AutismKB 2.0

Annotation Detail for CCDC18


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Basic Information Top
Gene Symbol:CCDC18 ( NY-SAR-41,dJ717I23.1 )
Gene Full Name: coiled-coil domain containing 18
Band: 1p22.1
Quick LinksEntrez ID:343099; OMIM: NA; Uniprot ID:CCD18_HUMAN; ENSEMBL ID: ENSG00000122483; HGNC ID: 30370
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of CCDC18 mRNAincreases expression 20406850
D016572 Cyclosporine Cyclosporine results in increased expression of CCDC18 mRNAincreases expression 20106945
C014347 decitabine decitabine results in decreased expression of CCDC18 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of CCDC18 mRNA]affects reaction|decreases expression 19363521
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CCDC18 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4715322242 14514962 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms decitabine 2.0619208741 18320071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7916705839
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6819215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.466135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002779 Cholestasis Cyclosporine 3.2119486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2415340226 8697196 16354765 15668235 12621046
MESH:D003110 Colonic Neoplasms decitabine 2.3817616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1118981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 15322242 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5818551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 15322242 16714409
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.8419294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Cyclosporine 3.2819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Cyclosporine 10.4212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.4220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.7419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716354765 18606429 8697196 15340226 16959395
MESH:D006973 Hypertension Cyclosporine 5.3510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3518670907 18850075
MESH:D007248 Infertility, Male decitabine 3.4517581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.548314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.4416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4412371664
MESH:D007938 Leukemia decitabine 3.2419235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.4317236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4318460780 18206229 19387464 18704418 19010910 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 6.1918055864
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.787678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.502876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5012151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008223 Lymphoma decitabine 3.6919470736
MESH:D008545 Melanoma decitabine 2.2816505122 17785578
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009101 Multiple Myeloma decitabine 3.6218172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5819010910 19157545 18608210 16882708
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.497678174 18551238
MESH:D009369 Neoplasms decitabine 2.8719470736 17925555 19116145
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.8316049721
MESH:D010051 Ovarian Neoplasms decitabine 2.7419259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 2.8719294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211896295 11399792 11222880 11118676
MESH:D055728 Primary Myelofibrosis decitabine 5.2917616702
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.8719155313
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D013964 Thyroid Neoplasms decitabine 3.6317967635
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.5916049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.5919087683 17616700
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.9510091137
MESH:D014604 Uveal Neoplasms decitabine 5.6417785578
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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