AutismKB 2.0

Annotation Detail for APOC3


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Basic Information Top
Gene Symbol:APOC3 ( APOCIII,MGC150353 )
Gene Full Name: apolipoprotein C-III
Band: 11q23.3
Quick LinksEntrez ID:345; OMIM: 107720; Uniprot ID:APOC3_HUMAN; ENSEMBL ID: ENSG00000110245; HGNC ID: 610
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03320PPAR signaling pathway
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500795Lipoprotein metabolism
500797HDL-mediated lipid transport
500796Chylomicron-mediated lipid transport
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1749Transient hypertension of pregnancy
1870Drug abuse
1904Diabetes mellitus
1918Atherosclerosis
1974Metabolic syndrome X
2007Liver tumor
2022Liver cancer
2091Hypertension
2040Hyperglycemia
2070Cholelithiasis
2097Hyperlipidemia
2146Lupus erythematosus
Desease Name
HDL cholesterol
insulin sensitivity
cholesterol
cardiovascular risk
apoB
familial combined hyperlipidemia
cholesterol cholesterol, HDL cholesterol, LDL lipoprotein triglycerides
increased number of circulating VLDL and IDL particles
cholesterol, HDL
cholesterol, HDL triglycerides
triacylglycerol
AGING
Atherosclerosis
lipid metabolism disorders
atherosclerosis, coronary
blood pressure, arterial
CARDIOVASCULAR
metabolism disorders
diabetes, type 1
atherosclerosis, carotid
diverse hyperlipidaemic phenotypes
lipids triglycerides
cholesterol, LDL
Alzheimer's disease
Plasma Lipid Levels
dyslipemia
PHARMACOGENOMIC
atherosclerosis, coronary lipoprotein triglycerides
nephropathy, diabetic
RENAL
hypertension
lipoprotein, LDL
lipoprotein
IMMUNE
metabolic syndrome
NEUROLOGICAL
hyperlipidemia
METABOLIC
variation in plasma lipoproteins
LDL cholesterol
triglycerides
obesity
hypertension, pregnancy induced preeclampsia
cholesterol, total
cerebrovascular disease
diabetes, type 2
longevity
Hypertriglyceridemia
apoA1
gallstones
atherosclerosis, generalized
No data
Desease Name
Apolipoprotein C3 deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene results in decreased expression of APOC3 mRNAdecreases expression 17070881
C035314 1-nitropropane 1-nitropropane results in increased expression of APOC3 mRNAincreases expression 17070881
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of APOC3 mRNAdecreases expression 17070881
C025235 2,6-diaminotoluene 2,6-diaminotoluene results in decreased expression of APOC3 mRNAdecreases expression 17070881
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in decreased expression of APOC3 mRNAdecreases expression 17070881
C016617 2-nitropropane 2-nitropropane results in decreased expression of APOC3 mRNAdecreases expression 17070881
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in decreased expression of APOC3 mRNAdecreases expression 17070881
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of APOC3 proteinaffects expression 20106945
C095105 bexarotene bexarotene results in decreased expression of APOC3 mRNAdecreases expression 16648578
C032036 bromobenzene bromobenzene results in decreased expression of APOC3 mRNAdecreases expression 12628495
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of APOC3 mRNAaffects expression 15963342
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of APOC3 mRNAdecreases expression 16239168
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of APOC3 mRNAaffects cotreatment|decreases expression 19509184
D008076 Cholesterol, HDL APOC3 gene polymorphism affects the abundance of Cholesterol, HDLaffects abundance 16030523
D016572 Cyclosporine Cyclosporine results in decreased expression of APOC3 mRNAdecreases expression 20106945
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of APOC3 mRNAaffects cotreatment|decreases expression 19509184
D004041 Dietary Fats Dietary Fats affects the expression of APOC3 mRNAaffects expression 18457598
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]decreases expression|decreases reaction 16297877
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal results in increased expression of APOC3 mRNAincreases expression 16297877
D004365 Drugs, Chinese Herbal PPARA protein affects the reaction [Drugs, Chinese Herbal inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
D004365 Drugs, Chinese Herbal PPARA protein affects the reaction [Drugs, Chinese Herbal results in increased expression of APOC3 mRNA]affects reaction|increases expression 16297877
