AutismKB 2.0

Annotation Detail for IGFBP4


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Basic Information Top
Gene Symbol:IGFBP4 ( BP-4,HT29-IGFBP,IBP4,IGFBP-4 )
Gene Full Name: insulin-like growth factor binding protein 4
Band: 17q21.2
Quick LinksEntrez ID:3487; OMIM: 146733; Uniprot ID:IBP4_HUMAN; ENSEMBL ID: ENSG00000141753; HGNC ID: 5473
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Diabetes pathways
Pathway IDPathway Name
200055Wnt signaling network
No data
Pathway IDPathway Name
500133Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Protei
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in increased expression of IGFBP4 mRNAincreases expression 19901195
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IGFBP4 proteinaffects expression 20106945
C032311 aluminum fluoride aluminum fluoride results in decreased expression of IGFBP4 mRNAdecreases expression 11996908
C032311 aluminum fluoride aluminum fluoride results in decreased expression of IGFBP4 proteindecreases expression 11996908
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IGFBP4 mRNAaffects expression 16483693
C058317 arsenic disulfide arsenic disulfide results in increased expression of IGFBP4 mRNAincreases expression 16918137
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of IGFBP4 mRNAaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IGFBP4 mRNAincreases expression 20713471
C053541 bicalutamide bicalutamide results in increased expression of IGFBP4 mRNAincreases expression 10604720
C006780 bisphenol A bisphenol A results in increased expression of IGFBP4 mRNAincreases expression 16474171
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of IGFBP4 mRNAincreases expression 15336504
C459604 candoxin candoxin results in decreased expression of IGFBP4 mRNAdecreases expression 16309724
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of IGFBP4 mRNAaffects expression 17484886
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP4 mRNA]decreases reaction|increases expression 18200517
D003513 Cycloheximide [Cycloheximide co-treated with Estradiol] results in increased expression of IGFBP4 mRNAaffects cotreatment|increases expression 15072547
D003513 Cycloheximide Cycloheximide results in increased expression of IGFBP4 mRNAincreases expression 15072547
D003520 Cyclophosphamide IGFBP4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C004742 daidzein daidzein results in increased expression of IGFBP4 mRNAincreases expression 15757668
D004041 Dietary Fats Dietary Fats results in decreased expression of IGFBP4 mRNAdecreases expression 18457598
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of IGFBP4 mRNAincreases expression 17005392
D004317 Doxorubicin IGFBP4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004610 Ellagic Acid Ellagic Acid results in decreased expression of IGFBP4 mRNAdecreases expression 12002526
D004958 Estradiol [Cycloheximide co-treated with Estradiol] results in increased expression of IGFBP4 mRNAaffects cotreatment|increases expression 15072547
D004958 Estradiol Estradiol affects the expression of IGFBP4 mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with ESR1 protein] results in increased expression of IGFBP4 mRNAaffects cotreatment|increases expression 12399409
D004958 Estradiol [Estradiol co-treated with ESR2 protein] results in increased expression of IGFBP4 mRNAaffects cotreatment|increases expression 12399409
D004958 Estradiol Estradiol results in increased expression of IGFBP4 mRNAincreases expression 15072547
16474171
15757668
D004958 Estradiol Estradiol results in increased expression of IGFBP4 mRNAincreases expression 12469912
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of IGFBP4 proteinincreases expression 15817916
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of IGFBP4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of IGFBP4 mRNAdecreases expression 17108234
D005472 Fluorouracil IGFBP4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C070081 fulvestrant fulvestrant results in decreased expression of IGFBP4 mRNAdecreases expression 15072547
D019833 Genistein Genistein results in increased expression of IGFBP4 mRNAincreases expression 16474171
15757668
C071834 glycidamide glycidamide results in decreased expression of IGFBP4 mRNAdecreases expression 17822822
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of IGFBP4 mRNAincreases expression 15072547
C022838 nickel chloride nickel chloride results in decreased expression of IGFBP4 mRNAdecreases expression 12839937
D017239 Paclitaxel IGFBP4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D017239 Paclitaxel Paclitaxel results in increased expression of IGFBP4 mRNAincreases expression 19682730
D010656 Phenylephrine IGFBP4 protein affects the susceptibility to Phenylephrineaffects response to substance 11159833
C006253 pirinixic acid pirinixic acid results in decreased expression of IGFBP4 mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of IGFBP4 mRNA]decreases expression|increases reaction 20059764
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of IGFBP4 mRNAincreases expression 16474171
D011189 Potassium Chloride IGFBP4 protein affects the susceptibility to Potassium Chlorideaffects response to substance 11159833
C467746 propyl pyrazole triol [propyl pyrazole triol co-treated with ESR1 protein] results in increased expression of IGFBP4 mRNAaffects cotreatment|increases expression 12399409
