds to and results in decreased activity of HTR2C proteinaffects binding|decreases activity 15542624
C036139 norfluoxetine norfluoxetine binds to HTR2C proteinaffects binding 18083778
C076029 olanzapine HTR2C gene polymorphism affects the susceptibility to olanzapineaffects response to substance 19142110
C076029 olanzapine HTR2C gene polymorphism results in increased susceptibility to olanzapineincreases response to substance 19434072
C076029 olanzapine HTR2C gene SNP affects the susceptibility to olanzapineaffects response to substance 15666332
C076029 olanzapine HTR2C protein affects the susceptibility to olanzapineaffects response to substance 19434072
C076029 olanzapine olanzapine binds to HTR2C proteinaffects binding 16983399
D010862 Pilocarpine Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [CQ 32085 binds to HTR2C protein]]affects binding|affects reaction|decreases reaction 19700373
D010862 Pilocarpine Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]decreases expression|decreases reaction 19439326
D010862 Pilocarpine Carbamazepine inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]decreases reaction|increases expression 19700373
D010862 Pilocarpine Pilocarpine affects the reaction [CQ 32085 binds to HTR2C protein]affects binding|affects reaction 19700373
19439326
D010862 Pilocarpine Pilocarpine results in decreased expression of HTR2C mRNAdecreases expression 19439326
D010862 Pilocarpine Pilocarpine results in increased expression of HTR2C mRNAincreases expression 19700373
D010862 Pilocarpine Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [CQ 32085 binds to HTR2C protein]]affects binding|affects reaction|decreases reaction 19700373
D010862 Pilocarpine Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]decreases expression|decreases reaction 19439326
D010862 Pilocarpine Plant Extracts inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]decreases reaction|increases expression 19700373
D010936 Plant Extracts Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [CQ 32085 binds to HTR2C protein]]affects binding|affects reaction|decreases reaction 19700373
D010936 Plant Extracts Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]decreases expression|decreases reaction 19439326
D010936 Plant Extracts Plant Extracts inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]decreases reaction|increases expression 19700373
D018967 Risperidone HTR2C gene polymorphism affects the susceptibility to Risperidoneaffects response to substance 19142101
D018967 Risperidone HTR2C protein affects the susceptibility to Risperidoneaffects response to substance 19142101
D016713 Ritanserin Ritanserin binds to and results in decreased activity of HTR2C proteinaffects binding|decreases activity 19228979
C094868 SB 206553 SB 206553 results in increased expression of HTR2C proteinincreases expression 18083778
D020280 Sertraline [Estradiol co-treated with Sertraline] affects the expression of HTR2C mRNAaffects cotreatment|affects expression 18650020
D020280 Sertraline Estradiol promotes the reaction [Sertraline results in increased expression of HTR2C mRNA]increases expression|increases reaction 18650020
D020280 Sertraline Sertraline results in increased expression of HTR2C mRNAincreases expression 18650020
D014196 Trazodone Trazodone binds to HTR2C proteinaffects binding 18083778
D014196 Trazodone Trazodone binds to and results in decreased activity of HTR2C proteinaffects binding|decreases activity 19623435
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 4.218986270
MESH:D000138 Acidosis Ammonium Chloride 3.2218287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.7218653653 11850527
MESH:D000230 Adenocarcinoma Estradiol 2.0111473722
MESH:D000380 Agranulocytosis Clozapine 4.7212649775 16160616 14617031
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.0016487989
MESH:D000544 Alzheimer Disease Plant Extracts 4.7716962711
MESH:D000544 Alzheimer Disease Trazodone 4.7716856516 17897735
MESH:D001008 Anxiety Disorders Citalopram 13.8818083778
MESH:D001008 Anxiety Disorders Fluoxetine 13.8818083778
MESH:D001008 Anxiety Disorders Sertraline 13.8818822694
MESH:D001161 Arteriosclerosis Dietary Fats 3.5615238619
MESH:D001169 Arthritis, Experimental Plant Extracts 3.7414686799
MESH:D020817 Asperger Syndrome Risperidone 5.2116401163
MESH:D001249 Asthma Mustard Gas 2.6110378619
