AutismKB 2.0

Annotation Detail for FREM2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FREM2 ( DKFZp686J0811,DKFZp781I048,KIAA1074 )
Gene Full Name: FRAS1 related extracellular matrix protein 2
Band: 13q13.3
Quick LinksEntrez ID:341640; OMIM: 608945; Uniprot ID:FREM2_HUMAN; ENSEMBL ID: ENSG00000150893; HGNC ID: 25396
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FREM2 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of FREM2 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of FREM2 mRNAdecreases expression 20106945
D009151 Mustard Gas Mustard Gas affects the expression of FREM2 mRNAaffects expression 15651846
D010615 Phenacetin Phenacetin results in decreased expression of FREM2 mRNAdecreases expression 17082564
C030299 phenylhydrazine phenylhydrazine results in decreased expression of FREM2 mRNAdecreases expression 17082564
D014635 Valproic Acid Valproic Acid results in increased expression of FREM2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000740 Anemia Phenacetin 10.792444515
MESH:D000740 Anemia phenylhydrazine 10.792444515
MESH:D000743 Anemia, Hemolytic Phenacetin 12.011949026 17082564 17698508
MESH:D000743 Anemia, Hemolytic phenylhydrazine 12.0117084956 17698508 17082564
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001249 Asthma Mustard Gas 2.7810378619
MESH:D001321 Autistic Disorder Valproic Acid 1.9918985861 19232924 17507914 18940202 20603192 19460635 18316065 17157402 18558336 18177632 17688650 18396377 16609825 15238991 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.2017594078 20046352
MESH:D001768 Blister Mustard Gas 5.5619167455
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D001943 Breast Neoplasms Estradiol 2.1217289903 17018787 18497071 16675129 14630087 17261762 12948864 19861407
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.4217687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1412619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1416924424
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1918566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2319641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004487 Edema Mustard Gas 3.5911402378 9260866 11428647 11428631
MESH:D016889 Endometrial Neoplasms Estradiol 3.1511473722 18566989 19148513
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.363922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.847562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D004890 Erythema Mustard Gas 5.569357497
MESH:D005234 Fatty Liver Cyclosporine 8.7119224547
MESH:D005234 Fatty Liver Valproic Acid 8.7119224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4618558336 8888407
MESH:D005355 Fibrosis Cyclosporine 3.5012168785 12639820
MESH:D058497 Fraser Syndrome marker/mechanism 17163535
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007249 Inflammation Mustard Gas 2.9111428647 17524151 9357497 11428620 16001271 9260866 11402378 8975870 11428631
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.428314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.4215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D007680 Kidney Neoplasms Estradiol 8.0615610895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.439163691 15890375 2125692 18177683
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.908603461
MESH:D008171 Lung Diseases Mustard Gas 3.6218161513 18702808
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.7014755239
MESH:D008175 Lung Neoplasms Mustard Gas 2.703148597 8781369
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7211807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D008708 Methemoglobinemia Phenacetin 5.254834387 1949026 16296465 3537620
MESH:D008881 Migraine Disorders Valproic Acid 3.3818765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 3.9816427766 11399458
MESH:D009436 Neural Tube Defects Valproic Acid 3.308888407 16359493
MESH:D009503 Neutropenia Mustard Gas 4.2716761898 7688884
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D011041 Poisoning Mustard Gas 4.1015727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011537 Pruritus Mustard Gas 4.4918058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.9811422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0110334151 17720292 17266442 17620002 17894541
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9111044598 11738929 3137016 15475178 1511512 17978042 14763951 16876388
MESH:D012871 Skin Diseases Mustard Gas 2.7712880345 15451306 16961503
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013436 Sulfhemoglobinemia Phenacetin 7.00978859
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 3.9011144890
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved