AutismKB 2.0

Annotation Detail for ID3


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Basic Information Top
Gene Symbol:ID3 ( HEIR-1,bHLHb25 )
Gene Full Name: inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Band: 1p36.12
Quick LinksEntrez ID:3399; OMIM: 600277; Uniprot ID:ID3_HUMAN; ENSEMBL ID: ENSG00000117318; HGNC ID: 5362
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04350TGF-beta signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1887Carcinoma
1841Stomach cancer
2047Rett syndrome
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ID3 mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ID3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ID3 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ID3 proteinaffects expression 20106945
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of ID3 mRNAincreases expression 16541417
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ID3 mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of ID3 mRNAdecreases expression 16704987
D001374 Azacitidine Azacitidine results in increased expression of ID3 mRNAincreases expression 19194470
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ID3 mRNAincreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ID3 mRNAdecreases expression 19150397
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of ID3 mRNAincreases expression 15912405
C006780 bisphenol A bisphenol A results in decreased expression of ID3 mRNAdecreases expression 16474171
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ID3 mRNAincreases expression 15003993
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ID3 mRNAaffects expression 12734012
C014347 decitabine decitabine results in increased expression of ID3 mRNAincreases expression 19194470
D004041 Dietary Fats Dietary Fats results in increased expression of ID3 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ID3 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ID3 mRNA]decreases reaction|increases expression 17942915
D004317 Doxorubicin Doxorubicin results in increased expression of ID3 mRNAincreases expression 15205334
D004958 Estradiol Estradiol results in decreased expression of ID3 mRNAdecreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of ID3 mRNA]decreases reaction|increases expression 12072388
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ID3 mRNAdecreases expression 15576828
17557909
12655037
15834898
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of ID3 mRNAincreases expression 15954086
D005419 Flavonoids Flavonoids results in increased expression of ID3 mRNAincreases expression 18035473
D005472 Fluorouracil Fluorouracil results in increased expression of ID3 mRNAincreases expression 16557594
15205334
D005665 Furosemide Furosemide results in decreased expression of ID3 mRNAdecreases expression 16526316
D019833 Genistein Genistein results in decreased expression of ID3 mRNAdecreases expression 16474171
C008493 methylselenic acid methylselenic acid results in decreased expression of ID3 mRNAdecreases expression 12517777
C008493 methylselenic acid methylselenic acid results in increased expression of ID3 mRNAincreases expression 18548127
D009151 Mustard Gas Mustard Gas results in increased expression of ID3 mRNAincreases expression 15674844
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of ID3 mRNAincreases expression 17616710
C041786 palm oil palm oil results in increased expression of ID3 mRNAincreases expression 18042831
C084656 paricalcitol [Phosphorus co-treated with paricalcitol] results in increased expression of ID3 mRNAaffects cotreatment|increases expression 17715259
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ID3 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ID3 mRNAdecreases expression 19482888
19270015
D019800 Phenol Phenol results in increased expression of ID3 mRNAincreases expression 17547211
D010758 Phosphorus [Phosphorus co-treated with paricalcitol] results in increased expression of ID3 mRNAaffects cotreatment|increases expression 17715259
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ID3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid affects the expression of ID3 mRNAaffects expression 18445702
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in decreased expression of ID3 mRNAdecreases expression 16474171
D011374 Progesterone Progesterone results in increased expression of ID3 mRNAincreases expression 18037150
C009166 retinol acetate retinol acetate results in increased expression of ID3 mRNAincreases expression 16772331
C009277 sodium arsenate sodium arsenate results in decreased expression of ID3 mRNAdecreases expression 12727804
C017947 sodium arsenite sodium arsenite results in decreased expression of ID3 mRNAdecreases expression 12727804
C017947 sodium arsenite sodium arsenite results in increased expression of ID3 mRNAincreases expression 16966095
12760830
C017947 sodium arsenite sodium arsenite results in decreased expression of ID3 mRNAdecreases expression 16014739
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ID3 mRNAdecreases expression 19684285
17257637
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ID3 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of ID3 mRNAaffects expression 16611356
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ID3 mRNAdecreases expression 19684285
19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ID3 mRNAincreases expression 19684285