D020849 Raloxifene Raloxifene affects the expression of IGFBP4 mRNAaffects expression 14699072
C059514 resveratrol resveratrol inhibits the reaction [IL1B protein results in increased degradation of IGFBP4 protein]decreases reaction|increases degradation 16338976
C059514 resveratrol resveratrol inhibits the reaction [TNF protein results in increased degradation of IGFBP4 protein]decreases reaction|increases degradation 16338976
C010327 salinomycin salinomycin results in decreased expression of IGFBP4 mRNAdecreases expression 19682730
D012643 Selenium Selenium results in increased expression of IGFBP4 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of IGFBP4 mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of IGFBP4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of IGFBP4 mRNAaffects expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IGFBP4 mRNAdecreases expression 19901195
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IGFBP4 mRNAdecreases expression 19465110
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP4 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of IGFBP4 mRNAincreases expression 18200517
D002762 Cholecalciferol Cholecalciferol results in increased expression of IGFBP4 mRNAincreases expression 17170073
D014810 Vitamin E Vitamin E results in increased expression of IGFBP4 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.1218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4917505938
MESH:D058186 Acute Kidney Injury resveratrol 3.4616538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.7118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 18.8520127859 20464547
MESH:D000230 Adenocarcinoma daidzein 18.8511473722
MESH:D000230 Adenocarcinoma Doxorubicin 18.8517418594
MESH:D000230 Adenocarcinoma Estradiol 18.8511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 18.8514692618
MESH:D000230 Adenocarcinoma Fluorouracil 18.8517638652
MESH:D000230 Adenocarcinoma Genistein 18.8511473722
MESH:D000236 Adenoma Benzo(a)pyrene 5.926695378
MESH:D000236 Adenoma resveratrol 5.9215688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.4316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.4316835633
MESH:D000419 Albuminuria Doxorubicin 10.0621441931
MESH:D000419 Albuminuria Raloxifene 10.0617308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6317887948
MESH:D000544 Alzheimer Disease Curcumin 6.0415590663
MESH:D000544 Alzheimer Disease Raloxifene 6.0415800139
MESH:D000544 Alzheimer Disease resveratrol 6.0416162502 16183991
MESH:D000686 Amyloidosis Diethylstilbestrol 4.0615469931
MESH:D000740 Anemia Fluorouracil 7.4115504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.4111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6419183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.7317460149
MESH:D001161 Arteriosclerosis Cyclophosphamide 14.5715014928
MESH:D001161 Arteriosclerosis Dietary Fats 14.5715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 14.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4315885639
MESH:D001169 Arthritis, Experimental resveratrol 6.4317115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6216807698
MESH:D050197 Atherosclerosis Curcumin 6.0118704882
MESH:D050197 Atherosclerosis resveratrol 6.0116873680 17967414
MESH:D001284 Atrophy fulvestrant 4.4311514358
MESH:D001327 Autoimmune Diseases Cholecalciferol 9.6616142846
MESH:D001327 Autoimmune Diseases Curcumin 9.6619761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4715746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2514601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.1615867366
MESH:D001862 Bone Resorption bisphenol A 3.4711985600
MESH:D001919 Bradycardia Phenylephrine 4.1015306635
MESH:D001930 Brain Injuries Raloxifene 4.0416580743
MESH:D002545 Brain Ischemia Curcumin 8.8516770732
MESH:D002545 Brain Ischemia resveratrol 8.8517600658
MESH:D001932 Brain Neoplasms Curcumin 7.6917596214
MESH:D001932 Brain Neoplasms Doxorubicin 7.6917150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 16.6920146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 16.6917123778
MESH:D001943 Breast Neoplasms Curcumin 16.6918593918 18462866 19250217 16243823
MESH:D001943 Breast Neoplasms Cyclophosphamide 16.6917388661 17020986 18234424 16978400 11325840 15136595 12006526 15093573 18323546
MESH:D001943 Breast Neoplasms Dietary Fats 16.6920435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 16.6915324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 16.6915668708 15136595 16595493 16264153 16322301 19526202 15692762 18695136 15634643 16096432 15994142 18628466 18382427 15993339 17983394 17426702 11325840 18234424 16935488 15939500 17369602 16826403 16115903 15567936
MESH:D001943 Breast Neoplasms Estradiol 16.6917289903 18497071 12948864 17018787 16675129 17261762 14630087 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 16.6919217205 16110121 15136595 18608205 18357371 16595493 16557594
MESH:D001943 Breast Neoplasms fulvestrant 16.6918984771
MESH:D001943 Breast Neoplasms Genistein 16.6916541309 16873071 17200150
MESH:D001943 Breast Neoplasms Paclitaxel 16.6916115903 15136595 11325840 16273361 18223236 18323546 18234424 16244791
MESH:D001943 Breast Neoplasms Raloxifene 16.6915572757 17261762 16912660 17952589 17893378 17440819 17242785 15775269 15758505 16837676 17049068 17595753
MESH:D001943 Breast Neoplasms resveratrol 16.6917651959 17534123 16393696
