AutismKB 2.0

Annotation Detail for IFIT3


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Basic Information Top
Gene Symbol:IFIT3 ( CIG-49,GARG-49,IFI60,IFIT4,IRG2,ISG60,RIG-G )
Gene Full Name: interferon-induced protein with tetratricopeptide repeats 3
Band: 10q23.31
Quick LinksEntrez ID:3437; OMIM: 604650; Uniprot ID:IFIT3_HUMAN; ENSEMBL ID: ENSG00000119917; HGNC ID: 5411
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026114 2-xylene 2-xylene results in increased expression of IFIT3 mRNAincreases expression 20359517
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of IFIT3 mRNA]affects reaction|increases expression 18700144
D001104 Arbutin Arbutin results in decreased expression of IFIT3 mRNAdecreases expression 17103032
D016589 Astemizole Astemizole results in decreased expression of IFIT3 mRNAdecreases expression 20221588
D001554 Benzene Benzene results in increased expression of IFIT3 mRNAincreases expression 20359517
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IFIT3 mRNAincreases expression 19152381
D001564 Benzo(a)pyrene chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFIT3 mRNA]decreases reaction|increases expression 19152381
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IFIT3 mRNAdecreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IFIT3 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of IFIT3 mRNAincreases expression 15003993
14729362
D002087 Butyrates [Tretinoin co-treated with Butyrates] results in increased expression of IFIT3 mRNAaffects cotreatment|increases expression 12130515
C007020 chlorophyllin chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFIT3 mRNA]decreases reaction|increases expression 19152381
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in decreased expression of IFIT3 mRNA]affects reaction|decreases expression 17585979
D004041 Dietary Fats Dietary Fats affects the expression of IFIT3 mRNAaffects expression 17086191
D004041 Dietary Fats resveratrol inhibits the reaction [Dietary Fats affects the expression of IFIT3 mRNA]affects expression|decreases reaction 17086191
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of IFIT3 mRNAincreases expression 15289156
D002117 Calcitriol Calcitriol results in decreased expression of IFIT3 mRNAdecreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IFIT3 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of IFIT3 mRNAincreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of IFIT3 mRNAincreases expression 15289156
C004912 ethylbenzene ethylbenzene results in increased expression of IFIT3 mRNAincreases expression 20359517
D019833 Genistein Genistein results in increased expression of IFIT3 mRNAincreases expression 15289156
C014026 hexamethylene bisacetamide [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of IFIT3 mRNAaffects cotreatment|increases expression 12130515
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of IFIT3 mRNAincreases expression 15860229
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of IFIT3 mRNAdecreases expression 20713471
D008752 Methylene Chloride Methylene Chloride results in increased expression of IFIT3 mRNAincreases expression 20359517
D010126 Ozone Ozone results in decreased expression of IFIT3 mRNAdecreases expression 16183385
C006253 pirinixic acid pirinixic acid results in increased expression of IFIT3 mRNAincreases expression 17426115
C059514 resveratrol resveratrol inhibits the reaction [Dietary Fats affects the expression of IFIT3 mRNA]affects expression|decreases reaction 17086191
D013629 Tamoxifen Tamoxifen results in increased expression of IFIT3 mRNAincreases expression 19155303
C004648 testosterone enanthate testosterone enanthate affects the expression of IFIT3 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IFIT3 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IFIT3 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IFIT3 mRNAincreases expression 17337447
D013876 Thiophenes Thiophenes analog promotes the reaction [Tretinoin results in increased expression of IFIT3 mRNA]increases expression|increases reaction 16140954
D014050 Toluene Toluene results in increased expression of IFIT3 mRNAincreases expression 20359517
D014212 Tretinoin Thiophenes analog promotes the reaction [Tretinoin results in increased expression of IFIT3 mRNA]increases expression|increases reaction 16140954
D014212 Tretinoin [Tretinoin co-treated with Butyrates] results in increased expression of IFIT3 mRNAaffects cotreatment|increases expression 12130515
D014212 Tretinoin [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of IFIT3 mRNAaffects cotreatment|increases expression 12130515
D014212 Tretinoin Tretinoin results in increased expression of IFIT3 mRNAincreases expression 16140954
12130515
D014212 Tretinoin Tretinoin results in increased expression of IFIT3 proteinincreases expression 15059897
D014241 Trichloroethylene Trichloroethylene results in increased expression of IFIT3 mRNAincreases expression 20359517
D014635 Valproic Acid Valproic Acid results in increased expression of IFIT3 mRNAincreases expression 19949822
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2314745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.2811752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6519490988
MESH:D058186 Acute Kidney Injury resveratrol 3.5816538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.0911850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.0918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.5920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.5911473722
MESH:D000230 Adenocarcinoma Genistein 6.5911473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.246695378
MESH:D000236 Adenoma Methylcholanthrene 10.2410545420 6695378
MESH:D000236 Adenoma resveratrol 10.2415688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8716835633
MESH:D000505 Alopecia Tretinoin 3.3715955085
MESH:D000544 Alzheimer Disease Ozone 4.1315513908
MESH:D000544 Alzheimer Disease resveratrol 4.1316162502 16183991
MESH:D000550 Amblyopia Valproic Acid 4.9217688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1815469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6811748828
MESH:D000741 Anemia, Aplastic Benzene 4.1317661222 14761424 11369114
MESH:D000799 Angioedema Acetaminophen 10.9710982225
MESH:D000799 Angioedema Astemizole 10.972883202
MESH:D001008 Anxiety Disorders Valproic Acid 3.3317497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7719183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.5915238619
MESH:D001169 Arthritis, Experimental resveratrol 6.8817115116
MESH:D001169 Arthritis, Experimental Tretinoin 6.8816412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.4015570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4016292516
MESH:D001249 Asthma Ozone 4.6217854713 16373670
MESH:D001249 Asthma Tretinoin 4.6216456186
MESH:D050197 Atherosclerosis Methylcholanthrene 6.3511922910
MESH:D050197 Atherosclerosis resveratrol 6.3517967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518558336 17157402 15238991 18396377 17507914 19232924 18316065 19460635 18985861 17688650 20603192 18940202 18775368 16609825 18177632
MESH:D001471 Barrett Esophagus Tretinoin 4.1116935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9220046352 17594078
MESH:D001778 Blood Coagulation Disorders Clofibrate 19.6919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.6919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.6912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 19.6916206674 16197459
MESH:D001836 Body Weight Changes 2-xylene 11.057457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.0515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.3615746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.368888407
MESH:D001855 Bone Marrow Diseases Benzene 4.9116183116
MESH:D002545 Brain Ischemia resveratrol 3.9717600658
MESH:D001943 Breast Neoplasms Benzene 12.2017162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 12.2020146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 12.2011237771
MESH:D001943 Breast Neoplasms Dietary Fats 12.2020435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 12.2015324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 12.2019861407 17289903 17018787 12948864 14630087 16675129 17261762 18497071
MESH:D001943 Breast Neoplasms Genistein 12.2016873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylcholanthrene 12.2017474063
MESH:D001943 Breast Neoplasms Methylene Chloride 12.2015986119
MESH:D001943 Breast Neoplasms resveratrol 12.2017651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 12.2020065188 19189210 16273361 19189212 21138602 19115204 17261762 19084267 17242785 11161223 19059307 18815881 20005174 15668708 19103187 18351453 16873071 19142967 19066611 15565566 19289846 19221464 18425577 19155303 19487384 18855134 18984771 16202921 19244106 19011961 20390343 18629630 16818667 17893378 17049068 20544844 19288272 20135344 18821012 17440819 18997820 19200415 19410462 20859285 21152245
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 12.2020435547
MESH:D001943 Breast Neoplasms Tretinoin 12.2016166294 16443354 16873071
MESH:D001943 Breast Neoplasms Trichloroethylene 12.2015986119
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4419059883 18315731 17626835 15516495 16777450 18417511 14754758
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2816813970
MESH:D002100 Cachexia Ozone 4.4316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D002277 Carcinoma Methylcholanthrene 7.5310545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8416168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.233084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.2315948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.2316924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.2316924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.2319321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.2316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.231917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2816675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.0120419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.0111237771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.0116227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.0116051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2016120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 6.8016332659
MESH:D002318 Cardiovascular Diseases resveratrol 6.8015458977
MESH:D002386 Cataract Acetaminophen 6.6210977129
MESH:D002386 Cataract Tretinoin 6.6217460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.3420889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.341399818
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.3418566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 14.3416192471
MESH:D002547 Cerebral Palsy Toluene 5.549294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9016835633
MESH:D002779 Cholestasis pirinixic acid 2.6019176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8416461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3212621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.329407595
MESH:D003092 Colitis resveratrol 8.6216474422
MESH:D003092 Colitis Tretinoin 8.6217035595
MESH:D003110 Colonic Neoplasms Butyrates 5.6415936596
MESH:D003110 Colonic Neoplasms Genistein 5.6417182828
MESH:D003110 Colonic Neoplasms resveratrol 5.6416338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8017141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.5516507316
MESH:D019465 Craniofacial Abnormalities Benzene 6.9415643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.9410048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 6.949294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.9416925845 10589399 9224671 17551590 9142499 9211117 14991402 9664655 9125849 8800419
MESH:D019465 Craniofacial Abnormalities Valproic Acid 6.948888407 17688650 16575769
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2616002989 12952375
MESH:D003643 Death Toluene 5.356431079
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0619031437
MESH:D003872 Dermatitis Benzene 4.4615902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2818249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5216873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.0516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0517107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.5219279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.5216286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.5219279558
MESH:D004244 Dizziness Astemizole 6.153105558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.1919085960 12153990 16109766 10663392 11287661 18713872 11461765 19164858 19370779 16485898 12958197 15619225 11421492 17562736 17522070 19923254 19739265 2444490 16227642 10774834 12705907 16393943 10915739 14550746 16081117 11739529 16781746 11743745 11834606 19420014 18071297 11529661 17906064 12392966 14986274 12540782 16177239 12594235 15968718 19416960 14725611
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1920420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 8.197120509
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.191733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7819426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:D050171 Dyslipidemias Clofibrate 8.0816707586
MESH:D050171 Dyslipidemias Dietary Fats 8.0818367378
MESH:D004421 Dystonia Valproic Acid 3.761851702
MESH:D004487 Edema pirinixic acid 9.8412083418
MESH:D004487 Edema resveratrol 9.848985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.8412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8915322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.8918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 13.7515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 13.7517872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.7519031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.8616402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.8616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 21.2016804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 21.2019148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 21.2011473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 21.2016202921 20544844 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 21.2016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7610568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0917637181 15328337 15821434
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5417923197
MESH:D004802 Eosinophilia Astemizole 4.501355641
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.8517275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.603922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7820417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.337562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.753659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.0620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.089664655 16938888
MESH:D005234 Fatty Liver Clofibrate 21.7219224547
MESH:D005234 Fatty Liver Dietary Fats 21.7219004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 21.7219236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 21.7214986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 21.7214986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.5816002989 16513791 15751030 16611131 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.5816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.848888407 18558336
MESH:D005334 Fever Lipopolysaccharides 3.759205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8719069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6314633661 10962813
MESH:D005355 Fibrosis Dietary Fats 13.0118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.0120067830
MESH:D005355 Fibrosis Tretinoin 13.0117994277
MESH:D005499 Folliculitis Astemizole 5.601671328
MESH:D005756 Gastritis Acetaminophen 3.3616983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6416452187
MESH:D005909 Glioblastoma Genistein 6.5416598420
MESH:D005909 Glioblastoma Tretinoin 6.5417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8416084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.1320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.1310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.139664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.3520558911
MESH:D006402 Hematologic Diseases Benzene 4.3716183116
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006529 Hepatomegaly 2-xylene 12.837457013 7457028
MESH:D006529 Hepatomegaly pirinixic acid 12.8319176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.8315340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D006561 Herpes Simplex resveratrol 3.8716876885
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.4317440010
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7315340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.8216870215
MESH:D006930 Hyperalgesia Tretinoin 6.8216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 8.2921332399
MESH:D006937 Hypercholesterolemia resveratrol 8.2917188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2616778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9220558911
MESH:D006949 Hyperlipidemias Dietary Fats 8.3421332399
MESH:D006949 Hyperlipidemias resveratrol 8.3416873680
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1314722030 12960047
MESH:D006973 Hypertension Benzene 4.9017940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9018670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0317488730
MESH:D007021 Hypospadias Diethylstilbestrol 4.2816002989
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3417600658
MESH:D007246 Infertility Diethylstilbestrol 4.0615036965
MESH:D007249 Inflammation Dietary Fats 14.1220412841
MESH:D007249 Inflammation Lipopolysaccharides 14.1217237260 17255318 12878042 17963957 9205823
MESH:D007249 Inflammation resveratrol 14.1216366677
MESH:D007249 Inflammation Tamoxifen 14.1219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.1212878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.2316624496
MESH:D007333 Insulin Resistance Dietary Fats 11.1211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.1216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.1216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4617994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3417255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.0116580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.0115992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 5.2915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.2915618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.0315003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 11.0315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.0318625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7617184923
MESH:D007938 Leukemia Benzene 9.6617119257 14694614 15935818 18335105
MESH:D007938 Leukemia Genistein 9.6618980019 17468513
MESH:D007938 Leukemia Tretinoin 9.6617143497
MESH:D007951 Leukemia, Myeloid Benzene 8.7617506065
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7616482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Benzene 5.8219478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.8216294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.8216294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 11.8316087638
MESH:D015473 Leukemia, Promyelocytic, Acute Thiophenes 11.8316140955 16140954
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.8317294898 17368321 19642359 16140955 19075265 12679006 19035177 15748426 17649720 19029980 17361223 16331271 16891316 19225113 16823087 17506722 9834237 16766008 17712046 17217047 17339181 16935935 16788101 17301526 17107899
MESH:D007970 Leukopenia Lipopolysaccharides 4.3915821434
MESH:D017513 Lichen Nitidus Astemizole 6.152563723
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.099224671
MESH:D008064 Lipidoses Tamoxifen 2.9415342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.7118296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.2614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.2617823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.2612878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.2615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.2618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.2612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.2616248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.5619014921 11587558 12969438 16611625 19784758 12587719 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.3821137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 16.3816712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 16.3820007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 16.3819812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms Tamoxifen 16.3816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.3816984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 12.6312562636
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 12.63598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.6312151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 12.637955063
MESH:D008133 Long QT Syndrome Astemizole 4.3611989578 18472280
MESH:D008171 Lung Diseases Ozone 3.178266340 19066396
MESH:D017563 Lung Diseases, Interstitial Benzene 10.3314698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.3317228818
MESH:D055370 Lung Injury Lipopolysaccharides 8.2321114838
MESH:D055370 Lung Injury Ozone 8.2320417186
MESH:D008175 Lung Neoplasms Benzene 10.0512562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.0517053015 20464547 18520028 18816296 6695378 18569708 20135361 20869020 20064080
MESH:D008175 Lung Neoplasms Methylcholanthrene 10.0516337739 21163286 15390079 20512841 20970405 6695378 7750092 11893704 1399818 17909032 9230183 10545420 16271038
MESH:D008175 Lung Neoplasms Methylene Chloride 10.0515172992
MESH:D008175 Lung Neoplasms Ozone 10.058597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 10.0518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0519555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8415166399
MESH:D008223 Lymphoma Benzene 7.1217119257 17584886
MESH:D008223 Lymphoma Diethylstilbestrol 7.1215700306
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0117088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6214749477
MESH:D008288 Malaria Astemizole 4.5316816845
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2016002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 15.0112562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 15.0115688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 15.0119428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 16.7211921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.7211807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 16.7214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 16.728985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.7216827153 11731420 19196722 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.5919453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.5919453300
MESH:D008527 Medulloblastoma Tretinoin 2.6617453147
MESH:D008545 Melanoma resveratrol 4.7917992120
MESH:D008545 Melanoma Tamoxifen 4.7912393984 19393235
MESH:D008545 Melanoma Tretinoin 4.7916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2619513568
MESH:D008591 Meningomyelocele Tretinoin 4.1216940565
MESH:D008607 Mental Retardation Toluene 3.549294310
MESH:D008654 Mesothelioma hexamethylene bisacetamide 4.6915543656
MESH:D008659 Metabolic Diseases resveratrol 4.1017112576
MESH:D008679 Metaplasia Ozone 4.7910496685
MESH:D008881 Migraine Disorders Valproic Acid 2.9718765137 18803445
MESH:D019957 Motor Skills Disorders Toluene 4.959294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9616381670
MESH:D009101 Multiple Myeloma Benzene 6.9017119195
MESH:D009101 Multiple Myeloma resveratrol 6.9017164350 16490592 17935668 17049120 16267019 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.758888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.8017596541
MESH:D009203 Myocardial Infarction Genistein 8.7217141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.7219151258
MESH:D009203 Myocardial Infarction resveratrol 8.7216525036 17015251 17188708 16456233 16317513 17125593
MESH:D017202 Myocardial Ischemia resveratrol 8.2017125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.2012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.8116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.8117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.8116411023
MESH:D009205 Myocarditis resveratrol 4.4517322642
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.0811141357
MESH:D009369 Neoplasms Diethylstilbestrol 14.0815313581
MESH:D009369 Neoplasms pirinixic acid 14.0817405874
MESH:D009369 Neoplasms Tretinoin 14.0816594593 16946489
MESH:D009369 Neoplasms Trichloroethylene 14.0811911487
MESH:D009374 Neoplasms, Experimental resveratrol 3.708985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6819200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4217289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 27.5911399458
MESH:D009421 Nervous System Malformations Estradiol 27.5916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 27.5916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 27.5914600291
MESH:D009421 Nervous System Malformations Tretinoin 27.599125849
MESH:D009436 Neural Tube Defects Benzene 11.0615643154
MESH:D009436 Neural Tube Defects Tretinoin 11.069142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.0616359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5218514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.5217652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1117929310
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.639802331
MESH:D009759 Nystagmus, Pathologic Astemizole 6.156135121
MESH:D009765 Obesity Dietary Fats 4.1621332399 18457598 17217161 16723640 19632207 20132043 20518802 18674790 11836018
MESH:D009765 Obesity pirinixic acid 4.1620558911
MESH:D009784 Occupational Diseases Benzene 3.9116737584 17178637 15913788 15576619 15935809 17479406 15612468 17119257 15727169
MESH:D010024 Osteoporosis Genistein 3.0619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.2016169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.2017513867
MESH:D010051 Ovarian Neoplasms Benzene 10.4712562636
MESH:D010051 Ovarian Neoplasms Estradiol 10.4719401270
MESH:D010051 Ovarian Neoplasms Genistein 10.4719005980
MESH:D010051 Ovarian Neoplasms Tretinoin 10.4716936753
MESH:D010146 Pain Acetaminophen 5.7716870215
MESH:D010146 Pain Tretinoin 5.7716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.3515976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D010538 Peritonitis Ozone 3.8316369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3715687265 16977796
MESH:D011014 Pneumonia Lipopolysaccharides 10.0712224865 11605937
MESH:D011014 Pneumonia Ozone 10.0718007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2618163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 20.7017184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 20.7016679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 20.7011118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 20.7020603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0517292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0516289102 15754350 16644109 12479363 18247401
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0517136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.0516740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0516925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms resveratrol 2.0515767336 17636462 17718901 17804756 16731767 17675339
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0515067354
MESH:D011507 Proteinuria Tretinoin 3.3216636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.2312752131 11422049
MESH:D011625 Pterygium Tretinoin 4.4816723453
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.2716325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.0619058328
MESH:D015427 Reperfusion Injury resveratrol 6.0615827377 16314181 17058453 16317513 17520802
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5310835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.9116283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.9119155313
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.1110822083
MESH:D012559 Schizophrenia Valproic Acid 2.0319110320 15737665
MESH:D012640 Seizures Toluene 5.696431079 9294310
MESH:D012640 Seizures Valproic Acid 5.6917978042 11044598 15475178 1511512 11738929 3137016 16876388 14763951
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.3319755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 16.338985016 15837718
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.338532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.3316192470
MESH:D012878 Skin Neoplasms Tretinoin 16.3316467112
MESH:D013088 Spermatocele Diethylstilbestrol 10.7916709447 16002989
MESH:D013088 Spermatocele Tamoxifen 10.7916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2312833885
MESH:D013274 Stomach Neoplasms Benzene 3.2312562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.232093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 3.2317261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2116321402
MESH:D013733 Testicular Diseases Toluene 4.6510048760 10514026
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9015821434
MESH:D013953 Thymus Neoplasms Benzene 4.6410850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms Butyrates 6.8017967635
MESH:D013964 Thyroid Neoplasms Tretinoin 6.8017045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.3719048282
MESH:D014062 Tongue Neoplasms resveratrol 9.0216227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.0216051514
MESH:D016171 Torsades de Pointes Astemizole 4.909583453 8256756
MESH:D014178 Translocation, Genetic Valproic Acid 4.9217262798
MESH:D014376 Tuberculosis Tretinoin 3.0416040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.213119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.6017053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.6016452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.6016712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.348888407
MESH:D014581 Urticaria Acetaminophen 8.0810982225
MESH:D014581 Urticaria Astemizole 8.081976298 3134034 3080510 2147912 2885854 2883202 2568189 2568013 2859714 3097109 1683191 2565098
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.3716175088
MESH:D002583 Uterine Cervical Neoplasms resveratrol 14.3717473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.3716129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8514652134
MESH:D014594 Uterine Neoplasms Benzene 14.5012562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 14.5015809267 16690809
MESH:D014594 Uterine Neoplasms resveratrol 14.5017044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.2916752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1316002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0017488730
MESH:D014717 Vertigo Astemizole 6.153105558
MESH:D014820 Vitiligo Tretinoin 3.7616761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D015430 Weight Gain Dietary Fats 3.4816723640
MESH:D009396 Wilms Tumor Tretinoin 3.7116287080
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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