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.5618349709
MESH:D001321 Autistic Disorder Citalopram 5.6218775368 19232924
MESH:D001321 Autistic Disorder Fluoxetine 5.6218775368 19232924
MESH:D001321 Autistic Disorder Haloperidol 5.6218080171 19368416
MESH:D001321 Autistic Disorder mirtazapine 5.6216648008
MESH:D001321 Autistic Disorder olanzapine 5.6217069543 18685284
MESH:D001321 Autistic Disorder Risperidone 5.6215994720 16239862 16948927 17069546 16730335 19013209 15543515 16379507 18080171 19368416 17929164 18026891 17019624 18349709 18775368 15930063 16601648 15492353 19232924 19154706 18278980
MESH:D001321 Autistic Disorder Sertraline 5.6218775368
MESH:D001714 Bipolar Disorder Carbamazepine 7.4920046352 17594078
MESH:D001714 Bipolar Disorder Risperidone 7.4919154706 18278980
MESH:D001768 Blister Mustard Gas 4.8219167455
MESH:D002545 Brain Ischemia Plant Extracts 4.3916041641
MESH:D001943 Breast Neoplasms Calcitriol 1.9811237771
MESH:D001943 Breast Neoplasms Dieldrin 1.9811859874 15770527
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Estradiol 1.9819861407 17289903 17018787 12948864 17261762 18497071 14630087 16675129
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6317687719 10378619
MESH:D002057 Burns, Chemical Plant Extracts 4.999625245
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.3812907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.3816924424
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 4.3818834353
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.5311237771
MESH:D006332 Cardiomegaly Plant Extracts 3.6117645561
MESH:D002375 Catalepsy Haloperidol 4.571977408 15215559
MESH:D002389 Catatonia olanzapine 5.9016772815 18071103
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.8012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.8018566989
MESH:D002637 Chest Pain Trazodone 5.6715238202
MESH:D002659 Child Development Disorders, Pervasive Citalopram 4.4315782081
MESH:D002779 Cholestasis Cyclosporine 2.6719486331
MESH:D003072 Cognition Disorders Clozapine 4.6317123785
MESH:D003128 Coma Trazodone 5.7810836866
MESH:D019465 Craniofacial Abnormalities Carbamazepine 4.409014606
MESH:D019465 Craniofacial Abnormalities Mianserin 4.4010978843
MESH:D019465 Craniofacial Abnormalities Ritanserin 4.4010978843 14991402
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.1216037377
MESH:D016757 Death, Sudden, Cardiac Haloperidol 10.4120210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 10.4120210726
MESH:D003704 Dementia Haloperidol 15.1711575062
MESH:D003704 Dementia Risperidone 15.1711575062
MESH:D003704 Dementia Trazodone 15.1711575062 12587811
MESH:D003866 Depressive Disorder Amitriptyline 43.9815014590 18083778
MESH:D003866 Depressive Disorder Citalopram 43.9815014590
MESH:D003866 Depressive Disorder Clomipramine 43.9818083778
MESH:D003866 Depressive Disorder Fluoxetine 43.9815014590
MESH:D003866 Depressive Disorder Mianserin 43.9818083778
MESH:D003866 Depressive Disorder mirtazapine 43.9818083778
MESH:D003866 Depressive Disorder nefazodone 43.9818083778 16410371
MESH:D003866 Depressive Disorder Sertraline 43.9815014590 18822694 20305041
MESH:D003866 Depressive Disorder Trazodone 43.984066620 3690436 19623435 3378227 20305041 18083778 15014590
MESH:D003865 Depressive Disorder, Major Sertraline 9.9416968574
MESH:D003865 Depressive Disorder, Major Trazodone 9.9416968574
MESH:D002658 Developmental Disabilities olanzapine 4.4617069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.8916402076
MESH:D003928 Diabetic Nephropathies Estradiol 8.2419279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 8.2419706694
MESH:D006970 Disorders of Excessive Somnolence Clozapine 13.2915331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 13.2916379507
MESH:D053207 Diurnal Enuresis Risperidone 6.3317822346
MESH:D004314 Down Syndrome Risperidone 4.8218349709
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.1111748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.2016538176 16538175 20216337 15057820
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 3.1417465707
MESH:D004362 Drug Toxicity Carbamazepine 4.2120216337
MESH:D004409 Dyskinesia, Drug-Induced Trazodone 5.583690436
MESH:D050171 Dyslipidemias Clozapine 8.0616402076
MESH:D050171 Dyslipidemias Dietary Fats 8.0618367378
MESH:D004417 Dyspnea Diazinon 4.4616487989
MESH:D004421 Dystonia Trazodone 5.323700695
