AutismKB 2.0

Annotation Detail for SP110


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Basic Information Top
Gene Symbol:SP110 ( FLJ22835,IFI41,IFI75,IPR1,VODI )
Gene Full Name: SP110 nuclear body protein
Band: 2q37.1
Quick LinksEntrez ID:3431; OMIM: 604457; Uniprot ID:SP110_HUMAN; ENSEMBL ID: ENSG00000135899; HGNC ID: 5401
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1767Immunologic deficiency syndrome
2052Infection
1805Mycobacterium infection, Atypical
Desease Name
CANCER
Chronic lymphocytic leukemia
No data
Desease Name
Mycobacterium tuberculosis, susceptibility to
Hepatic venoocclusive disease with immunodeficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SP110 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SP110 mRNAdecreases expression 20064835
D002945 Cisplatin SP110 protein results in decreased susceptibility to Cisplatindecreases response to substance 16734730
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SP110 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of SP110 mRNAincreases expression 19619570
C004648 testosterone enanthate testosterone enanthate affects the expression of SP110 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SP110 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SP110 mRNAincreases expression 19619570
C025643 vinclozolin vinclozolin affects the expression of SP110 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 11752688 15322242
MESH:D058186 Acute Kidney Injury Cisplatin 4.2412690470 17670903 15814532
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.4720464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 7.4717638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 7.4711473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.3314601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9820146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 1.9818382427 19526202
MESH:D001943 Breast Neoplasms Estradiol 1.9816675129 18497071 12948864 19861407 17289903 14630087 17261762 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8516705839
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.8517982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1116685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.986189445 17066447 18337622
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 8697196 15668235 15340226 16354765
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Cisplatin 8.8612649298 12231392 15033597 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.1511473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.8016530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.8015173087 16481741 15464296 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8915464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.5519898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.6515464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8810048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:C537257 Hepatic venoocclusive disease with immunodeficiency marker/mechanism
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1917440010
MESH:D006689 Hodgkin Disease Cisplatin 3.8416170182 16200630
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916354765 8697196 16959395 15340226 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007248 Infertility, Male vinclozolin 3.2116467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.5815464296
MESH:D007674 Kidney Diseases Cisplatin 6.7518289764 12231392 15190930 19839026 12649298
MESH:D007674 Kidney Diseases Estradiol 6.7515618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms Estradiol 8.1515610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.2411231351
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6221137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5618520028 6695378 20869020 18816296 17053015 20135361 20064080 18569708 20464547
MESH:D008175 Lung Neoplasms Cisplatin 3.5611798837 6189445 17225452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5611884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7211807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008545 Melanoma Cisplatin 2.5017023156 18176117 18332650 16432458 12374674 16248763 11135225 15577323 12883367 18505091 16809738 17761969 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.1715990972
MESH:D008654 Mesothelioma Cisplatin 3.3417638057
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5911141357
MESH:D009369 Neoplasms Cisplatin 5.5916773208
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.9315464296
MESH:D009421 Nervous System Malformations Estradiol 10.5816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5814600291
MESH:D009447 Neuroblastoma Cisplatin 3.578761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.098761367
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6912819281 16049721
MESH:D010051 Ovarian Neoplasms Cisplatin 5.2415464296 19769630 6897625 17225452
MESH:D010051 Ovarian Neoplasms Estradiol 5.2419401270
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0719003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.6415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.7917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.8411118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.8418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0517292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D051437 Renal Insufficiency Cisplatin 4.7715464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.7614601052
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.7915464296
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.592093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 2.5918396642 17522103 15958060
MESH:D013736 Testicular Neoplasms Cisplatin 4.9317225452 15464296
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014376 Tuberculosis marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.9016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.9017053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.9012973940 15464296 17225452
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.4716803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.9715577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D014839 Vomiting Cisplatin 5.1611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35104
    • No data
    Releated disease ID Related disease Name
    PA444750Leukemia
    PA446169Leukemia, Lymphocytic, Chronic, B-Cell
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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