AutismKB 2.0

Annotation Detail for APOA4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:APOA4 ( MGC142154,MGC142156 )
Gene Full Name: apolipoprotein A-IV
Band: 11q23.3
Quick LinksEntrez ID:337; OMIM: 107690; Uniprot ID:; ENSEMBL ID: ENSG00000110244; HGNC ID: 602
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1904Diabetes mellitus
1907Depression
1914Cerebrovascular disorder
1918Atherosclerosis
1998Enteritis
2094Ulcerative colitis
2097Hyperlipidemia
2203Nephrosis
Desease Name
HDL cholesterol
cholesterol
cholesterol cholesterol, HDL cholesterol, LDL lipoprotein triglycerides
cholesterol, HDL triglycerides
atherosclerosis, coronary
CARDIOVASCULAR
cholesterol, LDL
lipoproteins
cholesterol, VLDL
lipoprotein
cardiovascular
METABOLIC
LDL cholesterol
triglycerides
choesterol absorption
obesity
depression
cholesterol, total
cerebrovascular disease
diabetes, type 2
Hypertriglyceridemia
gallstones
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene results in decreased expression of APOA4 mRNAdecreases expression 17070881
C035314 1-nitropropane 1-nitropropane results in decreased expression of APOA4 mRNAdecreases expression 17070881
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of APOA4 mRNAdecreases expression 17070881
C025235 2,6-diaminotoluene 2,6-diaminotoluene results in decreased expression of APOA4 mRNAdecreases expression 17070881
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in decreased expression of APOA4 mRNAdecreases expression 17070881
C016617 2-nitropropane 2-nitropropane results in decreased expression of APOA4 mRNAdecreases expression 17070881
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in increased expression of APOA4 mRNAincreases expression 18544908
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of APOA4 mRNAincreases expression 18648102
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in decreased expression of APOA4 mRNAdecreases expression 17070881
D000082 Acetaminophen Acetaminophen affects the expression of APOA4 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of APOA4 mRNAincreases expression 18544908
11264010
D000638 Amiodarone Amiodarone affects the expression of APOA4 mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of APOA4 mRNAaffects expression 19483382
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APOA4 mRNAaffects cotreatment|decreases expression 18164116
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of APOA4 mRNAincreases expression 12082028
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of APOA4 mRNAdecreases expression 15963578
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of APOA4 mRNAincreases expression 15963578
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of APOA4 mRNAaffects expression 15963342
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of APOA4 mRNAdecreases expression 16239168
D008076 Cholesterol, HDL APOA4 gene polymorphism affects the abundance of Cholesterol, HDLaffects abundance 16030523
D002994 Clofibrate Clofibrate affects the expression of APOA4 mRNAaffects expression 19483382
D003907 Dexamethasone Dexamethasone affects the expression of APOA4 mRNAaffects expression 15102944
D004041 Dietary Fats Dietary Fats affects the expression of APOA4 mRNAaffects expression 17086191
D004041 Dietary Fats Dietary Fats results in increased expression of APOA4 mRNAincreases expression 15238619
18457598
D004041 Dietary Fats resveratrol inhibits the reaction [Dietary Fats affects the expression of APOA4 mRNA]affects expression|decreases reaction 17086191
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APOA4 mRNAaffects cotreatment|decreases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of APOA4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with IL1B protein] results in increased expression of APOA4 mRNAaffects cotreatment|increases expression 12072388
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of APOA4 mRNAincreases expression 12072388
14976129
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APOA4 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of APOA4 mRNAdecreases expression 15953391
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of APOA4 mRNAincreases expression 12082028
D005001 Ethionine Ethionine affects the expression of APOA4 mRNAaffects expression 19483382
D011345 Fenofibrate Fenofibrate results in decreased expression of APOA4 mRNAdecreases expression 11798191
D005419 Flavonoids Flavonoids results in decreased expression of APOA4 mRNAdecreases expression 18035473
D015725 Fluconazole Fluconazole results in decreased expression of APOA4 mRNAdecreases expression 16643972
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in decreased expression of APOA4 mRNAdecreases expression 17070881
D005632 Fructose Fructose results in increased expression of APOA4 mRNAincreases expression 11983814
C056933 fumonisin B1 fumonisin B1 results in increased expression of APOA4 mRNAincreases expression 16221962
C029424 hydrazine hydrazine results in increased expression of APOA4 mRNAincreases expression 15282401
C029424 hydrazine hydrazine results in decreased expression of APOA4 proteindecreases expression 15370871
C051140 iron(II)-ascorbic acid complex iron(II)-ascorbic acid complex results in decreased expression of APOA4 proteindecreases expression 10898742
C099406 L 742694 L 742694 affects the expression of APOA4 mRNAaffects expression 15102944
D009853 Omeprazole Omeprazole affects the expression of APOA4 mRNAaffects expression 19483382
D010269 Paraquat Paraquat results in increased expression of APOA4 mRNAincreases expression 17275934