17942748
15591033
D014212 Tretinoin Tretinoin affects the expression of ID3 mRNAaffects expression 16054129
D014212 Tretinoin Tretinoin results in increased expression of ID3 mRNAincreases expression 17138961
16494909
C034613 triacsin C triacsin C results in decreased expression of ID3 mRNAdecreases expression 16704987
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of ID3 mRNAdecreases expression 16330358
D002762 Cholecalciferol Cholecalciferol results in decreased expression of ID3 mRNAdecreases expression 16508948
D015032 Zinc Zinc affects the expression of ID3 mRNAaffects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.726195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.7215322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.0818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4617505938
MESH:D000169 Acrodermatitis Zinc 4.9316889938 17190629 17202136
MESH:D055371 Acute Lung Injury pirinixic acid 2.6818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 15.2320127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 15.2317418594
MESH:D000230 Adenocarcinoma Estradiol 15.2311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.2314692618
MESH:D000230 Adenocarcinoma Fluorouracil 15.2317638652
MESH:D000230 Adenocarcinoma Genistein 15.2311473722
MESH:D000236 Adenoma Benzo(a)pyrene 9.586695378
MESH:D000236 Adenoma Diethylnitrosamine 9.5810737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 9.586695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.9518056438 17620307 16434500 19061943 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.9517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.9516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.9516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4216712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.0921441931
MESH:D000505 Alopecia Tretinoin 3.2415955085
MESH:D000544 Alzheimer Disease Zinc 2.6416325427 16580781 17119284 16410023
MESH:D000740 Anemia Fluorouracil 7.3115504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.3111748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.4516916123
MESH:D000799 Angioedema Acetaminophen 3.3610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6119183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.3715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.3711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.1915885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1416292516
MESH:D001249 Asthma Mustard Gas 7.0110378619
MESH:D001249 Asthma Tretinoin 7.0116456186
MESH:D001249 Asthma Zinc 7.0117085522
MESH:D001321 Autistic Disorder Acetaminophen 2.2318445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2318582451
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.5716142846
MESH:D001471 Barrett Esophagus Tretinoin 3.9516935849
MESH:D001768 Blister Mustard Gas 4.6819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.8119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.8112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.8116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2114601052
MESH:D001859 Bone Neoplasms Phenol 4.7710556009
MESH:D001862 Bone Resorption bisphenol A 3.4411985600
MESH:D001913 Bowen's Disease Phenol 5.2719293009
MESH:D001927 Brain Diseases Ethylnitrosourea 4.4714991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8517868700
MESH:D001930 Brain Injuries Progesterone 9.5015665606 15845082 15380490
MESH:D001930 Brain Injuries Zinc 9.5017109824
MESH:D001932 Brain Neoplasms Doxorubicin 7.7217150277
MESH:D001932 Brain Neoplasms Ethylnitrosourea 7.7218412241 15144691 16651633 16357521 16436596
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.8617474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 8.8617123778
MESH:D001943 Breast Neoplasms decitabine 8.8619208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 8.8620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 8.8617474063
MESH:D001943 Breast Neoplasms Doxorubicin 8.8615939500 17369602 16096432 16115903 15136595 15994142 16264153 18382427 18628466 15993339 18695136 17983394 19526202 18234424 16322301 17426702 15668708 16826403 16935488 16595493 15567936 15634643 15692762 11325840
MESH:D001943 Breast Neoplasms Estradiol 8.8617289903 16675129 12948864 14630087 17261762 18497071 19861407 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 8.8619217205 16110121 15136595 18357371 18608205 16557594 16595493
MESH:D001943 Breast Neoplasms Genistein 8.8616873071 17200150 16541309
MESH:D001943 Breast Neoplasms Progesterone 8.8616175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 8.8616166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4917687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3216192424 16227642 3786805 15721981 10355542 15700767 16097048 15673190 16050911 16011737 18705752 16124888
MESH:D002276 Carcinoid Tumor Doxorubicin 10.7316051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.7316051944
