AutismKB 2.0

Annotation Detail for IFNGR1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IFNGR1 ( CD119,FLJ45734,IFNGR )
Gene Full Name: interferon gamma receptor 1
Band: 6q23.3
Quick LinksEntrez ID:3459; OMIM: 107470; Uniprot ID:INGR1_HUMAN; ENSEMBL ID: ENSG00000027697; HGNC ID: 5439
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa05142Chagas disease
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200110IFN-gamma pathway
Pathway IDPathway Name
P00035Interferon-gamma signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00089IFN-gamma/IL-12 axis
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
1781Rheumatoid arthritis
1950Parasitic disease
2051Leukemia
2052Infection
2059Communicable disease
2146Lupus erythematosus
2193Helicobacter infection
2247Osteomyelitis
Desease Name
Carcinoma
tuberculosis
atopic dermatitis, ocular
tuberculosis tumor necrosis factor-alpha
CANCER
Helicobacter Infections
Hepatitis B, Chronic
cerebral malaria
Gastritis
Asthma
allergic rhinitis
IMMUNE
Stomach Neoplasms
VISION
H. pylori infection
arthritis lupus erythematosus
HIV
Lupus
allergic disease
INFECTION
No data
Desease Name
Tuberculosis, susceptibility to
BCG infection, generalized familial
Hepatitis B virus infection, susceptibility to
H. pylori infection, susceptibility to
Mycobacterial infection, atypical, familial disseminated
Mycobacterium tuberculosis infection, protection against
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of IFNGR1 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of IFNGR1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IFNGR1 proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in increased expression of IFNGR1 proteinincreases expression 16085646
C068073 Am 580 Am 580 results in increased expression of IFNGR1 proteinincreases expression 16085646
C068073 Am 580 Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein]decreases reaction|increases expression 16085646
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IFNGR1 mRNAaffects expression 16483693
D000666 Amphotericin B Amphotericin B results in increased expression of IFNGR1increases expression 12803856
D000967 Antimony Sodium Gluconate Antimony Sodium Gluconate results in increased expression of IFNGR1 mRNAincreases expression 12803856
D000967 Antimony Sodium Gluconate Antimony Sodium Gluconate results in increased expression of IFNGR1 proteinincreases expression 12803856
D001554 Benzene Benzene results in increased expression of IFNGR1 mRNAincreases expression 15929907
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IFNGR1 mRNAdecreases expression 19150397
C095105 bexarotene bexarotene results in increased expression of IFNGR1 mRNAincreases expression 16648578
C006780 bisphenol A bisphenol A results in decreased expression of IFNGR1 mRNAdecreases expression 20678512
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of IFNGR1 mRNAaffects expression 12734012
C007262 deoxynivalenol deoxynivalenol inhibits the reaction [IFNG protein results in increased expression of IFNGR1 protein]decreases reaction|increases expression 19549553
C007262 deoxynivalenol deoxynivalenol results in decreased expression of IFNGR1 mRNAdecreases expression 17090620
D004041 Dietary Fats Dietary Fats results in decreased expression of IFNGR1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of IFNGR1 mRNAincreases expression 19638242
D004391 Dust Dust results in decreased expression of IFNGR1 mRNAdecreases expression 17805423
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IFNGR1 mRNAaffects cotreatment|increases expression 17942748
C041786 palm oil palm oil results in decreased expression of IFNGR1 mRNAdecreases expression 18042831
D010419 Pentamidine Pentamidine results in increased expression of IFNGR1 mRNAincreases expression 12803856
D010419 Pentamidine Pentamidine results in increased expression of IFNGR1 proteinincreases expression 12803856
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of IFNGR1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of IFNGR1 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of IFNGR1 mRNAincreases expression 18301758
C487081 PXD101 PXD101 results in increased expression of IFNGR1 mRNAincreases expression 19606018
C084904 Ro 41-5253 Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein]decreases reaction|increases expression 16085646
C017947 sodium arsenite sodium arsenite results in increased expression of IFNGR1 mRNAincreases expression 12016162
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IFNGR1 mRNAincreases expression 12377990
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IFNGR1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IFNGR1 mRNAdecreases expression 19933214
D014212 Tretinoin Tretinoin results in increased expression of IFNGR1 proteinincreases expression 16085646
