AutismKB 2.0

Annotation Detail for APOE


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Basic Information Top
Gene Symbol:APOE ( AD2,LDLCQ5,LPG,MGC1571 )
Gene Full Name: apolipoprotein E
Band: 19q13.32
Quick LinksEntrez ID:348; OMIM: 107741; Uniprot ID:APOE_HUMAN; ENSEMBL ID: ENSG00000130203; HGNC ID: 613
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05010Alzheimer's disease
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500795Lipoprotein metabolism
500797HDL-mediated lipid transport
500796Chylomicron-mediated lipid transport
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
H00156Hyperlipoproteinemia, type III
Neurodegenerative diseases
Inherited disorders of lipid/glycolipid metabolism
H00056Alzheimer's disease
Genetic disorders
Desease IDDesease Name
1712Yersinia infection
1716Hypoglycemia
1731Growth retardation
1735Learning disorder
1781Rheumatoid arthritis
1811Drug-Induced dyskinesia
1822Infectious lung disease
1828Encephalitis
1831Prostate cancer
1840Macular degeneration
1848Embryoma
1850Herpes
1859Ovarian cancer
1870Drug abuse
1872Chronic simple glaucoma
1878Ischemia
1883Polycystic kidney
1902Kidney failure
1904Diabetes mellitus
1907Depression
1914Cerebrovascular disorder
1944Breast cancer
1958Glomerulonephritis
1972Histiocytosis
1983Down syndrome
1991Mycoses
1994Biliary cancer
1997Dental plaque
2008Liver disease
2022Liver cancer
2060Glaucoma
2062Neurodegenerative disorder
2070Cholelithiasis
2085Vascular dementia
2039Hyperhomocysteinemia
2097Hyperlipidemia
2124Autistic disorder
2126Encephalopathies
1874Stress disorder, post-traumatic
2134Amyotrophic lateral sclerosis
2145Subarachnoid hemorrhage
2146Lupus erythematosus
2184Rectum cancer
2198Psychotic disorder
2203Nephrosis
2220Dermatitis
2233Cirrhosis
2236Cardiovascular disease
1882Malaria
Desease Name
hypercholesterolemia
HDL cholesterol
Lupus Erythematosus, Systemic
persistent vegetative state
type III hyperlipoproteinemia
cholesterol
Macular Degeneration
diabetic nephropathy
anti-atherogenic lipoprotein profile
cholesterol cholesterol, HDL cholesterol, LDL lipoprotein triglycerides
aneurysmal subarachnoid hemorrhage
cognitive function
cardiovascular disease
Parkinson's disease
cholesterol, HDL
rapid motor decline
endogenous hypertriglyceridemia and familial hypercholesterolemia
AGING
Alzheimer`s Disease
lipid metabolism disorders
atherosclerosis, coronary
C-reactive protein
CARDIOVASCULAR
Coronary Artery Disease
myocardial infarct
diabetes, type 1
cholesterol, LDL
early onset ischemic heart disease.
left-handedness and visuospatial skills
high coronary heart disease risk particularly affects ser
neuropathy, Alzheimer's disease related
Alzheimer's disease
Creutzfeldt-Jakob disease
Bone Mineral Density
altered brain levels of apolipoprotein E
PSYCH
Plasma Lipid Levels
arterial wall thickness
Coronary Disease
PHARMACOGENOMIC
lipids
warfarin sensitivity
nephropathy, diabetic
RENAL
apoB-100
hypertension
multiple sclerosis
Severe type III hyperlipoproteinemia
premature coronary heart disease.
lipoprotein
memory decline
cardiovascular
selenium
IMMUNE
apoE
NEUROLOGICAL
Alzheimer Disease
apolipoprotein E mutation [apolipoprotein E (delta149 Leu)]
traumatic brain injury.
glaucoma, primary open-angle
hyperlipidemia
sleep-disordered breathing
quantitative traits
Confusion
outcome after head injury
schizophrenia
METABOLIC
Epilepsy, Temporal Lobe
Stroke
Myocardial Infarction
dementia, vascular
VISION
glaucoma
LDL cholesterol
triglycerides
Gout
Alzheimer's disease (late onset)
obesity
preeclampsia
psoriasis
bulbar-onset motor neuron disease
cholesterol, total
coronary heart disease
familial dysbetalipoproteinemia
Psychomotor Agitation
cerebrovascular disease
diabetes, type 2
cholesterol, HDL cholesterol, LDL
Dementia
longevity
apoA1
anticholinergic challenge-induced memory impairment
carotid atherosclerosis
differential expansion rates of small abdominal aortic aneurysms
Hypertension/complications*
cognitive ability
temporal lobe epilepsy
life expectancy
Down Syndrome
serum lipids
Traumatic Brain Imjury
Brain imaging
Desease Name
Alzheimer's disease (late onset)
Brain imaging
Alzheimer's disease
C-reactive protein
Cardiovascular disease risk factors
LDL cholesterol
Desease Name
Myocardial infarction susceptibility
Alzheimer disease-2
Hyperlipoproteinemia, type III
Lipoprotein glomerulopathy
Sea-blue histiocyte disease
Macular degeneration, age-related
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000074 Acenocoumarol APOE gene polymorphism affects the susceptibility to Acenocoumarolaffects response to substance 15861030
D000082 Acetaminophen Acetaminophen affects the expression of APOE proteinaffects expression 16099942
D000082 Acetaminophen Acetaminophen results in decreased expression of APOE proteindecreases expression 16687475
D000109 Acetylcholine APOE protein affects the susceptibility to Acetylcholineaffects response to substance 17899169
D000171 Acrolein Acrolein affects the folding of APOE proteinaffects folding 17580963
D000171 Acrolein Acrolein results in decreased activity of APOE proteindecreases activity 17580963
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of APOE proteinaffects expression 20106945
C096920 AGN 193109 AGN 193109 inhibits the reaction [Tretinoin results in increased expression of APOE mRNA]decreases reaction|increases expression 16505366
D013196 Dihydrotestosterone APOE gene polymorphism affects the reaction [Dihydrotestosterone affects the phosphorylation of MAPK10 protein]affects phosphorylation|affects reaction 17395708
D013196 Dihydrotestosterone APOE gene polymorphism affects the reaction [Dihydrotestosterone affects the phosphorylation of MAPK9 protein]affects phosphorylation|affects reaction 17395708
D013196 Dihydrotestosterone APOE gene polymorphism affects the susceptibility to Dihydrotestosteroneaffects response to substance 17395708
C061621 alpha-naphthyl isocyanate alpha-naphthyl isocyanate affects the expression of APOE proteinaffects expression 16099942
D000638 Amiodarone Amiodarone results in decreased expression of APOE mRNAdecreases expression 17991464
D000643 Ammonium Chloride Ammonium Chloride affects the expression of APOE mRNAaffects expression 16483693
D001151 Arsenic APOE polymorphism results in increased susceptibility to Arsenicincreases response to substance 18022660
C065179 atorvastatin [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with atorvastatin co-treated with valsartan] results in decreased expression of APOE proteinaffects cotreatment|decreases expression 19603250
D001629 Bezafibrate [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with atorvastatin co-treated with valsartan] results in decreased expression of APOE proteinaffects cotreatment|decreases expression 19603250
C053342 brevetoxin brevetoxin analog results in decreased expression of APOE mRNAdecreases expression 14529743
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of APOE mRNAincreases expression 15336504
D002118 Calcium APOE protein affects the abundance of Calciumaffects abundance 17899169
D002118 Calcium Calcium affects the expression of APOE mRNAaffects expression 15913539
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of APOE proteinincreases expression 16845489
D002784 Cholesterol APOE protein affects the susceptibility to Cholesterolaffects response to substance 16179587
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of APOE mRNAaffects cotreatment|decreases expression 19509184
D008076 Cholesterol, HDL APOE gene polymorphism affects the abundance of Cholesterol, HDLaffects abundance 16030523
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of APOE mRNAdecreases expression 15331540
D016572 Cyclosporine Cyclosporine results in decreased expression of APOE mRNAdecreases expression 20106945
C017160 cypermethrin cypermethrin results in decreased expression of APOE mRNAdecreases expression 9650644
11428908
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of APOE mRNAaffects cotreatment|decreases expression 19509184
D004041 Dietary Fats Dietary Fats results in decreased expression of APOE mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of APOE proteinaffects cotreatment|increases expression 20935162
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of APOE mRNAincreases expression 15766595
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of APOE mRNAdecreases expression 15171707
D004176 Dipyridamole [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with atorvastatin co-treated with valsartan] results in decreased expression of APOE proteinaffects cotreatment|decreases expression 19603250
D004656 Enalapril [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with atorvastatin co-treated with valsartan] results in decreased expression of APOE proteinaffects cotreatment|decreases expression 19603250
