AutismKB 2.0

Annotation Detail for IFIT1


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Basic Information Top
Gene Symbol:IFIT1 ( C56,G10P1,GARG-16,IFI-56,IFI-56K,IFI56,IFIT-1,IFNAI1,ISG56,RNM561 )
Gene Full Name: interferon-induced protein with tetratricopeptide repeats 1
Band: 10q23.31
Quick LinksEntrez ID:3434; OMIM: 147690; Uniprot ID:IFIT1_HUMAN; ENSEMBL ID: ENSG00000185745; HGNC ID: 5407
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026114 2-xylene 2-xylene results in increased expression of IFIT1 mRNAincreases expression 20359517
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of IFIT1 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IFIT1 mRNAaffects expression 16483693
D001554 Benzene Benzene results in increased expression of IFIT1 mRNAincreases expression 20359517
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IFIT1 mRNAincreases expression 19152381
D001564 Benzo(a)pyrene chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFIT1 mRNA]decreases reaction|increases expression 19152381
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IFIT1 mRNAdecreases expression 20713471
C053541 bicalutamide bicalutamide results in decreased expression of IFIT1 mRNAdecreases expression 15638997
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of IFIT1 mRNAdecreases expression 15336504
D020122 tert-Butylhydroperoxide IFIT1 protein results in decreased susceptibility to tert-Butylhydroperoxidedecreases response to substance 15003993
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of IFIT1 mRNAincreases expression 14729362
15003993
15336504
C007020 chlorophyllin chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFIT1 mRNA]decreases reaction|increases expression 19152381
D016572 Cyclosporine Cyclosporine results in decreased expression of IFIT1 mRNAdecreases expression 20106945
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IFIT1 mRNAaffects cotreatment|increases expression 16054899
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of IFIT1 mRNAincreases expression 15289156
D002117 Calcitriol Calcitriol results in decreased expression of IFIT1 mRNAdecreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IFIT1 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of IFIT1 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of IFIT1 mRNAincreases expression 19619570
D004958 Estradiol Estradiol affects the expression of IFIT1 mRNAaffects expression 15598610
D004958 Estradiol Estradiol results in increased expression of IFIT1 mRNAincreases expression 15289156
C004912 ethylbenzene ethylbenzene results in increased expression of IFIT1 mRNAincreases expression 20359517
D005472 Fluorouracil Fluorouracil results in increased expression of IFIT1 mRNAincreases expression 17039268
C056507 gemcitabine gemcitabine results in increased expression of IFIT1 mRNAincreases expression 17039268
D019833 Genistein Genistein results in increased expression of IFIT1 mRNAincreases expression 15289156
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IFIT1 mRNAaffects cotreatment|increases expression 16054899
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of IFIT1 mRNAincreases expression 15860229
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of IFIT1 mRNAdecreases expression 20713471
D008752 Methylene Chloride Methylene Chloride results in increased expression of IFIT1 mRNAincreases expression 20359517
D010126 Ozone Ozone results in decreased expression of IFIT1 mRNAdecreases expression 16183385
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IFIT1 mRNAaffects binding|increases activity|increases expression 19710929
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IFIT1 mRNAaffects cotreatment|increases expression 16054899
C017947 sodium arsenite sodium arsenite results in decreased expression of IFIT1 mRNAdecreases expression 12727804
D013629 Tamoxifen Tamoxifen results in increased expression of IFIT1 mRNAincreases expression 19155303
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IFIT1 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IFIT1 mRNAdecreases expression 12377990
19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IFIT1 mRNAincreases expression 16704738
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IFIT1 mRNAincreases expression 15644576
D014050 Toluene Toluene results in increased expression of IFIT1 mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of IFIT1 mRNAincreases expression 20359517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of IFIT1 mRNAincreases expression 17982090
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT1 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.549612607
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.1411850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.1418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.5220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.5211473722
MESH:D000230 Adenocarcinoma Fluorouracil 9.5217638652
MESH:D000230 Adenocarcinoma Genistein 9.5211473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.223712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.226695378
MESH:D000236 Adenoma Methylcholanthrene 10.226695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6016712894 17306315
MESH:D000544 Alzheimer Disease Ozone 4.2515513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.2519621015
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2015469931
MESH:D000740 Anemia Fluorouracil 7.8315504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.8311748828
MESH:D000741 Anemia, Aplastic Benzene 4.1517661222 14761424 11369114
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7819183758
MESH:D001169 Arthritis, Experimental Dexamethasone 3.3617659584
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4915570426
MESH:D001249 Asthma Ozone 2.5517854713 16373670
MESH:D050197 Atherosclerosis Methylcholanthrene 3.2811922910
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7211289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.8919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8912125929
MESH:D001836 Body Weight Changes 2-xylene 11.107457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.1015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001855 Bone Marrow Diseases Benzene 4.9316183116
MESH:D001943 Breast Neoplasms Benzene 10.7217162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 10.7220146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 10.7211237771
MESH:D001943 Breast Neoplasms Diethylstilbestrol 10.7217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 10.7212948864 16675129 17289903 17018787 19861407 17261762 14630087 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 10.7219217205 16595493 15136595 16557594 18608205 16110121 18357371
MESH:D001943 Breast Neoplasms gemcitabine 10.7217039268 18382427
MESH:D001943 Breast Neoplasms Genistein 10.7216873071 16541309 17200150
MESH:D001943 Breast Neoplasms Methylcholanthrene 10.7217474063