C066075 vanadium pentoxide vanadium pentoxide results in decreased expression of IFNGR1 mRNAdecreases expression 17459161
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.486195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8918653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7514692618
MESH:D000236 Adenoma Diethylnitrosamine 2.716695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.8217162532 17620307 18056438 19052882 16434500 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.8217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.8216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6517306315 16712894
MESH:D017088 AIDS-Related Opportunistic Infections Pentamidine 6.1011806628
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000544 Alzheimer Disease Amphotericin B 4.4112755626
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000741 Anemia, Aplastic Benzene 4.1811369114 14761424 17661222
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D001161 Arteriosclerosis Dietary Fats 9.1015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.9912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.9916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001855 Bone Marrow Diseases Benzene 4.9816183116
MESH:D001862 Bone Resorption bisphenol A 3.6411985600
MESH:D001943 Breast Neoplasms alitretinoin 4.5316344269
MESH:D001943 Breast Neoplasms Benzene 4.5311921183 17162533
MESH:D001943 Breast Neoplasms bexarotene 4.5316344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 4.5317123778
MESH:D001943 Breast Neoplasms Dietary Fats 4.5320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.5317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5320435547
MESH:D001943 Breast Neoplasms Tretinoin 4.5316873071 16443354 16166294
MESH:D001991 Bronchitis vanadium pentoxide 5.9917459161
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5415673190 18705752 15700767 3786805 15721981 16124888 16227642 10355542 16050911 16011737 16097048 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.443084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.4421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.4418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.4420935162 17428255 20007298 17173139 16830150 18788625 20512989 18210153 16807293 19171122 18665156 16328049 16540662 20214788 19822196 19539802 10737359 17978847 18785209 19919837 3581430 18506893 16779866 20514400 18971187 16288022 11831363 3084413 21159647 20727157 19394651 16878318 16698587 17055752 18978308 10672840 19519916 19701751 18494052 16935385 20084675 19208518 19107877 17761372 19383236 16502159 17162532 16569478 20101231 19052882 20524982 17138121 19335982 18393292 19418558 16681979 18056438 18691550 20432363
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.4417173139 1701930 20935162 6705139 20007298
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.4415276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.441917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7417123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1416247446
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.4418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.4416096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2318850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 11.6410977129
MESH:D002386 Cataract Am 580 11.6417460283
MESH:D002386 Cataract Tretinoin 11.6417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.2420889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.2417174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.2420056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.014080065
MESH:D002524 Cerebellar Ataxia Antimony Sodium Gluconate 6.3516432602
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1511677210 17681005 15861022 16919318 17333356 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 7.1519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4215668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Am 580 9.1317035595
MESH:D003092 Colitis Tretinoin 9.1317035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 3.6815643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6810048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.689211117 16925845 9142499 10589399 14991402 17551590 9664655 9125849 9224671 8800419
MESH:D003872 Dermatitis Benzene 4.5215902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.3218071297 19923254 11461765 11743745 11287661 14550746 17906064 12392966 16227642 12153990 11834606 10774834 16109766 19164858 16177239 10663392 14986274 17562736 19085960 16393943 12705907 12540782 12958197 12594235 15968718 15619225 16081117 11739529 11421492 19370779 10915739 11529661 17522070 2444490 19416960 19420014 14725611 18713872 19739265 16485898 16781746
