AutismKB 2.0

Annotation Detail for APOA2


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Basic Information Top
Gene Symbol:APOA2 ( Apo-AII,ApoA-II,apoAII )
Gene Full Name: apolipoprotein A-II
Band: 1q23.3
Quick LinksEntrez ID:336; OMIM: 107670; Uniprot ID:APOA2_HUMAN; ENSEMBL ID: ENSG00000158874; HGNC ID: 601
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03320PPAR signaling pathway
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500796Chylomicron-mediated lipid transport
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1904Diabetes mellitus
1918Atherosclerosis
2097Hyperlipidemia
Desease Name
body mass cholesterol, HDL food consumption lipids
CARDIOVASCULAR
body mass
apo A-II gene polymorphism
METABOLIC
plasma HDL-C levels
Hypertriglyceridemia
No data
Desease Name
Hypercholesterolemia, familial, modification of
Apolipoprotein A-II deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene results in decreased expression of APOA2 mRNAdecreases expression 17070881
C035314 1-nitropropane 1-nitropropane results in increased expression of APOA2 mRNAincreases expression 17070881
C046728 2,2'-azobis(2-amidinopropane) 2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 proteinincreases oxidation 12576517
C046728 2,2'-azobis(2-amidinopropane) [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]affects cotreatment|decreases reaction|increases oxidation 12576517
C046728 2,2'-azobis(2-amidinopropane) Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]decreases reaction|increases oxidation 12576517
C046728 2,2'-azobis(2-amidinopropane) Pentetic Acid inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]decreases reaction|increases oxidation 12576517
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of APOA2 mRNAdecreases expression 17070881
C025235 2,6-diaminotoluene 2,6-diaminotoluene results in decreased expression of APOA2 mRNAdecreases expression 17070881
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in decreased expression of APOA2 mRNAdecreases expression 17070881
C016617 2-nitropropane 2-nitropropane results in decreased expression of APOA2 mRNAdecreases expression 17070881
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in decreased expression of APOA2 mRNAdecreases expression 17070881
D000082 Acetaminophen Acetaminophen results in decreased expression of APOA2 mRNAdecreases expression 15120968
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of APOA2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of APOA2 mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in decreased expression of APOA2 mRNAdecreases expression 16648578
D002084 Butylated Hydroxytoluene [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]affects cotreatment|decreases reaction|increases oxidation 12576517
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]decreases reaction|increases oxidation 12576517
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of APOA2 mRNAincreases expression 11566570
D002995 Clofibric Acid Clofibric Acid affects the expression of APOA2 mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of APOA2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of APOA2 mRNAdecreases expression 19638242
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in decreased expression of APOA2 mRNAdecreases expression 17070881
C039281 furan furan results in decreased expression of APOA2 mRNAdecreases expression 15120968
C029424 hydrazine hydrazine results in decreased expression of APOA2 mRNAdecreases expression 15370871
D004369 Pentetic Acid [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]affects cotreatment|decreases reaction|increases oxidation 12576517
D004369 Pentetic Acid Pentetic Acid inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]decreases reaction|increases oxidation 12576517
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of APOA2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of APOA2 mRNAincreases expression 17426115
C017947 sodium arsenite sodium arsenite affects the expression of APOA2 mRNAaffects expression 17450228
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000236 Adenoma 2-Acetylaminofluorene 6.7410737359
MESH:D000236 Adenoma Diethylnitrosamine 6.746695378 10737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.866705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.5919052882 17620307 19061943 17162532 16434500 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.5916434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7517306315 16712894
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0119483382
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.1311921183
MESH:D001943 Breast Neoplasms bexarotene 2.1316344269 16818667
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1317474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6318705752 16097048 10355542 16124888 16050911 16011737 16192424 3786805 15673190 16227642 15700767 15721981
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 11.0717761372 10737359 3084413 6705139 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.073084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.0721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.0718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.0719539802 19335982 17978847 11831363 16328049 18785209 18506893 19052882 16502159 16807293 20727157 20101231 19701751 16681979 18788625 3084413 19919837 20084675 18210153 20007298 16878318 18393292 20514400 19519916 17173139 20935162 16288022 18056438 19171122 19822196 17138121 17162532 18971187 18494052 10672840 17761372 16830150 19383236 20512989 16779866 18978308 19107877 19418558 18691550 19208518 19394651 18665156 17428255 17055752 20432363 16698587 21159647 16540662 3581430 20214788 20524982 16569478 10737359 16935385
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.0715276417 17306315 16507464
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1816247446
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3418572023
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.5812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.587505956 21159647 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.5820056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5619052882
MESH:D002779 Cholestasis Cyclosporine 7.3919486331
MESH:D002779 Cholestasis pirinixic acid 7.3919176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1620387270
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 8.6815804453 16445897 20517888
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.6819164858 16781746 15619225 19370779 19923254 12705907 2444490 16177239 14550746 16227642 11739529 16109766 11743745 16081117 19420014 12958197 11529661 16393943 12540782 12392966 12594235 15968718 11287661 17522070 18713872 14725611 10663392 10774834 19416960 16485898 19739265 11834606 11461765 11421492 18071297 17562736 12153990 14986274 10915739 19085960 17906064