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of APOE mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of APOE mRNAdecreases expression 14976129
16174780
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of APOE mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of APOE mRNAdecreases expression 17351261
17557909
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of APOE mRNAincreases expression 16174780
D015025 Zearalenone Zearalenone results in decreased expression of APOE mRNAdecreases expression 19371625
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of APOE mRNAaffects cotreatment|decreases expression 19509184
C100093 gentamicin C APOE protein inhibits the reaction [gentamicin C results in decreased expression of and results in decreased activity of SLC5A1 protein]decreases activity|decreases expression|decreases reaction 15777622
C100093 gentamicin C APOE protein inhibits the reaction [gentamicin C results in decreased expression of SLC5A1 mRNA]decreases expression|decreases reaction 15777622
C100093 gentamicin C APOE protein results in decreased uptake of gentamicin Cdecreases uptake 15777622
C473027 GW 3965 GW 3965 results in increased expression of APOE mRNAincreases expression 17449538
C029424 hydrazine hydrazine results in decreased expression of APOE mRNAdecreases expression 15370871
C029424 hydrazine hydrazine results in decreased expression of APOE proteindecreases expression 15370871
D000960 Hypolipidemic Agents Hypolipidemic Agents results in decreased expression of APOE proteindecreases expression 19603250
D007501 Iron APOE gene polymorphism results in increased susceptibility to Ironincreases response to substance 15993987
D007657 Ketone Bodies Ketone Bodies results in increased expression of APOE mRNAincreases expression 16807920
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of APOE mRNAdecreases expression 16847310
C029938 nickel sulfate nickel sulfate results in decreased expression of APOE mRNAdecreases expression 16780908
C029938 nickel sulfate nickel sulfate results in increased expression of APOE mRNAincreases expression 16780908
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of APOE mRNAdecreases expression 17616710
D010126 Ozone Ozone results in decreased expression of APOE mRNAdecreases expression 12763052
C041786 palm oil palm oil results in decreased expression of APOE mRNAdecreases expression 18042831
C084656 paricalcitol [Phosphorus co-treated with paricalcitol] results in decreased expression of APOE mRNAaffects cotreatment|decreases expression 17715259
D010634 Phenobarbital Phenobarbital affects the expression of APOE proteinaffects expression 16099942
D010634 Phenobarbital [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of APOE proteinaffects cotreatment|increases expression 20935162
D010656 Phenylephrine APOE protein affects the susceptibility to Phenylephrineaffects response to substance 17899169
D010672 Phenytoin Phenytoin results in increased expression of APOE mRNAincreases expression 15136057
D010758 Phosphorus [Phosphorus co-treated with paricalcitol] results in decreased expression of APOE mRNAaffects cotreatment|decreases expression 17715259
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP51 mRNA]affects reaction|increases expression 18155511
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP7B1 mRNA]affects reaction|increases expression 18155511
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS1 mRNA]affects reaction|increases expression 18155511
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS2 mRNA]affects reaction|increases expression 18155511
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCR mRNA]affects reaction|increases expression 18155511
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCS1 mRNA]affects reaction|increases expression 18155511
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HSD17B7 mRNA]affects reaction|increases expression 18155511
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of LPIN1 mRNA]affects reaction|increases expression 18155511
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of PPARGC1B mRNA]affects reaction|increases expression 18155511
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of SQLE mRNA]affects reaction|increases expression 18155511
C006253 pirinixic acid pirinixic acid affects the expression of APOE proteinaffects expression 16099942
C025299 polyphenols polyphenols results in decreased expression of APOE proteindecreases expression 16046716
D011794 Quercetin Quercetin results in increased expression of APOE mRNAincreases expression 16455785
C059514 resveratrol resveratrol results in increased expression of APOE mRNAincreases expression 19371625
C009166 retinol acetate retinol acetate results in increased expression of APOE mRNAincreases expression 16772331
D012643 Selenium Selenium results in increased expression of APOE mRNAincreases expression 19244175
D012643 Selenium Selenium affects the expression of APOE proteinaffects expression 17996733
C017947 sodium arsenite sodium arsenite results in decreased expression of APOE mRNAdecreases expression 19822182
D013311 Streptozocin Streptozocin results in increased expression of APOE mRNAincreases expression 16684804
D013311 Streptozocin vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of APOE mRNA]decreases reaction|increases expression 16684804
D013629 Tamoxifen APOE gene polymorphism affects the susceptibility to Tamoxifenaffects response to substance 19103187
D013629 Tamoxifen Tamoxifen affects the expression of APOE mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of APOE mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin APOE protein affects the susceptibility to Tetrachlorodibenzodioxinaffects response to substance 12213967
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of APOE mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of APOE mRNAdecreases expression 15703262
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of APOE mRNAincreases expression 16267337
C423915 TO-901317 TO-901317 results in increased expression of APOE mRNAincreases expression 17449538
C423915 TO-901317 TO-901317 results in increased expression of APOE mRNAincreases expression 19665519
C024746 tobacco tar tobacco tar results in decreased expression of APOE mRNAdecreases expression 19559774
C066340 tolcapone tolcapone binds to APOE proteinaffects binding 19783845
D014212 Tretinoin AGN 193109 inhibits the reaction [Tretinoin results in increased expression of APOE mRNA]decreases reaction|increases expression 16505366
D014212 Tretinoin Tretinoin results in increased expression of APOE mRNAincreases expression 16505366
D014331 Tropicamide APOE gene polymorphism results in increased susceptibility to Tropicamideincreases response to substance 8724673
9137131
C081489 valsartan [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with atorvastatin co-treated with valsartan] results in decreased expression of APOE proteinaffects cotreatment|decreases expression 19603250
C081489 valsartan valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein]decreases expression|decreases reaction 17785354
C034028 vanadyl sulfate vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of APOE mRNA]decreases reaction|increases expression 16684804
D014812 Vitamin K APOE protein affects the abundance of Vitamin Kaffects abundance 15952022
D014812 Vitamin K APOE protein affects the uptake of Vitamin Kaffects uptake 16847429
D014859 Warfarin APOE gene polymorphism affects the susceptibility to Warfarinaffects response to substance 17325732
16847429
17048007
D014859 Warfarin APOE protein affects the susceptibility to Warfarinaffects response to substance 15952022
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.8614745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.496195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 10.4910563481 9677735 6195326 8986270 3425630 9118846
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.4911752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 2.8918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.2617505938
MESH:D058186 Acute Kidney Injury resveratrol 3.2616538975
MESH:D055371 Acute Lung Injury Acrolein 16.7521297076 20525806
MESH:D055371 Acute Lung Injury Lipopolysaccharides 16.7518653653 11850527
MESH:D055371 Acute Lung Injury nickel sulfate 16.7516100012 19131640 12718980 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 16.7518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.6214692618
MESH:D000236 Adenoma Diethylnitrosamine 5.456695378 10737359
MESH:D000236 Adenoma resveratrol 5.4515688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.3819061943 16434500 17620307 17162532 19052882 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.3817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.3816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.3816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.0115276417
