AutismKB 2.0

Annotation Detail for IGFBP7


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Basic Information Top
Gene Symbol:IGFBP7 ( AGM,FSTL2,IBP-7,IGFBP-7,IGFBP-7v,IGFBPRP1,MAC25,PSF,TAF )
Gene Full Name: insulin-like growth factor binding protein 7
Band: 4q12
Quick LinksEntrez ID:3490; OMIM: 602867; Uniprot ID:IBP7_HUMAN; ENSEMBL ID: ENSG00000163453; HGNC ID: 5476
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1944Breast cancer
2066Lung cancer
Desease Name
CANCER
breast carcinoma
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of IGFBP7 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of IGFBP7 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IGFBP7 proteinaffects expression 20106945
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of IGFBP7 mRNAdecreases expression 16704987
C006632 arsenic trioxide arsenic trioxide results in decreased expression of IGFBP7 mRNAdecreases expression 15725085
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IGFBP7 mRNAincreases expression 20106945
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of IGFBP7 mRNAaffects cotreatment|decreases expression 12634122
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of IGFBP7 mRNAincreases expression 16239168
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of IGFBP7 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of IGFBP7 mRNAaffects cotreatment|decreases expression 12634122
D016572 Cyclosporine Cyclosporine results in increased expression of IGFBP7 mRNAincreases expression 20106945
C014347 decitabine decitabine affects the methylation of IGFBP7 exonaffects methylation 17334979
C014347 decitabine decitabine results in increased expression of IGFBP7 mRNAincreases expression 18981723
16367923
C014347 decitabine decitabine results in increased expression of IGFBP7 proteinincreases expression 18981723
D004041 Dietary Fats Dietary Fats results in increased expression of IGFBP7 mRNAincreases expression 18457598
18503570
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of IGFBP7 mRNAincreases expression 19638242
D004317 Doxorubicin IGFBP7 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of IGFBP7 mRNAincreases expression 17108234
D005047 Etoposide IGFBP7 protein affects the susceptibility to Etoposideaffects response to substance 16217747
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of IGFBP7 mRNAaffects cotreatment|decreases expression 12634122
D008727 Methotrexate IGFBP7 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D008942 Mitoxantrone IGFBP7 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D010126 Ozone Ozone results in decreased expression of IGFBP7 mRNAdecreases expression 12763052
D011794 Quercetin Quercetin results in increased expression of IGFBP7 mRNAincreases expression 16455785
C010327 salinomycin salinomycin results in decreased expression of IGFBP7 mRNAdecreases expression 19682730
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of IGFBP7 mRNAaffects cotreatment|decreases expression 12634122
D018038 Sodium Selenite Sodium Selenite results in increased expression of IGFBP7 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IGFBP7 mRNAdecreases expression 17101203
20106945
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IGFBP7 mRNAaffects cotreatment|affects expression 16979875
D019772 Topotecan IGFBP7 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C034613 triacsin C triacsin C results in decreased expression of IGFBP7 mRNAdecreases expression 16704987
C025643 vinclozolin vinclozolin affects the expression of IGFBP7 mRNAaffects expression 19015723
D015032 Zinc Zinc affects the expression of IGFBP7 mRNAaffects expression 16979875
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IGFBP7 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 7.6112039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.6115322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6417505938
MESH:D000169 Acrodermatitis Zinc 5.1117202136 17190629 16889938
MESH:D000230 Adenocarcinoma arsenic trioxide 9.5111798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.5120127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 9.5117418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.5114692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.066695378
MESH:D000236 Adenoma Diethylnitrosamine 6.066695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.0718056438 19052882 17162532 17620307 16434500 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6016712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.2621441931
MESH:D000544 Alzheimer Disease Ozone 4.2115513908
MESH:D000544 Alzheimer Disease Zinc 4.2116410023 16325427 16580781 17119284
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6911748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.9817084956
MESH:D000755 Anemia, Sickle Cell Zinc 4.6216916123
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4119015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7819183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4815885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.7217286800
MESH:D001172 Arthritis, Rheumatoid Ozone 4.7215570426
MESH:D001249 Asthma Ozone 4.8617854713 16373670
MESH:D001249 Asthma Zinc 4.8617085522
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6815336622
MESH:D001321 Autistic Disorder Acetaminophen 2.2318445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2318582451
MESH:D001327 Autoimmune Diseases Quercetin 4.1219761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.0816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.1614601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 11.1614601052
MESH:D001930 Brain Injuries Zinc 4.4017109824
MESH:D001932 Brain Neoplasms Doxorubicin 3.5617150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.6720146248 17474063
MESH:D001943 Breast Neoplasms decitabine 6.6719208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 6.6720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.6717474063
MESH:D001943 Breast Neoplasms Doxorubicin 6.6715136595 16935488 16096432 16826403 18628466 18234424 18695136 16115903 15939500 15993339 19526202 16595493 16264153 17426702 15668708 15634643 15692762 16322301 17983394 18382427 15994142 15567936 11325840 17369602
MESH:D001943 Breast Neoplasms Etoposide 6.6716322251
MESH:D001943 Breast Neoplasms Methotrexate 6.6716978400
MESH:D001943 Breast Neoplasms Quercetin 6.6718628248
MESH:D001943 Breast Neoplasms salinomycin 6.6719682730
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.6720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4515516495 19059883 18417511 14754758 18315731 16777450 17626835
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0611589617
MESH:D002100 Cachexia Ozone 4.4416183385
MESH:D002105 Cadmium Poisoning Quercetin 5.2516962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4916124888 16227642 16050911 15721981 10355542 15673190 3786805 15700767 16192424 16097048 16011737 18705752
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5116051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.013084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.0121507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.0115553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.0118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.0121159647 19208518 11831363 17173139 18971187 18210153 16779866 16569478 16807293 20727157 19335982 16935385 10737359 18393292 19822196 17978847 17428255 17761372 20084675 19919837 19519916 19171122 20512989 16328049 19394651 10672840 19418558 3084413 20007298 16502159 3581430 19052882 20432363 20214788 18691550 18788625 18785209 17055752 20524982 18506893 16681979 19539802 18665156 20514400 18056438 17138121 20935162 19701751 16830150 16878318 17162532 16288022 16698587 18494052 18978308 19107877 20101231 19383236 16540662
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.0118059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Quercetin 16.0119519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.0116507464 17306315 15276417
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5719014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.0216201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8612490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 16.9020419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 16.9019215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 16.906189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 16.9018572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 16.9018922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 16.9016543248
MESH:D006332 Cardiomegaly Quercetin 6.2619794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2618670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3417351982 17519947 16651473 17131338 18627295 17329180 17007740 15476868 17382496 16364871 17974986 16109756 16455267 15505089 16278810 16269455 17924179 16731534 15811867 17308081 16612575 16242529 15792986 16952015 17928571
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8417334414 16243910
MESH:D002318 Cardiovascular Diseases Zinc 3.4616936243
MESH:D002386 Cataract Acetaminophen 2.4110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.0212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.0217174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.0219524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5016835633
MESH:D002779 Cholestasis Cyclosporine 7.0619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0617681005 17333356 16105132 15861022 16919318 11677210 17110522
MESH:D019457 Chromosome Breakage Sodium Selenite 4.4615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9816354765 8697196 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms decitabine 3.7417616700
MESH:D003110 Colonic Neoplasms Quercetin 3.7411134977 19056647 15741050 16640504 17148506 19440933 17191121
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.5720501625
MESH:D015179 Colorectal Neoplasms decitabine 4.5718981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.5718802399 18259882
MESH:D015179 Colorectal Neoplasms Quercetin 4.5718095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.9810525206
MESH:D019465 Craniofacial Abnormalities lead acetate 6.9819769572
MESH:D019465 Craniofacial Abnormalities Methotrexate 6.9812039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.9820055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 6.9819302082
MESH:D003456 Cryptorchidism vinclozolin 4.0614966744
MESH:D003550 Cystic Fibrosis Methotrexate 3.9919747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8215213294
MESH:D003882 Dermatomyositis Methotrexate 4.8420191521
MESH:D003920 Diabetes Mellitus Sodium Selenite 8.5716285004
MESH:D003920 Diabetes Mellitus Zinc 8.5716479319
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5019496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9617107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.0416081117 16393943 14986274 19164858 19739265 15619225 15968718 11529661 11834606 11743745 14725611 19370779 16109766 19420014 16227642 11739529 16781746 12594235 19085960 14550746 11461765 17562736 18071297 12153990 19416960 10663392 17522070 12392966 11421492 2444490 16177239 16485898 12958197 11287661 12705907 19923254 17906064 12540782 10915739 10774834 18713872
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.0419085960 10092053 16177239 15998439 16227642 3732212 9327722 7120509 21278145 11566570 17522070 7179309 10915739 3786805 4309450 19336974 7440962 6884620 15968718 6623471 2869522 15027814
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.0419107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 14.0417416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 14.0415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.0420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Doxorubicin 7.3918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.3911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2418367378
MESH:D004487 Edema Arachidonic Acid 10.167990266 11698051 9599246 15177302 9831321 16716910
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.1612711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 10.1616716910 8273558 11698051 8113982 15177302 9599246 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9112538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8219294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.2617359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.779294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8618037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.8412903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.8416530937
MESH:D004938 Esophageal Neoplasms Zinc 6.8416543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005234 Fatty Liver arsenic trioxide 27.2815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.2815959796 17595544 12795759 16045604 12631006 19224547 16239168 61145
MESH:D005234 Fatty Liver Cyclosporine 27.2819224547
MESH:D005234 Fatty Liver Dietary Fats 27.2817967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 27.2821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.2815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.1019769572
MESH:D005334 Fever Arachidonic Acid 4.4011852909
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 24.6518705752
MESH:D005355 Fibrosis Cyclosporine 24.6512639820 12168785
MESH:D005355 Fibrosis Dietary Fats 24.6518296743
MESH:D005355 Fibrosis Quercetin 24.6519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.6520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9816904648
MESH:D005756 Gastritis Acetaminophen 10.1716983495
MESH:D005756 Gastritis Zinc 10.1717241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6416973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0016417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D005909 Glioblastoma Doxorubicin 6.7517150277
MESH:D005909 Glioblastoma Quercetin 6.7519804834
MESH:D005910 Glioma Quercetin 2.9417643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.8616518429
MESH:D006130 Growth Disorders Zinc 3.7717217573
MESH:D006258 Head and Neck Neoplasms decitabine 7.3019215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.3015692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9311294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 7.3912587719 14766674 18674790 16879835 16707910 18006777 17888722 17875725 16244371 16495754 16330681 16244372 16144979
MESH:D006331 Heart Diseases Mitoxantrone 7.3916019553
MESH:D006333 Heart Failure Doxorubicin 6.8417481944
MESH:D006333 Heart Failure Zinc 6.8417162251
MESH:D006335 Heart Injuries Zinc 5.4717074742
MESH:D016481 Helicobacter Infections Zinc 4.2617241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6415692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3219110552 19900420
MESH:D006527 Hepatolenticular Degeneration Zinc 4.4017276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6112621046 15340226 16120746
MESH:D006561 Herpes Simplex Etoposide 4.2710809021
MESH:D006689 Hodgkin Disease Doxorubicin 10.9617606976 18501091 15147373
MESH:D006689 Hodgkin Disease Etoposide 10.9617606976 15147373 18180244 16200630 16135485
MESH:D006689 Hodgkin Disease sodium arsenite 10.9612676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7516959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.4716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2416899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3321332399
MESH:D006943 Hyperglycemia Quercetin 3.7818262572 11834736
MESH:D006949 Hyperlipidemias Dietary Fats 3.3421332399
MESH:D006973 Hypertension Cyclosporine 7.9010903974
MESH:D006973 Hypertension Quercetin 7.9018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1912013081
MESH:D007248 Infertility, Male decitabine 14.4417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.4417937319
MESH:D007248 Infertility, Male sodium arsenite 14.4412646999 15346721
MESH:D007248 Infertility, Male vinclozolin 14.4416467254
MESH:D007249 Inflammation Arachidonic Acid 14.2317371808 15177302 9831321
MESH:D007249 Inflammation Dietary Fats 14.2320412841
MESH:D007249 Inflammation Diethylnitrosamine 14.2318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.2312200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 14.2311698051 8273558 7562506 7812673 15177302
MESH:D007251 Influenza, Human Quercetin 4.2116624496
MESH:D007333 Insulin Resistance Dietary Fats 6.8511836018 18457598
MESH:D007333 Insulin Resistance Sodium Selenite 6.8514714311
MESH:D007511 Ischemia Zinc 4.3416584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0716580747
MESH:D007627 Keloid Quercetin 4.6717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Acetaminophen 26.2415629191 12587719
MESH:D007674 Kidney Diseases Cadmium Chloride 26.2416962696
MESH:D007674 Kidney Diseases Cyclosporine 26.2418776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 26.2415369732 16775033 15699352
MESH:D007674 Kidney Diseases Quercetin 26.2416962696
MESH:D007674 Kidney Diseases sodium arsenite 26.2420008137
MESH:D007674 Kidney Diseases Zinc 26.2416960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.3016707910
MESH:D007676 Kidney Failure, Chronic Zinc 9.3016518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.5012371664
MESH:D007805 Language Development Disorders Methotrexate 4.839562676
MESH:D007938 Leukemia arsenic trioxide 9.6915070760
MESH:D007938 Leukemia decitabine 9.6919235587 18980019
MESH:D007938 Leukemia Quercetin 9.6917468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8616085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6618172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.7119077051
MESH:D007951 Leukemia, Myeloid decitabine 8.7117236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8020471514 16467208 16968895 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.8017679729 19387464 18460780 18206229 19010910 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1618055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0217649720 19225113 16823087 12679006 19075265 17217047 16891316 12018890 19642359 15622746 17712046 11161223 19035177 16966277 9834237 16330433 15213294 16331271 16112521 15748426 11468182 17869043 12712474 15336539 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0716882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4416417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.4516943688 16239168 11408273 11903743 17157831 17174718 21278145 17334410 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 14.4518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.4518522880 20032147 18665156 19638242 18407596
MESH:D008103 Liver Cirrhosis Methotrexate 14.4514986274
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.6618705752 18412020 17944888 18277467 17565644 15931870 18187930 12632514 15650968 18376398 18429990 18251166 12609069 12546737 15057751 17714472 18263696 14620537 14716833 16136751 18156304 17698563 18166357 12389079 15959796 15925388 17976157 14748882 18420326 16248980 17525996 17481882 16011737 15338365 12667390 12649538 18418968 15370692 20821823 18472094 13678700 18472332 18395095 18395914 18317297 17557913 15876570 18210741 17631135 17922224 12445421 18006644 17640975 16015684 18481824 12445418 15893842 14512876 16097048 15730626 12632512 16638106 16192424 17869086 16116963 17805973 17900296 12898905 16033810 17823541 15052691 14716496 17766677 18054572 14724832 17761835 12958196 17708605 16027843 12666154 11481614 15818738 10355542 15673190 18205269 17721639 12741479 15996030 12586293 15123356 18279442 18339082 15362042
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.6616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 4.6612741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6612878042
MESH:D008107 Liver Diseases Acetaminophen 5.9912969438 16610002 19014921 12587719 19460945 11587558 19784758 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.9915830285 15720792 16246199 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 5.9917034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.5614706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 23.939163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 23.9314682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.9321137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 23.9319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 23.9315885732 19690152 19255062 20452335 19996281 19254457 20583210 19638242 21167192 18644402 9163691 18648771 19833225 18754104 10737359 19812893 19073162 12112319 19090486 19499222 19850985 12771043 2862719 18977376 20434301 19294768 19551842 19426721 20492335 15175105 20118626 20137499 19256749 20101389 18978307 21278145 16942905 19642983 20501860 21071580 2422723 19427195 21047994 20405173
MESH:D008113 Liver Neoplasms Quercetin 23.9318980244
MESH:D008113 Liver Neoplasms sodium arsenite 23.9315276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.9316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.458603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 25.4520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.4512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.453124819 18544905 9362446 16267830 17854601 18775883 2563599 19539802 19519916 19009564 17174075 18079962 17942915 18308698 19126423 21159647 19004024 18282651 18164116 16842330 18253720 18093689
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 25.4516842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 25.4519519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.4512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1315213294
MESH:D008171 Lung Diseases Ozone 6.8619066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 6.8619095001
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.7218516814
MESH:D055370 Lung Injury Ozone 3.5620417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 17.0814755239
MESH:D008175 Lung Neoplasms arsenic trioxide 17.0811798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 17.0820464547 20135361 18569708 18520028 18816296 20869020 6695378 17053015 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 17.0820970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 17.0817418594 6189445
MESH:D008175 Lung Neoplasms Ozone 17.088597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 17.0816280456
MESH:D008175 Lung Neoplasms sodium arsenite 17.0816712894 15276417 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 17.0819555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 17.0811807781
MESH:D008223 Lymphoma decitabine 16.2419470736
MESH:D008223 Lymphoma Doxorubicin 16.2416098063
MESH:D008223 Lymphoma Etoposide 16.2412854902 12556972
MESH:D008223 Lymphoma Methotrexate 16.2417352296
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.7914737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5517654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.8515458769
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 12.8519682730
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 12.858985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 12.8512773700
MESH:D008545 Melanoma decitabine 4.8617785578 16505122
MESH:D008545 Melanoma Doxorubicin 4.8616827129
MESH:D008545 Melanoma sodium arsenite 4.8616487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008654 Mesothelioma Doxorubicin 2.9417638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D008679 Metaplasia Ozone 4.8110496685
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2315792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9716381670
MESH:D052016 Mucositis Doxorubicin 11.5317415656
MESH:D052016 Mucositis Methotrexate 11.5317488658
MESH:D009101 Multiple Myeloma arsenic trioxide 6.6915949261 19417148 11468182 19549372 14977855
MESH:D009101 Multiple Myeloma decitabine 6.6918172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.9416882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 6.9419010910 18608210 19157545 16882708
MESH:D009203 Myocardial Infarction Doxorubicin 5.6015857846 19429709
MESH:D009203 Myocardial Infarction Quercetin 5.6019595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.5719207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6816624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.483581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.4818259882
MESH:D009369 Neoplasms Benzo(a)pyrene 14.1811141357
MESH:D009369 Neoplasms decitabine 14.1817925555 19116145 19470736
MESH:D009369 Neoplasms Mitoxantrone 14.1816640825
MESH:D009369 Neoplasms Quercetin 14.1815185748
MESH:D009369 Neoplasms sodium arsenite 14.1811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3820056578
