AutismKB 2.0

Annotation Detail for STRA8


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Basic Information Top
Gene Symbol:STRA8 ( - )
Gene Full Name: stimulated by retinoic acid gene 8 homolog (mouse)
Band: 7q33
Quick LinksEntrez ID:346673; OMIM: 609987; Uniprot ID:STRA8_HUMAN; ENSEMBL ID: ENSG00000146857; HGNC ID: 30653
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C096920 AGN 193109 AGN 193109 inhibits the reaction [Tretinoin results in increased expression of STRA8 mRNA]decreases reaction|increases expression 16574651
D007654 Ketoconazole Ketoconazole results in increased expression of STRA8 mRNAincreases expression 16461896
C406527 R 115866 R 115866 results in increased expression of STRA8 mRNAincreases expression 16461896
D014212 Tretinoin AGN 193109 inhibits the reaction [Tretinoin results in increased expression of STRA8 mRNA]decreases reaction|increases expression 16574651
D014212 Tretinoin Tretinoin results in increased expression of STRA8 mRNAincreases expression 16604517
16461896
16574651
D014212 Tretinoin Tretinoin results in increased expression of STRA8 mRNAincreases expression 17303670
D014801 Vitamin A Vitamin A results in increased expression of STRA8 mRNAincreases expression 16461896
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000015 Abnormalities, Multiple Vitamin A 5.2410992263
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000740 Anemia Vitamin A 4.8716960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 5.1416960172
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 5.5116456186
MESH:D001249 Asthma Vitamin A 5.5116732791
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 14.8916813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 14.8917426644 17377406
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.911917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D015362 Child Nutrition Disorders Vitamin A 6.0916153327
MESH:D002779 Cholestasis Vitamin A 4.5616175620
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 6.769407595
MESH:D002972 Cleft Palate Vitamin A 6.7616054864
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D003110 Colonic Neoplasms Vitamin A 3.0816267017 17219422
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.119142499 9664655 9224671 17551590 9211117 10589399 16925845 9125849 8800419 14991402
MESH:D019465 Craniofacial Abnormalities Vitamin A 3.1110992263
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.5916506275
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 3.5218289764
MESH:D015352 Dry Eye Syndromes Vitamin A 6.3416146918
MESH:C538011 Eales disease Vitamin A 6.239068938
MESH:D004480 Ectromelia Vitamin A 6.4316054864
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D005124 Eye Abnormalities Tretinoin 3.8416938888 9664655
MESH:D005327 Fetal Resorption Vitamin A 5.9816054864
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 7.6614991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 7.6610992263 16080930
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.7116490937 16877224 16292552 16863852 17436238 15707848
MESH:D015658 HIV Infections Vitamin A 3.9816960176
MESH:D006679 HIV Seropositivity Vitamin A 6.1417209195
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006986 Hypervitaminosis A Vitamin A 6.7816054864
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D019586 Intracranial Hypertension Vitamin A 6.4315955940
MESH:D007569 Jaw Abnormalities Tretinoin 4.2715992940 17551590
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 5.0019744259 1311351 8889330 2166429
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 4.8111332679
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3716766008 19225113 15748426 19029980 17712046 17361223 19035177 16788101 17368321 17649720 9834237 17301526 17107899 16140955 19642359 17506722 17339181 12679006 17217047 16823087 16331271 16935935 17294898 19075265 16891316
MESH:D017880 Limb Deformities, Congenital Tretinoin 9.349224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 9.3416054864
MESH:D008064 Lipidoses Ketoconazole 4.8117567588
MESH:D008103 Liver Cirrhosis Vitamin A 4.0516256175
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.9718397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 2.9716248980
MESH:D008107 Liver Diseases Vitamin A 3.2116175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 5.6416762690
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 3.8817113696
MESH:D008171 Lung Diseases Vitamin A 4.3216863852
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009101 Multiple Myeloma Vitamin A 4.3016374440
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009369 Neoplasms Tretinoin 2.5516594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects Tretinoin 8.389142499
MESH:D009436 Neural Tube Defects Vitamin A 8.3817400914
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D011471 Prostatic Neoplasms Ketoconazole 4.5017404083
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 6.3416877224
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016116481 16283617
MESH:D012871 Skin Diseases Vitamin A 3.4218709164
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014802 Vitamin A Deficiency Vitamin A 5.6816175781 16146918 16960172
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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