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in decreased expression of APOA4 mRNAdecreases expression 16221955
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of APOA4 mRNAdecreases expression 16221955
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of APOA4 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of APOA4 mRNAincreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of APOA4 mRNAdecreases expression 12807726
D010634 Phenobarbital Phenobarbital results in increased expression of APOA4 mRNAincreases expression 12082028
16940010
D010672 Phenytoin Phenytoin results in increased expression of APOA4 mRNAincreases expression 15136057
C006253 pirinixic acid pirinixic acid results in decreased expression of APOA4 mRNAdecreases expression 20059764
15375163
16221962
11798191
C006253 pirinixic acid pirinixic acid results in increased expression of APOA4 mRNAincreases expression 18445702
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of APOA4 mRNA]decreases expression|increases reaction 20059764
C006253 pirinixic acid pirinixic acid affects the expression of APOA4 mRNAaffects expression 19483382
C045950 propiconazole propiconazole results in decreased expression of APOA4 mRNAdecreases expression 19423681
D011441 Propylthiouracil Propylthiouracil affects the expression of APOA4 mRNAaffects expression 19483382
C030984 pyrene pyrene results in decreased expression of APOA4 mRNAdecreases expression 15963578
C059514 resveratrol resveratrol inhibits the reaction [Dietary Fats affects the expression of APOA4 mRNA]affects expression|decreases reaction 17086191
C488333 Ro 65-7199 Ro 65-7199 affects the expression of APOA4 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of APOA4 mRNAaffects expression 14610520
C017947 sodium arsenite sodium arsenite affects the expression of APOA4 mRNAaffects expression 19590694
C017947 sodium arsenite sodium arsenite results in decreased expression of APOA4 mRNAdecreases expression 17450228
C446685 systhane systhane results in decreased expression of APOA4 mRNAdecreases expression 16643972
19423681
D013629 Tamoxifen Tamoxifen affects the expression of APOA4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APOA4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of APOA4 mRNAdecreases expression 16054898
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of APOA4 mRNAincreases expression 15644576
D013853 Thioacetamide Thioacetamide affects the expression of APOA4 mRNAaffects expression 19483382
D014212 Tretinoin Tretinoin results in decreased expression of APOA4 mRNAdecreases expression 18230668
C032910 triadimefon triadimefon results in decreased expression of APOA4 mRNAdecreases expression 16643972
19423681
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0014745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.246195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 11.243425630 9677735 9118846 8986270 6195326 10563481
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.2411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3917505938
MESH:D058186 Acute Kidney Injury resveratrol 3.3816538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.6318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.6614692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 17.5210737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 17.523712494
MESH:D000236 Adenoma beta-Naphthoflavone 17.5219389873
MESH:D000236 Adenoma Diethylnitrosamine 17.5210737359 6695378
MESH:D000236 Adenoma resveratrol 17.5215688382
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.466705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.4519052882 17162532 19061943 18056438 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.4517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.4516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.4516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3516712894 17306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.2411874814
MESH:D000505 Alopecia Tretinoin 3.1815955085
MESH:D000544 Alzheimer Disease resveratrol 2.4416162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4811748828
MESH:D000799 Angioedema Acetaminophen 3.3010982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3420041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 8.1715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.1711256880
MESH:D001169 Arthritis, Experimental Dexamethasone 14.6717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 14.6715885639
MESH:D001169 Arthritis, Experimental resveratrol 14.6717115116
MESH:D001169 Arthritis, Experimental Tretinoin 14.6716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1216292516
MESH:D001249 Asthma Tretinoin 2.1616456186
MESH:D050197 Atherosclerosis Phenytoin 6.0215136057
MESH:D050197 Atherosclerosis resveratrol 6.0216873680 17967414
MESH:D001281 Atrial Fibrillation Amiodarone 3.4919698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4918445737
MESH:D001471 Barrett Esophagus Tretinoin 3.8916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.4711289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 55.5319483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 55.5319483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 55.5319483382
MESH:D001778 Blood Coagulation Disorders Ethionine 55.5319483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 55.5319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 55.5319483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 55.5319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 55.5312125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 55.5319483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 55.5316197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4015746008