MESH:D018246 Adrenocortical Adenoma Arsenic 11.5217306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 11.5217306315 16712894
MESH:D000382 Agricultural Workers' Diseases cypermethrin 4.2716487989
MESH:D017109 Akathisia, Drug-Induced tolcapone 5.6111080934
MESH:D000505 Alopecia Tretinoin 3.0715955085
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 4.9816640825
MESH:D000544 Alzheimer Disease marker/mechanism 19734902
MESH:D000544 Alzheimer Disease Acrolein 13.1414715435 17570602 15207723
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 13.1420157255
MESH:D000544 Alzheimer Disease Iron 13.1416640825 16563566
MESH:D000544 Alzheimer Disease Ozone 13.1415513908
MESH:D000544 Alzheimer Disease resveratrol 13.1416162502 16183991
MESH:D000544 Alzheimer Disease tolcapone 13.1420150427
MESH:C536595 Alzheimer disease type 2 marker/mechanism
MESH:D000686 Amyloidosis marker/mechanism 15993987
MESH:D000686 Amyloidosis Diethylstilbestrol 3.8415469931
MESH:D000740 Anemia Iron 6.9716434484 16566752
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.9711748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.6317084956
MESH:D018798 Anemia, Iron-Deficiency Iron 4.0617375513 16569441 17163184 17162259 17147795
MESH:D000756 Anemia, Sideroblastic Iron 4.2016910769
MESH:D000799 Angioedema Acetaminophen 3.1610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 11.6618057881 20041841 18218290
MESH:D001145 Arrhythmias, Cardiac Iron 11.6616604332
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 11.6617460149
MESH:D020261 Arsenic Poisoning Arsenic 2.6416835338 16251483 18414634 12569548
MESH:D001161 Arteriosclerosis Acrolein 25.0615014928
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 25.0615552841
MESH:D001161 Arteriosclerosis Cyclophosphamide 25.0615014928
MESH:D001161 Arteriosclerosis Dietary Fats 25.0615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 25.0611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 9.6615885639
MESH:D001169 Arthritis, Experimental resveratrol 9.6617115116
MESH:D001169 Arthritis, Experimental Tretinoin 9.6616412693
MESH:D001172 Arthritis, Rheumatoid Ozone 3.9615570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 3.9616292516
MESH:D001249 Asthma Ozone 4.0817854713 16373670
MESH:D001249 Asthma Tretinoin 4.0816456186
MESH:D001260 Ataxia Telangiectasia Iron 10.8815336622
MESH:D001260 Ataxia Telangiectasia Quercetin 10.8815336622
MESH:D050197 Atherosclerosis marker/mechanism 9169506
MESH:D050197 Atherosclerosis Acrolein 20.0616126721 16037261 17363696
MESH:D050197 Atherosclerosis Arsenic 20.0612928151 19371607
MESH:D050197 Atherosclerosis Cholesterol 20.0616632123
MESH:D050197 Atherosclerosis Iron 20.0616640825 16632123
MESH:D050197 Atherosclerosis Phenytoin 20.0615136057
MESH:D050197 Atherosclerosis resveratrol 20.0616873680 17967414
MESH:D001281 Atrial Fibrillation Amiodarone 3.3818651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Iron 2.1617352947
MESH:D001327 Autoimmune Diseases Quercetin 3.7519761891
MESH:D001424 Bacterial Infections Iron 4.5216640825
MESH:D001471 Barrett Esophagus Tretinoin 3.7616935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 17.0119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 17.0119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.0112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 17.0116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3015746008
MESH:D001919 Bradycardia Phenylephrine 3.8815306635
MESH:D002545 Brain Ischemia resveratrol 3.6217600658
MESH:D001943 Breast Neoplasms Cyclophosphamide 4.8418234424 15093573 17388661 15136595 11325840 16978400 17020986 12006526 18323546
MESH:D001943 Breast Neoplasms Dietary Fats 4.8420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.8417474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.8417129689 15324884
MESH:D001943 Breast Neoplasms Quercetin 4.8418628248
MESH:D001943 Breast Neoplasms resveratrol 4.8417651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 4.8417242785 15565566 16818667 17049068 19155303 15668708 20065188 19011961 20135344 19221464 18821012 19142967 18629630 20544844 19066611 18815881 18351453 16202921 19289846 19189212 18425577 19115204 11161223 19084267 18997820 16873071 18855134 17440819 19103187 17893378 19200415 19189210 19244106 19410462 21152245 21138602 17261762 19487384 20390343 20005174 18984771 19059307 20859285 19288272 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.8420435547
MESH:D001943 Breast Neoplasms Tretinoin 4.8416443354 16873071 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.1418417511 19059883 15516495 16777450 18315731 14754758 17626835
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9216813970
MESH:D002100 Cachexia Ozone 4.0716183385
MESH:D002105 Cadmium Poisoning Quercetin 4.8616962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.1318705752 16050911 3786805 15700767 10355542 15673190 16097048 16227642 16124888 16192424 16011737 15721981
MESH:D002276 Carcinoid Tumor Streptozocin 4.9216051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.2616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.1715504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.4716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 31.313084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 31.3112907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 31.3116507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 31.3118788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 31.3119701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 31.3120727157 20524982 18393292 17428255 19539802 16779866 16328049 16288022 16502159 11831363 19208518 19171122 3084413 19822196 17055752 17978847 19701751 17173139 17761372 17138121 18210153 20007298 16935385 20935162 20214788 18506893 19052882 21159647 16569478 20512989 18494052 19394651 10672840 19107877 20514400 18691550 18785209 18056438 20084675 3581430 16807293 16698587 16681979 19418558 19919837 17162532 18971187 19383236 20101231 10737359 18978308 18665156 19519916 16540662 16878318 16830150 20432363 19335982 18788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 31.3116924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 31.3120935162 1701930 6705139 17173139 20007298
MESH:D006528 Carcinoma, Hepatocellular Quercetin 31.3119519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 31.3119321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 31.3117306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 31.3116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 31.311917145
MESH:D006528 Carcinoma, Hepatocellular Vitamin K 31.3116328049
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 9.2616152834
MESH:D018827 Carcinoma, Lewis Lung resveratrol 9.2616675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.3017234771
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.1816201981
MESH:D002294 Carcinoma, Squamous Cell Arsenic 8.7215504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell resveratrol 8.7216227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 8.7218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.7216051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 7.5418640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.5417572228
MESH:D006332 Cardiomegaly atorvastatin 17.1018360054
MESH:D006332 Cardiomegaly Phenylephrine 17.1015728586 11754973 17124262 17287366 11179087 16170337
MESH:D006332 Cardiomegaly Quercetin 17.1019794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 17.1018670907 18850075 16120746
MESH:D006332 Cardiomegaly valsartan 17.1019597038
MESH:D009202 Cardiomyopathies Iron 6.9316640825
MESH:D009202 Cardiomyopathies valsartan 6.9316247790
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.2115710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Iron 5.2116604332
MESH:D002318 Cardiovascular Diseases Arsenic 9.5515738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases resveratrol 9.5515458977
MESH:D002318 Cardiovascular Diseases valsartan 9.5511230374
MESH:D002340 Carotid Artery Diseases marker/mechanism 18022660
MESH:D002340 Carotid Artery Diseases Arsenic 3.7316973168 18022660
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.4118974383
MESH:D016893 Carotid Stenosis marker/mechanism 17243563
MESH:D002386 Cataract Acetaminophen 5.7810977129
MESH:D002386 Cataract Tretinoin 5.7817460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.0712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.077505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 12.0719524636 20056578
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 12.0719559774
MESH:D002493 Central Nervous System Diseases Phenobarbital 9.494080065
MESH:D002493 Central Nervous System Diseases Phenytoin 9.494080065
MESH:D016657 Cerebral Amyloid Angiopathy marker/mechanism 11061249