MESH:D001943 Breast Neoplasms Methylene Chloride 10.7215986119
MESH:D001943 Breast Neoplasms Tamoxifen 10.7218425577 19189210 19103187 16202921 20005174 19115204 17242785 19221464 18984771 17893378 19059307 19011961 21138602 20544844 16273361 15668708 19200415 19189212 20859285 19155303 19410462 19084267 21152245 18629630 17440819 11161223 20065188 18815881 19289846 18351453 18997820 19142967 18821012 18855134 19244106 15565566 16818667 20135344 16873071 17049068 19066611 19288272 17261762 20390343 19487384
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.7220435547
MESH:D001943 Breast Neoplasms Trichloroethylene 10.7215986119
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4514754758 18417511 16777450 15516495 19059883 18315731 17626835
MESH:D002100 Cachexia Ozone 4.4416183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3716051944
MESH:D002277 Carcinoma Fluorouracil 12.6517121937
MESH:D002277 Carcinoma Methylcholanthrene 12.6510545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2219066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.283581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.2815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.2816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.2817088986 17045692 17971768 16332177 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.2816924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.2815276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.2816924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.037296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.0318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.0520419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.0511237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.0516757204 16280240 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.0518572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.1016332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 18.967505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.9612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.9618566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 18.9616192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 18.9619524636 20056578
MESH:D002547 Cerebral Palsy Toluene 5.559294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.1319486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.1319486331
MESH:D002779 Cholestasis pirinixic acid 12.1319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9815668235 15340226 12621046 8697196 16354765
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.2616804969 17991707 18200517 17936198 16474422 16867261 11698051 18023891 16782535
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3417276891
MESH:D003110 Colonic Neoplasms Dexamethasone 5.5515824018
MESH:D003110 Colonic Neoplasms Fluorouracil 5.5517169374 16510598 18772588 15001691 16340194 17725105 17016597 17172411 17018589 17287894
MESH:D003110 Colonic Neoplasms Genistein 5.5517182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 1.9920501625 17594712 18802399 14970324 16303861 16391804 16282729 18949393 18383874 18288408 15148649 15289873 16524972 17094418 16331619 18448328 17695437 17255274 17454858 17016601 17401013 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8114669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 5.2015643154
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.2017728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Toluene 5.209294310
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2816002989 12952375
MESH:D007644 Darier Disease Fluorouracil 4.5016733453
MESH:D003643 Death Toluene 5.376431079
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0719031437
MESH:D003872 Dermatitis Benzene 4.4815902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.108156756 2524372 18759878 8970840 12868966 11298694 11906362 14531868
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.1012438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.223621924 2952479
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0517446233
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7516647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 6.7512642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7517107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.0219279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.0219279558
MESH:D003967 Diarrhea Dexamethasone 3.427237001
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 5.807440962 18692083 18648102 18289764 1440618 6482804 16192314 9022650 9328219 9653073 8291058 6679447 11289319
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8020420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 5.807120509
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5211462148
MESH:D004362 Drug Toxicity Zidovudine 7.5215040536
MESH:D004485 Eczema Dexamethasone 4.1812438553
MESH:D004487 Edema Dexamethasone 14.3119703484
MESH:D004487 Edema pirinixic acid 14.3112083418
MESH:D004487 Edema rosiglitazone 14.3112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.3112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.2915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.2919031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.9116402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.9116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.2215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 16.2219148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 16.2211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.2216202921 17893378 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.779294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1017637181 15328337 15821434
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.763581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.7616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.7615173087 17638652 16337965 16481741 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005234 Fatty Liver Cyclosporine 21.8719224547
MESH:D005234 Fatty Liver pirinixic acid 21.8719236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 21.8719196556
MESH:D005234 Fatty Liver Tamoxifen 21.8719224547 14986274
MESH:D005234 Fatty Liver Zidovudine 21.8718299183
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.6216002989 16513791 16534752 16611131 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.6216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005334 Fever Lipopolysaccharides 3.769205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.726705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8919069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6414633661 10962813
MESH:D005355 Fibrosis Cyclosporine 13.1612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.1620067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 13.1617994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.8316452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.8316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D005909 Glioblastoma Genistein 3.0716598420