MESH:D004487 Edema Amitriptyline 23.1812798668
MESH:D004487 Edema Clomipramine 23.1812798668
MESH:D004487 Edema Fluoxetine 23.1812798668
MESH:D004487 Edema Mustard Gas 23.1811402378 9260866 11428631 11428647
MESH:D004487 Edema Plant Extracts 23.1812787963
MESH:D004487 Edema Trazodone 23.1812798668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.5915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 8.5917654737
MESH:D016889 Endometrial Neoplasms Estradiol 2.7618566989 11473722 19148513
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.3315268973
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0615821434 15328337 17637181
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.9318855540 16538176 20485159 19915237 16415921
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 4.8817275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.6316628512 17116037 15008574
MESH:D004827 Epilepsy Carbamazepine 10.477988514 20417680 18234410 9014606 19700373 17465707 19439326 821787 17178248 19620853
MESH:D004827 Epilepsy Pilocarpine 10.4719700373 19439326 11162239
MESH:D004827 Epilepsy Plant Extracts 10.4719439326 19700373
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.027750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 4.7815276670 3659116
MESH:D007172 Erectile Dysfunction Trazodone 5.167604472
MESH:D004890 Erythema Mustard Gas 4.829357497
MESH:D004916 Erythromelalgia Carbamazepine 5.3819549232
MESH:D020329 Essential Tremor Trazodone 5.773296121
MESH:D005076 Exanthema Carbamazepine 5.1320485159
MESH:D005234 Fatty Liver Cyclosporine 11.4919224547
MESH:D005234 Fatty Liver Dietary Fats 11.4917967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Plant Extracts 11.4915975614
MESH:D005329 Fetishism (Psychiatric) mirtazapine 6.9718439117
MESH:D005334 Fever Lipopolysaccharides 3.7211852909 9205823
MESH:D005355 Fibrosis Cyclosporine 7.5912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 7.5918296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.888708960
MESH:D006330 Heart Defects, Congenital Ritanserin 5.1314991402
MESH:D006333 Heart Failure Plant Extracts 3.6618097624
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0815720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0916366002
MESH:D006505 Hepatitis Diazinon 4.2516487989
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D006561 Herpes Simplex Plant Extracts 4.2910715843
MESH:D015658 HIV Infections Plant Extracts 3.5012878215
MESH:D019584 Hot Flashes Estradiol 21.6617088409
MESH:D019584 Hot Flashes Fluoxetine 21.6614716179
MESH:D019584 Hot Flashes Plant Extracts 21.6617454163 16566672 14716179
MESH:D019584 Hot Flashes Trazodone 21.6619711746
MESH:D006816 Huntington Disease Sertraline 5.6918403212
MESH:D006930 Hyperalgesia Trazodone 4.6112790215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2921332399
MESH:D006943 Hyperglycemia Risperidone 4.8718278980
MESH:D020138 Hyperhomocysteinemia Carbamazepine 8.8910459572
MESH:D020138 Hyperhomocysteinemia Plant Extracts 8.8916484555
MESH:D006948 Hyperkinesis Clozapine 4.5716046005
MESH:D006949 Hyperlipidemias Dietary Fats 8.4121332399
MESH:D006949 Hyperlipidemias Plant Extracts 8.4115268973 15975614
MESH:D006963 Hyperphagia olanzapine 5.8917933447
MESH:D006965 Hyperplasia Carbamazepine 4.8818773962
MESH:D006973 Hypertension Cyclosporine 1.9710903974
MESH:D007024 Hypotension, Orthostatic Trazodone 5.6715811171
MESH:D007247 Infertility, Female Dieldrin 4.6210630421
MESH:D007248 Infertility, Male Diazinon 3.6016466525 12948887
MESH:D007249 Inflammation Amitriptyline 25.4912798668
MESH:D007249 Inflammation Clomipramine 25.4912798668
MESH:D007249 Inflammation Dietary Fats 25.4920412841
MESH:D007249 Inflammation Fluoxetine 25.4912798668
MESH:D007249 Inflammation Lipopolysaccharides 25.499205823 12878042 17255318 17237260 17963957
MESH:D007249 Inflammation Mustard Gas 25.498975870 11402378 17524151 9357497 9260866 11428647 11428620 11428631 16001271
MESH:D007249 Inflammation Plant Extracts 25.4912787963 16366677 15997105 19332304
MESH:D007249 Inflammation Trazodone 25.4912798668
MESH:D007333 Insulin Resistance Dietary Fats 6.6311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 6.6316393666 16627594
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.3212351151 12584176 12628509
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3217255318