MESH:D002543 Cerebral Hemorrhage Warfarin 5.2011061249
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9216129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.4119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.4116835633
MESH:D002779 Cholestasis Cyclosporine 10.3519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.3517110522 11677210 15861022 17333356 16105132 17681005 16919318
MESH:D002779 Cholestasis pirinixic acid 10.3519176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.2011748493
MESH:D002822 Choriocarcinoma Tretinoin 4.4716461808
MESH:D002971 Cleft Lip Phenytoin 3.762227380
MESH:D002972 Cleft Palate Phenytoin 7.976856622 3877104 2227380 10789828 6862529 1687470
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 7.9712621046 15340226 15668235 16354765 8697196
MESH:D002972 Cleft Palate Tretinoin 7.979407595
MESH:D003092 Colitis resveratrol 12.2716474422
MESH:D003092 Colitis Selenium 12.2717936198
MESH:D003092 Colitis Tretinoin 12.2717035595
MESH:D003103 Coloboma Phenytoin 4.549212184
MESH:D003110 Colonic Neoplasms Iron 6.8916640825
MESH:D003110 Colonic Neoplasms polyphenols 6.8916293270
MESH:D003110 Colonic Neoplasms Quercetin 6.8919440933 11134977 15741050 16640504 19056647 17191121 17148506
MESH:D003110 Colonic Neoplasms resveratrol 6.8916338953
MESH:D015179 Colorectal Neoplasms Acrolein 3.1717597105
MESH:D015179 Colorectal Neoplasms Quercetin 3.1718095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 3.1716550006
MESH:D000013 Congenital Abnormalities Phenytoin 7.4810627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.4814669216 17141729
MESH:D003324 Coronary Artery Disease atorvastatin 5.9216368305
MESH:D003324 Coronary Artery Disease valsartan 5.9217719468
MESH:D003327 Coronary Disease Fructose 7.2318504504
MESH:D003327 Coronary Disease resveratrol 7.2316507316
MESH:D023903 Coronary Restenosis Warfarin 5.0412872399
MESH:D003371 Cough Enalapril 5.5411725383
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.2020579077 20497562
MESH:D003384 Coxsackievirus Infections valsartan 5.1720392896
MESH:D006259 Craniocerebral Trauma marker/mechanism
MESH:D019465 Craniofacial Abnormalities Phenytoin 3.318986270 9212184 19952982
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.3115322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.319664655 10589399 14991402 17551590 9125849 16925845 8800419 9142499 9224671 9211117
MESH:D003456 Cryptorchidism Diethylstilbestrol 3.9216002989 12952375
MESH:D003556 Cystitis Acrolein 9.8112161096
MESH:D003556 Cystitis Cyclophosphamide 9.8110700343 12913760 17010015 17979934 18295254 18433785 16651033 15643279 18483878 18710439 12161096 12388444 10498854 16989017 18093676 16413132 18372110 16614059 11948286 15276878
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7119031437
MESH:D003866 Depressive Disorder tolcapone 3.8111224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 4.3310440460
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.0711298694 16780908 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.0718249437
MESH:D003920 Diabetes Mellitus Iron 7.9216640825 16604332
MESH:D003920 Diabetes Mellitus Streptozocin 7.9216285004
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 30.3311751995 10990075 15331540
MESH:D003921 Diabetes Mellitus, Experimental Fructose 30.3318603373
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 30.3319496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 30.3316873680
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 30.3312093613 15862027 12644472 17874149 17442507 12083368 6379147 12446591 15298345 19586609 19298542 19496084 11055810 18715473 8740154 16286809 7637645 18603373 19960420 11260395 1374869 2177838 16684804 15831366
MESH:D003921 Diabetes Mellitus, Experimental valsartan 30.3311508273
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 30.3316684804
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 10.6618772604
MESH:D003922 Diabetes Mellitus, Type 1 Iron 10.6616506275
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 10.6618603373
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 10.6618772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 11.2720387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 11.2718603373
MESH:D003924 Diabetes Mellitus, Type 2 Iron 11.2716506275
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 11.2719586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 11.2717107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.0516025228
MESH:D003928 Diabetic Nephropathies resveratrol 22.0816286809
MESH:D003928 Diabetic Nephropathies Streptozocin 22.0819682444 19960420
MESH:D003928 Diabetic Nephropathies Tamoxifen 22.0819279558
MESH:D003928 Diabetic Nephropathies valsartan 22.0811427623 18630688
MESH:D003928 Diabetic Nephropathies Warfarin 22.0812644472
MESH:D003930 Diabetic Retinopathy Streptozocin 4.7817662242
OMIM:607208 DRAVET SYNDROME Phenytoin 4.7311748493
MESH:D003875 Drug Eruptions Phenytoin 10.8015024534
MESH:D003875 Drug Eruptions Warfarin 10.8014723717
MESH:D056486 Drug-Induced Liver Injury marker/mechanism 16099942
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.6317522070 14550746 16227642 17562736 11834606 10663392 14986274 19370779 15619225 19164858 11421492 12594235 15968718 11529661 12958197 16393943 19420014 12392966 10774834 19923254 19085960 2444490 16109766 12540782 14725611 12153990 12705907 16485898 19416960 11287661 16177239 11743745 18071297 18713872 16781746 16081117 19739265 17906064 11739529 11461765 10915739
MESH:D056486 Drug-Induced Liver Injury Amiodarone 17.6318218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.637120509 10092053 3732212 15027814 6884620 21278145 7179309 10915739 15998439 19336974 3786805 16177239 6623471 19085960 16227642 2869522 7440962 9327722 17522070 4309450 11566570 15968718
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.6319107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 17.6319370779
MESH:D056486 Drug-Induced Liver Injury Selenium 17.6315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.6320420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 17.6316604736 19783845
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.2511462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 4.7211455177
MESH:D050171 Dyslipidemias Dietary Fats 2.9518367378
MESH:D004417 Dyspnea cypermethrin 4.7116487989
MESH:D004421 Dystonia Phenobarbital 3.381851702
MESH:D004487 Edema pirinixic acid 8.0012083418
MESH:D004487 Edema resveratrol 8.008985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.6716714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 9.6718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.7712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 16.7717654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 16.7717872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.7719031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.0216402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 9.7615700306 16804899
MESH:D016889 Endometrial Neoplasms Tamoxifen 9.7620544844 19155303 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 9.7616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.449294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 3.7315328337 15821434 17637181
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.1917923197
MESH:D004802 Eosinophilia Cyclophosphamide 3.5711006010
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.5620235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.556251365 1399206
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.453659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.083922381 11558140
MESH:D004828 Epilepsies, Partial Phenytoin 8.0817116037 11558140
MESH:D004827 Epilepsy Phenobarbital 5.7320417680
MESH:D004827 Epilepsy Phenytoin 5.7311434505 20417680 821787
MESH:D004832 Epilepsy, Absence Phenobarbital 2.976401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.497750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 9.497750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.633659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 8.633659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.4316302075
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.5815878914 15623463 16510608 16704527 15547733 15150132 15264214 15547721 16805852
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.2619578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.1011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.1016938888 9664655
MESH:D005234 Fatty Liver Amiodarone 43.2714986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 43.2761145 16239168 19224547 15959796 12795759 16045604 12631006 17595544
MESH:D005234 Fatty Liver Cyclosporine 43.2719224547
MESH:D005234 Fatty Liver Dietary Fats 43.2717967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 43.2721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 43.2715345470