MESH:D002277 Carcinoma Fluorouracil 6.9317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6716168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 26.9016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 26.903084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 26.9021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 26.9018788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 26.9018506893 17138121 18393292 19171122 16878318 17761372 16328049 17978847 18210153 16288022 18788625 17173139 19701751 19519916 19208518 20101231 16569478 3581430 19052882 16681979 16935385 20432363 20727157 20512989 19919837 11831363 20214788 18056438 10672840 21159647 20514400 16807293 19539802 18494052 17055752 16698587 3084413 20524982 19394651 19107877 17162532 19335982 18978308 18691550 16779866 19822196 19383236 18785209 18665156 16502159 18971187 16540662 20007298 20935162 16830150 10737359 19418558 20084675 17428255
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 26.9018059187 17876044 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 26.9016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 26.9016799960 16332177 18930000 17045692 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 26.9016924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 26.9017173139 20935162 20007298 6705139 1701930
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 26.9015276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 26.901917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.5117123778
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.8716201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.8718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 19.5020419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 19.5019215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 19.506189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 19.5016757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 19.5018572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 19.5016096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 19.5016543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0916120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.2116612575 15476868 17974986 17329180 16952015 16651473 16278810 16109756 17382496 17308081 15792986 15505089 15811867 17131338 17924179 17351982 17007740 17519947 17928571 18627295 16455267 16364871 16242529 16269455 16731534
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7716243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 6.4716332659
MESH:D002318 Cardiovascular Diseases Zinc 6.4716936243
MESH:D002386 Cataract Acetaminophen 6.2510977129
MESH:D002386 Cataract Tretinoin 6.2517460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 22.026135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 22.0220889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 22.0217174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 22.0218566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 22.0216003739
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 22.0219524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.794080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.5017160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.9919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.9916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.5617110522 16919318 15861022 17681005 11677210 16105132 17333356
MESH:D002779 Cholestasis pirinixic acid 6.5619176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.0416354765 8697196 15668235 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.049407595
MESH:D003092 Colitis Tretinoin 3.2417035595
MESH:D003110 Colonic Neoplasms decitabine 5.2317616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.2315001691 17016597 17172411 16340194 16510598 17287894 17725105 17018589 18772588 17169374
MESH:D003110 Colonic Neoplasms Genistein 5.2317182828
MESH:D015179 Colorectal Neoplasms Azacitidine 5.8719934284
MESH:D015179 Colorectal Neoplasms decitabine 5.8718981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 5.8718802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 5.8715148649 15289873 18509181 18949393 17454858 17094418 16303861 16524972 17401013 16391804 18383874 17016601 18802399 17594712 16282729 17255274 16331619 18448328 17695437 18288408 20501625 14970324
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 5.8715531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6614669216 17141729
MESH:D019465 Craniofacial Abnormalities sodium arsenate 4.9210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9210048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.929125849 17551590 9224671 10589399 9211117 16925845 8800419 14991402 9142499 9664655
MESH:D019465 Craniofacial Abnormalities Zinc 4.9219302082
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.5518551238
MESH:D007644 Darier Disease Fluorouracil 4.3116733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.2816140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1918249437
MESH:D003920 Diabetes Mellitus Zinc 3.8016479319
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 3.9916684804
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.2816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0317187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 16.1218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.1212540782 11421492 14550746 14986274 11529661 12705907 17562736 12958197 15619225 16227642 19370779 17906064 19923254 11834606 12153990 11287661 2444490 14725611 16393943 16781746 18713872 19085960 12594235 16109766 11739529 16081117 19164858 15968718 11743745 17522070 10663392 19416960 16485898 10915739 19420014 16177239 12392966 11461765 10774834 18071297 19739265