MESH:D002545 Brain Ischemia resveratrol 3.7517600658
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 3.3111921183
MESH:D001943 Breast Neoplasms Dietary Fats 3.3120435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.3117474063
MESH:D001943 Breast Neoplasms resveratrol 3.3116393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tamoxifen 3.3117893378 16818667 19115204 19155303 19288272 18997820 21138602 19142967 19487384 19244106 19221464 16202921 19410462 18821012 19011961 19066611 15668708 20065188 18815881 18855134 20544844 19189210 15565566 16273361 17049068 17242785 21152245 18629630 17261762 18351453 19103187 20135344 18984771 19189212 20005174 19059307 20390343 11161223 20859285 19084267 16873071 18425577 17440819 19200415 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.3120435547
MESH:D001943 Breast Neoplasms Tretinoin 3.3116166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0516813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2615673190 3786805 16227642 16192424 18705752 16124888 15700767 16050911 15721981 16097048 16011737 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3716835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6116168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 26.4110737359 3581430 17761372 6705139 3084413
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 26.417296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 26.413084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 26.411701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 26.4118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 26.4116779866 16502159 16807293 17055752 16698587 10672840 18785209 18393292 19539802 17761372 19519916 20214788 3581430 16935385 19394651 19208518 18506893 16569478 20007298 3084413 19822196 19919837 20935162 19052882 20524982 16328049 19701751 18210153 11831363 19107877 17173139 18665156 17138121 17162532 18978308 20727157 19335982 16681979 21159647 20512989 17978847 16540662 20084675 20514400 19171122 10737359 17428255 19383236 16288022 20432363 18788625 18494052 16830150 18971187 20101231 18691550 19418558 18056438 16878318
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 26.4120935162 1701930 20007298 17173139 6705139
MESH:D006528 Carcinoma, Hepatocellular resveratrol 26.4119321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 26.4115276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 26.4116924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 26.4117997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 26.411917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0516675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.407296757
MESH:D002294 Carcinoma, Squamous Cell resveratrol 6.4916227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.4918572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.4916096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0518670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.6915710769 19225199
MESH:D002318 Cardiovascular Diseases resveratrol 3.1015458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5518974383
MESH:D002386 Cataract Acetaminophen 6.1110977129
MESH:D002386 Cataract Tretinoin 6.1117460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.937505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 12.931399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.937505956 21159647 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 12.9319524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 9.934080065
MESH:D002493 Central Nervous System Diseases Phenytoin 9.934080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0516129372
MESH:D002637 Chest Pain Omeprazole 4.5615447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.4919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.4916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 13.4918291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 11.0219486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 11.0217681005 15861022 16105132 16919318 17110522 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 11.0219176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.3311748493
MESH:D002822 Choriocarcinoma Tretinoin 4.6116461808
MESH:D002971 Cleft Lip Phenytoin 3.852227380
MESH:D002972 Cleft Palate Fluconazole 15.9416781842
MESH:D002972 Cleft Palate Phenytoin 15.943877104 10789828 6862529 2227380 1687470 6856622
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 15.9415668235 16354765 8697196 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 15.949407595
MESH:D002972 Cleft Palate triadimefon 15.9416781842
MESH:D003092 Colitis resveratrol 7.8916474422
MESH:D003092 Colitis Tretinoin 7.8917035595
MESH:D003103 Coloboma Phenytoin 4.679212184
MESH:D003110 Colonic Neoplasms Dexamethasone 3.5915824018
MESH:D003110 Colonic Neoplasms resveratrol 3.5916338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Phenytoin 7.8710627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.8717141729 14669216
MESH:D003327 Coronary Disease Fructose 7.5818504504
MESH:D003327 Coronary Disease resveratrol 7.5816507316
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.5117728286
MESH:D019465 Craniofacial Abnormalities Phenytoin 6.5119952982 9212184 8986270
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.5120055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.519142499 9664655 9211117 14991402 8800419 9125849 16925845 10589399 9224671 17551590
MESH:D019465 Craniofacial Abnormalities triadimefon 6.5116875885 15834900
