AutismKB 2.0

Annotation Detail for SLC35B2


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Basic Information Top
Gene Symbol:SLC35B2 ( PAPST1,SLL,UGTrel4 )
Gene Full Name: solute carrier family 35, member B2
Band: 6p21.1
Quick LinksEntrez ID:347734; OMIM: 610788; Uniprot ID:S35B2_HUMAN; ENSEMBL ID: ENSG00000157593; HGNC ID: 16872
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500363Transport of nucleotide sugars
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC35B2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SLC35B2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SLC35B2 mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SLC35B2 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SLC35B2 mRNAaffects cotreatment|increases expression 18164116
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SLC35B2 mRNAincreases expression 17616710
D010269 Paraquat Paraquat affects the expression of SLC35B2 mRNAaffects expression 16854511
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma beta-Naphthoflavone 7.3719389873
MESH:D000236 Adenoma Diethylnitrosamine 7.376695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3017620307 19061943 16434500 19052882 18056438 17162532
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.1611874814
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.853084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8518056438 16502159 18971187 19107877 16698587 18788625 18506893 10672840 20935162 17761372 17978847 20514400 20007298 20512989 20524982 16569478 17428255 17055752 18210153 16935385 17173139 17162532 19701751 20101231 16830150 19208518 17138121 16878318 11831363 18494052 16540662 19383236 19822196 18978308 16807293 19919837 16288022 20214788 19418558 16328049 19052882 18393292 10737359 20727157 21159647 18785209 18665156 16779866 18691550 20084675 19539802 19335982 19394651 3581430 16681979 20432363 19171122 19519916 3084413
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.316135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.317505956 2727394 21159647 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5512958197 14550746 16081117 11287661 14986274 12392966 15968718 12540782 19085960 10774834 2444490 10663392 14725611 18713872 19420014 11739529 19923254 18071297 12594235 19370779 16177239 10915739 19164858 16485898 15619225 17562736 11834606 12153990 17906064 16393943 11421492 11743745 11461765 11529661 19416960 12705907 16227642 16109766 19739265 16781746 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.5519107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.8315150132 15878914 15623463 16510608 16704527 15264214 15547733 15547721 16805852
MESH:D005234 Fatty Liver Diethylnitrosamine 3.4621071580 20387270
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005911 Gliosis Paraquat 5.6111124998
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007248 Infertility, Male Paraquat 3.424850670
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9618522880 19638242 18665156 20032147 18407596
MESH:D008107 Liver Diseases Acetaminophen 4.1011587558 19014921 16610002 19784758 12587719 16611625 12969438 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1017034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.047678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 8.0419389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0420434301 20137499 18977376 20492335 19812893 10737359 20452335 19255062 15175105 18644402 21167192 19427195 19850985 19090486 15885732 2422723 20101389 20583210 19294768 19073162 18648771 19256749 19254457 20501860 19690152 19551842 21278145 19642983 16942905 21071580 19499222 19638242 19833225 19426721 21047994 2862719 12112319 20118626 18754104 19996281 9163691 12771043 18978307 20405173
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.872876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.8718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.8719539802 18093689 18544905 18282651 16842330 2563599 18079962 19126423 16267830 19519916 21159647 18164116 18308698 17174075 17854601 9362446 19009564 3124819 19004024 18775883 17942915 18253720
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 20970405 6695378 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.707678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.663581430 9029167
MESH:D009410 Nerve Degeneration Paraquat 3.9316893418
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.9720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D010300 Parkinson Disease Paraquat 2.9011445065 16140633 16510128 12911755 15451049 11124998 15824117 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.7916190885
MESH:D011014 Pneumonia Paraquat 4.8512504350
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D011658 Pulmonary Fibrosis Paraquat 3.0017997886 16324872
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.2111700416
MESH:D012135 Respiratory Sounds Paraquat 4.4111874814
MESH:D012162 Retinal Degeneration Paraquat 4.0716458197
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6718456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6712958204 17575124
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3216049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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