AutismKB 2.0

Annotation Detail for HYAL1


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Basic Information Top
Gene Symbol:HYAL1 ( HYAL-1,LUCA1,MGC45987,NAT6 )
Gene Full Name: hyaluronoglucosaminidase 1
Band: 3p21.31
Quick LinksEntrez ID:3373; OMIM: 607071; Uniprot ID:HYAL1_HUMAN; ENSEMBL ID: ENSG00000114378; HGNC ID: 5320
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6576dermatan sulfate degradation (metazoa)
PWY-6573chondroitin sulfate degradation (metazoa)
Pathway IDPathway Name
hsa04142Lysosome
hsa00531Glycosaminoglycan degradation
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Lysosomal storage diseases
H00133Mucopolysaccharidosis type IX (MPS9)
Genetic disorders
Desease IDDesease Name
1786Neck cancer
1788Infiltrating cancer
1831Prostate cancer
1860Brain tumor
1904Diabetes mellitus
1944Breast cancer
1976Squamous cell cancer
2066Lung cancer
No data
No data
Desease Name
Mucopolysaccharidosis type IX
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of HYAL1 mRNAincreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of HYAL1 mRNAaffects expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HYAL1 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of HYAL1 mRNAincreases expression 20458559
D016572 Cyclosporine Cyclosporine results in decreased expression of HYAL1 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HYAL1 mRNAaffects cotreatment|increases expression 17942748
D010634 Phenobarbital Phenobarbital results in increased expression of HYAL1 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HYAL1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of HYAL1 mRNAincreases expression 18301758
C017947 sodium arsenite sodium arsenite results in increased expression of HYAL1 mRNAincreases expression 12377979
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HYAL1 mRNAincreases expression 12377990
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HYAL1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1015322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4111798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.7417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.7416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.7416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1717306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.3116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.147296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.1412907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.1411135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.1417173139 20007298 1701930 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 9.1417306315 15276417 16507464
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4218572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.857505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8512371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.8519524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 20.2819486331 9022650
MESH:D002779 Cholestasis Cyclosporine 20.2819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 20.2816919318 11677210 16105132 17110522 17681005 15861022 17333356
MESH:D002779 Cholestasis pirinixic acid 20.2819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 15340226 12621046 8697196 16354765
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5110048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0118759878 8970840 12868966 14531868 8156756 11298694 2524372 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.849328219 18289764 16192314 18692083 6482804 7440962 1440618 6679447 18648102 11289319 8291058 9653073 9022650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.603581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6012903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver arsenic trioxide 20.2315073043
MESH:D005234 Fatty Liver Cyclosporine 20.2319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2315345470
MESH:D005234 Fatty Liver pirinixic acid 20.2320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Cyclosporine 9.2112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly Phenobarbital 15.6916109766
MESH:D006529 Hepatomegaly pirinixic acid 15.6918467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.6915340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 15340226 16354765 8697196 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0117937319
MESH:D007248 Infertility, Male sodium arsenite 7.0112646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.328314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 6.3220008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.756582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7512371664
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 20471514 17050201 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3219642359 19225113 16112521 15336539 17649720 16331271 11468182 15622746 12712474 11161223 17107899 17217047 16823087 15748426 17712046 16966277 9834237 12679006 19035177 17869043 19075265 12018890 16891316 16330433 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1812878042
MESH:D008107 Liver Diseases Phenobarbital 2.2019363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.769163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 18.7614682389
MESH:D008113 Liver Neoplasms Phenobarbital 18.7619812893 21047994 8742319 19482888 19073162 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 18.7620007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 18.7616712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.7616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.77598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 19.778603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 19.7720377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.7717172636 6150874 1399818 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.7712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9914755239
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9919825857 11798837
MESH:D008175 Lung Neoplasms sodium arsenite 4.9916712894 19931552 17306315 17077188 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9919555203 11884234
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
OMIM:601492 MUCOPOLYSACCHARIDOSIS TYPE IX marker/mechanism
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2219549372 19417148 11468182 15949261 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms pirinixic acid 5.2017405874
MESH:D009369 Neoplasms sodium arsenite 5.2011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.776679447
MESH:D009436 Neural Tube Defects arsenic trioxide 12.7710525206
MESH:D009436 Neural Tube Defects sodium arsenite 12.7712854658
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0616624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0617306315 15276417
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4815580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.4812371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.482563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2619131511
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2616039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012640 Seizures Phenobarbital 2.8016876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms sodium arsenite 5.8419524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.743712494 6582329 7505956 1399818 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.7419014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.741399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.698074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.6912845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.6917306315 11723127 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:00531 Glycosaminoglycan degradation
KEGG:04142 Lysosome
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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