MESH:D001943 Breast Neoplasms salinomycin 16.6919682730
MESH:D001943 Breast Neoplasms Tamoxifen 16.6917893378 20065188 19189212 16273361 20135344 21138602 18629630 19059307 18855134 17261762 16202921 17242785 19155303 20005174 15668708 17049068 11161223 18425577 19221464 16873071 19011961 19288272 20544844 18984771 19142967 19066611 18351453 19487384 19115204 20390343 19084267 16818667 19189210 19244106 15565566 19289846 18815881 18997820 21152245 18821012 20859285 19410462 19200415 19103187 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 16.6920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.5016192424 15673190 3786805 16227642 18705752 15721981 10355542 15700767 16050911 16097048 16011737 16124888
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.5016050911
MESH:D002276 Carcinoid Tumor Doxorubicin 10.8516051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.8516051944
MESH:D002277 Carcinoma Curcumin 11.9518593918
MESH:D002277 Carcinoma Fluorouracil 11.9517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.9516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0719066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 24.0521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 24.0518788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 24.0519701751
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 24.0516924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 24.0516023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 24.0516924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 24.0518930000 17045692 16799960 16332177 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 24.0516924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 24.0516313753
MESH:D006528 Carcinoma, Hepatocellular resveratrol 24.0519321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 24.0516924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.5417123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 10.0116152834
MESH:D018827 Carcinoma, Lewis Lung resveratrol 10.0116675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8118414057
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 9.6116201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 9.6116201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.6118695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.7620419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 12.7618462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 12.766189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.7616757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 12.7616227395
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.2317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.2317572228
MESH:D006332 Cardiomegaly Phenylephrine 6.0317124262 11754973 15728586 16170337 11179087 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.0316120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.2317007740 18627295 16455267 17308081 16612575 17351982 16242529 15505089 17382496 16364871 15811867 15476868 15792986 17519947 17974986 17329180 17924179 16109756 16952015 17131338 16278810 16269455 17928571 16651473 16731534
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7817334414 16243910
MESH:D002318 Cardiovascular Diseases daidzein 14.8516332659
MESH:D002318 Cardiovascular Diseases Genistein 14.8516332659
MESH:D002318 Cardiovascular Diseases Raloxifene 14.8515775269
MESH:D002318 Cardiovascular Diseases resveratrol 14.8515458977
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.4718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.6515861022 16105132 17110522 17681005 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 6.6519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9116354765 15340226 15668235 8697196 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.1915800139
MESH:D003092 Colitis Curcumin 19.3518200517 16804969 16782535
MESH:D003092 Colitis resveratrol 19.3516474422
MESH:D003092 Colitis Selenium 19.3517936198
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 19.3516867261 11698051 17991707 16474422 17936198 16804969 18023891 18200517 16782535
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.2817276891
MESH:D003103 Coloboma Curcumin 4.1518809619
MESH:D003110 Colonic Neoplasms Curcumin 7.5019359593 16340194
MESH:D003110 Colonic Neoplasms Fluorouracil 7.5017287894 15001691 17172411 17725105 18772588 17169374 16340194 16510598 17018589 17016597
MESH:D003110 Colonic Neoplasms Genistein 7.5017182828
MESH:D003110 Colonic Neoplasms resveratrol 7.5016338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 5.9318259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 5.9318949393 17695437 18448328 16524972 18288408 16331619 17255274 15148649 16391804 18383874 14970324 16282729 17594712 17454858 15289873 16303861 17016601 18509181 17094418 17401013 18802399 20501625
MESH:D015179 Colorectal Neoplasms Paclitaxel 5.9318802399
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 5.9315531428
MESH:D015179 Colorectal Neoplasms resveratrol 5.9316550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6917141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.4618497527
MESH:D003327 Coronary Disease resveratrol 3.4616507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3215322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.3219769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.1416002989 12952375
