AutismKB 2.0

Annotation Detail for BEX5


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Basic Information Top
Gene Symbol:BEX5 ( MGC104434,MGC126446,NGFRAP1L1 )
Gene Full Name: brain expressed, X-linked 5
Band: Xq22.1
Quick LinksEntrez ID:340542; OMIM: 300693; Uniprot ID:BEX5_HUMAN; ENSEMBL ID: ENSG00000184515; HGNC ID: 27990
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of BEX5 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of BEX5 mRNAincreases expression 20106945
D014635 Valproic Acid Valproic Acid results in increased expression of BEX5 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.238875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.4119490988
MESH:D000550 Amblyopia Valproic Acid 6.1017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.9417497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9819460635 18316065 17688650 15238991 18177632 17507914 19232924 20603192 18396377 18985861 16609825 18940202 18775368 18558336 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.2617594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.668888407
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9912619106 12907637 21507988
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.8212371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8320734317
MESH:D002779 Cholestasis Cyclosporine 3.2419486331
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.918888407 17688650 16575769
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2619641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.581851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.8117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.783922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.1220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 4.006254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.957750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.813659116
MESH:D005234 Fatty Liver Cyclosporine 9.4119224547
MESH:D005234 Fatty Liver Valproic Acid 9.4119224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.7516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.718888407 18558336
MESH:D005355 Fibrosis Cyclosporine 3.7912168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.968708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.1615720958
MESH:D006849 Hydrocephalus Valproic Acid 5.6117688650
MESH:D006973 Hypertension Cyclosporine 2.2310903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.1212371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.2017596541 16294345
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.4715890375 2125692 9163691 18177683
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.998603461
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 5.1317228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8814755239
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.6516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.5018765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.518888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3717596541
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7019348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.3916359493 8888407
MESH:D011230 Precancerous Conditions Cyclosporine 3.6412371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.5720603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.4112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.3416882103
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.7019155313
MESH:D012559 Schizophrenia Valproic Acid 2.1115737665 19110320
MESH:D012640 Seizures Valproic Acid 3.0211738929 1511512 16876388 15475178 11044598 17978042 14763951 3137016
MESH:D016135 Spinal Dysraphism Valproic Acid 4.1319490988
MESH:D013226 Status Epilepticus Valproic Acid 5.4112833885
MESH:D014178 Translocation, Genetic Valproic Acid 6.1017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.263119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.308888407
MESH:D014605 Uveitis Cyclosporine 4.851336536
MESH:D014985 Xerophthalmia Cyclosporine 5.3117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018