D000431 Ethanol Ethanol results in increased expression of APOC3 mRNAincreases expression 17920746
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in decreased expression of APOC3 mRNAdecreases expression 17070881
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of APOC3 mRNAaffects cotreatment|decreases expression 19509184
C039281 furan furan results in decreased expression of APOC3 mRNAdecreases expression 15120968
C055328 ginsenoside Rf ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]decreases expression|decreases reaction 16297877
C055328 ginsenoside Rf ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 protein]decreases expression|decreases reaction 16297877
C055328 ginsenoside Rf ginsenoside Rf results in decreased expression of APOC3 proteindecreases expression 16297877
C055328 ginsenoside Rf ginsenoside Rf results in increased expression of APOC3 mRNAincreases expression 16297877
C055328 ginsenoside Rf PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
C055328 ginsenoside Rf PPARA protein affects the reaction [ginsenoside Rf results in increased expression of APOC3 mRNA]affects reaction|increases expression 16297877
D036145 Ginsenosides Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]decreases expression|decreases reaction 16297877
D036145 Ginsenosides Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOC3 protein]decreases expression|decreases reaction 16297877
D036145 Ginsenosides Ginsenosides results in decreased expression of APOC3 proteindecreases expression 16297877
D036145 Ginsenosides Ginsenosides results in increased expression of APOC3 mRNAincreases expression 16297877
D036145 Ginsenosides PPARA protein affects the reaction [Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
D036145 Ginsenosides PPARA protein affects the reaction [Ginsenosides results in increased expression of APOC3 mRNA]affects reaction|increases expression 16297877
C029424 hydrazine hydrazine results in decreased expression of APOC3 mRNAdecreases expression 15370871
D008701 Methapyrilene Methapyrilene results in decreased expression of APOC3 mRNAdecreases expression 15120968
C076029 olanzapine APOC3 gene polymorphism affects the susceptibility to olanzapineaffects response to substance 17726453
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of APOC3 mRNAdecreases expression 17681415
C006253 pirinixic acid Drugs, Chinese Herbal inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]decreases expression|decreases reaction 16297877
C006253 pirinixic acid ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]decreases expression|decreases reaction 16297877
C006253 pirinixic acid ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 protein]decreases expression|decreases reaction 16297877
C006253 pirinixic acid Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]decreases expression|decreases reaction 16297877
C006253 pirinixic acid Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOC3 protein]decreases expression|decreases reaction 16297877
C006253 pirinixic acid pirinixic acid results in decreased expression of APOC3 mRNAdecreases expression 16297877
16807375
17932310
C006253 pirinixic acid pirinixic acid results in decreased expression of APOC3 proteindecreases expression 16297877
C006253 pirinixic acid PPARA protein affects the reaction [Drugs, Chinese Herbal inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
C006253 pirinixic acid PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
C006253 pirinixic acid PPARA protein affects the reaction [Ginsenosides inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]affects reaction|decreases expression|decreases reaction 16297877
C006253 pirinixic acid PPARGC1B protein inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]decreases expression|decreases reaction 17932310
C025299 polyphenols polyphenols results in decreased expression of APOC3 mRNAdecreases expression 16293270
D011341 Probucol Probucol results in decreased expression of APOC3 mRNAdecreases expression 16292755
D013752 Tetracycline Tetracycline results in decreased expression of APOC3 mRNAdecreases expression 16917069
C017953 tetramethylpyrazine tetramethylpyrazine results in decreased expression of APOC3 mRNAdecreases expression 15520497
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.6317676605 18926900
MESH:D000038 Abscess Drugs, Chinese Herbal 6.0115043669
MESH:D000138 Acidosis Ethanol 4.2011192467
MESH:D055371 Acute Lung Injury pirinixic acid 2.8518653653