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0915604871
MESH:D007674 Kidney Diseases Cyclosporine 5.2818776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 5.2815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.3712371664
MESH:D007680 Kidney Neoplasms Estradiol 6.3715610895
MESH:D007970 Leukopenia Lipopolysaccharides 4.3615821434
MESH:D008064 Lipidoses Amitriptyline 27.4815342952 17567588
MESH:D008064 Lipidoses Citalopram 27.4817567588
MESH:D008064 Lipidoses Clomipramine 27.4815342952 17567588
MESH:D008064 Lipidoses Clozapine 27.4817567588
MESH:D008064 Lipidoses Fluoxetine 27.4817567588 15342952
MESH:D008064 Lipidoses Sertraline 27.4817567588
MESH:D008103 Liver Cirrhosis Dietary Fats 6.3418296743
MESH:D008103 Liver Cirrhosis Plant Extracts 6.3417157831
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.4512878042
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 3.4515479170
MESH:D008107 Liver Diseases Plant Extracts 2.9317034775
MESH:D017114 Liver Failure, Acute Trazodone 5.1219857765
MESH:D008113 Liver Neoplasms Aflatoxin B1 6.9618177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Dieldrin 6.969539021 8742319
MESH:D008113 Liver Neoplasms Plant Extracts 6.9619168119
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.548603461
MESH:D008133 Long QT Syndrome olanzapine 8.3520210726
MESH:D008133 Long QT Syndrome Trazodone 8.3518167038
MESH:D008171 Lung Diseases Mustard Gas 3.2218161513 18702808
MESH:D055370 Lung Injury Lipopolysaccharides 3.6821114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4014755239
MESH:D008175 Lung Neoplasms Mustard Gas 3.408781369 3148597
MESH:D008175 Lung Neoplasms Plant Extracts 3.4020869020
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.4716628512
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.3511807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.1419453300
MESH:D001523 Mental Disorders Amitriptyline 67.3516856516
MESH:D001523 Mental Disorders Citalopram 67.3516856516
MESH:D001523 Mental Disorders Clomipramine 67.3516856516
MESH:D001523 Mental Disorders Clozapine 67.3516856516
MESH:D001523 Mental Disorders Fluoxetine 67.3516856516
MESH:D001523 Mental Disorders Haloperidol 67.3516856516
MESH:D001523 Mental Disorders Mianserin 67.3516856516
MESH:D001523 Mental Disorders mirtazapine 67.3516856516
MESH:D001523 Mental Disorders norfluoxetine 67.3516856516
MESH:D001523 Mental Disorders olanzapine 67.3516856516
MESH:D001523 Mental Disorders Risperidone 67.3516856516 16596465
MESH:D001523 Mental Disorders Sertraline 67.3516856516
MESH:D001523 Mental Disorders Trazodone 67.3516856516
MESH:D008607 Mental Retardation Carbamazepine 6.299014606
MESH:D008607 Mental Retardation Risperidone 6.2918349709
MESH:D008659 Metabolic Diseases olanzapine 5.0919142110
MESH:D024821 Metabolic Syndrome X marker/mechanism 17632216 18515891 19142101
MESH:D024821 Metabolic Syndrome X Clozapine 9.2719142101
MESH:D024821 Metabolic Syndrome X Risperidone 9.2719142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4416801185
MESH:D008881 Migraine Disorders Amitriptyline 4.5518803445
MESH:D019964 Mood Disorders Risperidone 5.5017019624
MESH:D009069 Movement Disorders Trazodone 5.454066620
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0216810080
MESH:D009207 Myoclonus Fluoxetine 5.548041377
MESH:D009224 Myotonia Congenita Carbamazepine 5.1320399394
MESH:D009369 Neoplasms Dieldrin 3.318820588
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0018481113 19348381
MESH:D009421 Nervous System Malformations Carbamazepine 14.9316990009
MESH:D009421 Nervous System Malformations Estradiol 14.9316427766 11399458
MESH:D009421 Nervous System Malformations Pilocarpine 14.9315987249
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.8517168769
MESH:D009503 Neutropenia Mustard Gas 3.667688884 16761898
MESH:D053206 Nocturnal Enuresis Risperidone 5.9817822346
MESH:D009765 Obesity marker/mechanism 17702092 19142110
MESH:D009765 Obesity Clozapine 10.0218515891 19142110
MESH:D009765 Obesity Dietary Fats 10.0221332399 20132043 17217161 20518802 16723640 18674790 19632207 18457598 11836018
MESH:D009765 Obesity olanzapine 10.0218515891
MESH:D009765 Obesity Plant Extracts 10.0220132043 19056576
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.1420418887
MESH:D053578 Opsoclonus-Myoclonus Syndrome Trazodone 6.111318289