MESH:D003556 Cystitis Cyclophosphamide 4.5310498854 10700343 16614059 11948286 18372110 17979934 18433785 18483878 16413132 16989017 18093676 17010015 15643279 16651033 12388444 18710439 12913760 12161096 15276878 18295254
MESH:D007644 Darier Disease Fluorouracil 4.3516733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.3116140633
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9319031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7917474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2118249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 7.4811751995 10990075 15331540
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.4816873680
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0718772604
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.2518403477
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 9.2516647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.2516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.2517107852
MESH:D003928 Diabetic Nephropathies Curcumin 24.1318204486
MESH:D003928 Diabetic Nephropathies Estradiol 24.1319279558
MESH:D003928 Diabetic Nephropathies Raloxifene 24.1317308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies resveratrol 24.1316286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 24.1319279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 7.753732212 15968718 6884620 7440962 3786805 17522070 7120509 10915739 10092053 2869522 15027814 19085960 7179309 6623471 19336974 4309450 11566570 21278145 15998439 16227642 9327722 16177239
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 7.7517416283
MESH:D056486 Drug-Induced Liver Injury Selenium 7.7515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.7520420201
MESH:D004362 Drug Toxicity Doxorubicin 7.0118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.0111462148
MESH:D004381 Duodenal Ulcer Curcumin 3.6317351913
MESH:D050171 Dyslipidemias Dietary Fats 3.1318367378
MESH:C538011 Eales disease Vitamin E 4.259068938
MESH:D004487 Edema pirinixic acid 13.2312083418
MESH:D004487 Edema Raloxifene 13.2315860553
MESH:D004487 Edema resveratrol 13.238985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.2312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4515322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 18.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 18.4915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 18.4917872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 18.4919031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.4216402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.4216402032
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 30.5319148513
MESH:D016889 Endometrial Neoplasms daidzein 30.5311473722
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 30.5316804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 30.5317359293
MESH:D016889 Endometrial Neoplasms Estradiol 30.5319148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 30.5311473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 30.5320544844 16202921 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.649294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7018037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4217923197
MESH:D004802 Eosinophilia Cyclophosphamide 3.7911006010
MESH:D007172 Erectile Dysfunction daidzein 4.6014972507
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.5616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.5615173087 16481741 16337965 16785472 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 6.5616481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6811564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 30.9115959796 19224547 12795759 16239168 12631006 61145 17595544 16045604
MESH:D005234 Fatty Liver Curcumin 30.9119297423
MESH:D005234 Fatty Liver Dietary Fats 30.9117967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 30.9115345470
MESH:D005234 Fatty Liver pirinixic acid 30.9120131406 19236843
MESH:D005234 Fatty Liver Raloxifene 30.9117473493
MESH:D005234 Fatty Liver Tamoxifen 30.9114986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.2915751030 16513791 16534752 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.2916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0814745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.9719069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.9719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 23.1818705752
MESH:D005355 Fibrosis Curcumin 23.1818705752
MESH:D005355 Fibrosis Dietary Fats 23.1818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.1820067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 23.1817994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2618462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.5016452187
MESH:D005909 Glioblastoma Curcumin 10.2917596214
MESH:D005909 Glioblastoma Doxorubicin 10.2917150277
MESH:D005909 Glioblastoma Genistein 10.2916598420
MESH:D005910 Glioma Fluorouracil 2.6816145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0711389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1410696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.6016376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Curcumin 11.2818462866 18829502
MESH:D006258 Head and Neck Neoplasms Doxorubicin 11.2815692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.2815102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.6820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.6810048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 9.6816080930
MESH:D006331 Heart Diseases Doxorubicin 6.8117875725 16244371 16879835 17888722 16244372 16144979 14766674 18674790 18006777 16707910 16495754 12587719 16330681
MESH:D006331 Heart Diseases Raloxifene 6.8111110106
MESH:D006333 Heart Failure Doxorubicin 10.1817481944
MESH:D006333 Heart Failure pirinixic acid 10.1820558911
MESH:D006333 Heart Failure Selenium 10.1817162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5115692506
MESH:D006467 Hemophilia A Cyclophosphamide 4.8611918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9411000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.0814986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1819110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 6.8319772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.8316120746 12621046 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6117701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5416863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.5815709030
MESH:D006561 Herpes Simplex resveratrol 3.7416876885
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.4916135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 6.4917606976 18501091 15147373
MESH:D019584 Hot Flashes Estradiol 8.5517088409
MESH:D019584 Hot Flashes Vitamin E 8.5514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5916959395 15340226 18606429 8697196 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0916899240
MESH:D006937 Hypercholesterolemia Curcumin 13.0818704882
MESH:D006937 Hypercholesterolemia Dietary Fats 13.0821332399
MESH:D006937 Hypercholesterolemia resveratrol 13.0817188708
MESH:D006943 Hyperglycemia pirinixic acid 2.8020558911
MESH:D006949 Hyperlipidemias Dietary Fats 7.9421332399
MESH:D006949 Hyperlipidemias resveratrol 7.9416873680
MESH:D006965 Hyperplasia Diethylstilbestrol 4.0014722030 12960047
MESH:D006973 Hypertension daidzein 10.9317169123
MESH:D006973 Hypertension Phenylephrine 10.938949925 12717712
MESH:D006973 Hypertension Raloxifene 10.9317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.9318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6615338365
MESH:D006984 Hypertrophy Phenylephrine 4.1618502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9217488730
MESH:D007021 Hypospadias Diethylstilbestrol 9.8016002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.8016569931 16945680
MESH:D007154 Immune System Diseases Cyclophosphamide 4.8816076520
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.2117600658
MESH:D007246 Infertility Diethylstilbestrol 3.9415036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0512013081
MESH:D007248 Infertility, Male Cyclophosphamide 9.647193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.6417937319
MESH:D007248 Infertility, Male fulvestrant 9.6411514358
MESH:D007249 Inflammation Curcumin 13.2818403477 17151092 16956363
MESH:D007249 Inflammation Dietary Fats 13.2820412841
MESH:D007249 Inflammation resveratrol 13.2816366677
MESH:D007249 Inflammation Tamoxifen 13.2819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.2812200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.0518200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.0518200517
MESH:D007251 Influenza, Human resveratrol 16.0116624496
MESH:D007251 Influenza, Human Selenium 16.0116624496
MESH:D007251 Influenza, Human Vitamin E 16.0116624496
MESH:D007333 Insulin Resistance bisphenol A 15.2116393666
MESH:D007333 Insulin Resistance Dietary Fats 15.2118457598 11836018
MESH:D007333 Insulin Resistance Estradiol 15.2116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 15.2116306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.1817994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.8410783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9416580747
MESH:D007674 Kidney Diseases Doxorubicin 8.6215699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 8.6215618244
MESH:D007674 Kidney Diseases Vitamin E 8.6212488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.6716707910
MESH:D007676 Kidney Failure, Chronic Selenium 8.6716518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 14.8515003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 14.8515610895
MESH:D007680 Kidney Neoplasms Fluorouracil 14.8516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 14.8518625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.6317184923
MESH:D007889 Leiomyoma Curcumin 9.8018555241
MESH:D007889 Leiomyoma Raloxifene 9.8016973256
MESH:D007938 Leukemia Curcumin 9.2918462866
MESH:D007938 Leukemia Cyclophosphamide 9.2910602166
MESH:D007938 Leukemia Genistein 9.2918980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7016085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3018587576 17802794 18172266 17008537 17296974 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8116106398
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 8.0612421474
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 8.0610373061
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.2816087638
MESH:D015458 Leukemia, T-Cell Curcumin 4.3416106398
MESH:D007970 Leukopenia Cyclophosphamide 4.5211830472 10052129
