AutismKB 2.0

Annotation Detail for IGF2R


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Basic Information Top
Gene Symbol:IGF2R ( CD222,CIMPR,M6P-R,MPR1,MPRI )
Gene Full Name: insulin-like growth factor 2 receptor
Band: 6q25.3
Quick LinksEntrez ID:3482; OMIM: 147280; Uniprot ID:MPRI_HUMAN; ENSEMBL ID: ENSG00000197081; HGNC ID: 5467
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
Pathway IDPathway Name
Membrane Trafficking
No data
Pathway IDPathway Name
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00006Apoptosis signaling pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00048Hepatocellular carcinoma
Desease IDDesease Name
1740Alzheimer's disease
1904Diabetes mellitus
1934Cancer
Desease Name
oral cancer
birth weight fetal growth
CANCER
Brain lesion load
IMMUNE
REPRODUCTION
Desease Name
Brain lesion load
Desease Name
Hepatocellular carcinoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of IGF2R mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IGF2R mRNAaffects expression 16483693
D001151 Arsenic IGF2R mRNA results in increased susceptibility to Arsenicincreases response to substance 17976673
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IGF2R mRNAdecreases expression 20064835
C006780 bisphenol A bisphenol A results in decreased expression of IGF2R mRNAdecreases expression 20505776
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of IGF2R mRNAincreases expression 17553608
D002104 Cadmium Cadmium results in increased expression of IGF2R mRNAincreases expression 17327699
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of IGF2R mRNAincreases expression 17327699
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of IGF2R mRNAaffects expression 15963342
D016572 Cyclosporine Cyclosporine results in increased expression of IGF2R mRNAincreases expression 20106945
D016190 Carboplatin Carboplatin results in decreased expression of IGF2R mRNAdecreases expression 18172885
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of IGF2R mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of IGF2R mRNAdecreases expression 19542621
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGF2R mRNAaffects cotreatment|increases expression 17942748
C071834 glycidamide glycidamide results in increased expression of IGF2R mRNAincreases expression 17822822
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of IGF2R mRNAaffects cotreatment|decreases expression 18544905
D010269 Paraquat Paraquat results in increased expression of IGF2R mRNAincreases expression 16328009
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of IGF2R mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of IGF2R mRNAincreases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of IGF2R mRNAincreases expression 12807726
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IGF2R mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of IGF2R mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of IGF2R mRNAincreases expression 17426115
C059514 resveratrol resveratrol results in increased expression of IGF2R mRNAincreases expression 12002526
C010327 salinomycin salinomycin results in decreased expression of IGF2R mRNAdecreases expression 19682730
D012643 Selenium Selenium results in decreased expression of IGF2R mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of IGF2R mRNAdecreases expression 19822182
C017947 sodium arsenite sodium arsenite results in increased expression of IGF2R mRNAincreases expression 17451858
17077188
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGF2R mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin promotes the reaction [IGF2R binds to and results in increased secretion of IGF2 protein modified form]affects binding|increases reaction|increases secretion 16680587
D014415 Tunicamycin Tunicamycin results in decreased expression of IGF2R mRNAdecreases expression 17127020
D014415 Tunicamycin Tunicamycin results in increased expression of IGF2R mRNAincreases expression 17127020
D014635 Valproic Acid Valproic Acid results in increased expression of IGF2R mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in decreased expression of IGF2R mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.876195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.8715322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.878875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7219490988
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D058186 Acute Kidney Injury resveratrol 3.6516538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.9820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9814692618
MESH:D000236 Adenoma Benzo(a)pyrene 10.446695378
MESH:D000236 Adenoma Diethylnitrosamine 10.4410737359 6695378
MESH:D000236 Adenoma resveratrol 10.4415688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.9717620307 16434500 19052882 17162532 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.9717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.9716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma Arsenic 13.0217306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 13.0216712894 17306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5411874814
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000544 Alzheimer Disease resveratrol 2.5216183991 16162502
MESH:D000550 Amblyopia Valproic Acid 5.0017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.3917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8018414634 12569548 16835338 16251483
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.4715885639
MESH:D001169 Arthritis, Experimental resveratrol 11.4717115116
MESH:D001169 Arthritis, Experimental Tretinoin 11.4716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D050197 Atherosclerosis Arsenic 10.3712928151 19371607
MESH:D050197 Atherosclerosis Cadmium 10.3715687053
MESH:D050197 Atherosclerosis resveratrol 10.3717967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8520603192 17157402 18558336 19460635 18985861 16609825 15238991 18940202 17507914 18775368 18316065 18177632 17688650 18396377 19232924