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.3211566570 17522070 7120509 15968718 6884620 9327722 7179309 4309450 19336974 10915739 6623471 2869522 3732212 21278145 15027814 19085960 15998439 16227642 10092053 16177239 3786805 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.3219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2818367378
MESH:D004421 Dystonia Phenobarbital 3.781851702
MESH:D004487 Edema pirinixic acid 5.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9512538720
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.623922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.346401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.773659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2416938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.3012795759 15959796 12631006 19224547 61145 16239168 17595544 16045604
MESH:D005234 Fatty Liver Dietary Fats 22.3019004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 22.3021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.3015345470
MESH:D005234 Fatty Liver pirinixic acid 22.3020131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 19.1618705752
MESH:D005355 Fibrosis Dietary Fats 19.1618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.1620067830
MESH:D005355 Fibrosis Tretinoin 19.1617994277
MESH:D005756 Gastritis Acetaminophen 3.4316983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4316452187
MESH:D005909 Glioblastoma Tretinoin 2.8517312396
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.8216524712 15173396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.1114991402 9664655
MESH:D006331 Heart Diseases Antimony Sodium Gluconate 4.7811049798
MESH:D006333 Heart Failure pirinixic acid 2.3920558911
MESH:D016481 Helicobacter Infections marker/mechanism
MESH:D006402 Hematologic Diseases Benzene 4.4316183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3619110552 19900420
MESH:D006509 Hepatitis B marker/mechanism
MESH:D006529 Hepatomegaly Phenobarbital 12.9816109766
MESH:D006529 Hepatomegaly pirinixic acid 12.9818467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.9815340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 2.9512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8016354765 8697196 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.9916870215
MESH:D006930 Hyperalgesia Tretinoin 6.9916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3921332399
MESH:D006973 Hypertension Benzene 5.0017940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1017937319
MESH:D007248 Infertility, Male sodium arsenite 6.1012646999 15346721
MESH:D007249 Inflammation Dietary Fats 7.5320412841
MESH:D007249 Inflammation Diethylnitrosamine 7.5318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5312200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 11.4116393666
MESH:D007333 Insulin Resistance Dietary Fats 11.4111836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 11.4116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.3916144296
MESH:D007674 Kidney Diseases Acetaminophen 5.5015629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 5.5020008137
MESH:D007896 Leishmaniasis Amphotericin B 14.3221063981 20404924 17205440
MESH:D007896 Leishmaniasis Antimony Sodium Gluconate 14.328059918 20139272 7960131 7945751
MESH:D007896 Leishmaniasis Pentamidine 14.3215340016
MESH:D016773 Leishmaniasis, Cutaneous Antimony Sodium Gluconate 8.9619744259 7682386 1329273 8407083 14512915 9234779 10886148 9770149 10233236 10617787 7570843 1323630 12032913 17278657 7724530 10542306 1311351 15234329 10647737 9314461 15610669 9499605 1314873 1322070 15259478 20438389 15678803 11528583 10786029 2160914 9299828 2166429
MESH:D016773 Leishmaniasis, Cutaneous Pentamidine 8.9611806628 12453009 8889330 10617787
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony Sodium Gluconate 11.6016135192 2173461 1322070 1325634 7519887 1645930
MESH:D007897 Leishmaniasis, Mucocutaneous Pentamidine 11.6010881086
MESH:D007898 Leishmaniasis, Visceral Amphotericin B 12.7010603400 18765878 10569788 17911647 15868188 16131481 9625910 18087708 9756784 17035822 11049798 9498473 16269185 7983993
MESH:D007898 Leishmaniasis, Visceral Antimony Sodium Gluconate 12.701337639 10886148 11069076 9625910 9856145 7903366 1658990 10604050 15896700 9665985 1645929 8394861 10952587 1319700 12955641 12379707 10617787 15868188 18765878 10569788 20576500 7932924 9844051 11417033 1659303 12803856 9498473 1315396 17911647 9756784 7498017 8916804 16131481 7844400 7983993 11035738 11398119 12870129 2098410 7715298 12718341 15610669 15328135 10603400 9531339 15716043 15518175 1852133 17382981 1314709 11049798 8607595 10467834 16432602 10805470 17300636 12898450 1315397 11751149 16117959
MESH:D007898 Leishmaniasis, Visceral Pentamidine 12.707715298 10467834 12803856 16131481 1659303 7498017
MESH:D007938 Leukemia Benzene 6.1417119257 14694614 15935818 18335105
MESH:D007938 Leukemia Tretinoin 6.1417143497
MESH:D007951 Leukemia, Myeloid Benzene 8.9517506065