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8419031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.358156756 11906362 2524372 11298694 12868966 18759878 14531868 8970840
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 5.3512438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.002952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Fructose 7.3718603373
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.3716873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 6.2618603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2617107852
MESH:D003928 Diabetic Nephropathies resveratrol 7.5316286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.5319279558
MESH:D003967 Diarrhea Dexamethasone 3.207237001
OMIM:607208 DRAVET SYNDROME Phenytoin 4.8611748493
MESH:D003875 Drug Eruptions Phenytoin 4.9715024534
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 22.0516445897 15804453 20517888
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 22.0518692083 1440618 6482804 7440962 9328219 16192314 11289319 18289764 9022650 6679447 18648102 8291058 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 22.0518713872 11287661 17562736 19923254 19370779 16109766 16485898 12958197 12392966 15968718 11529661 15619225 12153990 2444490 16393943 11834606 10663392 19085960 10774834 14986274 17906064 19164858 14550746 16177239 12705907 12594235 16781746 19739265 19416960 17522070 12540782 11421492 18071297 19420014 14725611 16081117 11461765 16227642 11743745 10915739 11739529
MESH:D056486 Drug-Induced Liver Injury Amiodarone 22.0515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 22.052869522 4309450 10092053 16177239 7179309 7120509 15027814 19085960 9327722 17522070 21278145 3786805 6884620 15968718 10915739 7440962 16227642 19336974 3732212 11566570 15998439 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 22.0519107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 22.0516221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 22.0520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 22.0512963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3611462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.8217151854 16613094 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 12.3516707586
MESH:D050171 Dyslipidemias Dietary Fats 12.3518367378
MESH:D050171 Dyslipidemias Fenofibrate 12.3516707586
MESH:D004421 Dystonia Phenobarbital 3.511851702
MESH:D004485 Eczema Dexamethasone 3.9512438553
MESH:D004487 Edema Dexamethasone 16.6119703484
MESH:D004487 Edema perfluorooctanoic acid 16.6117259670 12083418
MESH:D004487 Edema pirinixic acid 16.6112083418
MESH:D004487 Edema resveratrol 16.618985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.1215322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.1218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.8012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 17.8017654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 17.8017872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.8019031437
MESH:D016889 Endometrial Neoplasms Fenofibrate 10.4516569247
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.4519155303 20544844 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 10.4516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.569294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3217923197
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.6920235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.681399206 6251365
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.583659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.5311558140 3922381
MESH:D004828 Epilepsies, Partial Phenytoin 8.5311558140 17116037
MESH:D004827 Epilepsy Phenobarbital 6.0320417680
MESH:D004827 Epilepsy Phenytoin 6.0320417680 11434505 821787
MESH:D004832 Epilepsy, Absence Phenobarbital 3.096401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.937750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 9.937750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.063659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 9.063659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5716302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 1.963581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.4811564622
MESH:D005124 Eye Abnormalities Tretinoin 7.4816938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.1716456712
MESH:D005234 Fatty Liver Amiodarone 40.3614986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 40.3616045604 17595544 19224547 16239168 12795759 15959796 61145 12631006
MESH:D005234 Fatty Liver Clofibrate 40.3619224547
MESH:D005234 Fatty Liver Dietary Fats 40.3619004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 40.3620387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 40.3615345470
MESH:D005234 Fatty Liver Fructose 40.3618395287 18641190 19196556
MESH:D005234 Fatty Liver pirinixic acid 40.3619236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 40.3619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8916709447
MESH:D005313 Fetal Death Phenytoin 9.0010627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.0011858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.476705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 22.2118705752
MESH:D005355 Fibrosis Dietary Fats 22.2118296743
MESH:D005355 Fibrosis Fructose 22.2118504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.2120067830
MESH:D005355 Fibrosis Tretinoin 22.2117994277
MESH:D005756 Gastritis Acetaminophen 3.1316983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1416452187
MESH:D005885 Gingival Hyperplasia Phenytoin 5.139029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.6816390469 14659971