MESH:D008064 Lipidoses Tamoxifen 2.8415342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.4117353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.7811903743 16943688 17157831 11408273 17334410 21278145 17174718 16239168 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 5.7818296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.3312445418 17761835 18412020 17708605 16136751 12632514 15338365 17805973 14716496 15730626 17823541 15673190 18054572 12586293 14620537 11481614 17922224 18418968 12389079 16033810 17714472 17976157 16638106 15362042 16015684 15650968 14512876 13678700 16248980 16097048 12546737 12667390 18251166 18166357 15931870 16192424 18395914 15052691 18210741 15876570 18277467 17640975 18006644 16116963 18472094 18705752 17557913 18156304 18376398 18420326 12649538 12958196 12666154 18429990 12898905 15893842 17698563 18279442 18472332 16027843 17869086 17944888 17481882 14724832 15370692 10355542 15818738 18339082 14748882 12741479 20821823 18205269 17900296 17565644 15959796 18395095 15123356 12445421 16011737 17525996 12609069 18263696 15057751 12632512 18481824 15925388 15996030 17721639 14716833 18317297 17766677 18187930 17631135
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 14.3318006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 14.3316595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 14.3317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.3315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.3312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 14.3316169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.8317285989 15830285 16964402 15720792 16246199
MESH:D008107 Liver Diseases Curcumin 3.8316956363
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3114706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 26.469163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 26.4620195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 26.4619294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 26.4615890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 26.4618383874 17045692 15113037 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 26.4620007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 26.4619812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 26.4616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 26.4616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.658603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.6515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 15.6517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 15.651423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.6512151625
MESH:D008171 Lung Diseases Vitamin E 2.8816863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 11.7914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.7920464547 17053015 18816296 18520028 18569708 20064080 20869020 6695378 20135361
MESH:D008175 Lung Neoplasms Curcumin 11.7918462866 19359593 16243823
MESH:D008175 Lung Neoplasms Doxorubicin 11.796189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 11.7915246190
MESH:D008175 Lung Neoplasms Tamoxifen 11.7918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.7919555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 11.7911062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3515086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7115166399
MESH:D008223 Lymphoma Curcumin 15.3118462866
MESH:D008223 Lymphoma Cyclophosphamide 15.3112854902
MESH:D008223 Lymphoma Diethylstilbestrol 15.3115700306
MESH:D008223 Lymphoma Doxorubicin 15.3116098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 9.1216675587
MESH:D016393 Lymphoma, B-Cell resveratrol 9.1217088997
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 17.7611911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 17.7617654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 17.7614749477
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 17.7614749477
MESH:D016399 Lymphoma, T-Cell Curcumin 10.1316173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 10.1315621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.0616002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.5315688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.5319428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 24.0415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 24.0411807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 24.0414578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 24.0411606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 24.0419682730
MESH:D008325 Mammary Neoplasms, Experimental Selenium 24.0415318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 24.0411731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.1419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.1419453300
MESH:D008545 Melanoma Curcumin 8.7917885582 18462866
MESH:D008545 Melanoma Doxorubicin 8.7916827129
MESH:D008545 Melanoma Paclitaxel 8.7916342250 12025231 12040289
MESH:D008545 Melanoma resveratrol 8.7917992120
MESH:D008545 Melanoma Tamoxifen 8.7912393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7415990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.3716388313
MESH:D008569 Memory Disorders Curcumin 3.7417263510
MESH:D008654 Mesothelioma Doxorubicin 5.6517638057
MESH:D008654 Mesothelioma Selenium 5.6515107826
MESH:D008659 Metabolic Diseases resveratrol 3.9817112576
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1015792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1015863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.4016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.4016757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.3517415656
