AutismKB 2.0

Annotation Detail for ICA1


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Basic Information Top
Gene Symbol:ICA1 ( ICA69,ICAp69 )
Gene Full Name: islet cell autoantigen 1, 69kDa
Band: 7p21.3
Quick LinksEntrez ID:3382; OMIM: 147625; Uniprot ID:ICA69_HUMAN; ENSEMBL ID: ENSG00000003147; HGNC ID: 5343
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04940Type I diabetes mellitus
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of ICA1 mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of ICA1 mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ICA1 mRNAaffects cotreatment|increases expression 18164116
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ICA1 mRNAaffects expression 17484886
D003520 Cyclophosphamide ICA1 protein affects the susceptibility to Cyclophosphamideaffects response to substance 11751995
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ICA1 mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ICA1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ICA1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ICA1 mRNAaffects cotreatment|increases expression 17942748
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of ICA1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in increased expression of ICA1 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ICA1 mRNAaffects cotreatment|increases expression 17942748
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of ICA1 mRNAdecreases expression 16330358
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of ICA1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of ICA1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.1419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.146695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7116434500 17620307 18056438 19061943 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001161 Arteriosclerosis Cyclophosphamide 10.7615014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.7611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Cyclophosphamide 1.9317020986 17388661 18323546 18234424 16978400 11325840 12006526 15136595 15093573
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.5316097048 15700767 16050911 16227642 16011737 15721981 18705752 15673190 3786805 16124888 10355542 16192424
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.5316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.093084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0918788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 9.0919701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0916328049 10737359 19701751 16807293 16502159 19383236 20727157 19107877 19919837 18785209 19171122 16698587 17978847 17162532 16878318 20007298 20214788 20101231 17761372 17428255 20514400 18056438 18393292 18691550 18210153 16681979 17138121 18978308 19052882 20432363 17055752 18494052 19208518 19394651 16935385 11831363 16288022 16540662 19539802 20084675 18788625 18971187 3084413 16830150 10672840 20935162 18506893 19418558 17173139 20524982 16569478 19519916 19822196 20512989 19335982 18665156 16779866 3581430 21159647
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.0816152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.5916201981
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.016135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.017505956 17174075 2727394 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817110522 17681005 15861022 16105132 11677210 16919318 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515340226 12621046 8697196 15668235 16354765
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5215322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003556 Cystitis Cyclophosphamide 5.2010700343 18433785 12161096 12913760 18483878 16614059 16989017 18372110 16651033 15276878 17979934 15643279 17010015 10498854 11948286 18093676 18710439 12388444 18295254 16413132
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 9.3010990075 11751995 15331540
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 9.3016684804
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2618772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.7718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.7712594235 11421492 12540782 17522070 11739529 16781746 19370779 14725611 19164858 17906064 12153990 12958197 14550746 12705907 17562736 11287661 11529661 15968718 10663392 10915739 19420014 19416960 10774834 18071297 12392966 11461765 2444490 19739265 16393943 16081117 15619225 11834606 19923254 19085960 11743745 16109766 18713872 14986274 16485898 16227642 16177239
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.773732212 10915739 6623471 19085960 6884620 15968718 15027814 16227642 7179309 9327722 7120509 16177239 15998439 2869522 3786805 21278145 10092053 4309450 19336974 17522070 11566570 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.7719107877
MESH:D056486 Drug-Induced Liver Injury Selenium 15.7715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.7720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 4.3911006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.9315959796 61145 12631006 16239168 12795759 16045604 17595544 19224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.9320387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.9315345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.1918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1920067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D018316 Gliosarcoma Cyclophosphamide 5.7111389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.2115172196 11014644 16376943
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8016080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006467 Hemophilia A Cyclophosphamide 5.4711918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.7514986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.9117606976 16135485
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007154 Immune System Diseases Cyclophosphamide 5.5516076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Cyclophosphamide 7.1816517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1817937319
MESH:D007249 Inflammation Diethylnitrosamine 5.1218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1212878042 12200463
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.2212488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0916705839
MESH:D007938 Leukemia Cyclophosphamide 3.5510602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5518587576 17802794 18172266 17658394 17296974 17008537
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.1910373061
MESH:D007970 Leukopenia Cyclophosphamide 5.1611830472 10052129
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8516239168 16943688 21278145 11408273 16221502 17334410 17157831 11903743 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8518665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5415818738 15057751 17823541 14716833 17869086 11481614 15925388 14724832 14512876 16033810 12546737 18166357 18395914 18395095 18251166 17944888 17698563 12609069 18472332 18705752 18054572 18420326 16015684 18481824 16248980 12667390 12666154 17525996 18472094 15893842 18412020 12958196 15673190 15650968 14748882 17900296 20821823 13678700 17708605 18205269 14716496 16097048 17761835 16192424 15730626 17721639 16136751 10355542 17557913 18279442 18277467 15959796 12389079 17766677 17481882 18263696 17922224 15996030 12445418 17565644 17805973 15052691 12898905 18187930 18210741 18156304 16638106 18339082 18006644 18429990 15123356 12741479 18376398 15362042 14620537 12632512 15370692 12586293 15931870 16027843 15338365 16116963 12649538 16011737 17714472 12445421 12632514 18317297 17640975 17976157 15876570 17631135 18418968
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5412878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5416169303
MESH:D008107 Liver Diseases Acetaminophen 6.6619784758 12587719 19460945 16610002 19014921 16611625 12969438 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.6615720792 15830285 16246199 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 6.6617034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8516899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.777678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.7721295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.7719294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.7719850985 19642983 18978307 18644402 20118626 19812893 16942905 19426721 20501860 18977376 21071580 20101389 9163691 15175105 19255062 19638242 20583210 19294768 15885732 18754104 21167192 19499222 19427195 20452335 19090486 12771043 10737359 20137499 20492335 19690152 19256749 18648771 20405173 19254457 2422723 21278145 19551842 12112319 2862719 21047994 20434301 19833225 19996281 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.572876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.5718164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.5712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.573124819 18079962 18093689 19539802 19519916 18775883 21159647 18308698 18282651 18544905 17174075 19009564 16842330 16267830 19004024 17942915 18253720 18164116 9362446 2563599 17854601 19126423
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.5712151625
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.476695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4719555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.4711062179
MESH:D008223 Lymphoma Cyclophosphamide 3.9312854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.7516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.2811911406
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 11.4319513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 11.4316388313
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009369 Neoplasms Cyclophosphamide 3.1918854779
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009447 Neuroblastoma Cyclophosphamide 3.7015176712 8761367 16115947
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.0812837982 8761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009503 Neutropenia Cyclophosphamide 4.478291058
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D009845 Oligospermia Cyclophosphamide 4.9016517039
MESH:D010146 Pain Acetaminophen 7.2416870215
MESH:D010146 Pain Cyclophosphamide 7.2412161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.6611332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.6616540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8721297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.5117136230
MESH:D011471 Prostatic Neoplasms Vitamin E 3.5115084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3316636934
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.9716636934
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.7116517039
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.2512837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4916049721
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.4914692829
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:04940 Type I diabetes mellitus
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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