AutismKB 2.0

Annotation Detail for HTR3A


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Basic Information Top
Gene Symbol:HTR3A ( 5-HT-3,5-HT3A,5-HT3R,5HT3R,HTR3 )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 3A
Band: 11q23.2
Quick LinksEntrez ID:3359; OMIM: 182139; Uniprot ID:5HT3A_HUMAN; ENSEMBL ID: ENSG00000166736; HGNC ID: 5297
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
P043755HT3 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1765Gilles de la Tourette syndrome
1836Panic disorder
1848Embryoma
1850Herpes
1986Eating disorder
2091Hypertension
2053Colon cancer
2069Schizophrenia
2185Obsessive-compulsive disorder
Desease Name
bipolar disorder
hormone disturbance
bipolar affective disorder
PSYCH
METABOLIC
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C118559 1-bromopropane 1-bromopropane affects the expression of HTR3A mRNAaffects expression 19576243
C045918 2-methyl-5-HT 2-methyl-5-HT binds to and results in increased activity of HTR3A proteinaffects binding|increases activity 15802305
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HTR3A mRNAaffects expression 16483693
D020001 1-Butanol 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|increases activity|increases reaction 17360702
D020001 1-Butanol 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|increases activity|increases reaction 17360702
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of HTR3A mRNAdecreases expression 16644059
D003024 Clozapine Clozapine binds to and results in decreased activity of HTR3A proteinaffects binding|decreases activity 19696922
D003024 Clozapine HTR3A protein affects the susceptibility to Clozapineaffects response to substance 20168265
D003024 Clozapine Clozapine binds to and results in decreased activity of HTR3A proteinaffects binding|decreases activity 19696922
D003976 Diazinon Diazinon results in increased expression of HTR3A mRNAincreases expression 18835401
D004026 Dieldrin Dieldrin results in decreased expression of HTR3A mRNAdecreases expression 18835401
D004298 Dopamine Dopamine binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]affects binding|increases activity 17360702
D004298 Dopamine Dopamine binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]affects binding|increases activity 17360702
D000431 Ethanol Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|increases activity|increases reaction 17360702
D000431 Ethanol Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|increases activity|increases reaction 17360702
D000441 Hexanols Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|decreases reaction|increases activity 17360702
D000441 Hexanols Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|decreases reaction|increases activity 17360702
D012701 Serotonin 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|increases activity|increases reaction 17360702
D012701 Serotonin 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|increases activity|increases reaction 17360702
D012701 Serotonin 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|increases activity|increases reaction 17360702
D012701 Serotonin 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|increases activity|increases reaction 17360702
D012701 Serotonin Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|increases activity|increases reaction 17360702
D012701 Serotonin Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|increases activity|increases reaction 17360702
D012701 Serotonin Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|decreases reaction|increases activity 17360702
D012701 Serotonin Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|decreases reaction|increases activity 17360702
D012701 Serotonin Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|decreases reaction|increases activity 17360702
D012701 Serotonin Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|decreases reaction|increases activity 17360702
D012701 Serotonin Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|increases activity|increases reaction 17360702
D012701 Serotonin Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|increases activity|increases reaction 17360702
D012701 Serotonin Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]affects binding|increases activity 17360702
D012701 Serotonin Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]affects binding|increases activity 17360702
D008070 Lipopolysaccharides HTR3A protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]increases reaction|increases secretion 15802305
D008070 Lipopolysaccharides HTR3A protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]increases reaction|increases secretion 15802305
D008070 Lipopolysaccharides HTR3A protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL8 protein]increases reaction|increases secretion 15802305
D009532 Nickel Nickel affects the expression of HTR3A mRNAaffects expression 18835401
D000442 Octanols Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|decreases reaction|increases activity 17360702