MESH:D007951 Leukemia, Myeloid Tretinoin 8.9516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.9319478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9316294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9919029980 17361223 16766008 9834237 17506722 16823087 17217047 17294898 16331271 17649720 12679006 17339181 17368321 19035177 17301526 17107899 16140955 19642359 16935935 16788101 15748426 17712046 19225113 19075265 16891316
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.6516943688 17174718 11408273 16221502 16239168 17334410 11903743 21278145 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 14.6518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.6520032147 18407596 18522880 19638242 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 14.6521047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.6612445418 17900296 15370692 15893842 18277467 16097048 18210741 15876570 18412020 12609069 17481882 18395095 17869086 20821823 18472332 18420326 17823541 18317297 15925388 15123356 17922224 18418968 18472094 18481824 12546737 16011737 15931870 11481614 17708605 12667390 18006644 17976157 17698563 17525996 12632514 12586293 16015684 18156304 17761835 18263696 18251166 18429990 14512876 17565644 18376398 10355542 18395914 15057751 15818738 18279442 12898905 16027843 17557913 15362042 18054572 16116963 16136751 14724832 14716496 17721639 15338365 14716833 12389079 17944888 16248980 18339082 17714472 15052691 15673190 18205269 16638106 18166357 14748882 16033810 12649538 15996030 18187930 12445421 12666154 18705752 14620537 15650968 15730626 15959796 17805973 12741479 17766677 13678700 12958196 16192424 12632512 17631135 17640975
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.6615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.6618397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 11.8419784758 16610002 19014921 16611625 12969438 12587719 19460945 11587558
MESH:D008107 Liver Diseases Antimony Sodium Gluconate 11.847570843
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.8417285989 15830285 16964402 15720792 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 11.8417034775
MESH:D008107 Liver Diseases Phenobarbital 11.8419363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7016899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.459163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.4519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.4519642983 18644402 2862719 15175105 21071580 12112319 18978307 19690152 20118626 18977376 20501860 20101389 16942905 19499222 19073162 19294768 19996281 20137499 20434301 18754104 20405173 19254457 19850985 19812893 20492335 9163691 19090486 12771043 15885732 19638242 2422723 20452335 10737359 21278145 19833225 18648771 21047994 19426721 19427195 19256749 20583210 21167192 19551842 19255062
MESH:D008113 Liver Neoplasms Phenobarbital 20.4519812893 15975961 19482888 19073162 21047994 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 20.4520007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 20.4516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.4516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 21.408603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 21.4012562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.4015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.4019539802 2563599 18544905 17854601 18079962 18093689 19009564 18308698 16267830 17942915 18775883 21159647 19519916 18282651 17174075 18253720 9362446 18164116 19004024 19126423 16842330 3124819
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.402563599 17172636 18308698 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.4012151625
MESH:D008171 Lung Diseases sodium arsenite 3.0119095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.5614698565
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.4314755239
MESH:D008175 Lung Neoplasms alitretinoin 12.4316413115
MESH:D008175 Lung Neoplasms Benzene 12.4312562636
MESH:D008175 Lung Neoplasms bexarotene 12.4317849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.436695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 12.4317306315 15276417 16712894 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.4311884234 19555203
MESH:D008175 Lung Neoplasms vanadium pentoxide 12.4312376484
MESH:D008223 Lymphoma Benzene 3.5617584886 17119257
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9011161223
MESH:D008231 Lymphopenia Antimony Sodium Gluconate 6.159770149
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.2012562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.0211921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.0215591091 19196722 19196723
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma sodium arsenite 3.2016487513 19082730
