AutismKB 2.0

Annotation Detail for ID4


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Basic Information Top
Gene Symbol:ID4 ( IDB4,bHLHb27 )
Gene Full Name: inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Band: 6p22.3
Quick LinksEntrez ID:3400; OMIM: 600581; Uniprot ID:ID4_HUMAN; ENSEMBL ID: ENSG00000172201; HGNC ID: 5363
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04350TGF-beta signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2047Rett syndrome
Desease Name
CHEMDEPENDENCY
alcohol dependence
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ID4 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of ID4 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of ID4 mRNAincreases expression 16541417
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ID4 mRNAaffects expression 16483693
D001554 Benzene Benzene results in decreased expression of ID4 mRNAdecreases expression 17905399
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ID4 mRNAaffects cotreatment|decreases expression 18164116
C014347 decitabine decitabine results in increased expression of ID4 mRNAincreases expression 16367923
D002945 Cisplatin ID4 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004041 Dietary Fats Dietary Fats results in increased expression of ID4 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ID4 mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ID4 mRNAdecreases expression 19638242
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ID4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ID4 mRNAdecreases expression 17557909
D016685 Mitomycin ID4 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C041786 palm oil palm oil results in increased expression of ID4 mRNAincreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of ID4 mRNAincreases expression 18158353
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of ID4 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of ID4 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of ID4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ID4 mRNAdecreases expression 18691609
19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ID4 mRNAdecreases expression 19490992
C025643 vinclozolin vinclozolin affects the expression of ID4 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.9217670903 12690470 15814532
MESH:D000230 Adenocarcinoma Cisplatin 4.4217638652 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4214692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.8019389873
MESH:D000236 Adenoma Diethylnitrosamine 6.806695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.9416434500 19052882 18056438 17620307 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9416835633
MESH:D000419 Albuminuria Raloxifene 4.5517308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5315800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000741 Anemia, Aplastic Benzene 4.3311369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6019015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0717460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.7815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001855 Bone Marrow Diseases Benzene 5.2016183116
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8614601052
MESH:D001919 Bradycardia Phenylephrine 4.5115306635
MESH:D001930 Brain Injuries Raloxifene 4.4416580743
MESH:D001943 Breast Neoplasms Benzene 4.7117162533 11921183
MESH:D001943 Breast Neoplasms Cisplatin 4.7118382427 19526202
MESH:D001943 Breast Neoplasms decitabine 4.7118320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 4.7120435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.7117474063
MESH:D001943 Breast Neoplasms Raloxifene 4.7115572757 17440819 17893378 17952589 17049068 17595753 15758505 17242785 16912660 17261762 15775269 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 4.7119103187 15668708 17440819 19084267 19244106 18629630 19289846 11161223 19066611 16202921 17242785 20135344 20859285 19142967 17261762 19189212 18821012 18855134 19410462 19155303 16273361 19011961 21138602 18351453 19200415 19189210 19487384 19221464 20005174 17893378 18984771 19115204 20065188 15565566 19288272 18815881 18425577 20544844 20390343 19059307 16818667 21152245 17049068 18997820 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.7120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.533084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.5317982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.533084413 19519916 19539802 11831363 19208518 20084675 16502159 18971187 18210153 16681979 16569478 18691550 18506893 3581430 17761372 19394651 17138121 19335982 16878318 18978308 19052882 18056438 20214788 19418558 16328049 18785209 17055752 16807293 16288022 19822196 19701751 21159647 17173139 20524982 19919837 10737359 20514400 17428255 19171122 16779866 17978847 20935162 10672840 18665156 20727157 20007298 18393292 20432363 16935385 18494052 18788625 19107877 16540662 17162532 20101231 16830150 20512989 16698587 19383236
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5316924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0216685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.926189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9219215824
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.3717572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.3717572228
MESH:D006332 Cardiomegaly Phenylephrine 6.8017124262 11179087 15728586 16170337 17287366 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8016120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4115775269
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.8317174075 21159647 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8417110522 16919318 17333356 17681005 11677210 16105132 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815340226 16354765 8697196 15668235 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.5815800139
MESH:D003110 Colonic Neoplasms decitabine 2.3317616700