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 6.3617162496
MESH:D005909 Glioblastoma Tretinoin 6.3617312396
MESH:D005911 Gliosis Paraquat 4.6211124998
MESH:D018149 Glucose Intolerance Fructose 4.8319165636
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.547505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.5111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.5114991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.1920558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.776705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 3.936705139
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8511000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.0915929193 18665440 17276928
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 12.786705139
MESH:D006505 Hepatitis Carbon Tetrachloride 12.7819110552 19900420
MESH:D006505 Hepatitis Thioacetamide 12.7816456712
MESH:D006529 Hepatomegaly Amiodarone 44.3015265979
MESH:D006529 Hepatomegaly fumonisin B1 44.3016221962
MESH:D006529 Hepatomegaly perfluorooctanoic acid 44.303609246
MESH:D006529 Hepatomegaly Phenobarbital 44.3016109766
MESH:D006529 Hepatomegaly pirinixic acid 44.3018467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly propiconazole 44.3017178689 17178688
MESH:D006529 Hepatomegaly systhane 44.3017178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 44.3015340226 16120746 12621046
MESH:D006529 Hepatomegaly triadimefon 44.3017178688 17178689
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.867520565
MESH:D006561 Herpes Simplex resveratrol 3.6516876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.7112676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5018606429 16354765 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 10.6116870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 10.6112083418
MESH:D006930 Hyperalgesia Tretinoin 10.6116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9916899240
MESH:D006937 Hypercholesterolemia Amiodarone 12.568137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 12.5621332399
MESH:D006937 Hypercholesterolemia resveratrol 12.5617188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0416778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7220558911
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.2210459572
MESH:D006946 Hyperinsulinism Fructose 4.4515752949 19008412 18563319 14757778 18360027
MESH:D006949 Hyperlipidemias Dietary Fats 12.7321332399
MESH:D006949 Hyperlipidemias Fructose 12.7315752949
MESH:D006949 Hyperlipidemias resveratrol 12.7316873680
MESH:D006938 Hyperlipoproteinemia Type II marker/mechanism 16030523
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4215034207
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.0417604070
MESH:D006973 Hypertension Dexamethasone 7.4217042910
MESH:D006973 Hypertension Fructose 7.4219008412 14633139 14573337 16843071 14568997
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.4218850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5615338365
MESH:D015228 Hypertriglyceridemia Fructose 4.6119799862 19342510
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8317488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2816945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 9.8718020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 9.878137927 18031379
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1217600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.0817937319
MESH:D007248 Infertility, Male Paraquat 9.084850670
MESH:D007248 Infertility, Male sodium arsenite 9.0812646999 15346721
MESH:D007249 Inflammation Dexamethasone 23.2911099482 8960868
MESH:D007249 Inflammation Dietary Fats 23.2920412841
MESH:D007249 Inflammation Diethylnitrosamine 23.2918785209
MESH:D007249 Inflammation Flavonoids 23.2917296493
MESH:D007249 Inflammation perfluorooctanoic acid 23.2912083418
MESH:D007249 Inflammation resveratrol 23.2916366677
MESH:D007249 Inflammation Tamoxifen 23.2919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 23.2912200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.0016624496
MESH:D007333 Insulin Resistance Dietary Fats 10.3418457598 11836018
MESH:D007333 Insulin Resistance Fructose 10.3414573337 19799862 14633139 18057795 18563319 19342510 19008412 17133782 19586609 14757778 18981581
MESH:D007333 Insulin Resistance pirinixic acid 10.3416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2517994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.479022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 14.4716580747
MESH:D007569 Jaw Abnormalities Tretinoin 14.4717551590 15992940
MESH:D007569 Jaw Abnormalities triadimefon 14.4715834900 15992940
MESH:D007674 Kidney Diseases Acetaminophen 4.8712587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 4.8720008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 5.936582329
MESH:D007680 Kidney Neoplasms Tamoxifen 5.9318625569
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.6619248655
MESH:D007938 Leukemia Tretinoin 2.4817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2219285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9717596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.5516087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.5516766008 19225113 17368321 19029980 17712046 12679006 9834237 16823087 19075265 17294898 16788101 17649720 15748426 16891316 16331271 17361223 19642359 17506722 19035177 16935935 17339181 16140955 17107899 17217047 17301526
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.698812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.919224671
MESH:D008064 Lipidoses Amiodarone 6.6015342952 17567588