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 16.1215027814 10915739 19336974 4309450 15998439 16227642 6623471 9327722 3732212 17522070 6884620 2869522 7120509 19085960 3786805 16177239 10092053 7440962 7179309 15968718 11566570 21278145
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.1219107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 16.1217416283
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 16.1218186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.1220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6119426721
MESH:D004362 Drug Toxicity Doxorubicin 6.9218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.9211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1118367378
MESH:D004417 Dyspnea Furosemide 4.4616935035
MESH:D004421 Dystonia Phenobarbital 3.561851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.5018357618
MESH:D004487 Edema Arachidonic Acid 17.207990266 15177302 9831321 11698051 9599246 16716910
MESH:D004487 Edema Furosemide 17.2011834646
MESH:D004487 Edema Mustard Gas 17.209260866 11428631 11428647 11402378
MESH:D004487 Edema pirinixic acid 17.2012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.3316714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.3318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.5412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.5417692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.6319294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.1116402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 15.1717359293
MESH:D016889 Endometrial Neoplasms Estradiol 15.1718566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 15.1711473722
MESH:D016889 Endometrial Neoplasms Tretinoin 15.1716569247
MESH:D004715 Endometriosis Progesterone 7.5616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.569294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6718037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.643659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.146401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.797750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.543659116
MESH:D004890 Erythema Mustard Gas 4.689357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.2720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.2716530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.2715173087 16481741 16337965 17638652 16785472
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 12.2715264214 15878914 16510608 16805852 15547733 15547721 15623463 16704527 15150132
MESH:D004938 Esophageal Neoplasms Zinc 12.2716543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.6411564622
MESH:D005124 Eye Abnormalities Tretinoin 7.649664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.1419224547 12631006 16239168 12795759 16045604 15959796 61145 17595544
MESH:D005234 Fatty Liver Dietary Fats 20.1419551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 20.1421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.1415345470
MESH:D005234 Fatty Liver pirinixic acid 20.1420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9911858732
MESH:D005334 Fever Arachidonic Acid 4.2511852909
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.1119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 17.3418705752
MESH:D005355 Fibrosis Dietary Fats 17.3418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.3420067830
MESH:D005355 Fibrosis Tretinoin 17.3417994277
MESH:D005756 Gastritis Acetaminophen 9.5516983495
MESH:D005756 Gastritis Zinc 9.5517241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2016452187
MESH:D005909 Glioblastoma Doxorubicin 14.3717150277
MESH:D005909 Glioblastoma Ethylnitrosourea 14.3716436596
MESH:D005909 Glioblastoma Genistein 14.3716598420
MESH:D005909 Glioblastoma Tretinoin 14.3717312396
MESH:D005910 Glioma Ethylnitrosourea 5.6516651633 18412241 16357521
MESH:D005910 Glioma Fluorouracil 5.6516145905
MESH:D018149 Glucose Intolerance sodium arsenate 4.6419446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1110696789
MESH:D006130 Growth Disorders Zinc 3.6517217573
MESH:D006258 Head and Neck Neoplasms decitabine 15.7619215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 15.7615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 15.7615162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 15.7616096774
MESH:D034381 Hearing Loss Furosemide 4.4317868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.5410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.5414991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.1514766674 16244371 17875725 16144979 16879835 16707910 16244372 16330681 18006777 12587719 16495754 18674790 17888722
MESH:D006333 Heart Failure Doxorubicin 14.4417481944
MESH:D006333 Heart Failure Furosemide 14.4416845234 12660669 16011733
MESH:D006333 Heart Failure pirinixic acid 14.4420558911
MESH:D006333 Heart Failure Zinc 14.4417162251
MESH:D006335 Heart Injuries Zinc 5.2817074742
MESH:D016481 Helicobacter Infections Zinc 4.0917241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1519900420 19110552
MESH:D006527 Hepatolenticular Degeneration Zinc 4.2317276780
MESH:D006529 Hepatomegaly Phenobarbital 11.7016109766
MESH:D006529 Hepatomegaly pirinixic acid 11.7018467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.7016120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.5515709030