MESH:D010018 Osteomalacia Carbamazepine 5.1317016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.1119401270
MESH:D010146 Pain Amitriptyline 18.4312798668
MESH:D010146 Pain Carbamazepine 18.4315215642
MESH:D010146 Pain Clomipramine 18.4312798668
MESH:D010146 Pain Fluoxetine 18.4312798668
MESH:D010146 Pain Trazodone 18.4312798668 12790215
MESH:D010212 Papilloma Plant Extracts 4.1616517061 15173996
MESH:D010267 Parapsoriasis Carbamazepine 5.3716538176
MESH:D010300 Parkinson Disease Dieldrin 3.4011445065 11181820 16809432 17291500 16112328
MESH:D010302 Parkinson Disease, Secondary Trazodone 5.413378227
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.5817679678 17145499
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.678041377
MESH:D011014 Pneumonia Lipopolysaccharides 4.2112224865 11605937
MESH:D011041 Poisoning Diazinon 7.9817603234
MESH:D011041 Poisoning Mustard Gas 7.9815727166
MESH:D011230 Precancerous Conditions Cyclosporine 2.9412371664
MESH:D011248 Pregnancy Complications Carbamazepine 4.829014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 4.559014606
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4415572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5820887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.8216289102 18247401 16644109 15754350 12479363
MESH:D011471 Prostatic Neoplasms Estradiol 2.8216740699
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.8214666653 17804756
MESH:D011537 Pruritus Mustard Gas 3.7518058305
MESH:D019310 Pseudolymphoma Carbamazepine 5.259591791 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011595 Psychomotor Agitation Haloperidol 10.7111575062
MESH:D011595 Psychomotor Agitation olanzapine 10.7118685284
MESH:D011618 Psychotic Disorders Clozapine 8.3515331141
MESH:D011618 Psychotic Disorders Haloperidol 8.3511575062
MESH:D011657 Pulmonary Eosinophilia Trazodone 5.788520792
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8017894541 17620002 17266442 10334151 17720292
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5110835634
MESH:D012131 Respiratory Insufficiency Trazodone 5.458520792
MESH:D012559 Schizophrenia Clozapine 12.7218855531 17667964 20452607 16141801 11763009 18806925 20521326 20168265 20107430 17123785 17726453 19369910 20580759 11151749 20521320
MESH:D012559 Schizophrenia Haloperidol 12.7220107430 19369910 1830565 18513383
MESH:D012559 Schizophrenia norclozapine 12.7211151749
MESH:D012559 Schizophrenia olanzapine 12.7220521326 20107430 17726453
MESH:D012559 Schizophrenia Risperidone 12.7220107430 19154706 18278980
MESH:D012559 Schizophrenia Trazodone 12.727868106
MESH:D012640 Seizures Carbamazepine 6.2819414003 16876388 15946322 9046859 16180713 9844417 16938433
MESH:D012640 Seizures Pilocarpine 6.2819660546 7750514
MESH:D020230 Serotonin Syndrome Fluoxetine 12.148704074
MESH:D020230 Serotonin Syndrome Trazodone 12.149050436 8704074 7854515
MESH:D012871 Skin Diseases Mustard Gas 2.6216961503 15451306 12880345
MESH:D012878 Skin Neoplasms Plant Extracts 3.3216517061 15173996
MESH:D012892 Sleep Deprivation Trazodone 5.9119798453
MESH:D012893 Sleep Disorders Carbamazepine 16.3319414003
MESH:D012893 Sleep Disorders Risperidone 16.3318278980
MESH:D012893 Sleep Disorders Trazodone 16.3319395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 9.7915341891
MESH:D007319 Sleep Initiation and Maintenance Disorders Trazodone 9.7915341891 17225163 15062207
MESH:D013226 Status Epilepticus Pilocarpine 5.9115857427 19951488 19055492 11259499 19570321 15987249 19430551
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.8819915237 15057820 19694795 20485159 16538176 18855540 16415921
MESH:D013276 Stomach Ulcer Plant Extracts 3.6012787963 17135157 18193104 18237397 15255614
MESH:D020521 Stroke Trazodone 4.82810300
MESH:D013375 Substance Withdrawal Syndrome Mianserin 10.1412749364
MESH:D013375 Substance Withdrawal Syndrome Trazodone 10.14393279 12749364
MESH:D017180 Tachycardia, Ventricular Haloperidol 22.1520210726
MESH:D017180 Tachycardia, Ventricular olanzapine 22.1520210726
MESH:D017180 Tachycardia, Ventricular Risperidone 22.1520210726
MESH:D017180 Tachycardia, Ventricular Trazodone 22.152424891
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 5.1317997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8715821434
MESH:D013978 Tibial Fractures Estradiol 4.3419048282
MESH:D005879 Tourette Syndrome Risperidone 5.6119154706