MESH:D008545 Melanoma Tretinoin 3.2016752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D009101 Multiple Myeloma Benzene 3.4917119195
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009165 Mycobacterium Infections, Atypical marker/mechanism
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2317484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.479029167 3581430
MESH:D009369 Neoplasms alitretinoin 10.8916946489
MESH:D009369 Neoplasms pirinixic acid 10.8917405874
MESH:D009369 Neoplasms sodium arsenite 10.8911559025
MESH:D009369 Neoplasms Tretinoin 10.8916594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4320056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.5319196722
MESH:D009421 Nervous System Malformations bisphenol A 15.0111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.0114600291
MESH:D009421 Nervous System Malformations Tretinoin 15.019125849
MESH:D009436 Neural Tube Defects Benzene 11.3115643154
MESH:D009436 Neural Tube Defects sodium arsenite 11.3112854658
MESH:D009436 Neural Tube Defects Tretinoin 11.319142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D009765 Obesity Dietary Fats 4.2218674790 21332399 19632207 17217161 18457598 16723640 20132043 11836018 20518802
MESH:D009765 Obesity pirinixic acid 4.2220558911
MESH:D009784 Occupational Diseases Benzene 3.9715612468 15576619 15727169 17178637 15913788 17479406 15935809 17119257 16737584
MESH:D010018 Osteomalacia Phenobarbital 4.1217016548
MESH:D010049 Ovarian Diseases bisphenol A 4.7411985600
MESH:D010051 Ovarian Neoplasms Benzene 7.5112562636
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.5117306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 7.5116936753
MESH:D010146 Pain Acetaminophen 5.9416870215
MESH:D010146 Pain Tretinoin 5.9416870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.0816540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.0816965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.0815976015
MESH:D010195 Pancreatitis Antimony Sodium Gluconate 4.947519887
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010518 Periodontitis Antimony Sodium Gluconate 5.911325634
MESH:D011020 Pneumonia, Pneumocystis Pentamidine 6.4715340016
MESH:D017499 Porokeratosis alitretinoin 5.7516144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.412563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.412563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.6910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6911222880 11896295 11399792 11118676
MESH:D017096 Prion Diseases Amphotericin B 6.6612755626
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.4316740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.4316039940
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.2512752131
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5410548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716116481 16283617
MESH:D012640 Seizures Phenobarbital 2.533137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.576407741
MESH:D012878 Skin Neoplasms sodium arsenite 8.7518572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7516192470
MESH:D012878 Skin Neoplasms Tretinoin 8.7516467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6916709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6112854658
MESH:D013163 Splenomegaly Antimony Sodium Gluconate 5.999665985
MESH:D013274 Stomach Neoplasms Benzene 3.3012562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3018456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.3017261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.7416045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013953 Thymus Neoplasms Benzene 4.7110850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.907505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.901399818
MESH:D013964 Thyroid Neoplasms Tretinoin 10.9016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5716051514
MESH:D014352 Trypanosomiasis Pentamidine 6.2615340016
MESH:D014376 Tuberculosis marker/mechanism
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.4217306315 11723127 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.7011813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.7016129372
MESH:D014591 Uterine Diseases bisphenol A 4.7614652134
MESH:D014594 Uterine Neoplasms Benzene 8.7912562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.7914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014652 Vascular Diseases sodium arsenite 4.1817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
Pathway ID Pathway Name
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04630 Jak-STAT signaling pathway
KEGG:05140 Leishmaniasis
KEGG:05162 Measles
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
KEGG:05145 Toxoplasmosis
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00033 binder Interferon gamma-1b Immunomodulatory Agents;Antiviral Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved