AutismKB 2.0

Annotation Detail for IFNA4


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Basic Information Top
Gene Symbol:IFNA4 ( IFN-alpha4a,INFA4,MGC142200 )
Gene Full Name: interferon, alpha 4
Band: 9p21.3
Quick LinksEntrez ID:3441; OMIM: 147564; Uniprot ID:IFNA4_HUMAN; ENSEMBL ID: ENSG00000236637; HGNC ID: 5425
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04650Natural killer cell mediated cytotoxicity
hsa04140Regulation of autophagy
hsa05320Autoimmune thyroid disease
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of IFNA4 mRNAdecreases expression 18648102
D008070 Lipopolysaccharides Triclosan inhibits the reaction [Lipopolysaccharides results in increased expression of IFNA4 mRNA]decreases reaction|increases expression 20507366
D008770 Methylnitrosourea Methylnitrosourea results in decreased expression of IFNA4 mRNAdecreases expression 18675455
D008770 Methylnitrosourea Quercetin inhibits the reaction [Methylnitrosourea results in decreased expression of IFNA4 mRNA]decreases expression|decreases reaction 18675455
D010126 Ozone Ozone results in decreased expression of IFNA4 mRNAdecreases expression 12763052
D011794 Quercetin Quercetin inhibits the reaction [Methylnitrosourea results in decreased expression of IFNA4 mRNA]decreases expression|decreases reaction 18675455
D014260 Triclosan Triclosan inhibits the reaction [Lipopolysaccharides results in increased expression of IFNA4 mRNA]decreases reaction|increases expression 20507366
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.3811850527 18653653
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.1815688392 15113128
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D000544 Alzheimer Disease Ozone 2.4915513908
MESH:D000743 Anemia, Hemolytic Quercetin 4.5717084956
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Ozone 2.7117854713 16373670
MESH:D001260 Ataxia Telangiectasia Quercetin 5.4415336622
MESH:D001327 Autoimmune Diseases Quercetin 4.8219761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.541440618 11289319
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.6316253758 11306469 14633655
MESH:D001943 Breast Neoplasms Quercetin 2.6318628248
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9316777450 15516495 18315731 18417511 14754758 19059883 17626835
MESH:D002100 Cachexia Ozone 5.2016183385
MESH:D002105 Cadmium Poisoning Quercetin 6.0716962696
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.267296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.2619519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.3717234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D006332 Cardiomegaly Quercetin 3.4719794523
MESH:D002386 Cataract Methylnitrosourea 4.1512484553
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.747505956
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 7.742727394 7505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.389022650 19486331
MESH:D003110 Colonic Neoplasms Quercetin 2.4617191121 11134977 15741050 19440933 17148506 16640504 19056647
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D000013 Congenital Abnormalities Triclosan 5.4319283420
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.218970840 14531868 11298694 2524372 12868966 11906362 8156756 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0019496084
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0318692083 7440962 18289764 16192314 9328219 11289319 18648102 9653073 1440618 9022650 6482804 6679447 8291058
MESH:D019446 Endotoxemia Lipopolysaccharides 4.8617637181 15328337 15821434
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005334 Fever Lipopolysaccharides 4.3211852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.6911555667
MESH:D005355 Fibrosis Quercetin 4.3219474275
MESH:D005909 Glioblastoma Quercetin 3.5819804834
MESH:D005910 Glioma Methylnitrosourea 6.799825942
MESH:D005910 Glioma Quercetin 6.7917643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6916366002
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006943 Hyperglycemia Quercetin 4.3418262572 11834736
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Quercetin 2.9518356687
MESH:D007248 Infertility, Male Methylnitrosourea 8.327193160
MESH:D007248 Infertility, Male Triclosan 8.3220821571
MESH:D007249 Inflammation Lipopolysaccharides 6.3317237260 17963957 12878042 9205823 17255318
MESH:D007249 Inflammation Triclosan 6.339584910 20507366
MESH:D007251 Influenza, Human Quercetin 5.0316624496
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.9817255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007627 Keloid Quercetin 5.3717086741
MESH:D007674 Kidney Diseases Quercetin 3.2616962696
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D007938 Leukemia Quercetin 3.2917468513
MESH:D007970 Leukopenia Lipopolysaccharides 5.1615821434
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.4215526292
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.9012878042
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.9012741479
MESH:D008113 Liver Neoplasms Quercetin 2.7618980244
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.69598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.6919519916
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.8816080182
MESH:D008171 Lung Diseases Ozone 3.578266340 19066396
MESH:D055370 Lung Injury Lipopolysaccharides 10.6721114838
MESH:D055370 Lung Injury Ozone 10.6720417186
MESH:D008175 Lung Neoplasms Methylnitrosourea 3.8318062963
MESH:D008175 Lung Neoplasms Ozone 3.838597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 3.8316280456
MESH:D008223 Lymphoma Methylnitrosourea 4.2316257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 5.1214633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 7.5610838139 11751437 12931682 11807958 16944150 15113128 17131329 10767621 17020996 16619500 14633655 15313902 14999141 15688392 16051031 19196723 16827153
MESH:D008325 Mammary Neoplasms, Experimental Triclosan 7.5615358634
MESH:D008679 Metaplasia Ozone 5.6310496685
MESH:D009203 Myocardial Infarction Quercetin 3.1019595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 4.0319207477
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms Methylnitrosourea 6.0115533788
MESH:D009369 Neoplasms Quercetin 6.0115185748
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.8912696579
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D009442 Neurilemmoma Methylnitrosourea 5.9511555667
MESH:D020078 Neurogenic Inflammation Quercetin 4.7117929310
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.5719495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8119005980
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 6.0516965848
MESH:D010190 Pancreatic Neoplasms Quercetin 6.0516965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010538 Peritonitis Ozone 4.5516369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011014 Pneumonia Lipopolysaccharides 12.7011605937 12224865
MESH:D011014 Pneumonia Ozone 12.7018929643 18007984 18381685
MESH:D011230 Precancerous Conditions Quercetin 4.2719056647
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.6515682402 12376480
MESH:D011471 Prostatic Neoplasms Quercetin 3.6514715546 17292933
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9210835634
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.893692021
MESH:D012162 Retinal Degeneration Methylnitrosourea 9.8918172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.9511555667
MESH:D012554 Schistosomiasis japonica Quercetin 6.0716862918
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.7016257854 15930296 18593901
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.4715821434
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.6911418001
MESH:D013959 Thyroid Diseases Triclosan 6.5019910387
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.276582329 1399818 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 8.273078959 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.548074119
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.5416720314
Pathway ID Pathway Name
KEGG:05320 Autoimmune thyroid disease
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04623 Cytosolic DNA-sensing pathway
REACT:604 Hemostasis
KEGG:05160 Hepatitis C
KEGG:04630 Jak-STAT signaling pathway
KEGG:05162 Measles
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04140 Regulation of autophagy
KEGG:04622 RIG-I-like receptor signaling pathway
REACT:6900 Signaling in Immune system
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29664
    • No data
    Releated disease ID Related disease Name
    PA445537Retinitis Pigmentosa
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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