MESH:D005234 Fatty Liver Fructose 43.2718395287 18641190 19196556
MESH:D005234 Fatty Liver Iron 43.2716640825
MESH:D005234 Fatty Liver pirinixic acid 43.2719236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 43.2719224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.7316534752 16513791 16611131 16002989 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.7316709447
MESH:D005313 Fetal Death Phenytoin 8.5610627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 8.5611858732
MESH:D005334 Fever Lipopolysaccharides 3.4311852909 9205823
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.8614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.5119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 37.1618705752
MESH:D005355 Fibrosis Cyclosporine 37.1612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 37.1618296743
MESH:D005355 Fibrosis Fructose 37.1618504504
MESH:D005355 Fibrosis Quercetin 37.1619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 37.1620067830
MESH:D005355 Fibrosis Tretinoin 37.1617994277
MESH:D005355 Fibrosis valsartan 37.1616893502
MESH:D005534 Foot Diseases Arsenic 4.876392382
MESH:D005621 Friedreich Ataxia Iron 4.7716640825 16604332
MESH:D005756 Gastritis Acetaminophen 2.9916983495
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.0311794436
MESH:D005776 Gaucher Disease Warfarin 5.3212359135
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.5816452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.5816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 10.688708960
MESH:D005885 Gingival Hyperplasia Phenytoin 10.689029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.5516390469 14659971
MESH:D005909 Glioblastoma Quercetin 5.7019804834
MESH:D005909 Glioblastoma Tretinoin 5.7017312396
MESH:D005910 Glioma Quercetin 2.7517643826
MESH:D018316 Gliosarcoma Cyclophosphamide 4.8411389073
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 4.9016928621
MESH:D018149 Glucose Intolerance Fructose 4.7019165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9110696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.3815172196 11014644 16376943
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.7116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.4716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.2110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.219664655 14991402
MESH:D006331 Heart Diseases Streptozocin 3.7912093613
MESH:D006333 Heart Failure atorvastatin 17.4916360360
MESH:D006333 Heart Failure Enalapril 17.4910979640 12514674
MESH:D006333 Heart Failure pirinixic acid 17.4920558911
MESH:D006333 Heart Failure Selenium 17.4917162251
MESH:D006333 Heart Failure valsartan 17.4919027736
MESH:D006406 Hematoma Warfarin 6.0317493413
MESH:D006432 Hemochromatosis Iron 3.9817053826 16640825 16604332 16574947 17255318 17236123
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.7515720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.7916366002
MESH:D006467 Hemophilia A Cyclophosphamide 4.6311918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 8.4911000095
MESH:D006470 Hemorrhage Warfarin 8.4918429757
MESH:D006486 Hemosiderosis Iron 4.5316604332
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 4.8514986274
MESH:D006505 Hepatitis Carbon Tetrachloride 7.7219900420 19110552
MESH:D006505 Hepatitis cypermethrin 7.7216487989
MESH:D006525 Hepatitis, Viral, Human Iron 4.7816640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.2817182432
MESH:D006529 Hepatomegaly Amiodarone 20.2615265979
MESH:D006529 Hepatomegaly Iron 20.2616890145
MESH:D006529 Hepatomegaly Phenobarbital 20.2616109766
MESH:D006529 Hepatomegaly pirinixic acid 20.2618467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 20.2615340226 16120746 12621046
MESH:D006561 Herpes Simplex resveratrol 3.5216876885
MESH:D015658 HIV Infections Iron 3.2916597321
MESH:D006689 Hodgkin Disease Cyclophosphamide 5.7416135485 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 5.7412676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3618606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 5.8316870215
MESH:D006930 Hyperalgesia Tretinoin 5.8316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.8616899240
MESH:D006937 Hypercholesterolemia Amiodarone 27.738137927 9751232
MESH:D006937 Hypercholesterolemia atorvastatin 27.7311583720
MESH:D006937 Hypercholesterolemia Cholesterol 27.7316933029
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 27.7310876104
MESH:D006937 Hypercholesterolemia Dietary Fats 27.7321332399
MESH:D006937 Hypercholesterolemia resveratrol 27.7317188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9116778211
MESH:D006943 Hyperglycemia pirinixic acid 7.2820558911
MESH:D006943 Hyperglycemia Quercetin 7.2811834736 18262572
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.1010459572
MESH:D006946 Hyperinsulinism Fructose 4.3314757778 18563319 19008412 18360027 15752949
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.8617050553
MESH:D006949 Hyperlipidemias Dietary Fats 12.0121332399
MESH:D006949 Hyperlipidemias Fructose 12.0115752949
MESH:D006949 Hyperlipidemias resveratrol 12.0116873680
MESH:D006951 Hyperlipoproteinemias marker/mechanism
MESH:D006938 Hyperlipoproteinemia Type II marker/mechanism 16030523
MESH:D006938 Hyperlipoproteinemia Type II atorvastatin 4.6216238680
MESH:D006952 Hyperlipoproteinemia Type III marker/mechanism
MESH:D006965 Hyperplasia Diethylstilbestrol 3.7812960047 14722030
MESH:D006973 Hypertension Arsenic 27.9616076760 11953799 9931084
MESH:D006973 Hypertension atorvastatin 27.9617042910
MESH:D006973 Hypertension Cyclosporine 27.9610903974
MESH:D006973 Hypertension Enalapril 27.9612717102 10903974
MESH:D006973 Hypertension Fructose 27.9614568997 16843071 14633139 19008412 14573337
MESH:D006973 Hypertension Phenylephrine 27.968949925 12717712
MESH:D006973 Hypertension Quercetin 27.9618356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 27.9618670907 18850075
MESH:D006973 Hypertension valsartan 27.9612692753 20102058 18390891 18344623 10903974 16475468 11427623 12850387
MESH:D006974 Hypertension, Malignant valsartan 5.7211560862
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.4315338365
MESH:D006976 Hypertension, Pulmonary Warfarin 4.3112359135
MESH:D015228 Hypertriglyceridemia marker/mechanism
MESH:D015228 Hypertriglyceridemia Fructose 4.4919342510 19799862
MESH:D006984 Hypertrophy Phenylephrine 3.9518502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.7117488730
MESH:D006987 Hypesthesia Arsenic 4.8716093927
MESH:D007006 Hypogonadism Iron 3.9016640825
MESH:D007021 Hypospadias Diethylstilbestrol 9.0716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.0716945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 9.5118020914 17991464
MESH:D007037 Hypothyroidism Iron 9.5116640825
MESH:D007154 Immune System Diseases Cyclophosphamide 4.6516076520
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 3.9917600658
MESH:D007246 Infertility Diethylstilbestrol 3.7215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.8412013081
MESH:D007248 Infertility, Male Cyclophosphamide 8.5216517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 8.5217937319
MESH:D007248 Infertility, Male sodium arsenite 8.5212646999 15346721
MESH:D007249 Inflammation atorvastatin 21.6816908763
MESH:D007249 Inflammation Dietary Fats 21.6820412841
MESH:D007249 Inflammation Diethylnitrosamine 21.6818785209
MESH:D007249 Inflammation Lipopolysaccharides 21.6817963957 9205823 17255318 17237260 12878042
MESH:D007249 Inflammation polyphenols 21.6816366677
MESH:D007249 Inflammation resveratrol 21.6816366677
MESH:D007249 Inflammation Tamoxifen 21.6819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 21.6812200463 12878042
MESH:D007251 Influenza, Human Quercetin 14.7216624496
MESH:D007251 Influenza, Human resveratrol 14.7216624496
MESH:D007251 Influenza, Human Selenium 14.7216624496
MESH:D007299 Insect Bites and Stings cypermethrin 5.2915189238
MESH:D007333 Insulin Resistance Dietary Fats 9.7418457598 11836018
MESH:D007333 Insulin Resistance Fructose 9.7414633139 19799862 18563319 17133782 19008412 14757778 19586609 18981581 19342510 14573337 18057795
MESH:D007333 Insulin Resistance pirinixic acid 9.7416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.1217994277
MESH:D019189 Iron Metabolism Disorders Iron 9.5217163184
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 9.5217255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.9216580747
MESH:D007569 Jaw Abnormalities Tretinoin 7.9215992940 17551590
MESH:D007627 Keloid Quercetin 4.3017086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.7615604871
MESH:D007642 Keratosis Arsenic 4.3216930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 26.4612587719 15629191
MESH:D007674 Kidney Diseases Acrolein 26.4612488133