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9620046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.0819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.0816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.548888407
MESH:D001862 Bone Resorption bisphenol A 3.6611985600
MESH:D002545 Brain Ischemia resveratrol 4.0617600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6220146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 3.6217123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6217474063
MESH:D001943 Breast Neoplasms resveratrol 3.6217651959 16393696 17534123
MESH:D001943 Breast Neoplasms salinomycin 3.6219682730
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6220435547
MESH:D001943 Breast Neoplasms Tretinoin 3.6216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3616813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.1915673190 18705752 16227642 10355542 15700767 16097048 15721981 16050911 16124888 3786805 16192424 16011737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.1916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4615504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.263084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 16.2617306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.2618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.2618056438 19919837 18978308 18788625 16779866 17173139 11831363 16502159 16698587 20514400 18971187 16569478 19822196 19539802 20007298 17055752 3581430 19052882 19335982 17978847 19418558 10672840 10737359 20214788 16830150 17761372 20101231 16288022 17162532 19701751 18665156 19519916 19383236 3084413 19107877 16935385 20512989 18393292 18494052 20727157 20432363 18210153 21159647 18506893 16540662 16328049 16681979 17138121 18691550 19171122 16807293 19208518 18785209 16878318 20935162 20524982 19394651 17428255 20084675
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.2617173139 6705139 1701930 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular resveratrol 16.2616227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.2616507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.261917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7617123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3616675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 3.9016685392
MESH:D002294 Carcinoma, Squamous Cell Arsenic 13.6115504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.6120419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 13.6116227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.6118572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.6116051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.8818640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 7.0515738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases resveratrol 7.0515458977
MESH:D002340 Carotid Artery Diseases Arsenic 4.1216973168 18022660
MESH:D002386 Cataract Acetaminophen 6.7810977129
MESH:D002386 Cataract Tretinoin 6.7817460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 14.7917332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.7912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.7917174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.7919524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.034080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6916835633
MESH:D002779 Cholestasis Cyclosporine 12.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3816919318 17333356 16105132 15861022 17681005 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 12.3819176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4515668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.459407595
MESH:D003092 Colitis resveratrol 14.7416474422
MESH:D003092 Colitis Selenium 14.7417936198
MESH:D003092 Colitis Tretinoin 14.7417035595
MESH:D003110 Colonic Neoplasms resveratrol 2.4216338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8717141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6116507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.189664655 10589399 14991402 17551590 8800419 16925845 9142499 9211117 9125849 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.188888407 16575769 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.1819769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5916873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0317107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.7716286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.3416393943 17906064 12594235 14986274 11743745 16177239 19164858 19085960 18713872 19739265 2444490 11461765 14550746 18071297 12153990 19416960 16485898 16227642 10663392 16081117 19923254 11834606 12392966 16109766 12540782 16781746 15619225 11287661 11739529 14725611 10774834 12958197 19420014 10915739 17562736 12705907 19370779 11421492 11529661 17522070 15968718
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.3410092053 2869522 7179309 17522070 6884620 10915739 3786805 7440962 3732212 16177239 19336974 4309450 11566570 15968718 15027814 19085960 7120509 21278145 15998439 9327722 6623471 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.3419107877
MESH:D056486 Drug-Induced Liver Injury Selenium 14.3415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.3420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 14.341733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D004421 Dystonia Phenobarbital 9.731851702
MESH:D004421 Dystonia Valproic Acid 9.731851702
MESH:C538011 Eales disease Vitamin E 4.479068938
MESH:D004487 Edema pirinixic acid 10.2512083418
MESH:D004487 Edema resveratrol 10.258985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.2512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1715322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.4012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.4017872969
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.829294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6217923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.043659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.0417275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.203922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 9.203922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.2820417680
MESH:D004827 Epilepsy Valproic Acid 6.2818234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 8.236401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.236426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.557750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.557750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.723659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.723659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2816938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.0412795759 61145 15959796 16239168 12631006 19224547 17595544 16045604
MESH:D005234 Fatty Liver Cyclosporine 28.0419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 28.0421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.0415345470
MESH:D005234 Fatty Liver pirinixic acid 28.0420131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 28.0414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.918888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 19.2818705752
MESH:D005355 Fibrosis Cyclosporine 19.2812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.2820067830
MESH:D005355 Fibrosis Tretinoin 19.2817994277
MESH:D005534 Foot Diseases Arsenic 5.336392382
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma Tretinoin 2.8617312396
MESH:D005911 Gliosis Paraquat 4.9311124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.9820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.9810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 14.9814991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 14.9816080930
MESH:D006333 Heart Failure pirinixic acid 6.4920558911
MESH:D006333 Heart Failure Selenium 6.4917162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3819110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 13.0816109766
MESH:D006529 Hepatomegaly pirinixic acid 13.0819772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0815340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6216490937 16863852
MESH:D006561 Herpes Simplex resveratrol 3.9516876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.9712676792
MESH:D019584 Hot Flashes Vitamin E 3.7414716179
MESH:D006849 Hydrocephalus Valproic Acid 4.6417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.818697196 16354765 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.0316870215
MESH:D006930 Hyperalgesia Tretinoin 7.0316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3016899240
MESH:D006937 Hypercholesterolemia resveratrol 3.8017188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2617050553
MESH:D006949 Hyperlipidemias resveratrol 3.8216873680
MESH:D006973 Hypertension Arsenic 8.0711953799 16076760 9931084
MESH:D006973 Hypertension Cyclosporine 8.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8615338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1017488730
MESH:D006987 Hypesthesia Arsenic 5.3316093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4217600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.3617937319
MESH:D007248 Infertility, Male Paraquat 10.364850670
MESH:D007248 Infertility, Male sodium arsenite 10.3612646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 7.6518785209
MESH:D007249 Inflammation resveratrol 7.6516366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6512200463 12878042
MESH:D007251 Influenza, Human resveratrol 17.2816624496
MESH:D007251 Influenza, Human Selenium 17.2816624496
MESH:D007251 Influenza, Human Vitamin E 17.2816624496
MESH:D007333 Insulin Resistance bisphenol A 6.8216393666
MESH:D007333 Insulin Resistance pirinixic acid 6.8216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2515992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007642 Keratosis Arsenic 4.7612749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 22.1815629191 12587719
MESH:D007674 Kidney Diseases Cadmium 22.1816226777 16322080 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 22.1816962696
MESH:D007674 Kidney Diseases Cyclosporine 22.1818776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 22.1820008137
MESH:D007674 Kidney Diseases Vitamin E 22.1812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.6816518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.5512371664
MESH:D007938 Leukemia Tretinoin 2.6617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4916482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7417596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.7416294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 11.9717339181
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 11.9716087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.9719035177 19225113 16823087 15748426 17294898 16766008 9834237 17217047 19075265 17506722 17361223 12679006 16891316 19029980 16788101 16331271 17649720 17368321 17107899 16140955 17712046 17301526 17339181 16935935 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.159224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3016943688 17157831 11408273 17334410 16239168 17174718 16221502 21278145 11903743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3020032147 19638242 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3021047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4117565644 18187930 15650968 18279442 15052691 17721639 15893842 10355542 14716496 12586293 16015684 18263696 15338365 14716833 16638106 15362042 16248980 17976157 18412020 17640975 12666154 16027843 12898905 14724832 18251166 17766677 18395914 18156304 15925388 15959796 14748882 16011737 17698563 18429990 17714472 12667390 18210741 17525996 16116963 16097048 14620537 12958196 18472094 18418968 17823541 15876570 18277467 12445421 16136751 17631135 15931870 17900296 14512876 12741479 18472332 18420326 17922224 15057751 18006644 18705752 15818738 12609069 12445418 18395095 17869086 18166357 17805973 16033810 12649538 12632512 18317297 15996030 15673190 11481614 12632514 18339082 12546737 18205269 17708605 13678700 15730626 18481824 17557913 17944888 17481882 20821823 18054572 15123356 12389079 16192424 15370692 18376398 17761835