MESH:D009401 Nephrosis Doxorubicin 4.4816899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.4818481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.4816889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9314600291
MESH:D009436 Neural Tube Defects arsenic trioxide 6.7010525206
MESH:D009436 Neural Tube Defects sodium arsenite 6.7012854658
MESH:D009447 Neuroblastoma Doxorubicin 6.7815555623
MESH:D009447 Neuroblastoma Topotecan 6.7815176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3920387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.0917929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D009765 Obesity Dietary Fats 2.2118457598 17217161 16723640 21332399 19632207 20132043 18674790 20518802 11836018
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.9519495926
MESH:D012516 Osteosarcoma Doxorubicin 3.8815930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.5219769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms decitabine 10.5219331143 19259094
MESH:D010051 Ovarian Neoplasms Quercetin 10.5219005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.5215276417 17306315
MESH:D010146 Pain Acetaminophen 2.1616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 19.0815580305
MESH:D010190 Pancreatic Neoplasms decitabine 19.0819294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 19.0816540662
MESH:D010190 Pancreatic Neoplasms Etoposide 19.0819003803
MESH:D010190 Pancreatic Neoplasms Quercetin 19.0816965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 19.0815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4111578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.018330346 12065085 18922899 18404319
MESH:D010235 Paraganglioma arsenic trioxide 3.8919927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D010538 Peritonitis Ozone 3.8416369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8617983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8617638057
MESH:D011014 Pneumonia Ozone 4.1018007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.8912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.892563599
MESH:D011230 Precancerous Conditions Quercetin 13.8919056647
MESH:D011225 Pre-Eclampsia Zinc 3.9517114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5011399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.5018220299 19015723 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.4417616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6418220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.3819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3817292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.3815749863 18437689 16868541 15897917 16888761 16729912
MESH:D011471 Prostatic Neoplasms Etoposide 2.3817172428
MESH:D011471 Prostatic Neoplasms Quercetin 2.3817292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3816039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.3818760546
MESH:D011471 Prostatic Neoplasms Zinc 2.3812429649 16517595 16606632 16700911
MESH:D011472 Prostatitis vinclozolin 4.6418629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.0216919318 15861022
MESH:D011565 Psoriasis Cyclosporine 5.5516882103
MESH:D011565 Psoriasis Methotrexate 5.5517410198
MESH:D051437 Renal Insufficiency Doxorubicin 9.5317922066
MESH:D051437 Renal Insufficiency Methotrexate 9.5317352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012162 Retinal Degeneration Zinc 3.9116584753
MESH:D012208 Rhabdomyosarcoma decitabine 4.1319155313
MESH:D012509 Sarcoma Doxorubicin 3.7317203757 16767912 17710206 18313854 15675481 15625365
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 15.6916646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 15.6916326096 14601052
MESH:D012512 Sarcoma, Ewing's Etoposide 15.6914601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4917846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.2516862918
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.4319755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 16.4315692506
MESH:D012878 Skin Neoplasms sodium arsenite 16.4319524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.4316192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 16.438330346 11807781 18404319 8985016 12065085
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2817203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6416709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5712854658
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.4617007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.4620155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 4.4619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4618456281
MESH:D013576 Syndactyly Methotrexate 4.759562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.3119014326
MESH:D013964 Thyroid Neoplasms decitabine 15.3117967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.317505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.3116010429 17909728
MESH:D014062 Tongue Neoplasms Zinc 4.1416543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6715213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 18.3412973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.3417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 18.3419087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 18.3417653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 18.3416720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.3416452187 17306315 11723127 16712894
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5111813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0214692618
MESH:D014604 Uveal Neoplasms decitabine 4.6117785578
MESH:D014605 Uveitis Cyclosporine 3.681336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9317678736 17638931 17334414 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D015430 Weight Gain Dietary Fats 3.4916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29709
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00030 - Insulin recombinant Hypoglycemic Agents
    DB00071 - Insulin, porcine Hypoglycemic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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