AutismKB 2.0

Annotation Detail for FMN1


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Basic Information Top
Gene Symbol:FMN1 ( DKFZp686C2281,DKFZp686G2387,FLJ45135,FMN,LD,MGC125288,MGC125289 )
Gene Full Name: formin 1
Band: 15q13.3
Quick LinksEntrez ID:342184; OMIM: 136535; Uniprot ID:C9IYD7_HUMAN; ENSEMBL ID: ENSG00000186031; HGNC ID: 3768
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
nonsyndromic cleft lip with or without cleft palate
DEVELOPMENTAL
Desease Name
Nonsyndromic cleft lip with or without cleft palate
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of FMN1 mRNAincreases expression 20406850
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FMN1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FMN1 mRNAdecreases expression 20382639
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FMN1 mRNAaffects cotreatment|decreases expression 17942748
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of FMN1 mRNAincreases expression 12057914
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of FMN1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of FMN1 mRNAdecreases expression 19482888
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FMN1 mRNAaffects cotreatment|decreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.656195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6515322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.3318653653 11850527
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3720464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3714692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.4417620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1216705839
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1217173139 1701930 20935162 20007298 6705139
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.266135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717333356 16919318 15861022 17681005 17110522 11677210 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015668235 15340226 12621046 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.7915821434 17637181 15328337
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005334 Fever Lipopolysaccharides 4.289205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8810048152 11294989
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6516366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Phenobarbital 9.6616109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.6616120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 16959395 18606429 16354765 8697196
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Lipopolysaccharides 5.5112878042 9205823 17237260 17963957 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5112200463 12878042
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.9317255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2116705839
MESH:D007970 Leukopenia Lipopolysaccharides 5.0915821434
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.5412878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5412878042
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.437678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4320195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 11.4319812893 8742319 19073162 19482888 15975961 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.752876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.7518308698 17172636 1399818 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7512151625
MESH:D055370 Lung Injury Lipopolysaccharides 4.3621114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2518816296 20464547 18569708 20869020 17053015 20064080 18520028 20135361 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2519555203 11884234
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.9512224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9010835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5318551238
MESH:D012640 Seizures Phenobarbital 6.533137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.4315821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2817053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28184
    • No data
    Releated disease ID Related disease Name
    PA446108Colorectal Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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