D000442 Octanols Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|decreases reaction|increases activity 17360702
D000439 Pentanols Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|increases activity|increases reaction 17360702
D000439 Pentanols Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|increases activity|increases reaction 17360702
D000433 1-Propanol 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]affects binding|increases activity|increases reaction 17360702
D000433 1-Propanol 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]affects binding|increases activity|increases reaction 17360702
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of HTR3A mRNAaffects cotreatment|decreases expression 19059307
C017947 sodium arsenite sodium arsenite results in increased expression of HTR3A mRNAincreases expression 12760830
D013629 Tamoxifen Tamoxifen affects the expression of HTR3A mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HTR3A mRNAaffects cotreatment|decreases expression 19059307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4714745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.8317676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 10.1818287403
MESH:D000138 Acidosis Ethanol 10.1811192467
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.3018653653 11850527
MESH:D055371 Acute Lung Injury Nickel 9.3016166738
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8216712894 17306315
MESH:D000380 Agranulocytosis Clozapine 4.9714617031 12649775 16160616
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.2516487989
MESH:D000419 Albuminuria Raloxifene 4.5117308373 17451421
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.2415451039 15451040
MESH:D000544 Alzheimer Disease Raloxifene 2.5215800139
MESH:D000853 Anophthalmos Ethanol 4.7315513904
MESH:D001008 Anxiety Disorders Ethanol 3.9311141031
MESH:D001259 Ataxia 1-Butanol 5.507820390
MESH:D001321 Autistic Disorder marker/mechanism 19184136
MESH:D001321 Autistic Disorder Serotonin 3.478570775 17157402 18062943 19221690 15132762 18361446 18405062
MESH:D001919 Bradycardia Serotonin 5.398112388
MESH:D001930 Brain Injuries Raloxifene 4.3916580743
MESH:D001943 Breast Neoplasms Dieldrin 2.0715770527 11859874
MESH:D001943 Breast Neoplasms Nickel 2.0715986119
MESH:D001943 Breast Neoplasms Raloxifene 2.0717261762 17893378 16837676 15572757 17049068 15758505 15775269 16912660 17242785 17952589 17440819 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 2.0716273361 19142967 17242785 19189210 19115204 18629630 18821012 19189212 19103187 20544844 18425577 19084267 18984771 15668708 20859285 16202921 19200415 18855134 17261762 19011961 17049068 19221464 18997820 15565566 19410462 18815881 16818667 17893378 17440819 20135344 19487384 11161223 19288272 19155303 20390343 18351453 21152245 21138602 20065188 20005174 19289846 16873071 19059307 19244106 19066611
MESH:D002056 Burns Ethanol 4.5616374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6915673190 16192424 15700767 10355542 15721981 16011737 16227642 16124888 3786805 18705752 16050911 16097048
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4219066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.5018788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.5015763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.5017306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5016924424
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3618572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.2317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.2317572228
MESH:D006332 Cardiomegaly Ethanol 3.3919332462
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3815775269
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.9319524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Serotonin 4.1321254450
MESH:D021081 Chronobiology Disorders Serotonin 6.6117157402
MESH:D002971 Cleft Lip Ethanol 3.5415513904
MESH:D002972 Cleft Palate Ethanol 3.1415513904
MESH:D003072 Cognition Disorders Clozapine 11.3917123785
MESH:D003072 Cognition Disorders Raloxifene 11.3915800139
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3211873399 19302082 15451040 15451039 15513904 10194807 11198716
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0817474826
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.8719470301 17100760 17244072
MESH:D003877 Dermatitis, Contact Nickel 4.552952479
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9516402076
MESH:D003928 Diabetic Nephropathies Raloxifene 8.7815920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.7819279558
MESH:D003967 Diarrhea Serotonin 4.688112388 11488427 10446763
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.4715331141
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0316227642 15027814 9327722 10092053 16177239 15968718 17522070 6623471 7440962 19336974 2869522 7179309 21278145 3786805 4309450 15998439 10915739 3732212 6884620 11566570 19085960 7120509