MESH:D007674 Kidney Diseases Cyclosporine 26.468314463 10903974 18776723
MESH:D007674 Kidney Diseases Enalapril 26.4610903974
MESH:D007674 Kidney Diseases Quercetin 26.4616962696
MESH:D007674 Kidney Diseases sodium arsenite 26.4620008137
MESH:D007674 Kidney Diseases Streptozocin 26.4612093613
MESH:D007674 Kidney Diseases valsartan 26.4616893502 10903974 12164870
MESH:D007676 Kidney Failure, Chronic Selenium 3.2816518626
MESH:D007680 Kidney Neoplasms Cyclosporine 9.2412371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 9.2416762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Tamoxifen 9.2418625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.3616316344
MESH:D007859 Learning Disorders Cholesterol 7.9517134702
MESH:D007859 Learning Disorders Diethylstilbestrol 7.9517184923
MESH:D007938 Leukemia Cyclophosphamide 8.3810602166
MESH:D007938 Leukemia Quercetin 8.3817468513
MESH:D007938 Leukemia Tretinoin 8.3817143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.1717802794 17658394 18172266 17008537 18587576 17296974
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.5710373061
MESH:D007951 Leukemia, Myeloid Tretinoin 3.1019285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9417596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 10.1017339181
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 10.1016087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 10.1017712046 16766008 9834237 15748426 16140955 17368321 19035177 12679006 19225113 17506722 17301526 17217047 17361223 16331271 16823087 16891316 17294898 19075265 16935935 19029980 19642359 16788101 17107899 17649720 17339181
MESH:D007970 Leukopenia Cyclophosphamide 9.5411830472 10052129
MESH:D007970 Leukopenia Lipopolysaccharides 9.5415821434
MESH:D020961 Lewy Body Disease Iron 4.7716563566
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.819224671
MESH:D008064 Lipidoses Amiodarone 6.2415342952 17567588
MESH:D008064 Lipidoses Tamoxifen 6.2415342952 17567588
OMIM:611771 LIPOPROTEIN GLOMERULOPATHY marker/mechanism
MESH:D054068 Livedo Reticularis Warfarin 6.0318280355
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 16.3621278145 11903743 17334410 16239168 11408273 16221502 17174718 16943688 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 16.3618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 16.3618665156 20032147 18522880 19638242 18407596
MESH:D008103 Liver Cirrhosis Iron 16.3616640825
MESH:D008103 Liver Cirrhosis Phenobarbital 16.3621047994
MESH:D008106 Liver Cirrhosis, Experimental alpha-naphthyl isocyanate 17.8016015684
MESH:D008106 Liver Cirrhosis, Experimental atorvastatin 17.8017347453
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 17.8015996030 12389079 18279442 15818738 12586293 14620537 18156304 17761835 16248980 18006644 12741479 15925388 17944888 14716496 17557913 17708605 17565644 18472332 12445421 16015684 16192424 14512876 18339082 15370692 17721639 12666154 18166357 17823541 15123356 18277467 12667390 18251166 10355542 18376398 15057751 17714472 15362042 14748882 15730626 17698563 16027843 16638106 15893842 18420326 15673190 18472094 18395914 17900296 17525996 12649538 12546737 14724832 18481824 12445418 13678700 14716833 18412020 20821823 16116963 17922224 12632514 16097048 18205269 18263696 15338365 11481614 12958196 15931870 17640975 17869086 17766677 18395095 17631135 17481882 12632512 17976157 12898905 15959796 18418968 18054572 15650968 12609069 18317297 16033810 18210741 16011737 17805973 15052691 15876570 16136751 18429990 18187930 18705752
MESH:D008106 Liver Cirrhosis, Experimental Enalapril 17.8017347453
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 17.8012878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 17.8015474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 17.8012741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 17.8018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 17.8012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 17.8018397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental valsartan 17.8015504291 16872305 15619341
MESH:D008107 Liver Diseases Acetaminophen 18.9112969438 11587558 16611625 19460945 19014921 16610002 19784758 12587719
MESH:D008107 Liver Diseases Arsenic 18.9111134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 18.9116246199 16964402 15830285 17285989 15720792
MESH:D008107 Liver Diseases cypermethrin 18.9115991261
MESH:D008107 Liver Diseases Diethylnitrosamine 18.9117034775
MESH:D008107 Liver Diseases Phenobarbital 18.9119363144
MESH:D008107 Liver Diseases Phenytoin 18.9114986274
MESH:D008107 Liver Diseases polyphenols 18.9116698588
MESH:D008108 Liver Diseases, Alcoholic Iron 4.3516737972 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.5115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.4517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.4516899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 38.952125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Arsenic 38.9516368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 38.9519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 38.9520583210 18648771 18978307 19690152 19090486 20101389 19551842 19254457 19642983 19426721 19850985 15175105 21071580 19812893 15885732 18644402 19996281 19294768 20118626 18977376 21167192 18754104 20405173 20452335 21047994 9163691 20501860 16942905 20434301 21278145 20492335 20137499 19255062 19499222 2862719 12112319 2422723 19256749 10737359 12771043 19638242 19427195 19833225 19073162
MESH:D008113 Liver Neoplasms Diethylstilbestrol 38.9515890375 16712894
MESH:D008113 Liver Neoplasms Iron 38.9516640825 20302851
MESH:D008113 Liver Neoplasms Phenobarbital 38.9519073162 8742319 19812893 15975961 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 38.9516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 38.9518980244
MESH:D008113 Liver Neoplasms resveratrol 38.9519321006 19073162 20405173 19812893
MESH:D008113 Liver Neoplasms sodium arsenite 38.9516712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 38.9516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 38.9516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.518603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.5115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.5117854601 19126423 19009564 18253720 9362446 18775883 16267830 18093689 17174075 18164116 17942915 18079962 19004024 18544905 3124819 16842330 19519916 18308698 2563599 18282651 21159647 19539802
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.5118308698 1399818 2563599 6150874 17172636
MESH:D008114 Liver Neoplasms, Experimental Quercetin 17.5119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.5112151625
MESH:D008133 Long QT Syndrome Amiodarone 3.0617391786 15350150 11989578
MESH:D008171 Lung Diseases Acrolein 13.7111504702
MESH:D008171 Lung Diseases Amiodarone 13.7112587719
MESH:D008171 Lung Diseases Ozone 13.7119066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 13.7119095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.8018516814
MESH:D055370 Lung Injury Lipopolysaccharides 7.0821114838
MESH:D055370 Lung Injury Ozone 7.0820417186
MESH:D008175 Lung Neoplasms marker/mechanism 19180532
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.9014755239
MESH:D008175 Lung Neoplasms Arsenic 12.9017306315 19168569 17976673
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.9021163286 6695378 20970405 20512841
MESH:D008175 Lung Neoplasms Iron 12.9016640825
MESH:D008175 Lung Neoplasms Ozone 12.908597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 12.9016280456
MESH:D008175 Lung Neoplasms sodium arsenite 12.9016712894 15276417 17077188 19931552 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 12.9018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.9019555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.4815166399
MESH:D008223 Lymphoma Cyclophosphamide 6.2212854902
MESH:D008223 Lymphoma Diethylstilbestrol 6.2215700306
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 8.4116675587
MESH:D016393 Lymphoma, B-Cell resveratrol 8.4117088997
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 7.1611911406
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.1614749477
MESH:D008268 Macular Degeneration marker/mechanism
MESH:D008268 Macular Degeneration Iron 3.5716640825
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.8316002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 7.7815688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 7.7819428831
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 7.368985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Selenium 7.3615318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 7.3619196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 3.8619453300
MESH:D008527 Medulloblastoma Tretinoin 2.4717453147
MESH:D008545 Melanoma resveratrol 5.9017992120