MESH:D009101 Multiple Myeloma Curcumin 14.7119372569
MESH:D009101 Multiple Myeloma Paclitaxel 14.7114749477
MESH:D009101 Multiple Myeloma Raloxifene 14.7116497877
MESH:D009101 Multiple Myeloma resveratrol 14.7117164350 16490592 16267019 17049120 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.9417962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.9417962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0816239165
MESH:D009203 Myocardial Infarction Doxorubicin 11.9219429709 15857846
MESH:D009203 Myocardial Infarction Genistein 11.9217141266
MESH:D009203 Myocardial Infarction pirinixic acid 11.9219151258
MESH:D009203 Myocardial Infarction resveratrol 11.9217188708 16456233 16525036 17125593 16317513 17015251
MESH:D017202 Myocardial Ischemia resveratrol 7.8417015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.2016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.2017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.2016411023
MESH:D009205 Myocarditis resveratrol 4.3217322642
MESH:D009232 Myxoma Raloxifene 5.1016343187
MESH:D009361 Neoplasm Invasiveness Curcumin 3.9518495463
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.4918259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 8.4915867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.4919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 13.2611141357
MESH:D009369 Neoplasms Cyclophosphamide 13.2618854779
MESH:D009369 Neoplasms Diethylstilbestrol 13.2615313581
MESH:D009369 Neoplasms Fluorouracil 13.2618239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 13.2617405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.578985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.3412497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.3419189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2917289903
MESH:D009401 Nephrosis Doxorubicin 4.3416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.6315640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 26.2911399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 26.2911399458
MESH:D009421 Nervous System Malformations Estradiol 26.2916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 26.2916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 26.2914600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.1818462866
MESH:D009447 Neuroblastoma Cyclophosphamide 6.4116115947 8761367 15176712
MESH:D009447 Neuroblastoma Doxorubicin 6.4115555623
MESH:D019636 Neurodegenerative Diseases resveratrol 3.4517652729
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.458761367 12837982
MESH:D020078 Neurogenic Inflammation resveratrol 3.9917929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1316436463
MESH:D009503 Neutropenia Cyclophosphamide 3.928291058
MESH:D009765 Obesity Curcumin 6.6819297423
MESH:D009765 Obesity Dietary Fats 6.6821332399 18674790 17217161 16723640 18457598 19632207 20518802 11836018 20132043
MESH:D009765 Obesity pirinixic acid 6.6820558911
MESH:D009845 Oligospermia Cyclophosphamide 4.2716517039
MESH:D010014 Osteolysis Paclitaxel 4.5415867366
MESH:D010024 Osteoporosis Curcumin 10.3318719352
MESH:D010024 Osteoporosis Genistein 10.3319401787
MESH:D010024 Osteoporosis Raloxifene 10.3317882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 14.5416169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 14.5415579764 17823083 15758505 17893378
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 14.5417513867
MESH:D012516 Osteosarcoma Doxorubicin 3.7615930896
MESH:D010049 Ovarian Diseases bisphenol A 4.5411985600
MESH:D010051 Ovarian Neoplasms Curcumin 10.0419020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 10.0419401270
MESH:D010051 Ovarian Neoplasms Genistein 10.0419005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 10.0411161223
MESH:D010146 Pain Cyclophosphamide 3.2812161096 18093676
MESH:D010190 Pancreatic Neoplasms Curcumin 7.7719401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 7.7711332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.7716500647 16929163 15113037 19003803
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.8017698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2811578682
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.2216702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8012520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7017983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.7214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.2415687265 16977796
MESH:D010954 Plasmacytoma Selenium 4.4415087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1418163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.5521297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 19.6310548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 19.6317184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 19.6316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.6311896295 11118676 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.2320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.2320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 9.5617292933
MESH:D011471 Prostatic Neoplasms bicalutamide 9.5619011039 19240160 18487222 17914592 15638997
MESH:D011471 Prostatic Neoplasms bisphenol A 9.5616740699
MESH:D011471 Prostatic Neoplasms Cholecalciferol 9.5617024972