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.6810915739 17522070 2869522 16227642 16177239 7440962 19085960 15998439 21278145 6623471 15968718 11566570 6884620 4309450 3786805 9327722 10092053 7120509 15027814 7179309 19336974 3732212
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.6819107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D050171 Dyslipidemias marker/mechanism
MESH:D004487 Edema pirinixic acid 2.3512083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.6117595544 15959796 19224547 16045604 16239168 12631006 61145 12795759
MESH:D005234 Fatty Liver Cyclosporine 17.6119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 17.6120387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 17.6120131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1718705752
MESH:D005355 Fibrosis Cyclosporine 8.1712168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.166705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.276705139
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 2.8516221962 19772884 19176532 18467677
MESH:D006689 Hodgkin Disease sodium arsenite 3.0312676792
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
OMIM:143890 HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT marker/mechanism
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.3717604070
MESH:D006973 Hypertension Cyclosporine 2.0410903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D007248 Infertility, Male sodium arsenite 2.8915346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 2.3018785209
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Acetaminophen 9.5015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.508314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 9.5020008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6112371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3316239168 16943688 11408273 17157831 21278145 11903743 17334410 17174718 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3320032147 18407596 19638242 18522880 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.2718412020 16015684 15338365 14716833 16136751 15650968 17922224 17976157 17714472 17721639 16638106 15925388 16248980 14512876 18210741 18395095 15931870 16033810 12546737 15959796 18251166 17565644 18395914 11481614 18277467 20821823 18472094 12609069 17557913 14716496 12649538 12666154 18376398 17900296 12898905 18166357 18472332 15893842 17869086 12389079 15818738 10355542 17481882 13678700 14748882 16011737 18429990 18054572 12958196 16116963 17766677 18420326 12632514 18317297 17631135 18705752 12741479 18263696 18339082 17698563 12586293 17944888 15996030 17823541 12445421 14724832 17525996 15052691 16192424 14620537 12632512 18481824 17708605 15057751 15673190 15370692 18156304 18006644 17805973 18205269 15362042 16027843 18187930 12445418 17640975 18279442 18418968 16097048 15730626 17761835 15123356 12667390 15876570
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2715474484
MESH:D008107 Liver Diseases Acetaminophen 6.2416610002 12969438 19784758 19460945 19014921 11587558 16611625 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2415720792 17285989 15830285 16964402 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9616899240 14706259
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 24.9810737359 11376686 18001218 16273603 14678523 10672840
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.982125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 24.9818177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.9819294768
MESH:D008113 Liver Neoplasms Clofibric Acid 24.9817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.9819294768 9163691 21278145 19256749 19426721 19833225 19499222 18644402 19638242 18978307 20137499 20492335 12771043 20452335 19690152 19427195 12112319 21047994 18977376 18754104 19090486 10737359 19551842 20501860 19255062 15885732 18648771 20118626 20101389 20405173 19850985 16942905 2862719 19812893 20434301 19073162 19254457 21167192 2422723 19642983 19996281 20583210 21071580 15175105
MESH:D008113 Liver Neoplasms pirinixic acid 24.9820007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 24.9816712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 13.411399818 534488 6150874
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.418603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.4115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.412563599 18544905 18308698 17174075 17854601 18253720 18282651 18775883 16842330 19126423 19519916 21159647 9362446 18164116 19009564 19004024 16267830 18093689 19539802 3124819 18079962 17942915
MESH:D008171 Lung Diseases sodium arsenite 3.0719095001
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 8.3311376686
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.3314755239
MESH:D008175 Lung Neoplasms bexarotene 8.3317849452
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 8.3319359593 18597497 11696405 15390079 11246140 19925653 16337739
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.3320970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 8.3315276417 17077188 19931552 17306315 16712894
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.0011161223
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 9.7711921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.7715591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 9.771500032
MESH:D008545 Melanoma sodium arsenite 2.0116487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D009336 Necrosis 2-nitropropane 5.4112195237
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.519029167 3581430
MESH:D009369 Neoplasms pirinixic acid 4.7017405874
MESH:D009369 Neoplasms sodium arsenite 4.7011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5220056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.6319196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1519348381 18481113
MESH:D009436 Neural Tube Defects sodium arsenite 3.0512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.3915276417 17306315
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3716540662
MESH:D011014 Pneumonia Butylated Hydroxytoluene 5.0111893704
MESH:D011230 Precancerous Conditions Cyclosporine 8.5112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.512563599
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3416039940
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D012878 Skin Neoplasms sodium arsenite 2.6319524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.877505956
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 5.2615289314 15867355 1399818
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2611723127 16452187 16712894 17306315
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6311813266
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24886
    • No data
    No data
    Releated drug ID Related drug Name
    PA450952phospholipids
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03122 - B-Octylglucoside Detergents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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