MESH:D000236 Adenoma 2-Acetylaminofluorene 3.5710737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.716705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.1916434500
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0215451039 15451040
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 3.7920157255
MESH:D000740 Anemia Drugs, Chinese Herbal 4.4115504547 17963324
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 5.1211477813
MESH:D000853 Anophthalmos Ethanol 4.5315513904
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.6715043669
MESH:D001008 Anxiety Disorders Ethanol 3.7711141031
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 9.7315552841
MESH:D001161 Arteriosclerosis Dietary Fats 9.7315238619
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 5.4619655406
MESH:D001321 Autistic Disorder olanzapine 3.4018685284 17069543
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.8819483382
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 4.569881647
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.1411921183
MESH:D001943 Breast Neoplasms bexarotene 2.1416818667 16344269
MESH:D001943 Breast Neoplasms Dietary Fats 2.1420435547
MESH:D002056 Burns Ethanol 4.3616374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4916050911 16124888 16192424 3786805 15673190 18705752 16227642 16011737 15700767 10355542 15721981 16097048
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 6.2310737359 17761372 6705139 3581430 3084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.2321507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.2318788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.2315763234 18788625 15289165
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1216247446
MESH:D006332 Cardiomegaly Ethanol 3.2819332462
MESH:D002389 Catatonia olanzapine 5.9518071103 16772815
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.3312371664
MESH:D002779 Cholestasis Cyclosporine 7.0419486331
MESH:D002779 Cholestasis pirinixic acid 7.0419176532
MESH:D002971 Cleft Lip Ethanol 3.4315513904
MESH:D002972 Cleft Palate Ethanol 3.0515513904
MESH:D003110 Colonic Neoplasms polyphenols 2.6316293270
MESH:D003327 Coronary Disease Fructose 4.2918504504
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3111873399 15451039 10194807 19302082 15451040 11198716 15513904
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D002658 Developmental Disabilities olanzapine 4.4917069543
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.2618603373
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 3.3118603373
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 17.2615804453 16445897 20517888
MESH:D056486 Drug-Induced Liver Injury bromobenzene 17.2610092053 12628495
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.2615027814 9327722 6884620 16177239 10915739 2869522 15998439 16227642 21278145 7440962 3732212 19085960 7179309 17522070 10092053 7120509 6623471 3786805 4309450 15968718 11566570 19336974
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 17.2615027814
MESH:D056486 Drug-Induced Liver Injury Ethanol 17.2611566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 17.2619370779
MESH:D056486 Drug-Induced Liver Injury Tetracycline 17.2617522070
MESH:D050171 Dyslipidemias marker/mechanism
MESH:D050171 Dyslipidemias Dietary Fats 3.2418367378
MESH:D004487 Edema perfluorooctanoic acid 6.1217259670 12083418
MESH:D004487 Edema pirinixic acid 6.1212083418
MESH:D004938 Esophageal Neoplasms Ethanol 2.6816704527
MESH:D005234 Fatty Liver Carbon Tetrachloride 32.9212631006 12795759 16239168 19224547 17595544 61145 15959796 16045604
MESH:D005234 Fatty Liver Cyclosporine 32.9219224547
MESH:D005234 Fatty Liver Dietary Fats 32.9219551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Ethanol 32.9216409862 19236843 18620774
MESH:D005234 Fatty Liver Fructose 32.9218641190 18395287 19196556
MESH:D005234 Fatty Liver pirinixic acid 32.9219236843 20131406
MESH:D005234 Fatty Liver Tetracycline 32.9219224547 16917069
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0016946407 15513904 15451040 10194807
MESH:D005355 Fibrosis Carbon Tetrachloride 18.8418705752
MESH:D005355 Fibrosis Cyclosporine 18.8412168785 12639820
MESH:D005355 Fibrosis Dietary Fats 18.8418296743
MESH:D005355 Fibrosis Fructose 18.8418504504
MESH:D005756 Gastritis Ethanol 4.3915046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D018149 Glucose Intolerance Fructose 5.0519165636