MESH:D008064 Lipidoses Tamoxifen 6.6017567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.1311903743 17157831 11408273 16239168 16943688 21278145 16221502 17334410 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 13.1318296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.1318665156 19638242 18522880 20032147 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 13.1321047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.8415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 11.6518251166 15650968 10355542 18317297 16027843 11481614 18205269 15931870 12958196 18339082 18156304 14724832 15876570 14748882 12445421 16011737 15996030 17766677 18418968 18187930 18429990 14716833 12898905 16116963 17557913 18277467 18412020 15052691 12586293 15057751 17525996 17631135 18279442 12649538 12741479 16136751 17714472 15123356 13678700 17565644 17721639 12632512 18376398 18472094 18395914 15893842 12667390 16638106 12546737 18420326 17640975 17976157 18006644 17944888 17761835 17922224 14620537 18481824 15925388 17481882 15818738 16033810 15730626 16097048 17698563 17900296 17805973 18395095 12389079 16192424 15338365 18166357 14512876 15362042 15370692 20821823 12666154 18263696 17823541 18472332 17708605 15959796 14716496 12609069 12632514 18705752 15673190 17869086 12445418 16248980 18210741 16015684 18054572
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 11.6516718785
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 11.6515474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 11.6515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 11.6518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.6512878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 11.6518031379 15288473 16126171 17127702 16343077 18395095 17292413 14739098 15078482 18295389 11172339 12175628 15474484 17629604 16248980 17050028 18458672 11481614 18032466 15334695 15716488 18263696 18380797 15075984 15316131 12679928 15288472 15095483 12557150 18416461 18606216 15362042 16489207 12531686 12891558 16098781 17355460 11682029 16511523 16097051 12085344 15465738 10677585 18615449 15158331
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 11.6518397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 23.4119784758 16610002 19460945 11587558 19014921 12587719 16611625 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 23.4115830285 17285989 16246199 16964402 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 23.4117034775
MESH:D008107 Liver Diseases Fluconazole 23.4114966256
MESH:D008107 Liver Diseases Phenobarbital 23.4119363144
MESH:D008107 Liver Diseases Phenytoin 23.4114986274
MESH:D008107 Liver Diseases propiconazole 23.4119363144
MESH:D008107 Liver Diseases Thioacetamide 23.4118374380 15158337 16337175
MESH:D008107 Liver Diseases triadimefon 23.4119363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 13.5416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 13.5414706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 13.5415313186 12479984 15633222 17276928
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 49.7616273603 14678523 10737359 11376686 18001218 10672840
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 49.7619389873 21295105
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 49.7618177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 49.7619294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 49.7619426721 20452335 21167192 18648771 21278145 19812893 19642983 15175105 19638242 12112319 19690152 19254457 21047994 18644402 20492335 18977376 10737359 20101389 16942905 18754104 19833225 19850985 19427195 20118626 19499222 19255062 12771043 19551842 19073162 19294768 20405173 20501860 21071580 20434301 20137499 18978307 2862719 19090486 19256749 15885732 9163691 2422723 19996281 20583210
MESH:D008113 Liver Neoplasms Fenofibrate 49.7618978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 49.7614757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 49.768742319 19812893 19482888 21047994 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 49.7620007298 16377806 15890375
MESH:D008113 Liver Neoplasms propiconazole 49.7619028983
MESH:D008113 Liver Neoplasms resveratrol 49.7619321006 19073162 19812893 20405173
MESH:D008113 Liver Neoplasms sodium arsenite 49.7615276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 49.7616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 49.7616984957
MESH:D008113 Liver Neoplasms triadimefon 49.7619028983
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 40.61534488 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 40.613712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 40.6118164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 40.6112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 40.6119126423 18079962 18308698 18544905 18253720 18775883 16842330 16267830 17942915 17854601 3124819 18282651 18093689 17174075 18164116 21159647 9362446 19539802 19519916 2563599 19004024 19009564
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 40.6118253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 40.6118308698 2563599 17172636 6150874 1399818
MESH:D008114 Liver Neoplasms, Experimental propiconazole 40.6117178689
MESH:D008114 Liver Neoplasms, Experimental systhane 40.6117178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 40.6112151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 40.6117178689
MESH:D008133 Long QT Syndrome Amiodarone 3.1715350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 10.4212587719
MESH:D008171 Lung Diseases Fluconazole 10.4214966256
MESH:D008171 Lung Diseases sodium arsenite 10.4219095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9318516814
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 9.3411376686
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 9.3415390079 11246140 19359593 16337739 18597497 11696405 19925653
MESH:D008175 Lung Neoplasms Dexamethasone 9.3415824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 9.346695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 9.3416712894 19931552 17077188 15276417 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 9.3418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.3411884234 19555203
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4314749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.2215688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.2219428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 11.4211921183
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 11.421500032
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 11.4211606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.4219196723 14580682 16827153 19196722 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.0019453300
MESH:D008527 Medulloblastoma Tretinoin 2.5517453147
MESH:D008545 Melanoma resveratrol 6.2817992120
MESH:D008545 Melanoma sodium arsenite 6.2816487513 19082730
MESH:D008545 Melanoma Tamoxifen 6.2812393984 19393235
MESH:D008545 Melanoma Tretinoin 6.2816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0419513568
MESH:D008591 Meningomyelocele Tretinoin 3.9016940565
MESH:D008607 Mental Retardation Phenytoin 3.469212184
MESH:D008659 Metabolic Diseases resveratrol 3.8917112576
MESH:D024821 Metabolic Syndrome X Fructose 4.3717261469 18497449 17098227 16815490 19165636
MESH:D009101 Multiple Myeloma Dexamethasone 6.2616118317 15867202 15744524
MESH:D009101 Multiple Myeloma resveratrol 6.2614749477 17164350 16267019 17049120 16490592 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.3317962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9816239165
MESH:D009181 Mycoses Amiodarone 4.3512754197 17974566
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.449809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.4417596541
MESH:D009203 Myocardial Infarction pirinixic acid 4.9019151258
MESH:D009203 Myocardial Infarction resveratrol 4.9017188708 17125593 16525036 16456233 16317513 17015251
MESH:D017202 Myocardial Ischemia resveratrol 7.5817015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.5812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.5316411023
MESH:D009205 Myocarditis resveratrol 4.2217322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 10.7017484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 10.7017484760
MESH:D009224 Myotonia Congenita Phenytoin 4.871896199
MESH:D009336 Necrosis 2-nitropropane 5.0312195237
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.033581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.033581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.0319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3219410462
MESH:D009369 Neoplasms pirinixic acid 6.5517405874
MESH:D009369 Neoplasms sodium arsenite 6.5511559025
MESH:D009369 Neoplasms Tretinoin 6.5516594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 7.498985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.4920056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4519196722 19200415 19189210
MESH:D009410 Nerve Degeneration Paraquat 3.3016893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.8214600291
MESH:D009421 Nervous System Malformations Tretinoin 7.829125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 14.376679447
MESH:D009436 Neural Tube Defects Phenytoin 14.379118846
MESH:D009436 Neural Tube Defects sodium arsenite 14.3712854658
MESH:D009436 Neural Tube Defects Tretinoin 14.379142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.5018514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.5020387270
MESH:D019636 Neurodegenerative Diseases resveratrol 11.5017652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.9017929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5720387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.319802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.319802331
MESH:D009765 Obesity Dietary Fats 6.5517217161 20132043 21332399 18457598 20518802 16723640 18674790 11836018 19632207
MESH:D009765 Obesity Fructose 6.5518585860 17707055
MESH:D009765 Obesity pirinixic acid 6.5520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.956482804 4026338
MESH:D014009 Onychomycosis Fluconazole 5.8014966256
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.473988306
MESH:D010018 Osteomalacia Phenobarbital 10.2917016548
MESH:D010018 Osteomalacia Phenytoin 10.2917016548
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.7617513867
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.2217306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 4.2216936753
MESH:D010146 Pain Acetaminophen 8.8216870215
MESH:D010146 Pain Phenytoin 8.8215215642
MESH:D010146 Pain Tretinoin 8.8216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.3016540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 7.3016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.3015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 2.977296757
MESH:D010300 Parkinson Disease Paraquat 2.6016140633 11181820 16510128 11124998 11445065 12911755 15451049 15824117
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.9116190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7012520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.926228378
MESH:D011014 Pneumonia Butylated Hydroxytoluene 9.5611893704
