AutismKB 2.0

Annotation Detail for HTR5A


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Basic Information Top
Gene Symbol:HTR5A ( 5-HT5A,MGC138226 )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 5A
Band: 7q36.2
Quick LinksEntrez ID:3361; OMIM: 601305; Uniprot ID:5HT5A_HUMAN; ENSEMBL ID: ENSG00000157219; HGNC ID: 5300
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
PSYCH
schizophrenia
depression, psychosis and antipsychotic response
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019386 Alendronate Alendronate affects the expression of HTR5A mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HTR5A mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of HTR5A mRNAincreases expression 16715494
D001761 Bleomycin Bleomycin results in decreased expression of HTR5A mRNAdecreases expression 15808516
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of HTR5A mRNAdecreases expression 16644059
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of HTR5A mRNAdecreases expression 17452286
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of HTR5A mRNAincreases expression 18835401
D003976 Diazinon Diazinon affects the expression of HTR5A mRNAaffects expression 17452286
D004026 Dieldrin Dieldrin results in increased expression of HTR5A mRNAincreases expression 18835401
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HTR5A mRNAaffects expression 16079270
D020849 Raloxifene Raloxifene affects the expression of HTR5A mRNAaffects expression 16079270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury Bleomycin 5.0717118201
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.9817119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.9816487989
MESH:D000419 Albuminuria Raloxifene 4.7917308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000860 Anoxia Bleomycin 5.6415782499
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder marker/mechanism 17203304
MESH:D001930 Brain Injuries Raloxifene 4.6916580743
MESH:D001943 Breast Neoplasms Dieldrin 2.7111859874 15770527
MESH:D001943 Breast Neoplasms Raloxifene 2.7117242785 15758505 17595753 15572757 17261762 17893378 17049068 16912660 17952589 16837676 17440819 15775269
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916124888 15673190 3786805 15721981 10355542 16227642 16011737 15700767 16050911 18705752 16192424 16097048
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8418788625
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 3.646189445
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2317572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5615775269
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017110522 17333356 11677210 17681005 15861022 16105132 16919318
MESH:D003072 Cognition Disorders Raloxifene 4.8315800139
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3117474826
MESH:D003928 Diabetic Nephropathies Raloxifene 4.0917451421 17308373 15920148
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0815968718 3732212 16227642 11566570 7440962 19336974 16177239 7120509 17522070 15998439 4309450 6623471 2869522 3786805 9327722 7179309 10915739 10092053 21278145 15027814 19085960 6884620
MESH:D004417 Dyspnea Diazinon 5.0616487989
MESH:D004487 Edema Bleomycin 8.1117118201
MESH:D004487 Edema Raloxifene 8.1115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.7815845917
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.1812795759 61145 12631006 19224547 15959796 16239168 16045604 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.1815345470
MESH:D005234 Fatty Liver Raloxifene 14.1817473493
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6718705752
MESH:D006331 Heart Diseases Raloxifene 3.6511110106
MESH:D006505 Hepatitis Carbon Tetrachloride 10.2819110552 19900420
MESH:D006505 Hepatitis Diazinon 10.2816487989
MESH:D006689 Hodgkin Disease Bleomycin 4.5218501091 15147373 17606976
MESH:D006930 Hyperalgesia Alendronate 4.8516769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006973 Hypertension Raloxifene 2.9215787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Dieldrin 10.9110630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 10.9112013081
MESH:D007248 Infertility, Male Diazinon 7.3212948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3217937319
MESH:D007249 Inflammation Bleomycin 3.8017118201
MESH:D007889 Leiomyoma Raloxifene 4.6816973256
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8911408273 17157831 16943688 11903743 16221502 21278145 16239168 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515650968 18472332 17721639 17869086 18156304 17708605 10355542 16136751 15876570 17698563 18395095 17557913 16116963 15370692 12741479 12898905 18317297 12632514 15959796 12389079 16033810 14748882 16011737 12546737 14716833 18251166 14724832 18006644 11481614 18054572 12586293 15730626 12609069 14620537 17565644 14512876 15057751 18472094 20821823 17761835 16027843 15818738 13678700 18376398 17640975 18277467 18420326 15931870 15996030 12649538 18279442 12445418 17631135 18210741 17766677 15673190 15123356 15925388 16097048 16248980 15362042 18395914 18205269 17714472 15052691 16638106 12632512 17922224 18429990 18412020 18705752 15338365 18339082 17481882 17976157 17805973 18263696 14716496 17944888 16015684 12958196 12666154 15893842 17823541 18166357 18187930 12445421 17900296 18418968 16192424 18481824 17525996 12667390
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.5615720792 17285989 15830285 16246199 16964402
MESH:D008107 Liver Diseases Chlorpyrifos 4.5615991261
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 5.1819294768
MESH:D008113 Liver Neoplasms Dieldrin 5.188742319 9539021
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7112014681 15583823
MESH:D008175 Lung Neoplasms Bleomycin 3.116189445
MESH:D008545 Melanoma Bleomycin 3.2715577320
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8215863610
MESH:D009041 Motion Sickness Dextroamphetamine 5.791613127
MESH:D009101 Multiple Myeloma Raloxifene 3.5616497877
MESH:D009232 Myxoma Raloxifene 5.8216343187
MESH:D009369 Neoplasms Dieldrin 3.548820588
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2815081274
MESH:D010024 Osteoporosis Alendronate 8.1217882678
MESH:D010024 Osteoporosis Raloxifene 8.1217882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4117823083 17893378 15758505 15579764
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010300 Parkinson Disease Dieldrin 3.5811445065 17291500 16809432 11181820 16112328
MESH:D011014 Pneumonia Bleomycin 5.6417071938 18024389 16317386
MESH:D011041 Poisoning Diazinon 4.5317603234
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5816220300 15731164 16536755
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D011654 Pulmonary Edema Bleomycin 5.5815808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.9218162602 18008008 15322207 17241526 21435439 16314464 17177178 16115399 17434272 14609568 12624602 12574379 15541506 11554783
MESH:D011693 Purpura Raloxifene 5.8215770314
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.8511874814 16611668 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.1617119214 16611668
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.356418539
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D020521 Stroke Raloxifene 3.9616837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013978 Tibial Fractures Raloxifene 5.4719048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8717572228
MESH:D014570 Urologic Diseases Diazinon 5.5416487989
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.4716837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8216343187
MESH:D015431 Weight Loss Bleomycin 5.8812624602
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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