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4116248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.4116169303
MESH:D008107 Liver Diseases Acetaminophen 11.8719784758 16610002 19014921 16611625 19460945 11587558 12969438 12587719
MESH:D008107 Liver Diseases Arsenic 11.8711134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.8717285989 15720792 15830285 16246199 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 11.8717034775
MESH:D008107 Liver Diseases Phenobarbital 11.8719363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7516899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 28.4616368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 28.4620195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.4619294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.4619551842 19294768 15885732 18754104 19073162 18644402 2422723 20101389 2862719 19254457 19090486 21278145 19996281 19690152 19255062 15175105 20583210 12771043 19850985 19812893 21071580 19426721 20434301 12112319 16942905 20137499 19833225 19499222 19427195 19638242 20501860 20452335 21047994 18977376 18978307 18648771 20118626 20405173 21167192 19256749 19642983 20492335 10737359 9163691
MESH:D008113 Liver Neoplasms Phenobarbital 28.468742319 19482888 21047994 15975961 19073162 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 28.4615890375 20007298 16377806
MESH:D008113 Liver Neoplasms resveratrol 28.4619812893 19073162 20405173 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 28.4616712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.4616984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.1512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.1518093689 18775883 16842330 18544905 18282651 19539802 17854601 18079962 2563599 19009564 9362446 16267830 19126423 18164116 3124819 18253720 19519916 17942915 21159647 17174075 18308698 19004024
MESH:D008114 Liver Neoplasms, Experimental kojic acid 17.1518544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.151399818 6150874 17172636 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.1512151625
MESH:D008171 Lung Diseases sodium arsenite 6.9419095001
MESH:D008171 Lung Diseases Vitamin E 6.9416863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0317228818
MESH:D008175 Lung Neoplasms Arsenic 8.1717306315 19168569 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.1718816296 18520028 18569708 20064080 20464547 20135361 20869020 17053015 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.1720970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms sodium arsenite 8.1716712894 15276417 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1719555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 8.1711062179
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6914749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0215688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.358985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 9.3519682730
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.3515318939
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Carboplatin 7.0312040289 11712820 16342250 16225601
MESH:D008545 Melanoma resveratrol 7.0317992120
MESH:D008545 Melanoma sodium arsenite 7.0316487513 19082730
MESH:D008545 Melanoma Tretinoin 7.0316752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008654 Mesothelioma Selenium 2.7015107826
MESH:D008659 Metabolic Diseases resveratrol 4.1717112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.0318765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0216381670
MESH:D009101 Multiple Myeloma resveratrol 3.3117049120 17164350 16490592 17935668 14749477 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6417962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.828888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9717596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.9717596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.4219151258
MESH:D009203 Myocardial Infarction resveratrol 5.4217188708 16317513 16525036 17015251 16456233 17125593
MESH:D017202 Myocardial Ischemia Arsenic 14.2715371236
MESH:D017202 Myocardial Ischemia resveratrol 14.2717125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 14.2712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7716411023
MESH:D009205 Myocarditis resveratrol 4.5317322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2517484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.489029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 14.5411141357
MESH:D009369 Neoplasms Carboplatin 14.5418854779 17925555
MESH:D009369 Neoplasms pirinixic acid 14.5417405874
MESH:D009369 Neoplasms sodium arsenite 14.5411559025
MESH:D009369 Neoplasms Tretinoin 14.5416946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 8.488985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.4820056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0919348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.5416893418
MESH:D009421 Nervous System Malformations bisphenol A 15.1116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.1114600291
MESH:D009421 Nervous System Malformations Tretinoin 15.119125849
MESH:D009436 Neural Tube Defects Arsenic 16.1416620997
MESH:D009436 Neural Tube Defects sodium arsenite 16.1412854658
MESH:D009436 Neural Tube Defects Tretinoin 16.149142499
MESH:D009436 Neural Tube Defects Valproic Acid 16.1416359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.9818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.9820387270
MESH:D019636 Neurodegenerative Diseases resveratrol 12.9817652729
MESH:D017599 Neuroectodermal Tumors Carboplatin 5.4112837982
MESH:D020078 Neurogenic Inflammation Arsenic 9.9917056641
MESH:D020078 Neurogenic Inflammation resveratrol 9.9917929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D010018 Osteomalacia Phenobarbital 4.1317016548