MESH:D011014 Pneumonia Paraquat 9.5612504350
MESH:D017689 Polydactyly Phenytoin 4.599212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.582563599
MESH:D011230 Precancerous Conditions Phenobarbital 7.582563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2221297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 13.2517132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 13.2516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.2511399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms resveratrol 2.8417718901 17804756 15767336 17675339 16731767 17636462
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.8416039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.8415067354
MESH:D011507 Proteinuria Tretinoin 3.1116636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7815861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 10.7312752131
MESH:D019310 Pseudolymphoma Phenytoin 10.738603615 1419762 12752131
MESH:D011625 Pterygium Tretinoin 4.2516723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.0612832656 11597910 12490602
MESH:D011658 Pulmonary Fibrosis Paraquat 5.0617997886 16324872
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0316325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.6119058328
MESH:D015427 Reperfusion Injury resveratrol 5.6117058453 16314181 15827377 17520802 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.6211700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.6211700416
MESH:D012135 Respiratory Sounds Paraquat 3.5411874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 7.553692021
MESH:D012162 Retinal Degeneration Paraquat 7.5516458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6016116481 16283617
MESH:D012640 Seizures Phenobarbital 5.133137016 4039156 16876388 11442880
MESH:D012640 Seizures Phenytoin 5.133691417 10029267 19919933 16876388 3137016 15946322 11044598 9844417
MESH:D003294 Seizures, Febrile Phenobarbital 4.286407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5518724381
MESH:D012878 Skin Neoplasms resveratrol 11.2715837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 11.2718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.2716192470
MESH:D012878 Skin Neoplasms Tretinoin 11.2716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 9.7416709447
MESH:D013088 Spermatocele Tamoxifen 9.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.5019457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3812854658
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.6320235791
MESH:D013272 Stomach Diseases Dexamethasone 8.6615472012
MESH:D013272 Stomach Diseases Omeprazole 8.6618545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.2618456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.2617261132
MESH:D013276 Stomach Ulcer Amiodarone 9.4418087811
MESH:D013276 Stomach Ulcer Dexamethasone 9.4415138204
MESH:D013276 Stomach Ulcer Omeprazole 9.4411906479 18237397 17977527 10750652 15991576 16755016
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0116321402
MESH:D013610 Tachycardia Amiodarone 3.7811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.6819225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7015669648
MESH:D013959 Thyroid Diseases Amiodarone 10.2319731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.2312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 22.683712494 1399818 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 22.687505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 22.681399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 22.6815710170
MESH:D013964 Thyroid Neoplasms Tretinoin 22.6817045167 16026305
MESH:D013964 Thyroid Neoplasms triadimefon 22.6817178689
MESH:D013971 Thyrotoxicosis Amiodarone 4.3319584973 18020914
MESH:D014062 Tongue Neoplasms resveratrol 8.3516227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.3516051514
MESH:D016171 Torsades de Pointes Amiodarone 3.6617467628 11989578
MESH:D014376 Tuberculosis Tretinoin 2.8816040207
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 9.9715867355 1399818 15289314
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 9.978074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 9.9716452187 17306315 11723127 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 9.9717572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 2.4910982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 13.1817473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.1811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.1816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.8114692618
MESH:D014594 Uterine Neoplasms resveratrol 7.8117044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.0616752155
MESH:D014605 Uveitis Dexamethasone 4.271336536
MESH:D014652 Vascular Diseases sodium arsenite 3.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0615869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.7817488730
MESH:D014820 Vitiligo Tretinoin 3.5516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7015886252
MESH:D015430 Weight Gain Dietary Fats 3.2816723640
MESH:D009396 Wilms Tumor Tretinoin 3.5116287080
Pathway ID Pathway Name
KEGG:04975 Fat digestion and absorption
KEGG:04977 Vitamin digestion and absorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24887
    • No data
    Releated disease ID Related disease Name
    PA447230HIV
    PA446213HIV Infections
    PA444528Hyperlipidemias
    Releated drug ID Related drug Name
    PA450952phospholipids
    PA451260ritonavir
    PA451089pravastatin
    PA450688olanzapine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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