MESH:D014202 Tremor Pilocarpine 5.4617594079
MESH:D014570 Urologic Diseases Diazinon 4.9316487989
MESH:D014605 Uveitis Cyclosporine 3.641336536
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.4218097624
MESH:D018879 Ventricular Premature Complexes Trazodone 6.482424891
MESH:D020257 Ventricular Remodeling Plant Extracts 4.9718097624
MESH:D015430 Weight Gain marker/mechanism 19434072
MESH:D015430 Weight Gain Clozapine 20.9020107430 20521320 17502770 16402076 16141801 20564506
MESH:D015430 Weight Gain Dietary Fats 20.9016723640
MESH:D015430 Weight Gain olanzapine 20.9019434072 17933447 20107430
MESH:D015430 Weight Gain Risperidone 20.9020564506 16379507
MESH:D015431 Weight Loss Clozapine 4.7417933447
MESH:D014947 Wounds and Injuries Plant Extracts 3.9820213670 19894650
MESH:D014985 Xerophthalmia Cyclosporine 4.0917120751
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04540 Gap junction
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA194
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    PA443530Body Weight Changes
    PA444938Metabolic Diseases
    PA447159Metabolic Syndrome X
    PA447198Autistic Disorder
    PA162370415metabolic syndrome
    PA128406954Weight gain
    PA445131Obesity
    PA443890Diabetes Mellitus, Type 2
    PA447216Schizophrenia
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA452229antidepressants
    PA451257risperidone
    PA451744trazodone
    PA450688olanzapine
    PA452233antipsychotics
    PA449061clozapine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00193 antagonist Tramadol Narcotics;Analgesics;Analgesics, Opioid
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00247 antagonist Methysergide Vasoconstrictor Agents;Sympatholytics;Serotonin Antagonists
    DB00248 agonist Cabergoline Antineoplastic Agents;Antiparkinson Agents;Dopamine Agonists
    DB00268 agonist Ropinirole Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00370 antagonist Mirtazapine Histamine H1 Antagonists;Adrenergic alpha-Antagonists;Antidepressive Agents, Tricyclic
    DB00408 antagonist Loxapine Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00413 unknown Pramipexole Antioxidants;Free Radical Scavengers;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00420 antagonist Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00434 antagonist Cyproheptadine Serotonin Antagonists;Antipruritics;Gastrointestinal Agents;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamine derivatives
    DB00574 agonist Fen-phen Anorexigenic Agents;Stimulants;Serotonin Agonists;Serotonin reuptake inhibitor
    DB00589 agonist Lisuride Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Serotonin Agonists
    DB00656 agonist Trazodone Anti-anxiety Agents;Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00714 agonist Homeopathic Remedy Thc No. 48 Dps Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00734 antagonist Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB00805 antagonist Minaprine Central Nervous System Agents;Antiparkinson Agents;Antidepressive Agents
    DB01079 antagonist Tegaserod Gastrointestinal Agents;Serotonin Agonists
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01149 antagonist Nefazodone Antidepressants;Analgesics;Antidepressive Agents, Second-Generation;Serotonin Agents
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01191 agonist Dexfenfluramine Appetite Depressants;Serotonin Agonists;Serotonin reuptake inhibitor;Antiobesity Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01238 other/unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01239 antagonist Chlorprothixene Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB01242 antagonist Clomipramine Antidepressive Agents, Tricyclic;Serotonin Uptake Inhibitors
    DB01267 antagonist Paliperidone Antipsychotic Agents
    DB01392 antagonist Yohimbine Mydriatics;Adrenergic alpha-Antagonists
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB01454 agonist 3,4-Methylenedioxymethamphetamine Adrenergic Uptake Inhibitors;Hallucinogens;Serotonin Agents
    DB06144 antagonist Sertindole Neuroleptics;Antipsychotic Agents
    DB06148 antagonist Mianserin Serotonin Antagonists;Histamine H1 Antagonists;Adrenergic alpha-Antagonists;Antidepressive Agents, Second-Generation
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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