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.0311566570
MESH:D050171 Dyslipidemias Clozapine 4.1216402076
MESH:D004417 Dyspnea Diazinon 4.7216487989
MESH:D004487 Edema Raloxifene 7.3515860553
MESH:D004487 Edema Serotonin 7.3518841975
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.9615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.9619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9919155303 17893378 20544844 16202921
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3115821434 17637181 15328337
MESH:D004938 Esophageal Neoplasms Ethanol 2.7316704527
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.1619224547 12795759 61145 15959796 17595544 12631006 16045604 16239168
MESH:D005234 Fatty Liver Ethanol 18.1619236843 18620774 16409862
MESH:D005234 Fatty Liver Raloxifene 18.1617473493
MESH:D005234 Fatty Liver Tamoxifen 18.1614986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5817920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1816709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.2116946407 15513904 10194807 15451040
MESH:D005334 Fever Lipopolysaccharides 3.939205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.3718705752
MESH:D005756 Gastritis Ethanol 4.6115046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D006331 Heart Diseases Raloxifene 3.4711110106
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3016366002
MESH:D006505 Hepatitis Carbon Tetrachloride 9.3319110552 19900420
MESH:D006505 Hepatitis Diazinon 9.3316487989
MESH:D015658 HIV Infections Nickel 3.7717263646
MESH:D006689 Hodgkin Disease sodium arsenite 3.0812676792
MESH:D006930 Hyperalgesia Ethanol 3.6518783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006948 Hyperkinesis Clozapine 4.8216046005
MESH:D006973 Hypertension Raloxifene 2.8315787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D007022 Hypotension Dopamine 4.936740701
MESH:D007247 Infertility, Female Dieldrin 4.8510630421
MESH:D007248 Infertility, Male Diazinon 6.9412948887 16466525
MESH:D007248 Infertility, Male sodium arsenite 6.9415346721 12646999
MESH:D007249 Inflammation Lipopolysaccharides 8.289205823 12878042 17255318 17237260 17963957
MESH:D007249 Inflammation Nickel 8.2816166738
MESH:D007249 Inflammation Tamoxifen 8.2819457130
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.5517255318
MESH:D007569 Jaw Abnormalities Ethanol 4.3215513904
MESH:D007674 Kidney Diseases sodium arsenite 2.7520008137
MESH:D007680 Kidney Neoplasms Tamoxifen 2.9718625569
MESH:D007859 Learning Disorders Ethanol 4.1215451040
MESH:D007889 Leiomyoma Raloxifene 4.4116973256
MESH:D007970 Leukopenia Lipopolysaccharides 4.6115821434
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7517676605
MESH:D008064 Lipidoses Clozapine 7.8717567588
MESH:D008064 Lipidoses Tamoxifen 7.8717567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6511408273 16221502 16943688 17157831 11903743 17334410 16239168 17174718 21278145
MESH:D008103 Liver Cirrhosis Ethanol 6.6515289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.0118295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9317761835 14724832 18376398 14716833 17823541 18420326 17481882 12609069 16248980 20821823 16015684 16033810 17708605 16097048 12898905 18395095 17869086 17900296 18472332 11481614 18251166 13678700 18395914 17721639 15818738 18156304 18006644 12445421 18277467 12741479 14620537 18263696 15370692 15123356 12649538 17766677 18472094 18418968 12546737 10355542 17714472 15959796 17805973 15362042 14512876 18339082 12666154 18187930 15673190 17944888 18412020 12632512 12632514 17631135 18210741 16116963 15338365 18705752 15931870 15057751 15730626 15876570 18054572 17525996 17557913 15893842 14748882 16027843 17922224 18279442 16136751 15052691 16638106 17565644 17698563 12958196 12389079 15996030 14716496 18429990 15925388 16011737 12445418 18205269 17976157 17640975 12667390 12586293 18317297 18481824 18166357 16192424 15650968
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.9318166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 4.9312878042
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9318564211
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0617285989 16246199 16964402 15830285 15720792
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5617347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6116899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.5019294768
MESH:D008113 Liver Neoplasms Dieldrin 10.508742319 9539021
MESH:D008113 Liver Neoplasms sodium arsenite 10.5015276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 10.5016684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.5615583823 12014681
MESH:D008171 Lung Diseases sodium arsenite 3.1119095001
MESH:D055370 Lung Injury Lipopolysaccharides 3.9221114838
MESH:D008175 Lung Neoplasms sodium arsenite 2.4616712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 2.4618625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6719428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5711731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.4719453300
