AutismKB 2.0

Annotation Detail for KCNT2


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Basic Information Top
Gene Symbol:KCNT2 ( KCa4.2,MGC119610,MGC119611,MGC119612,MGC119613,SLICK,SLO2.1 )
Gene Full Name: potassium channel, subfamily T, member 2
Band: 1q31.3
Quick LinksEntrez ID:343450; OMIM: 610044; Uniprot ID:KCNT2_HUMAN; ENSEMBL ID: ENSG00000162687; HGNC ID: 18866
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C447119 bazedoxifene acetate bazedoxifene acetate results in increased expression of KCNT2 mRNAincreases expression 19914376
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of KCNT2 mRNAaffects cotreatment|decreases expression 18164116
D016572 Cyclosporine Cyclosporine results in increased expression of KCNT2 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of KCNT2 mRNAaffects cotreatment|decreases expression 18164116
D002117 Calcitriol Calcitriol results in increased expression of KCNT2 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of KCNT2 mRNAincreases expression 17557909
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.4419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.4410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3616434500 17620307 18056438 19052882 17162532 19061943
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001943 Breast Neoplasms Calcitriol 2.2711237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2717474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8719208518 3581430 3084413 20084675 20727157 18665156 17978847 21159647 16288022 16779866 16878318 11831363 20514400 18971187 16328049 19822196 20214788 10737359 19052882 19519916 17761372 19394651 18978308 20512989 18210153 20935162 18788625 19418558 16569478 20007298 16935385 17428255 17138121 20432363 10672840 18785209 16502159 19335982 17173139 18691550 19701751 16681979 17055752 16807293 18506893 20524982 19539802 18056438 19919837 16698587 19171122 17162532 18393292 19107877 16830150 16540662 20101231 19383236 18494052
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6911237771
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.3117174075 7505956 2727394 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D002779 Cholestasis Cyclosporine 8.5519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5517681005 16919318 17110522 15861022 16105132 17333356 11677210
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1219107877
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 10.3915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.3912538720
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D005234 Fatty Liver Cyclosporine 15.0219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 15.0221071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.0215345470
MESH:D005355 Fibrosis Cyclosporine 3.5612168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Diethylnitrosamine 2.5218785209
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9820032147 18522880 18407596 18665156 19638242
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 5.1019389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.1018977376 10737359 18644402 19833225 18648771 19073162 15175105 19090486 18754104 2862719 19690152 19850985 19812893 21047994 19426721 20434301 20137499 19256749 21167192 20492335 20452335 19551842 19638242 20501860 20101389 18978307 21278145 16942905 19499222 20118626 19294768 19642983 19254457 9163691 12112319 20405173 12771043 19427195 15885732 2422723 20583210 21071580 19996281 19255062
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.7518164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.7521159647 18775883 18282651 18308698 9362446 18079962 17854601 19539802 19519916 16842330 2563599 16267830 17174075 18544905 3124819 19009564 17942915 19126423 19004024 18253720 18164116 18093689
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 21163286 20512841
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.679029167 3581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D011230 Precancerous Conditions Cyclosporine 9.9112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.912563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4915754350 16289102 12479363 16644109 18247401
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.227505956
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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