MESH:D011471 Prostatic Neoplasms Curcumin 9.5611398177 18769126 18156803 10851300 15129424 12497104 18226269
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 9.5617136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 9.5615046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Doxorubicin 9.5616868541 15897917 16888761 18437689 15749863 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 9.5616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 9.5618626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 9.5616925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Paclitaxel 9.5617172428 16356831 17136230 16729912
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 9.5615721890
MESH:D011471 Prostatic Neoplasms Raloxifene 9.5616220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms resveratrol 9.5617718901 17636462 15767336 17804756 16731767 17675339
MESH:D011471 Prostatic Neoplasms Tamoxifen 9.5615067354
MESH:D011471 Prostatic Neoplasms Vitamin E 9.5615084515
MESH:D011537 Pruritus Ethinyl Estradiol 2.8716919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.3410548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.1419168576
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.1016636934
MESH:D011693 Purpura Raloxifene 5.1015770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6416160472 15538739 18286688 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 3.7917922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1316325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.8019058328
MESH:D015427 Reperfusion Injury resveratrol 5.8016317513 16314181 17058453 17520802 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.6210666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4218990726
MESH:D012509 Sarcoma Curcumin 8.2918462866
MESH:D012509 Sarcoma Doxorubicin 8.2916767912 15675481 15625365 18313854 17710206 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.8214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3517846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.4116636934
MESH:D018805 Sepsis Curcumin 3.7118389075
MESH:D012852 Sinusitis Phenylephrine 4.267327846
MESH:D012871 Skin Diseases Vitamin E 2.3218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.5619755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 15.5615692506
MESH:D012878 Skin Neoplasms resveratrol 15.568985016 15837718
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.568532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.5616192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1315625365 17203757 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 17.5216002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 17.5216709447
MESH:D013088 Spermatocele Tamoxifen 17.5216709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0716517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6019457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.162093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.1617522103 16951190 18396642 19084572 16424979 17498489 18567086 15786421 19015929 17172411
MESH:D013274 Stomach Neoplasms Paclitaxel 3.1618506536 18396642
MESH:D013276 Stomach Ulcer Curcumin 3.1216631530 19188055
MESH:D020521 Stroke Raloxifene 7.5516837676
MESH:D020521 Stroke Vitamin E 7.5516517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0916321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.5416684133 16045194
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.6112837982
MESH:D024801 Tauopathies Paclitaxel 4.3716930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.0416010429 17909728
MESH:D013978 Tibial Fractures Estradiol 12.2119048282
MESH:D013978 Tibial Fractures Raloxifene 12.2119048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.7116280240
MESH:D014062 Tongue Neoplasms resveratrol 8.7116227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 21.2217053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 21.2218593936
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 21.2214692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 21.2217306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 21.2217653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 21.2217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 21.2216712894 17572228 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 4.8218462866
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 13.7416175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.7416803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 13.7417473185
MESH:D014591 Uterine Diseases bisphenol A 12.3114652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.3114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 13.6415809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.6414692618
MESH:D014594 Uterine Neoplasms resveratrol 13.6417044934
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.0016513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1412125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.7616837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.9017678736 17638931 17334414 16364871
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.9017488730
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8015886252
MESH:D015430 Weight Gain Dietary Fats 3.3716723640
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29706
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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