MESH:D008545 Melanoma sodium arsenite 3.2716487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.2712393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1015990972
MESH:D008569 Memory Disorders Ethanol 4.1018411066 15451040
MESH:D001523 Mental Disorders Clozapine 3.8616856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3419142101
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.4715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.3716497877
MESH:D009232 Myxoma Raloxifene 5.4716343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Dieldrin 5.368820588
MESH:D009369 Neoplasms sodium arsenite 5.3611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9219189210 19200415 19196722
MESH:D009436 Neural Tube Defects sodium arsenite 3.0812854658
MESH:D009765 Obesity Clozapine 3.0018515891 19142110
MESH:D010024 Osteoporosis Raloxifene 3.3417882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1417823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4115276417 17306315
MESH:D010190 Pancreatic Neoplasms Ethanol 2.9412384795
MESH:D010300 Parkinson Disease Dieldrin 3.4916112328 17291500 11445065 11181820 16809432
MESH:D011014 Pneumonia Lipopolysaccharides 4.4712224865 11605937
MESH:D011041 Poisoning Diazinon 4.2717603234
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6415731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6416039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6415067354
MESH:D011618 Psychotic Disorders Clozapine 4.1215331141
MESH:D011693 Purpura Raloxifene 5.4715770314
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6710835634
MESH:D012559 Schizophrenia Clozapine 2.7216141801 11763009 19369910 20521326 18806925 17726453 11151749 20107430 17667964 18855531 17123785 20580759 20521320 20452607 20168265
MESH:D012640 Seizures Ethanol 3.119754883
MESH:D012878 Skin Neoplasms sodium arsenite 2.6618572023 19524636
MESH:D013088 Spermatocele Tamoxifen 4.2116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.4517189318 17918041 9211565 16755016 9562338 11906479
MESH:D020521 Stroke Raloxifene 3.7516837676
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.179754883
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0815821434
MESH:D013978 Tibial Fractures Raloxifene 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.1917572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.1916712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.1916712894 8653321 17572228
MESH:D014570 Urologic Diseases Diazinon 5.1916487989
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6911813266
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054556 Venous Thromboembolism Raloxifene 5.1316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.4716343187
MESH:D015430 Weight Gain Clozapine 4.3920521320 20107430 20564506 17502770 16402076 16141801
MESH:D015431 Weight Loss Clozapine 4.9917933447
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29555
    • Releated gene ID Related gene Name
    PA29555HTR3A
    Releated disease ID Related disease Name
    PA445454Psychophysiologic Disorders
    PA447278Depression
    PA447207Depressive Disorder
    PA447216Schizophrenia
    PA447199Bipolar Disorder
    PA445048Nausea
    Releated drug ID Related drug Name
    PA449390dolasetron
    PA449809granisetron
    PA450705ondansetron
    PA161925594tropisetron
    PA452229antidepressants
    PA449015citalopram
    PA449673fluoxetine
    PA449690fluvoxamine
    PA450801paroxetine
    PA451333sertraline
    PA451257risperidone
    PA452233antipsychotics
    PA452621antineoplastic agents
    PA449061clozapine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00370 antagonist Mirtazapine Histamine H1 Antagonists;Adrenergic alpha-Antagonists;Antidepressive Agents, Tricyclic
    DB00377 antagonist Palonosetron Antiemetics;Serotonin Antagonists
    DB00604 agonist Cisapride Anti-Ulcer Agents;Gastrointestinal Agents;Serotonin Agonists;Prokinetic Agents
    DB00721 antagonist Procaine Anesthetics;Local Anesthetics;Anesthetics, Local
    DB00728 antagonist Rocuronium Skeletal Muscle Relaxants;Neuromuscular Nondepolarizing Agents
    DB00757 antagonist Dolasetron Antiemetics;Serotonin Antagonists
    DB00889 antagonist Granisetron Antiemetics;Serotonin Antagonists
    DB00904 antagonist Ondansetron Anti-anxiety Agents;Antiemetics;Antipsychotics;Serotonin Antagonists;Antipruritics;Antipsychotic Agents
    DB00969 antagonist Alosetron Serotonin Antagonists;Gastrointestinal Agents
    DB01043 antagonist Memantine Dopamine Agents;Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Excitatory Amino Acid Antagonists
    DB01161 antagonist Chloroprocaine Anesthetics, Local
    DB01199 antagonist Tubocurarine Skeletal Muscle Relaxants;Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB01224 other/unknown Quetiapine Antipsychotics;Antipsychotic Agents
    DB01238 other/unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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