AutismKB 2.0

Annotation Detail for NMNAT3


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Basic Information Top
Gene Symbol:NMNAT3 ( PNAT3 )
Gene Full Name: nicotinamide nucleotide adenylyltransferase 3
Band: 3q23
Quick LinksEntrez ID:349565; OMIM: 608702; Uniprot ID:NMNA3_HUMAN; ENSEMBL ID: ENSG00000163864; HGNC ID: 20989
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
NADSYN-PWYNAD biosynthesis II (from tryptophan)
NAD-BIOSYNTHESIS-IIINAD biosynthesis III
NAD-BIOSYNTHESIS-IINAD salvage pathway II
PWY-5653NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde
PWY3O-4106NAD salvage pathway III
PYRIDNUCSYN-PWYNAD biosynthesis I (from aspartate)
Pathway IDPathway Name
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of vitamins and cofactors
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1764Purpura, Thrombocytopenic, Idiopathic
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NMNAT3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NMNAT3 mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NMNAT3 mRNAaffects cotreatment|decreases expression 18164116
D020122 tert-Butylhydroperoxide NMNAT3 protein results in decreased susceptibility to tert-Butylhydroperoxidedecreases response to substance 18463239
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NMNAT3 mRNAaffects cotreatment|decreases expression 18164116
C415144 fenpyroximate NMNAT3 protein results in decreased susceptibility to fenpyroximatedecreases response to substance 18463239
D006861 Hydrogen Peroxide NMNAT3 protein results in decreased susceptibility to Hydrogen Peroxidedecreases response to substance 18463239
C428725 pyridaben NMNAT3 protein results in decreased susceptibility to pyridabendecreases response to substance 18463239
D012402 Rotenone NMNAT3 protein results in decreased susceptibility to Rotenonedecreases response to substance 18463239
D018038 Sodium Selenite Sodium Selenite results in decreased expression of NMNAT3 mRNAdecreases expression 18175754
D014750 Vincristine NMNAT3 protein results in decreased susceptibility to Vincristinedecreases response to substance 18463239
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Vincristine 3.7919825857
MESH:D000236 Adenoma beta-Naphthoflavone 7.1419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.1410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0917162532 19061943 19052882 17620307 16434500 18056438
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.633084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6316502159 20512989 17055752 19383236 19171122 19822196 16288022 16779866 10672840 20514400 18506893 16681979 18393292 20935162 17761372 18691550 20214788 20727157 17978847 19418558 16935385 18788625 19701751 17162532 17173139 16540662 19208518 17428255 16569478 18056438 19539802 19394651 20007298 18494052 3084413 16698587 17138121 16878318 20524982 18978308 19919837 20084675 19052882 10737359 16328049 21159647 18210153 20432363 19107877 18971187 20101231 19335982 18665156 16830150 16807293 11831363 19519916 18785209 3581430
MESH:D002292 Carcinoma, Renal Cell Vincristine 4.4116201981
MESH:D002294 Carcinoma, Squamous Cell Vincristine 3.866189445
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.6116936243
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.016135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.0117174075 7505956 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3019923254 19085960 17562736 16081117 19420014 16781746 19370779 11287661 16485898 15968718 11529661 16177239 15619225 19416960 16227642 11739529 12392966 14550746 12594235 11461765 11834606 19739265 11421492 11743745 12153990 12540782 19164858 12705907 16393943 14986274 17522070 10915739 2444490 18071297 10663392 17906064 12958197 14725611 10774834 16109766 18713872
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3019107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.3015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3221071580 20387270
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006689 Hodgkin Disease Vincristine 4.7217606976 16794504 16135485 15147373
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D007249 Inflammation Diethylnitrosamine 2.4418785209
MESH:D007333 Insulin Resistance Sodium Selenite 3.3614714311
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.4116518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0916705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8920032147 19638242 18522880 18407596 18665156
MESH:D008107 Liver Diseases Acetaminophen 4.0119014921 11587558 19460945 16611625 19784758 12587719 12969438 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.807678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.8021295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.8021071580 19254457 19850985 19690152 19090486 19426721 20501860 16942905 19996281 20452335 2422723 15175105 20492335 18648771 20118626 19812893 19255062 12112319 19642983 19499222 19551842 18644402 19256749 18977376 21167192 21278145 19294768 12771043 20583210 19427195 9163691 20101389 10737359 20137499 19073162 18754104 20434301 19638242 19833225 20405173 15885732 21047994 18978307 2862719
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.412876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.4118164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.4119539802 18544905 9362446 19126423 16267830 18164116 21159647 18079962 16842330 18775883 19519916 18253720 18282651 17174075 19009564 3124819 17854601 18093689 18308698 17942915 19004024 2563599
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.066695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Vincristine 3.066189445 19825857
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D018328 Melanoma, Amelanotic Vincristine 5.9815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009203 Myocardial Infarction Vincristine 4.1917284715
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009410 Nerve Degeneration Rotenone 3.9918619942 15790535 17356569
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D017599 Neuroectodermal Tumors Vincristine 5.9012837982
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D010212 Papilloma Hydrogen Peroxide 4.2612065085
MESH:D010300 Parkinson Disease Rotenone 3.0218619942 19114014 16412576 11535288 16140633 15451049 19232380 11445065 18191903
MESH:D020734 Parkinsonian Disorders Rotenone 4.2115927086 18197244 15795934 15574749
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 4.6921297632
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3718760546
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 6.1712065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.178532709
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D015173 Supratentorial Neoplasms Vincristine 6.0712837982
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3316049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:11193 Metabolism of vitamins and cofactors
KEGG:00760 Nicotinate and nicotinamide metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134952303
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    Releated drug ID Related drug Name
    PA448055l-alanine
    PA10090l-glutamine
    PA10323l-tryptophan
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB02596 - Alpha,Beta-Methyleneadenosine-5'-Triphosphate Antineoplastic Agents
    DB03227 - Nicotinamide Mononucleotide
    DB04099 - Deamido-Nad+
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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