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0417513867
MESH:D010049 Ovarian Diseases bisphenol A 4.7611985600
MESH:D010051 Ovarian Neoplasms Arsenic 7.5217306315
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.5215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 7.5216936753
MESH:D010146 Pain Acetaminophen 5.9816870215
MESH:D010146 Pain Tretinoin 5.9816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.1216540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.1216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.1215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010300 Parkinson Disease Paraquat 2.7311445065 16140633 15451049 16510128 12911755 15824117 11181820 11124998
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.2116190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 12.3216905509 6392382 15371236
MESH:D016491 Peripheral Vascular Diseases Cadmium 12.3215687053
MESH:D010954 Plasmacytoma Selenium 4.6615087411
MESH:D011014 Pneumonia Paraquat 4.2212504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.1612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.162563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.162563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 21.3610548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 21.3616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.3611896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 21.3620603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0020887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0716140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0716740699
MESH:D011471 Prostatic Neoplasms Cadmium 2.0717075824
MESH:D011471 Prostatic Neoplasms resveratrol 2.0717675339 16731767 17804756 15767336 17636462 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0716039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0715084515
MESH:D011507 Proteinuria Arsenic 8.5721343184
MESH:D011507 Proteinuria Tretinoin 8.5716636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0915861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 11.4212752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.4212752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5610548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8316324872 17997886
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3516325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.2019058328
MESH:D015427 Reperfusion Injury resveratrol 6.2017520802 16314181 16317513 15827377 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.7011700416
MESH:D012135 Respiratory Sounds Paraquat 3.8311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration Paraquat 3.7016458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.1616116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.1619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012640 Seizures Phenobarbital 5.493137016 11442880 16876388 4039156
MESH:D012640 Seizures Valproic Acid 5.4915475178 11044598 17978042 14763951 11738929 3137016 16876388 1511512
MESH:D003294 Seizures, Febrile Phenobarbital 4.596407741
MESH:D012871 Skin Diseases Arsenic 4.8419834688 17938729 16759981 17453740 18709164 17548696 6392382 16353154 16702368 15952646 17050553
MESH:D012871 Skin Diseases Vitamin E 4.8418709164
MESH:D012878 Skin Neoplasms Arsenic 21.0917029826 17050553 17976673 16251483 19538983 15504454
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 21.0919755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 21.098985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 21.0918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 21.0916192470
MESH:D012878 Skin Neoplasms Tretinoin 21.0916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7116709447
MESH:D016135 Spinal Dysraphism sodium arsenite 8.9712854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.9719490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.202093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2018456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.2017261132
MESH:D020521 Stroke Vitamin E 3.3416517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2816321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.7616684133 16045194
MESH:D015173 Supratentorial Neoplasms Carboplatin 5.5812837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.987505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.981399818
MESH:D013964 Thyroid Neoplasms Tretinoin 10.9816026305 17045167
MESH:D014062 Tongue Neoplasms resveratrol 9.2516227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.2516051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.0017262798
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.293119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 7.8417976673 17306315 11144890 18640142 19322015 19429237 15987713
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.8417053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.8417306315 16452187 16712894 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.428888407
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 14.7417473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.7411813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.7416129372
MESH:D014591 Uterine Diseases bisphenol A 4.7814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.7714692618
MESH:D014594 Uterine Neoplasms resveratrol 8.7717044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014652 Vascular Diseases Arsenic 11.0817056641
MESH:D014652 Vascular Diseases sodium arsenite 11.0817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0817488730
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:04142 Lysosome
REACT:11123 Membrane Trafficking
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29701
    • No data
    Releated disease ID Related disease Name
    PA444101Esophageal Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01277 - Mecasermin
    DB02900 - Alpha-D-Mannose-6-Phosphate
    DB02944 - Alpha-D-Mannose
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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