MESH:D005910 Glioma Fluorouracil 2.7516145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.767505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1918337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006402 Hematologic Diseases Benzene 10.1716183116
MESH:D006402 Hematologic Diseases Zidovudine 10.1712579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.236705139
MESH:D006529 Hepatomegaly 2-xylene 12.927457013 7457028
MESH:D006529 Hepatomegaly pirinixic acid 12.9216221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.9216120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.977520565
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D015658 HIV Infections Zidovudine 3.3420032539 17358032 11698656 11363243 11141242
MESH:D006689 Hodgkin Disease sodium arsenite 2.9112676792
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7515340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia rosiglitazone 3.6912083418
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.8715034207
MESH:D006965 Hyperplasia Diethylstilbestrol 9.8712960047 14722030
MESH:D006973 Hypertension Benzene 11.4417940673
MESH:D006973 Hypertension Cyclosporine 11.4410903974
MESH:D006973 Hypertension Dexamethasone 11.4417042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.4418850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 4.2916002989
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.1418306037
MESH:D007246 Infertility Diethylstilbestrol 4.0715036965
MESH:D007248 Infertility, Male sodium arsenite 2.8015346721 12646999
MESH:D007249 Inflammation Dexamethasone 14.238960868 11099482
MESH:D007249 Inflammation Lipopolysaccharides 14.2317255318 17237260 17963957 12878042 9205823
MESH:D007249 Inflammation rosiglitazone 14.2312083418
MESH:D007249 Inflammation Tamoxifen 14.2319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.2312878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.4618200517
MESH:D007333 Insulin Resistance Estradiol 11.2716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.2716306350
MESH:D007333 Insulin Resistance rosiglitazone 11.2716306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.3217994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3617255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.729022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0716580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.1418306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Cyclosporine 9.0718776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.0715618244
MESH:D007674 Kidney Diseases sodium arsenite 9.0720008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 31.406582329
MESH:D007680 Kidney Neoplasms Cyclosporine 31.4012371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 31.4015003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 31.4015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 31.4016985049
MESH:D007680 Kidney Neoplasms Tamoxifen 31.4018625569
MESH:D007680 Kidney Neoplasms Zidovudine 31.4012579204
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7717184923
MESH:D007938 Leukemia Benzene 6.1517119257 14694614 15935818 18335105
MESH:D007938 Leukemia Genistein 6.1517468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.1520370541
MESH:D007951 Leukemia, Myeloid Benzene 4.0617506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6519478238
MESH:D007970 Leukopenia Lipopolysaccharides 4.4015821434
MESH:D008064 Lipidoses Tamoxifen 2.9517567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 12.5416718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 12.5414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 12.5417823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 12.5412878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 12.5415474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 12.5417347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 12.5418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 12.5412878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.1221137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.1215890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 20.1216603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 20.1220007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 20.1216712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 20.1216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.1216984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 16.73598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Benzene 16.7312562636
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 16.73598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.7312151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 16.737955063
MESH:D008171 Lung Diseases Ozone 6.868266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 6.8619095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.5114698565
MESH:D055370 Lung Injury Lipopolysaccharides 8.2821114838
MESH:D055370 Lung Injury Ozone 8.2820417186
MESH:D008175 Lung Neoplasms Benzene 19.6412562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 19.6417053015 18569708 20869020 20464547 20135361 18816296 6695378 20064080 18520028
MESH:D008175 Lung Neoplasms Dexamethasone 19.6411195469 15824018
MESH:D008175 Lung Neoplasms Fluorouracil 19.6415246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 19.6417909032 10545420 6695378 11893704 21163286 16271038 20512841 9230183 20970405 15390079 16337739 7750092 1399818
MESH:D008175 Lung Neoplasms Methylene Chloride 19.6415172992
MESH:D008175 Lung Neoplasms Ozone 19.648597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 19.6417306315 15276417 16712894 19931552 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 19.6418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 19.6411884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 19.6418800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5015086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8515166399
MESH:D008223 Lymphoma Benzene 7.1517584886 17119257
MESH:D008223 Lymphoma Diethylstilbestrol 7.1515700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2216002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.0912562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.0919428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 16.8311921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.8311807958 17203775 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 16.8314578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 16.8316827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.8316827153 11731420 19196722 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.6519453300
MESH:D008545 Melanoma sodium arsenite 3.1416487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.1412393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8915990972
MESH:D008607 Mental Retardation Toluene 3.559294310
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1417261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D008679 Metaplasia Ozone 4.8110496685
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.5417358032
MESH:D019957 Motor Skills Disorders Toluene 4.969294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.7916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.7916757204 18986760
MESH:D009101 Multiple Myeloma Benzene 6.9517119195
MESH:D009101 Multiple Myeloma Dexamethasone 6.9515867202 15744524 16118317
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.379809623
MESH:D009203 Myocardial Infarction Genistein 5.2617141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.2619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.8816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.8817141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.8816411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.293581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.2919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 17.8811141357
MESH:D009369 Neoplasms Diethylstilbestrol 17.8815313581
MESH:D009369 Neoplasms Fluorouracil 17.8816928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 17.8817405874
MESH:D009369 Neoplasms sodium arsenite 17.8811559025
MESH:D009369 Neoplasms Trichloroethylene 17.8811911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7019200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0419348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.1411399458
MESH:D009421 Nervous System Malformations Estradiol 21.1416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 21.1416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.1414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.106679447
MESH:D009436 Neural Tube Defects Benzene 11.1015643154
MESH:D009436 Neural Tube Defects sodium arsenite 11.1012854658
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2416436463
MESH:D009765 Obesity pirinixic acid 1.7420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.314026338 6482804
MESH:D009784 Occupational Diseases Benzene 8.3115935809 17479406 16737584 15576619 15913788 17119257 15727169 17178637 15612468
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.723988306
MESH:D010024 Osteoporosis Genistein 3.0719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8116169203
MESH:D010051 Ovarian Neoplasms Benzene 10.5212562636
MESH:D010051 Ovarian Neoplasms Estradiol 10.5219401270
MESH:D010051 Ovarian Neoplasms Genistein 10.5219005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.5217306315 15276417
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3716929163 15113037 19003803 16500647
MESH:D010190 Pancreatic Neoplasms gemcitabine 5.3717440100 18383843 11504793 18992248 16929163
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.9317698068
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.207296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D010538 Peritonitis Ozone 3.8416369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.176228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3815687265 16977796
MESH:D011014 Pneumonia Lipopolysaccharides 10.1212224865 11605937
MESH:D011014 Pneumonia Ozone 10.1218007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9812371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3821297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.5817184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5811222880 11399792 11896295 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4815572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8517292933
MESH:D011471 Prostatic Neoplasms bicalutamide 2.8515638997 19240160 19011039 17914592 18487222
MESH:D011471 Prostatic Neoplasms Calcitriol 2.8512479363 16289102 15754350 16644109 18247401
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.8517136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.8516740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.8518626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.8515256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.8516039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.8515067354
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7616160472 15538739 18286688 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7518379247 11700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5410835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.163692021
MESH:D012640 Seizures Toluene 3.536431079 9294310
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.3910029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 12.3919524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.398532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.3916192470
MESH:D013088 Spermatocele Diethylstilbestrol 10.8416002989 16709447
MESH:D013088 Spermatocele Tamoxifen 10.8416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5712854658
MESH:D013272 Stomach Diseases Dexamethasone 4.0315472012
MESH:D013274 Stomach Neoplasms Benzene 4.5112562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5120155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5118396642 19084572 16424979 18567086 17522103 17498489 19015929 16951190 15786421 17172411
MESH:D013274 Stomach Neoplasms Zidovudine 4.5117696246
MESH:D013276 Stomach Ulcer Dexamethasone 3.2315138204
MESH:D013733 Testicular Diseases Toluene 4.6610048760 10514026
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9115821434
MESH:D013953 Thymus Neoplasms Benzene 4.6610850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.673712494 6582329 7505956 1399818 6587162
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7316280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.538074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.5317053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 14.5316452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.5317306315 16452187 16712894 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.5316712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.4316175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.4316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.4311813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8714652134
MESH:D014594 Uterine Neoplasms Benzene 8.9212562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.9215809267 16690809
MESH:D014605 Uveitis Cyclosporine 10.771336536
MESH:D014605 Uveitis Dexamethasone 10.771336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 10.1716002989 16513791
MESH:D014625 Vaginal Neoplasms Zidovudine 10.1712579204
MESH:D014652 Vascular Diseases sodium arsenite 4.1317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
Pathway ID Pathway Name
KEGG:05160 Hepatitis C
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29648
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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