MESH:D015179 Colorectal Neoplasms Cisplatin 2.7515273666
MESH:D015179 Colorectal Neoplasms decitabine 2.7518981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 2.6615643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.3014966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1217474826
MESH:D003872 Dermatitis Benzene 4.7315902427
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1817107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.9017451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.9019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.0510663392 11287661 12594235 12705907 14550746 18071297 19164858 17906064 19923254 15968718 12540782 19085960 12392966 10915739 15619225 16081117 10774834 17522070 11529661 11461765 16393943 12958197 18713872 19416960 16485898 16109766 12153990 14725611 19420014 16781746 19370779 11834606 11743745 11421492 11739529 19739265 2444490 16177239 17562736 14986274 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.0519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Cisplatin 8.0719839026 12649298 12231392 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0711462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4218367378
MESH:D004487 Edema Raloxifene 6.7215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.1212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.1215845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.1219031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0919294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0219155303 16202921 20544844 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D004938 Esophageal Neoplasms Cisplatin 2.7717638652 16481741 16785472 15464296 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Dietary Fats 24.2419004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 24.2421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2415345470
MESH:D005234 Fatty Liver Raloxifene 24.2417473493
MESH:D005234 Fatty Liver Tamoxifen 24.2419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005355 Fibrosis Dietary Fats 8.4918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4920067830
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.9215464296 15102660
MESH:D006258 Head and Neck Neoplasms decitabine 7.9219215824
MESH:D034381 Hearing Loss Cisplatin 4.2619898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3815464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3110048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.5011110106
MESH:D006402 Hematologic Diseases Benzene 4.6116183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8515340226 16120746 12621046
MESH:D006689 Hodgkin Disease Cisplatin 3.5616200630 16170182
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5521332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.5721332399
MESH:D006973 Hypertension Benzene 12.3117940673
MESH:D006973 Hypertension Phenylephrine 12.318949925 12717712
MESH:D006973 Hypertension Raloxifene 12.3117577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 12.3118850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.5118502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male decitabine 11.0717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.0717937319
MESH:D007248 Infertility, Male vinclozolin 11.0716467254
MESH:D007249 Inflammation Dietary Fats 11.7620412841
MESH:D007249 Inflammation Diethylnitrosamine 11.7618785209
MESH:D007249 Inflammation Tamoxifen 11.7619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.7612878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.0711836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.1115464296
MESH:D007674 Kidney Diseases Acetaminophen 6.0415629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 6.0412649298 19839026 15190930 18289764 12231392
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0118625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7711231351
MESH:D007889 Leiomyoma Raloxifene 4.4516973256
MESH:D007938 Leukemia Benzene 6.5917119257 14694614 15935818 18335105
MESH:D007938 Leukemia decitabine 6.5919235587 18980019
MESH:D007951 Leukemia, Myeloid Benzene 9.6617506065
MESH:D007951 Leukemia, Myeloid decitabine 9.6617236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.1719478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1718206229 18460780 18704418 17679729 19387464 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4318055864
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7016417039
MESH:D008064 Lipidoses Tamoxifen 3.1217567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 6.5518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.5520032147 19638242 18665156 18407596 18522880
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.2718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2712878042
MESH:D008107 Liver Diseases Acetaminophen 3.8719014921 11587558 12969438 12587719 19460945 16610002 19784758 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2016871587 17185352
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.0919389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.0919638242 20405173 21278145 19551842 18648771 10737359 19499222 20492335 19812893 2862719 19426721 21047994 18977376 16942905 19294768 19642983 19254457 21071580 20452335 21167192 20101389 19090486 20137499 20501860 18644402 19427195 12771043 9163691 18754104 19833225 12112319 19256749 19690152 20118626 15175105 2422723 19255062 18978307 15885732 19073162 20583210 19850985 19996281 20434301
MESH:D008113 Liver Neoplasms Mitomycin 14.0915113037
MESH:D008113 Liver Neoplasms Tamoxifen 14.0916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.0916984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 13.9412562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.9418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.942563599 19539802 16842330 18544905 9362446 16267830 19004024 18079962 18164116 19009564 17942915 18775883 18308698 17854601 3124819 18282651 19519916 21159647 17174075 18253720 19126423 18093689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.9412151625