MESH:D008545 Melanoma sodium arsenite 5.9019082730 16487513
MESH:D008545 Melanoma Tamoxifen 5.9012393984 19393235
MESH:D008545 Melanoma Tretinoin 5.9016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.5115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 14.7019513568
MESH:D008546 Melanoma, Experimental Acrolein 14.7010803710
MESH:D008546 Melanoma, Experimental Cyclophosphamide 14.7016388313
MESH:D008591 Meningomyelocele Tretinoin 3.7716940565
MESH:D008607 Mental Retardation Phenytoin 3.409212184
MESH:D008654 Mesothelioma Selenium 2.4815107826
MESH:D008659 Metabolic Diseases resveratrol 3.7717112576
MESH:D024821 Metabolic Syndrome X Fructose 4.2616815490 19165636 17098227 18497449 17261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1016801185
MESH:D008679 Metaplasia Ozone 4.4210496685
MESH:D009101 Multiple Myeloma resveratrol 2.9816267019 14749477 16490592 17935668 17049120 17164350
MESH:D009103 Multiple Sclerosis marker/mechanism
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 4.9917086897
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.2017962980
MESH:D009135 Muscular Diseases atorvastatin 14.1516239165
MESH:D009135 Muscular Diseases Bezafibrate 14.1516239165
MESH:D009135 Muscular Diseases pirinixic acid 14.1516239165
MESH:D009181 Mycoses Amiodarone 10.8717974566 12754197
MESH:D009181 Mycoses Iron 10.8716640825
MESH:D015878 Mydriasis Tropicamide 6.6716308726
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.6617596541
MESH:D009203 Myocardial Infarction marker/mechanism
MESH:D009203 Myocardial Infarction pirinixic acid 7.5719151258
MESH:D009203 Myocardial Infarction Quercetin 7.5719595682
MESH:D009203 Myocardial Infarction resveratrol 7.5717125593 16525036 16317513 17188708 17015251 16456233
MESH:D017202 Myocardial Ischemia Arsenic 17.3915371236
MESH:D017202 Myocardial Ischemia Iron 17.3916604332
MESH:D017202 Myocardial Ischemia resveratrol 17.3917125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 17.3912213967
MESH:D015428 Myocardial Reperfusion Injury Iron 11.2516604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.2516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 11.2519207477
MESH:D009205 Myocarditis resveratrol 4.0917322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 10.2617484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 10.2617484760
MESH:D009224 Myotonia Congenita Phenytoin 4.741896199
MESH:D009336 Necrosis Warfarin 4.8814723717
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.669029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2519410462
MESH:D009369 Neoplasms Acrolein 18.2017329238
MESH:D009369 Neoplasms Cyclophosphamide 18.2018854779
MESH:D009369 Neoplasms Diethylstilbestrol 18.2015313581
MESH:D009369 Neoplasms pirinixic acid 18.2017405874
MESH:D009369 Neoplasms Quercetin 18.2015185748
MESH:D009369 Neoplasms sodium arsenite 18.2011559025
MESH:D009369 Neoplasms Tretinoin 18.2016946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 7.078985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.0720056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.3219196722 19200415 19189210
MESH:D009393 Nephritis Acrolein 5.6012653641
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.7617954296
MESH:D009404 Nephrotic Syndrome atorvastatin 17.9819348381
MESH:D009404 Nephrotic Syndrome Cyclosporine 17.9819348381 18481113
MESH:D009404 Nephrotic Syndrome Hypolipidemic Agents 17.9819603250
MESH:D009404 Nephrotic Syndrome Iron 17.9817178036
MESH:D009421 Nervous System Malformations Diethylstilbestrol 12.7111399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 12.7114600291
MESH:D009421 Nervous System Malformations Tretinoin 12.719125849
MESH:D009436 Neural Tube Defects Arsenic 13.5516620997
MESH:D009436 Neural Tube Defects Phenytoin 13.559118846
MESH:D009436 Neural Tube Defects sodium arsenite 13.5512854658
MESH:D009436 Neural Tube Defects Tretinoin 13.559142499
MESH:D009447 Neuroblastoma Cyclophosphamide 3.258761367 15176712 16115947
MESH:D019636 Neurodegenerative Diseases Acetaminophen 20.4718514411
MESH:D019636 Neurodegenerative Diseases Acrolein 20.4711342003
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 20.4720387270
MESH:D019636 Neurodegenerative Diseases Iron 20.4717296847 16604332
MESH:D019636 Neurodegenerative Diseases resveratrol 20.4717652729
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.228761367 12837982
MESH:D020078 Neurogenic Inflammation Arsenic 14.2217056641
MESH:D020078 Neurogenic Inflammation Quercetin 14.2217929310
MESH:D020078 Neurogenic Inflammation resveratrol 14.2217929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.4320387270
MESH:D009503 Neutropenia Cyclophosphamide 3.718291058
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 5.0520557099 9802331
MESH:D009765 Obesity Dietary Fats 6.2121332399 20518802 18674790 20132043 19632207 18457598 11836018 17217161 16723640
MESH:D009765 Obesity Fructose 6.2118585860 17707055
MESH:D009765 Obesity pirinixic acid 6.2120558911
MESH:D009845 Oligospermia Cyclophosphamide 4.0416517039
MESH:D010003 Osteoarthritis Iron 3.5316640825
MESH:D010018 Osteomalacia Phenobarbital 9.8517016548
MESH:D010018 Osteomalacia Phenytoin 9.8517016548
MESH:D010024 Osteoporosis Calcium 6.2017882678
MESH:D010024 Osteoporosis Iron 6.2016648989 16640825
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.1419495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.1417513867
MESH:D010051 Ovarian Neoplasms Arsenic 9.0917306315
MESH:D010051 Ovarian Neoplasms Quercetin 9.0919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 9.0915276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 9.0916936753
MESH:D010146 Pain Acetaminophen 11.6516870215
MESH:D010146 Pain Cyclophosphamide 11.6518093676 12161096
MESH:D010146 Pain Phenytoin 11.6515215642
MESH:D010146 Pain Tretinoin 11.6516870215
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 13.1411332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 13.1416540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 13.1416965848
MESH:D010190 Pancreatic Neoplasms Quercetin 13.1416965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 13.1415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0611578682
MESH:D010212 Papilloma Iron 3.8412065085
MESH:D020447 Parasomnias Iron 5.3317352947
MESH:D010300 Parkinson Disease Acrolein 10.0117690948
MESH:D010300 Parkinson Disease Cholesterol, Dietary 10.0119014385
MESH:D010300 Parkinson Disease Iron 10.0116640825 16563566
MESH:D010300 Parkinson Disease tolcapone 10.0111586115 18328768 8739811 10651109 16758261 19578428 7566641 11432539 9708959 11793426 19783845 9333106 9591521 20334432 9305320 17089403 9754991 11746615 1977408 8635184 20216409
MESH:D020734 Parkinsonian Disorders Tropicamide 5.1717594079
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5612520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.5416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.326392382 15371236 16905509
MESH:D010538 Peritonitis Ozone 3.4816369182
MESH:D010787 Photosensitivity Disorders Acrolein 5.0511550810
MESH:D010900 Pituitary Diseases Diethylstilbestrol 11.7914722030
MESH:D010900 Pituitary Diseases Iron 11.7916604332
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.0116977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.2015087411
MESH:D011014 Pneumonia Lipopolysaccharides 8.8811605937 12224865
MESH:D011014 Pneumonia Ozone 8.8818929643 18007984 18381685
MESH:D011041 Poisoning Iron 3.6816604332
MESH:D017689 Polydactyly Phenytoin 4.479212184
MESH:D017119 Porphyria Cutanea Tarda Iron 8.9016640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 8.9018163543
MESH:D011230 Precancerous Conditions Cyclosporine 17.1812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 17.182563599
MESH:D011230 Precancerous Conditions Phenobarbital 17.182563599
MESH:D011230 Precancerous Conditions Quercetin 17.1819056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.3921297632
MESH:D011225 Pre-Eclampsia Iron 3.8916640825
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 12.4517184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 12.4516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.4511222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Arsenic 1.9716140617
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 1.9717136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9715846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Quercetin 1.9714715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 1.9715767336 17804756 16731767 17636462 17718901 17675339
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9715067354
MESH:D020151 Protein C Deficiency Warfarin 5.6718376272
MESH:D011507 Proteinuria Arsenic 12.0221343184
MESH:D011507 Proteinuria Tretinoin 12.0216636307
MESH:D011507 Proteinuria valsartan 12.0217664856 18344623 12164870
MESH:D011528 Protozoan Infections Iron 5.3316640825