MESH:D006689 Hodgkin Disease Doxorubicin 6.1618501091 15147373 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 6.1612676792
MESH:D019584 Hot Flashes Estradiol 3.2717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.568697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.3816870215
MESH:D006930 Hyperalgesia Tretinoin 6.3816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0516899240
MESH:D006934 Hypercalcemia Furosemide 4.6517652376
MESH:D053565 Hypercalciuria Furosemide 5.1817652376
MESH:D006937 Hypercholesterolemia Dietary Fats 3.1721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1016778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7720558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.1821332399
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.3915086907
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7218850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6215338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 4.8216612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.1811041285
MESH:D007019 Hypoproteinemia Furosemide 5.3916096441
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3416945680 16569931
MESH:D007022 Hypotension Furosemide 4.1811041285
MESH:D007024 Hypotension, Orthostatic Furosemide 4.9315811171
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0212013081
MESH:D007248 Infertility, Male decitabine 9.3417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.3417937319
MESH:D007248 Infertility, Male sodium arsenite 9.3412646999 15346721
MESH:D007249 Inflammation Arachidonic Acid 20.1815177302 17371808 9831321
MESH:D007249 Inflammation Dietary Fats 20.1820412841
MESH:D007249 Inflammation Diethylnitrosamine 20.1818785209
MESH:D007249 Inflammation Flavonoids 20.1817296493
MESH:D007249 Inflammation Mustard Gas 20.1811428647 11428620 16001271 17524151 11428631 8975870 9357497 9260866 11402378
MESH:D007249 Inflammation Progesterone 20.1815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.1812878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 15.0116393666
MESH:D007333 Insulin Resistance Dietary Fats 15.0111836018 18457598
MESH:D007333 Insulin Resistance Estradiol 15.0116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 15.0116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.3017994277
MESH:D007511 Ischemia Zinc 4.1716584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5116580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.5115992940 17551590
MESH:D055623 Keratosis, Actinic Phenol 5.9619293009
MESH:D007674 Kidney Diseases Acetaminophen 20.1415629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 20.1415369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 20.1415618244
MESH:D007674 Kidney Diseases Furosemide 20.1411041285
MESH:D007674 Kidney Diseases sodium arsenite 20.1420008137
MESH:D007674 Kidney Diseases Zinc 20.1416960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.7616707910
MESH:D007676 Kidney Failure, Chronic Zinc 8.7616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.6416705839
MESH:D007680 Kidney Neoplasms Estradiol 14.6415610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 14.6417379185
MESH:D007680 Kidney Neoplasms Fluorouracil 14.6416985049
MESH:D007938 Leukemia Azacitidine 12.9219148494
MESH:D007938 Leukemia decitabine 12.9218980019 19235587
MESH:D007938 Leukemia Genistein 12.9217468513 18980019
MESH:D007938 Leukemia Tretinoin 12.9217143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6716085563
MESH:D007951 Leukemia, Myeloid Azacitidine 13.6519077051
MESH:D007951 Leukemia, Myeloid decitabine 13.6519117987 18454857 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 13.6516932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 5.6317596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.6319010910 18206229 17679729 19387464 18460780 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.6317596541 16294345 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.9818055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.7519299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8317217047 16823087 15748426 17107899 12679006 17712046 17368321 19075265 16331271 19035177 17506722 17649720 16766008 9834237 16935935 17294898 17301526 17361223 19029980 19642359 19225113 17339181 16140955 16891316 16788101
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.969224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.4711408273 17157831 16943688 21278145 17334410 17174718 16239168 11903743 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 13.4718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.4718665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 13.4721047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.7518472094 13678700 14512876 17976157 15925388 17900296 12649538 17525996 14620537 15996030 17481882 11481614 18054572 18420326 17698563 12741479 12389079 17565644 15370692 18418968 17869086 18705752 16136751 12958196 12445418 15052691 18006644 17766677 12632514 16192424 12898905 18317297 17922224 15650968 17805973 15959796 18412020 18481824 15338365 15057751 16638106 16097048 18251166 16116963 16248980 10355542 17761835 17721639 18210741 15123356 18277467 16011737 18395914 17631135 15818738 12586293 14716496 18429990 15931870 18263696 15730626 18279442 18472332 15876570 12666154 18339082 17823541 16027843 18376398 15893842 12546737 17944888 15673190 18205269 14748882 12609069 17708605 12667390 16015684 16033810 17714472 18166357 17557913 18395095 18187930 14724832 18156304 12632512 12445421 20821823 17640975 14716833 15362042