MESH:D017563 Lung Diseases, Interstitial Benzene 4.7814698565
MESH:D008175 Lung Neoplasms Benzene 6.5512562636
MESH:D008175 Lung Neoplasms Cisplatin 6.5511798837 6189445 17225452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.5521163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 6.5518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5519555203 11884234
MESH:D008223 Lymphoma Benzene 7.7217119257 17584886
MESH:D008223 Lymphoma decitabine 7.7219470736
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.9612562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.9619428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.1511921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.1519196722 14580682 16827153 11731420 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.5219453300
MESH:D008545 Melanoma Cisplatin 5.1512883367 16809738 12374674 17761969 18332650 18505091 18176117 16248763 11135225 16432458 12393984 17023156 15577323
MESH:D008545 Melanoma decitabine 5.1517785578 16505122
MESH:D008545 Melanoma Tamoxifen 5.1512393984 19393235
MESH:D018328 Melanoma, Amelanotic Cisplatin 11.3915990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 11.3915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008654 Mesothelioma Cisplatin 3.2317638057
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5315863610
MESH:D009101 Multiple Myeloma Benzene 12.0717119195
MESH:D009101 Multiple Myeloma decitabine 12.0718172295
MESH:D009101 Multiple Myeloma Raloxifene 12.0716497877
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3618608210 19157545 16882708 19010910
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D009232 Myxoma Raloxifene 5.5316343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.673581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms Cisplatin 5.3116773208
MESH:D009369 Neoplasms decitabine 5.3119116145 19470736 17925555
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719189210 19196722 19200415
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4615464296
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009436 Neural Tube Defects Benzene 3.6415643154
MESH:D009447 Neuroblastoma Cisplatin 3.438761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.0618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.0620387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.668761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D009765 Obesity Dietary Fats 2.2820132043 21332399 11836018 17217161 20518802 18457598 16723640 18674790 19632207
MESH:D009784 Occupational Diseases Benzene 4.1415913788 15576619 15612468 17178637 15727169 17479406 16737584 17119257 15935809
MESH:D010024 Osteoporosis Raloxifene 3.3715775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1917823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms Benzene 8.0012562636
MESH:D010051 Ovarian Neoplasms Cisplatin 8.0017225452 19769630 6897625 15464296
MESH:D010051 Ovarian Neoplasms decitabine 8.0019259094 19331143
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 12.2919003803
MESH:D010190 Pancreatic Neoplasms decitabine 12.2919294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.2916540662
MESH:D010190 Pancreatic Neoplasms Mitomycin 12.2915113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2715464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.3117638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.512563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3711222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.3718220299 19015723 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.6917616702
MESH:D011469 Prostatic Diseases vinclozolin 4.9018220299
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3816220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3815067354
MESH:D011472 Prostatitis vinclozolin 4.9018629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.2816919318 15861022
MESH:D011693 Purpura Raloxifene 5.5315770314
MESH:D051437 Renal Insufficiency Cisplatin 4.3715464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.3619155313
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.3914601052
MESH:D012852 Sinusitis Phenylephrine 4.677327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0216192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.3115464296
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms Benzene 4.7512562636
MESH:D013274 Stomach Neoplasms Cisplatin 4.7518396642 15958060 17522103
MESH:D013274 Stomach Neoplasms decitabine 4.7519037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.7518456281
MESH:D020521 Stroke Raloxifene 3.7816837676
MESH:D013736 Testicular Neoplasms Cisplatin 4.5915464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013953 Thymus Neoplasms Benzene 4.9210850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms decitabine 7.1717967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.177505956
MESH:D013978 Tibial Fractures Raloxifene 5.1819048282
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 11.8512973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.8519087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.8517572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.8516712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.1716803524
MESH:D014594 Uterine Neoplasms Benzene 9.4312562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.4314692618
MESH:D014604 Uveal Neoplasms decitabine 4.8817785578
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5715577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.1816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D014839 Vomiting Cisplatin 4.6911897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D015430 Weight Gain Dietary Fats 3.7016723640
Pathway ID Pathway Name
KEGG:04350 TGF-beta signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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