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.026705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.146705139
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006505 Hepatitis Carbon Tetrachloride 8.7719110552 19900420
MESH:D006505 Hepatitis Drugs, Chinese Herbal 8.7718339527
MESH:D006529 Hepatomegaly perfluorooctanoic acid 7.753609246
MESH:D006529 Hepatomegaly pirinixic acid 7.7516221962 19772884 19176532 18467677
MESH:D006930 Hyperalgesia Ethanol 7.4718783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.4712083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2416899240
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 8.8110876104
MESH:D006937 Hypercholesterolemia Dietary Fats 8.8121332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006946 Hyperinsulinism Fructose 4.6518360027 19008412 18563319 14757778 15752949
MESH:D006949 Hyperlipidemias Dietary Fats 8.6521332399
MESH:D006949 Hyperlipidemias Fructose 8.6515752949
MESH:D006938 Hyperlipoproteinemia Type II marker/mechanism 16030523
MESH:D006963 Hyperphagia olanzapine 5.9317933447
MESH:D006973 Hypertension Cyclosporine 5.1910903974
MESH:D006973 Hypertension Fructose 5.1914633139 16843071 14573337 19008412 14568997
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8015338365
MESH:D015228 Hypertriglyceridemia Fructose 4.8219799862 19342510
MESH:D007249 Inflammation Dietary Fats 7.6320412841
MESH:D007249 Inflammation perfluorooctanoic acid 7.6312083418
MESH:D007249 Inflammation polyphenols 7.6316366677
MESH:D007333 Insulin Resistance Dietary Fats 11.3511836018 18457598
MESH:D007333 Insulin Resistance Fructose 11.3514573337 18563319 18981581 14633139 14757778 19799862 18057795 19008412 17133782 19586609 19342510
MESH:D007333 Insulin Resistance pirinixic acid 11.3516306350
MESH:D007569 Jaw Abnormalities Ethanol 4.1415513904
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007673 Kidney Cortex Necrosis tetramethylpyrazine 6.4118842672
MESH:D007674 Kidney Diseases Cyclosporine 2.178314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.5012371664
MESH:D007859 Learning Disorders Ethanol 3.9215451040
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.8015802533
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.938812269
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6017676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.4917334410 16943688 17174718 11903743 16221502 17157831 21278145 16239168 11408273
MESH:D008103 Liver Cirrhosis Dietary Fats 14.4918296743
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 14.4917163593
MESH:D008103 Liver Cirrhosis Ethanol 14.4915289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8018295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7118376398 17698563 12958196 14716833 18187930 18420326 18418968 16136751 17525996 15931870 12445421 18277467 18412020 15818738 17805973 17708605 15876570 18006644 12632514 12445418 15338365 18472094 15730626 16011737 17640975 16033810 13678700 16097048 12667390 17900296 16248980 17761835 18210741 14748882 17557913 16015684 18395914 17869086 18251166 14620537 18156304 16638106 17714472 17823541 15673190 12649538 12898905 14512876 12546737 14716496 17766677 17976157 16027843 15959796 15123356 15052691 18205269 17481882 18166357 18472332 18481824 15925388 17565644 18263696 16116963 17922224 15057751 15370692 18705752 12666154 18317297 18054572 17721639 12389079 17944888 12609069 18395095 16192424 12632512 17631135 10355542 15996030 18279442 12741479 18429990 14724832 15893842 15650968 12586293 20821823 18339082 15362042 11481614
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 4.7115849816 17629604 17666798 17036385 15763062 18237412 15383259 17348192 15744066 17881167 15641146 15864749 16610055 18567088 12632512 15754396 15818738 18371158 15339415 18606216
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.7118166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7115474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3115830285 17285989 15720792 16246199 16964402
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 6.3117207593
MESH:D008107 Liver Diseases polyphenols 6.3116698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3617207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4316899240 14706259
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 20.1314678523 10672840 18001218 11376686 16273603 10737359
