AutismKB 2.0

Annotation Detail for HTR4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HTR4 ( 5-HT4,5-HT4R )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 4
Band: 5q32
Quick LinksEntrez ID:3360; OMIM: 602164; Uniprot ID:5HT4R_HUMAN; ENSEMBL ID: ENSG00000164270; HGNC ID: 5299
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P043765HT4 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
2091Hypertension
2069Schizophrenia
2118Adenovirus infection
2190Attention deficit hyperactivity disorder
Desease Name
bipolar disorder
CARDIOVASCULAR
PSYCH
attention deficit hyperactivity disorder
schizophrenia
pulmonary function
Desease Name
Pulmonary function
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C447119 bazedoxifene acetate bazedoxifene acetate results in increased expression of HTR4 mRNAincreases expression 19914376
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of HTR4 mRNAincreases expression 15620428
D005047 Etoposide HTR4 protein affects the susceptibility to Etoposideaffects response to substance 16217747
C082871 GR 113808 GR 113808 binds to and results in decreased activity of HTR4 proteinaffects binding|decreases activity 15236628
D012701 Serotonin HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]affects phosphorylation|affects reaction 11880652
D008070 Lipopolysaccharides HTR4 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]decreases reaction|increases secretion 15802305
D008070 Lipopolysaccharides HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]increases reaction|increases secretion 15802305
D008070 Lipopolysaccharides HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]increases reaction|increases secretion 15802305
D008070 Lipopolysaccharides HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]increases reaction|increases secretion 15802305
D008070 Lipopolysaccharides HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL8 protein]increases reaction|increases secretion 15802305
C475107 RS 39604 RS 39604 binds to and results in decreased activity of HTR4 proteinaffects binding|decreases activity 15146954
D012643 Selenium Selenium results in increased expression of HTR4 mRNAincreases expression 19244175
C105050 tegaserod tegaserod binds to and results in increased activity of HTR4 proteinaffects binding|increases activity 11560869
D014635 Valproic Acid Valproic Acid results in increased expression of HTR4 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.2111850527 18653653
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000855 Anorexia marker/mechanism 15146954
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001321 Autistic Disorder Serotonin 2.6118405062 18361446 18062943 17157402 8570775 19221690 15132762
MESH:D001321 Autistic Disorder Valproic Acid 2.6120603192 17688650 18558336 18940202 15238991 18177632 18316065 19232924 17507914 17157402 18985861 19460635 18775368 18396377 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.4314601052
MESH:D001919 Bradycardia Serotonin 5.718112388
MESH:D001943 Breast Neoplasms Etoposide 3.0616322251
MESH:D002659 Child Development Disorders, Pervasive Serotonin 6.6321254450
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 6.6320734317
MESH:D021081 Chronobiology Disorders Serotonin 6.9617157402
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.6516037377
MESH:D003967 Diarrhea Serotonin 4.968112388 11488427 10446763
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1515131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.151733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema Serotonin 4.6418841975
MESH:D019446 Endotoxemia Lipopolysaccharides 4.6315821434 15328337 17637181
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D005234 Fatty Liver Valproic Acid 3.4714986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005334 Fever Lipopolysaccharides 4.179205823 11852909
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5516366002
MESH:D006561 Herpes Simplex Etoposide 4.8010809021
MESH:D006689 Hodgkin Disease Etoposide 4.0217606976 18180244 16200630 16135485 15147373
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D007249 Inflammation Lipopolysaccharides 2.959205823 17237260 17963957 12878042 17255318
MESH:D007251 Influenza, Human Selenium 4.4616624496
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8117255318
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D007970 Leukopenia Lipopolysaccharides 4.9315821434
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.2612878042
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D055370 Lung Injury Lipopolysaccharides 4.2221114838
MESH:D008223 Lymphoma Etoposide 4.0412556972 12854902
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D010190 Pancreatic Neoplasms Etoposide 3.3219003803
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011014 Pneumonia Lipopolysaccharides 4.7911605937 12224865
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms Etoposide 3.9917172428
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8410835634
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012512 Sarcoma, Ewing's Etoposide 4.9014601052
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8517978042 3137016 16876388 1511512 11738929 11044598 15475178 14763951
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3315821434
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29557
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    PA447178Pulmonary Disease, Chronic Obstructive
    PA443755Colonic Diseases, Functional
    Releated drug ID Related drug Name
    PA130413154tegaserod
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00604 agonist Cisapride Anti-Ulcer Agents;Gastrointestinal Agents;Serotonin Agonists;Prokinetic Agents
    DB00904 agonist Ondansetron Anti-anxiety Agents;Antiemetics;Antipsychotics;Serotonin Antagonists;Antipruritics;Antipsychotic Agents
    DB01079 partial agonist Tegaserod Gastrointestinal Agents;Serotonin Agonists
    DB01233 agonist Metoclopramide Antiemetics;Dopamine Antagonists;Prokinetic Agents
    DB08810 agonist Cinitapride Antiemetics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved