AutismKB 2.0

Annotation Detail for IDH3B


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Basic Information Top
Gene Symbol:IDH3B ( FLJ11043,H-IDHB,MGC903,RP46 )
Gene Full Name: isocitrate dehydrogenase 3 (NAD+) beta
Band: 20p13
Quick LinksEntrez ID:3420; OMIM: 604526; Uniprot ID:IDH3B_HUMAN; ENSEMBL ID: ENSG00000101365; HGNC ID: 5385
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5690TCA cycle variation III (eukaryotic)
Pathway IDPathway Name
hsa00020Citrate cycle (TCA cycle)
hsa01100Metabolic pathways
Pathway IDPathway Name
Pyruvate metabolism and Citric Acid (TCA) cycle
No data
No data
Pathway IDPathway Name
500713Citric acid cycle (TCA cycle)
Related Diseases/Disorders Top
No data
No data
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Desease Name
Retinitis pigmentosa-46
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of IDH3B mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of IDH3B mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IDH3B mRNAaffects expression 16483693
D004041 Dietary Fats Dietary Fats results in decreased expression of IDH3B mRNAdecreases expression 18042831
D005419 Flavonoids Flavonoids results in decreased expression of IDH3B mRNAdecreases expression 18035473
C041786 palm oil palm oil results in decreased expression of IDH3B mRNAdecreases expression 18042831
D012643 Selenium Selenium results in increased expression of IDH3B mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of IDH3B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001943 Breast Neoplasms Dietary Fats 2.2620435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.917296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.917505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3219486331 9022650
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1012868966 11906362 8156756 2524372 18759878 8970840 11298694 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.5511289319 16192314 18648102 7440962 6482804 6679447 9328219 18289764 9022650 18692083 9653073 1440618 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5516393943 16109766 17562736 18071297 15619225 11421492 14550746 16081117 10663392 11834606 11739529 19739265 10774834 16227642 19370779 11287661 19164858 12705907 2444490 10915739 12594235 16177239 12392966 19085960 12540782 15968718 19420014 12958197 16485898 17906064 11529661 14986274 18713872 11461765 11743745 16781746 12153990 19416960 19923254 14725611 17522070
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5515131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Dietary Fats 3.4819551842 19004024 17967931 18296743
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Dietary Fats 3.8318296743
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1016080930
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007249 Inflammation Dietary Fats 5.5820412841
MESH:D007249 Inflammation Flavonoids 5.5817296493
MESH:D007251 Influenza, Human Selenium 12.2516624496
MESH:D007251 Influenza, Human Vitamin E 12.2516624496
MESH:D007333 Insulin Resistance Dietary Fats 3.2518457598 11836018
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 6.3915629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.3912488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.176582329
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 12587719 19014921 11587558 12969438 16611625 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.67598648 3712494 1399818 6587162
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity Dietary Fats 2.3311836018 17217161 20132043 21332399 20518802 16723640 19632207 18457598 18674790
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012174 Retinitis Pigmentosa marker/mechanism 18806796
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.066582329 6587162 1399818 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.358074119
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
Pathway ID Pathway Name
KEGG:00020 Citrate cycle (TCA cycle)
KEGG:01100 Metabolic pathways
REACT:1046 Pyruvate metabolism and Citric Acid (TCA) cycle
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
No data
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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