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 9.7516439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.7514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 9.7517823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.7515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.7512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 9.7518397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 8.1416611625 12969438 11587558 19460945 12587719 19784758 16610002 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.1416964402 15830285 15720792 16246199 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 8.1417034775
MESH:D008107 Liver Diseases Phenobarbital 8.1419363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.0316871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.0314706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 29.977678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 29.979163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.9721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 29.9719294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.9719850985 20101389 21071580 21278145 20583210 19426721 19255062 19499222 21047994 15175105 20434301 18648771 15885732 18644402 19642983 19254457 9163691 18977376 2862719 18754104 2422723 19294768 21167192 19638242 10737359 19690152 18978307 19812893 19090486 12771043 19427195 20452335 20405173 12112319 20501860 20137499 16942905 19996281 20492335 20118626 19551842 19073162 19256749 19833225
MESH:D008113 Liver Neoplasms Fluorouracil 29.9717045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 29.9719812893 21047994 8742319 19073162 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 29.9720007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 29.9715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.9716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 27.882876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 27.888603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 27.8815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 27.8818079962 16842330 18775883 17174075 18544905 3124819 19009564 17854601 19539802 18308698 16267830 19004024 19126423 18282651 19519916 9362446 18253720 17942915 21159647 2563599 18093689 18164116
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 27.8817085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 27.881399818 18308698 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 27.881423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 27.8812151625
MESH:D008171 Lung Diseases Mustard Gas 6.4518161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 6.4519095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 16.2714755239
MESH:D008175 Lung Neoplasms Azacitidine 16.2721224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 16.2720464547 20135361 18569708 20869020 18816296 17053015 20064080 18520028 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 16.2720970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 16.2717418594 6189445
MESH:D008175 Lung Neoplasms Ethylnitrosourea 16.2717703301 16019985 6695378 16271038
MESH:D008175 Lung Neoplasms Fluorouracil 16.2715246190
MESH:D008175 Lung Neoplasms Mustard Gas 16.273148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 16.2717077188 16712894 19931552 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 16.2711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3115086387
MESH:D008223 Lymphoma decitabine 10.7019470736
MESH:D008223 Lymphoma Doxorubicin 10.7016098063
MESH:D008223 Lymphoma Ethylnitrosourea 10.7015790496
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4017654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 10.1515621674
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 10.1515375218
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 19.4915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 19.4911807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 19.4910767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Genistein 19.4914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 19.4917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Zinc 19.4912773700
MESH:D020149 Manganese Poisoning Estradiol 4.0019453300
MESH:D008527 Medulloblastoma Tretinoin 2.5817453147
MESH:D008545 Melanoma decitabine 6.4516505122 17785578
MESH:D008545 Melanoma Doxorubicin 6.4516827129
MESH:D008545 Melanoma sodium arsenite 6.4516487513 19082730
MESH:D008545 Melanoma Tretinoin 6.4516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1019513568
MESH:D008579 Meningioma Ethylnitrosourea 5.5017943659
MESH:D008591 Meningomyelocele Tretinoin 3.9616940565
MESH:D008654 Mesothelioma Doxorubicin 2.8517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0715792986
MESH:D009006 Monosomy Azacitidine 5.6019299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.3116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.3118986760 16757204
MESH:D052016 Mucositis Doxorubicin 4.3117415656
MESH:D009101 Multiple Myeloma Azacitidine 6.5519549372 18443271
MESH:D009101 Multiple Myeloma decitabine 6.5518172295
MESH:D009135 Muscular Diseases pirinixic acid 3.0416239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.4318186108
MESH:D009190 Myelodysplastic Syndromes Azacitidine 10.8018720364 17611569 19805378 17596541
MESH:D009190 Myelodysplastic Syndromes decitabine 10.8019157545 16882708 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.8017596541
MESH:D009203 Myocardial Infarction Doxorubicin 8.2119429709 15857846
MESH:D009203 Myocardial Infarction Genistein 8.2117141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.0416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.0417141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.0416411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0017484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.397678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.189029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.1818259882
MESH:D009369 Neoplasms Benzo(a)pyrene 16.5011141357
MESH:D009369 Neoplasms decitabine 16.5017925555 19116145 19470736
MESH:D009369 Neoplasms Fluorouracil 16.5016928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 16.5017405874
MESH:D009369 Neoplasms sodium arsenite 16.5011559025
MESH:D009369 Neoplasms Tretinoin 16.5016594593 16946489
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 7.8416707424
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.8420056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2617289903
MESH:D009397 Nephrocalcinosis Furosemide 5.3915086907
MESH:D009401 Nephrosis Doxorubicin 4.3016636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.6016889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 25.9516427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 25.9511399458 16427766
MESH:D009421 Nervous System Malformations Genistein 25.9516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.9514600291
MESH:D009421 Nervous System Malformations Tretinoin 25.959125849
MESH:D009436 Neural Tube Defects sodium arsenate 10.4119446573 10525206 11749123 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 10.4112854658
MESH:D009436 Neural Tube Defects Tretinoin 10.419142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 4.9416651423 16003739 17160924
MESH:D009447 Neuroblastoma Doxorubicin 3.0015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.8918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.8920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6320387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1116436463
MESH:D009503 Neutropenia Mustard Gas 3.547688884 16761898
MESH:D053206 Nocturnal Enuresis Furosemide 5.3917945291
MESH:D009765 Obesity Dietary Fats 3.9721332399 18457598 17217161 20132043 20518802 18674790 19632207 11836018 16723640
MESH:D009765 Obesity pirinixic acid 3.9720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.0216049721
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.5017160924
MESH:D010018 Osteomalacia Phenobarbital 3.8917016548
MESH:D010024 Osteoporosis Genistein 2.9519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.6516169203
MESH:D012516 Osteosarcoma Doxorubicin 3.7315930896
MESH:D010049 Ovarian Diseases bisphenol A 4.5111985600
MESH:D010051 Ovarian Neoplasms decitabine 16.6119331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 16.6119401270
MESH:D010051 Ovarian Neoplasms Genistein 16.6119005980
MESH:D010051 Ovarian Neoplasms Progesterone 16.6117393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 16.6117306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 16.6116936753
MESH:D010146 Pain Acetaminophen 9.1516870215
MESH:D010146 Pain Phenol 9.1517610455
MESH:D010146 Pain Tretinoin 9.1516870215
MESH:D010190 Pancreatic Neoplasms decitabine 14.2519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 14.2516540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 14.2516500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 14.2516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.2515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2511578682
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.2116702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7612520081
MESH:D010392 Pemphigus Phenol 5.9616522979 17163923
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6717983394
MESH:D010864 Pilonidal Sinus Phenol 5.9615622588 19655223
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6717638057
MESH:D011041 Poisoning Mustard Gas 7.7015727166
MESH:D011041 Poisoning Phenol 7.708825745
MESH:D011141 Polyuria Furosemide 5.1817945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1118163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.762563599
MESH:D011230 Precancerous Conditions Phenobarbital 7.762563599
MESH:D011225 Pre-Eclampsia Zinc 3.8117114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 7.9310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.9311399792 11896295 11222880 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.2617616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.1320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.1320887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17199135
MESH:D011471 Prostatic Neoplasms Azacitidine 4.6618324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 4.6617292933
MESH:D011471 Prostatic Neoplasms bisphenol A 4.6616740699
MESH:D011471 Prostatic Neoplasms Cholecalciferol 4.6617024972
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.6616868541 18437689 16888761 16729912 15749863 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 4.6616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 4.6618626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 4.6616925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms methylselenic acid 4.6616205645
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 4.6615721890
MESH:D011471 Prostatic Neoplasms sodium arsenite 4.6616039940
MESH:D011471 Prostatic Neoplasms Zinc 4.6616606632 12429649 16700911 16517595
MESH:D011507 Proteinuria Tretinoin 3.1716636307
MESH:D011537 Pruritus Ethinyl Estradiol 7.9515861022 16919318
MESH:D011537 Pruritus Mustard Gas 7.9518058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.0112752131
MESH:D011625 Pterygium Tretinoin 4.3216723453
MESH:D011629 Puberty, Precocious bisphenol A 4.3110548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7310334151 17894541 17620002 17266442 17720292
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6118722050 16160472 15538739 18286688
MESH:D051437 Renal Insufficiency Doxorubicin 3.7617922066
MESH:D015427 Reperfusion Injury marker/mechanism 16526316
MESH:D015427 Reperfusion Injury Furosemide 5.9716526316
MESH:D015427 Reperfusion Injury pirinixic acid 5.9719058328
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.1816096441 12394941 15912074
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3818990726
MESH:D012162 Retinal Degeneration Zinc 3.7716584753
MESH:D012208 Rhabdomyosarcoma decitabine 9.4919155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.4916283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6718045962
MESH:D012509 Sarcoma Doxorubicin 3.5816767912 17710206 15625365 18313854 17203757 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.7916326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3117846226
MESH:D012640 Seizures 2,6-dinitrotoluene 4.8418551238
MESH:D012640 Seizures Phenobarbital 4.843137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.346407741
MESH:D012871 Skin Diseases Mustard Gas 2.5816961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 19.3210029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 19.3215692506
MESH:D012878 Skin Neoplasms sodium arsenite 19.3218572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 19.328532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 19.3216192470
MESH:D012878 Skin Neoplasms Tretinoin 19.3216467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1017203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4416709447
MESH:D013088 Spermatocele Phenol 10.4418646496
MESH:D013119 Spinal Cord Injuries Progesterone 3.8016503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4312854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 9.422093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 9.4219037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 9.4218456281
MESH:D013274 Stomach Neoplasms Fluorouracil 9.4219084572 18396642 15786421 16424979 17172411 17522103 19015929 17498489 16951190 18567086
MESH:D013274 Stomach Neoplasms Furosemide 9.4217052386
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 9.4212958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 9.4217261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.5116045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7515669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.6815790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4212697716
MESH:D013964 Thyroid Neoplasms decitabine 18.6117967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 18.617505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 18.6116010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 18.611399818
MESH:D013964 Thyroid Neoplasms Tretinoin 18.6116026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.2019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 14.2116280240
MESH:D014062 Tongue Neoplasms Tretinoin 14.2116051514
MESH:D014062 Tongue Neoplasms Zinc 14.2116543248
MESH:D014277 Trigeminal Neuralgia Phenol 5.9616527771 10223447
MESH:D014376 Tuberculosis Tretinoin 2.9216040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 13.5916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.5917053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 13.5917616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 13.5917653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.5916712894 11723127 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.8410091137
MESH:D014581 Urticaria Acetaminophen 2.5410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.4716803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.4711813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.4716129372
MESH:D014591 Uterine Diseases bisphenol A 4.5214652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8514692618
MESH:D014604 Uveal Neoplasms decitabine 11.2117785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.2116752155
MESH:D014652 Vascular Diseases sodium arsenite 3.9517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1115869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.7617638931 17334414 16364871 17678736
MESH:D014820 Vitiligo Tretinoin 3.6016761959
MESH:D014860 Warts Phenol 5.6119122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7615886252
MESH:D015430 Weight Gain Dietary Fats 3.3416723640
MESH:D009396 Wilms Tumor Tretinoin 3.5616287080
Pathway ID Pathway Name
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29610
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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