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.1318177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.1319294768
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 20.1318339527
MESH:D008113 Liver Neoplasms Methapyrilene 20.1315890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 20.1314757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 20.1316377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 12.786150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.788603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.7815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Probucol 12.7812014681
MESH:D008133 Long QT Syndrome olanzapine 4.5020210726
MESH:D008175 Lung Neoplasms marker/mechanism 19180532
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 4.6911376686
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.6914755239
MESH:D008175 Lung Neoplasms bexarotene 4.6917849452
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 4.6918339527
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8611161223
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 9.2511921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.2519196723 19196722 15591091
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 9.2514758024
MESH:D008569 Memory Disorders Ethanol 3.9115451040 18411066
MESH:D001523 Mental Disorders olanzapine 4.3516856516
MESH:D008659 Metabolic Diseases olanzapine 5.1319142110
MESH:D024821 Metabolic Syndrome X Fructose 4.5817261469 18497449 19165636 17098227 16815490
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7216411023
MESH:D009336 Necrosis 2-nitropropane 5.2712195237
MESH:D009369 Neoplasms pirinixic acid 1.8117405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.4819196722
MESH:D009395 Nephritis, Interstitial Tetracycline 4.499884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0418481113 19348381
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.669802331
MESH:D009765 Obesity Dietary Fats 10.1018674790 16723640 20132043 17217161 20518802 18457598 11836018 21332399 19632207
MESH:D009765 Obesity Fructose 10.1017707055 18585860
MESH:D009765 Obesity olanzapine 10.1018515891
MESH:D009765 Obesity pirinixic acid 10.1020558911
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 4.7116548355
MESH:D010190 Pancreatic Neoplasms Ethanol 2.8612384795
MESH:D010300 Parkinson Disease Cholesterol, Dietary 4.0619014385
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.1311026799
MESH:D011230 Precancerous Conditions Cyclosporine 2.9812371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.1017132714
MESH:D017096 Prion Diseases Tetracycline 5.1210903871
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011595 Psychomotor Agitation olanzapine 5.2918685284
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 3.6016987627
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.6715043669
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 4.9715015336
MESH:D012559 Schizophrenia olanzapine 3.3920521326 20107430 17726453
MESH:D012640 Seizures Ethanol 2.989754883
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 2.9718339527
MESH:D013274 Stomach Neoplasms Ethanol 2.9718456281
MESH:D013276 Stomach Ulcer Ethanol 3.2817189318 16755016 9562338 11906479 9211565 17918041
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 5.4617634840
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.009754883
MESH:D017180 Tachycardia, Ventricular olanzapine 5.0520210726
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.9517997062
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 3.1615289314 15867355 1399818
MESH:D014605 Uveitis Cyclosporine 3.681336536
MESH:D015430 Weight Gain Dietary Fats 9.2616723640
MESH:D015430 Weight Gain olanzapine 9.2617933447 19434072 20107430
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 4.3016313111
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA53
    • No data
    Releated disease ID Related disease Name
    PA443796Coronary Artery Disease
    PA446213HIV Infections
    PA444528Hyperlipidemias
    PA447216Schizophrenia
    PA447230HIV
    PA446120Hypertriglyceridemia
    PA443425Arteriosclerosis
    PA444626Insulin Resistance
    PA444785Lipodystrophy
    Releated drug ID Related drug Name
    PA451159protease inhibitors
    PA450952phospholipids
    PA449061clozapine
    PA450688olanzapine
    PA451260ritonavir
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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