AutismKB 2.0

Annotation Detail for KLHL17


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Basic Information Top
Gene Symbol:KLHL17 ( RP11-54O7.6 )
Gene Full Name: kelch-like 17 (Drosophila)
Band: 1p36.33
Quick LinksEntrez ID:339451; OMIM: NA; Uniprot ID:KLH17_HUMAN; ENSEMBL ID: ENSG00000187961; HGNC ID: 24023
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of KLHL17 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KLHL17 mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KLHL17 mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KLHL17 mRNAaffects cotreatment|decreases expression 20360939
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLHL17 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000236 Adenoma Diethylnitrosamine 3.0310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.9618056438 17162532 16434500 19061943 17620307 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.9616434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1917474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1216705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1220514400 17162532 18393292 20101231 17978847 19418558 10672840 20935162 17173139 20512989 3084413 19822196 16502159 18665156 18210153 10737359 17055752 17428255 17138121 18971187 19171122 16779866 3581430 11831363 18788625 16540662 20727157 21159647 18506893 20524982 16288022 18056438 19052882 16807293 19701751 16681979 19539802 18691550 19208518 16830150 19335982 19394651 19919837 16935385 16569478 20432363 17761372 18494052 16328049 18978308 16878318 20214788 20007298 20084675 19383236 19107877 16698587 19519916 18785209
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.486135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.4817174075 21159647 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 4.0119052882
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5018551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.1719107877
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.7316302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.9520387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.9519236843 20131406
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4818467677 16221962 19176532 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007249 Inflammation Diethylnitrosamine 2.5318785209
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.9310783313
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.7315369732
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2816705839
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.2116766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9918665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.057678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0519256749 19426721 19551842 19812893 10737359 21278145 20492335 20452335 19255062 12112319 20434301 15175105 20405173 18977376 19850985 18754104 9163691 18644402 19090486 19499222 20583210 20137499 19073162 20101389 2422723 12771043 19642983 19690152 15885732 21047994 2862719 18648771 19996281 19638242 19294768 19254457 21167192 19427195 18978307 19833225 20118626 16942905 20501860 21071580
MESH:D008113 Liver Neoplasms pirinixic acid 8.0516377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.612876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.6116842330 19009564 19519916 19539802 18308698 16267830 2563599 18544905 18282651 3124819 17854601 18775883 18253720 18079962 17942915 19126423 18164116 18093689 19004024 9362446 21159647 17174075
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 20512841 21163286
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.407678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.689029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.7320387270
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7816049721
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5216540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.882563599
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7618551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.257505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4016049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.8610091137
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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