MESH:D011537 Pruritus Ethinyl Estradiol 2.6515861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 10.2912752131
MESH:D019310 Pseudolymphoma Phenytoin 10.291419762 8603615 12752131
MESH:D011565 Psoriasis marker/mechanism 16433808
MESH:D011565 Psoriasis Cyclosporine 1.9516882103
MESH:D011625 Pterygium Tretinoin 4.1216723453
MESH:D011655 Pulmonary Embolism Warfarin 5.6719300499
MESH:D011658 Pulmonary Fibrosis Amiodarone 10.7911597910 12490602 12832656
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 10.7916636934
MESH:D011658 Pulmonary Fibrosis Enalapril 10.7917265423
MESH:D011658 Pulmonary Fibrosis valsartan 10.7917241526
MESH:D051437 Renal Insufficiency Acrolein 9.1012732208
MESH:D051437 Renal Insufficiency Enalapril 9.1015728788
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.9016325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.3119058328
MESH:D015427 Reperfusion Injury resveratrol 5.3117520802 16317513 16314181 17058453 15827377
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 6.989413022
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 6.9810835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2018990726
MESH:D012148 Restless Legs Syndrome Iron 4.0216930377
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.4816116481 16283617
MESH:D012554 Schistosomiasis japonica Quercetin 4.8616862918
MESH:D012559 Schizophrenia marker/mechanism 18583979
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.2016636934
MESH:D012618 Sea-Blue Histiocyte Syndrome marker/mechanism
MESH:D012640 Seizures Phenobarbital 4.804039156 3137016 11442880 16876388
MESH:D012640 Seizures Phenytoin 4.8019919933 15946322 16876388 11044598 3691417 9844417 10029267 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.156407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.4118724381
MESH:D012852 Sinusitis Phenylephrine 4.037327846
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.2112269725
MESH:D012871 Skin Diseases Arsenic 2.5415952646 19834688 17548696 18709164 17050553 16702368 17453740 6392382 17938729 16353154 16759981
MESH:D012878 Skin Neoplasms Arsenic 21.5919538983 17050553 15504454 16251483 17029826 17976673
MESH:D012878 Skin Neoplasms Iron 21.5912065085
MESH:D012878 Skin Neoplasms resveratrol 21.5915837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 21.5919524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 21.598532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 21.5916192470
MESH:D012878 Skin Neoplasms Tretinoin 21.5916467112
MESH:D013088 Spermatocele Diethylstilbestrol 16.1916709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 16.1916709447
MESH:D013088 Spermatocele Tamoxifen 16.1916709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.8416517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.3719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.2612854658
MESH:D013163 Splenomegaly marker/mechanism
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.5020235791
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.9218456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.9212958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 2.9217261132
MESH:D013276 Stomach Ulcer Amiodarone 2.7418087811
MESH:D020521 Stroke Acrolein 7.7116269634
MESH:D020521 Stroke Warfarin 7.7119300499
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.8916321402
MESH:D013398 Sudden Infant Death Iron 4.7816640825
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.3912837982
MESH:D013610 Tachycardia Amiodarone 3.6511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.5519225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.5717997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.5815821434
MESH:D013923 Thromboembolism Acenocoumarol 11.8718698879
MESH:D013923 Thromboembolism Warfarin 11.8716960144 18698879
MESH:D019851 Thrombophilia Ethinyl Estradiol 8.9511994571
MESH:D019851 Thrombophilia Warfarin 8.9517493413
MESH:D013927 Thrombosis Ethinyl Estradiol 7.5115669648
MESH:D013927 Thrombosis Warfarin 7.5111518727 17245631 11307788 15720958 17672075 19300499
MESH:D013959 Thyroid Diseases Amiodarone 9.7819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 9.7812697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 8.937505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.931399818
MESH:D013964 Thyroid Neoplasms Tretinoin 8.9316026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.2018020914 19584973
MESH:D014062 Tongue Neoplasms resveratrol 7.9516227395
MESH:D014062 Tongue Neoplasms Tretinoin 7.9516051514
MESH:D016171 Torsades de Pointes Amiodarone 3.5211989578 17467628
MESH:D014202 Tremor Tropicamide 5.5217594079 19467297
MESH:D014376 Tuberculosis Iron 6.6716597321
MESH:D014376 Tuberculosis Tretinoin 6.6716040207
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.2619578428
MESH:D001749 Urinary Bladder Neoplasms Arsenic 15.7419429237 17976673 18640142 15987713 17306315 19322015 11144890
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 15.7414692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.7416712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Quercetin 15.7416720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.7416712894 17306315 11723127 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.7417572228 8653321 16712894
MESH:D014570 Urologic Diseases cypermethrin 5.1816487989
MESH:D014581 Urticaria Acetaminophen 2.3610982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 17.8216175088
MESH:D002583 Uterine Cervical Neoplasms resveratrol 17.8217473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 17.8211813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 17.8216129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.4814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 12.3916690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 12.3914692618
MESH:D014594 Uterine Neoplasms resveratrol 12.3917044934
MESH:D014604 Uveal Neoplasms Tretinoin 3.9316752155
MESH:D014605 Uveitis Cyclosporine 3.301336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.7816513791 16002989
MESH:D014652 Vascular Diseases Arsenic 9.6217056641
MESH:D014652 Vascular Diseases sodium arsenite 9.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9112125929
MESH:D014657 Vasculitis Warfarin 5.2120337814
MESH:D054556 Venous Thromboembolism Warfarin 5.6818776969
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 8.7314671159 15869587
MESH:D020246 Venous Thrombosis Warfarin 8.7314723717 15733061
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.6517488730
MESH:D020257 Ventricular Remodeling valsartan 5.0319027736
MESH:D014820 Vitiligo tolcapone 8.9710573327
MESH:D014820 Vitiligo Tretinoin 8.9716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5615886252
MESH:D015430 Weight Gain Dietary Fats 3.1616723640
MESH:D009396 Wilms Tumor Tretinoin 3.3916287080
MESH:D014985 Xerophthalmia Cyclosporine 3.7617120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA55
    • Releated gene ID Related gene Name
    PA55APOE
    PA120CRP
    PA38274TOMM40
    Releated disease ID Related disease Name
    PA446850Blindness, Cortical
    PA443970Dystonia
    PA445021Myoclonus
    PA446858Neurodegenerative Diseases
    PA165110266Posterior Cortical Atrophy
    PA447054Stroke
    PA444682Kidney Diseases
    PA443886Diabetes Mellitus
    PA443459Atrial Fibrillation
    PA445465Pulmonary Embolism
    PA446969Venous Thrombosis
    PA443635Cardiovascular Diseases
    PA445451Psoriasis
    PA446213HIV Infections
    PA162370415metabolic syndrome
    PA164946504normal tension glaucoma
    PA443796Coronary Artery Disease
    PA443890Diabetes Mellitus, Type 2
    PA444516Hypercholesterolemia
    PA165108110Dyslipidaemia
    PA443797Coronary Disease
    PA447216Schizophrenia
    PA447118Hypoxia-Ischemia, Brain
    PA443319Alzheimer Disease
    PA444528Hyperlipidemias
    PA447230HIV
    PA444785Lipodystrophy
    PA443425Arteriosclerosis
    PA446414Carotid Stenosis
    Releated drug ID Related drug Name
    PA452229antidepressants
    PA450952phospholipids
    PA449688fluvastatin
    PA448039acitretin
    PA451089pravastatin
    PA449750gemfibrozil
    PA451262rivastigmine
    PA451283rosiglitazone
    PA133950441hmg coa reductase inhibitors
    PA164712505Antivirals for treatment of HIV infections, combinations
    PA452632acenocoumarol
    PA450128isotretinoin
    PA451906warfarin
    PA449509estrogens
    PA449394donepezil
    PA449594fenofibrate
    PA451260ritonavir
    PA451576tacrine
    PA448976choline
    PA451363simvastatin
    PA164712423Anticholinesterases
    PA449726galantamine
    PA450688olanzapine
    PA450480metoprolol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00062 - Human Serum Albumin Serum substitutes
    DB00064 - Serum albumin iodonated Imaging Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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